Cited by 921Aquaculture disease management and microbiotaAquaculture Nutrition and GrowthAnimal Nutrition and Physiology

Beneficial roles of feed additives as immunostimulants in aquaculture: a review

Open access
Dawood, Mahmoud A.O., Koshio, Shunsuke, Esteban, Maria Ángeles·2018·Reviews in Aquaculture

Abstract

Abstract The use of antibiotics in the aquafeeds to mitigate infectious diseases or to boost growth performance is commonly practiced. Recently, the prophylactic use of antibiotics and chemotherapies have been criticized which eventually led to their ban in aquaculture by law on many countries. In view of the current restrictions on antibiotic use, there is a critical need to evaluate other possible alternatives. One potential substitute for antibiotics in aquafeeds is the use of functional feed additives. The present review is a comprehensive and an updated compilation of the available works on different feed additives, their examples, modes of action and useful applications for improving aquafeeds. It highlights several functional feed additives including probiotics, prebiotics, synbiotics, immunostimulants, organic acids, nucleotides and medicinal herbs. Apart from boosting aquafeeds and safeguarding general health of aquatic animals, some of these substances have been found to possess beneficial immunostimulant and anti‐stress relieving properties. Furthermore, the use of these natural substances increases the consumer confidence of farmed fish. Due care has been taken to cover the on‐going trends and recent advances with a perspective vision and their holistic usages and beneficial applications in aquatic animals’ systems. The current study also shed light regarding the management and production aspects of aquatic animals which will enlighten farmers and producers for better economic growth.

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Registry

Crossref · 10.1111/raq.12209

Cites

311 of 311 references verified0 citation errors · 0 not checkable

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  • Feeding of cell wall compounds like glucans, peptidoglycans, lipopolysaccharides, fucoidan, chitin, and whole algae can enhance the immune system in aquatic species.

    “Feeding of cell wall compounds like glucans, peptidoglycans, lipopolysaccharides, fucoidan, chitin, and whole algae can enhance the immune system in aquatic species (Dawood et al., 2018).”

    From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Dawood et al., 2018

  • Lutein pigment is used as a feed additive mainly for yellow/red colour.

    “Lutein pigment is also used as a feed additive mainly for yellow/red colour (Dawood et al., 2018).”

    From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Dawood et al., 2018

  • Microalgae that contain a high amount of lutein are Chlorella and Scenedesmus species.

    “Microalgae that contain a high amount of lutein are Chlorella and Scenedesmus species (Dawood et al., 2018).”

    From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Dawood et al., 2018

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Authors
Dawood, M. A. O., Koshio, S., & Esteban, M. Á.
Affiliations
  • Kagoshima University (JP)
  • Kafrelsheikh University (EG)
  • Fish Innate Immune System Group Department of Cell Biology and Histology Faculty of Biology Regional Campus of International Excellence “Campus Mare Nostrum” University of Murcia Murcia Spain
Corresponding author
Dawood, Mahmoud A.O.
Venue
Reviews in Aquaculture
Publisher
Wiley
Published
2017-08-18
Volume
10
Issue
4
Pages
950-974
ISSN
  • 1753-5123 (ISSN-L)
  • 1753-5131
OpenAlex
W2748223054
Cited by
921
References
311
Citations by year
2026: 117 · 2025: 105 · 2024: 132 · 2023: 127 · 2022: 118 · 2021: 119 · 2020: 113 · 2019: 72 · 2018: 11 · 2017: 5
FWCI
24.88
Type
journal article
Language
en
Open access
Locations
  • Reviews in Aquaculture (publishedVersion)
  • Hispana (publishedVersion, cc-by-nc-nd)
Funders
  • European Regional Development Fund (AGL2014‐51839‐C5‐1‐R)
  • Federación Española de Enfermedades Raras
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
feed additives, immunostimulants, aquaculture feed, antibiotic alternatives, probiotics, prebiotics, synbiotics, organic acids, nucleotides, medicinal plants, anti-stress effects, fish health, aquaculture disease control, growth performance

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