Platelet Factor 4 Limits Th17 Differentiation and Ischaemia–Reperfusion Injury After Liver Transplantation in Mice
Open accessAbstract
Liver ischaemia/reperfusion injury (IRI) is a serious pathologic process encountered in a number of clinical syndromes including liver transplantation, liver resection, trauma and haemorrhagic shock. Platelet factor 4 (PF 4) was the first discovered CXC chemokine and is found in platelet granules at very high concentration. In this study, we provide strong evidence that PF 4 is involved directly in liver innate immune response against IRI by regulating Th17 differentiation. PF 4 deficiency aggravates liver IRI, as shown by higher serum alanine aminotransferase (ALT) levels and Suzuki scores. PF 4 deficiency promotes Th17 response with higher levels of IL‐23, IL‐6 and IL‐17, which aggravates liver IRI. Furthermore, PF 4 deficiency limits suppressor of cytokine signalling 3 (SOCS 3) expressions, and PF 4 fails to suppress expression of IL‐17 in cells transfected with SOCS 3 Si RNA. In conclusion, PF 4 limits liver IRI through IL‐17 inhibition via upregulation of SOCS 3.
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PF4 expression is reduced in humans and mice with acute liver injury and inhibits ischemia-reperfusion injury in liver transplantation mouse models.
“PF4 expression is reduced in humans and mice with acute liver injury and inhibits ischemia-reperfusion injury in LT mouse models (43, 44).”
From The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells (2022) · cites this paper as [43]
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- John Wiley & Sons Ltd H. Guo et al. PF4 Limits Th17 Differentiation 133 .................................................................................................................................................................. 13653083, 2015, 2, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/sji.12257, Wiley Online Library on [18/08/2026]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License
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- Authors
- Guo, H., Wang, Y., Zhao, Z., & Shao, X.
- Affiliations
- Qiqihar Medical University (CN)
- Guilin Medical University (CN)
- Chinese People's Liberation Army (CN)
- Corresponding author
- Guo, H.
- ORCID
- Guo, H.
- Venue
- Scandinavian Journal of Immunology
- Publisher
- Wiley
- Published
- 2015-01-20
- Volume
- 81
- Issue
- 2
- Pages
- 129-134
- ISSN
- 0300-9475 (ISSN-L)
- 1365-3083
- OpenAlex
- W2013290749
- Cited by
- 9
- References
- 36
- Citations by year
- 2025: 1 · 2022: 3 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 1
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Scandinavian Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- platelet factor 4, liver ischaemia-reperfusion injury, liver transplantation, Th17 cell differentiation, IL-17, SOCS3, innate immunity, IL-23, interleukin-6, CXC chemokines, platelet granules
- MeSH terms
- Suppressor of Cytokine Signaling 3 Protein, Animals, Cell Differentiation, Cells, Cultured, Liver, Male, Mice, Inbred C57BL, Platelet Factor 4, Blotting, Western, Reperfusion Injury, Interleukin-6, Liver Transplantation, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-17, RNA Interference, Suppressor of Cytokine Signaling Proteins, Interleukin-23, Th17 Cells
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