STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

The hallmarks of cancer

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Structure and function of a new STAT-induced STAT inhibitor

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A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors.

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Twenty proteins containing a C-terminal SOCS box form five structural classes

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The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

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Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors

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A central role for Stat3 in IL‐6‐induced regulation of growth and differentiation in M1 leukemia cells.

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CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

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Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL‐6 signal transduction

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Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits <i>Janus</i> tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain

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The Suppressor of Cytokine Signaling (SOCS) 1 and SOCS3 but Not SOCS2 Proteins Inhibit Interferon-mediated Antiviral and Antiproliferative Activities

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Growth Hormone Preferentially Induces the Rapid, Transient Expression of SOCS-3, a Novel Inhibitor of Cytokine Receptor Signaling

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SOCS-3 Is Tyrosine Phosphorylated in Response to Interleukin-2 and Suppresses STAT5 Phosphorylation and Lymphocyte Proliferation

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Autoregulation of pituitary corticotroph SOCS-3 expression: Characterization of the murine SOCS-3 promoter

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Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice

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Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma.

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Negative regulators of cytokine signal transduction

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Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

Nielsen, M., Kaltoft, K., Nordahl, M., Röpke, C., Geisler, C., Mustelin, T., Dobson, P., Svejgaard, A., & Ødum, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6764 · Cited by 220 · see citing works

Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.

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Lipopolysaccharide Induces in Macrophages the Synthesis of the Suppressor of Cytokine Signaling 3 and Suppresses Signal Transduction in Response to the Activating Factor IFN-γ

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Cutting Edge: SOCS-1 Is a Potent Inhibitor of IL-4 Signal Transduction

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A Janus Kinase Inhibitor, JAB, Is an Interferon-γ–Inducible Gene and Confers Resistance to Interferons

Sakamoto, H., Yasukawa, H., Masuhara, M., Tanimura, S., Sasaki, A. T., Yuge, K., Ohtsubo, M., Ohtsuka, A., Fujita, T., Ohta, T., et al. (1998) · Blood · doi:10.1182/blood.v92.5.1668.417k09_1668_1676 · Cited by 177 · see citing works

Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression.

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Direct Association of STAT3 with the IFNAR-1 Chain of the Human Type I Interferon Receptor

Yang, C., Shi, W., Basu, L., Murti, A., Constantinescu, S. N., Blatt, L. M., Croze, E., Mullersman, J. E., & Pfeffer, L. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8057 · Cited by 135 · see citing works

Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3

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Establishment of two continuous T-cell strains from a single plaque of a patient with mycosis fungoides

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A continuous T-cell line from a patient with S�zary syndrome

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STAT Signaling in the Pathogenesis and Treatment of Cancer

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CIS Associates with the Interleukin-2 Receptor β Chain and Inhibits Interleukin-2-dependent Signaling

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The role of STATs in proliferation, differentiation, and apoptosis

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Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides : tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

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Cytogenetic Findings in Cell Lines from Cutaneous T-Cell Lymphoma

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Evidence for Translational Repression of the SOCS-1 Major Open Reading Frame by an Upstream Open Reading Frame

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Expression of multi-cytokine resistance and multi-growth factor independence in advanced stage metastatic cancer. Malignant melanoma as a paradigm.

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Superantigens Are Presented by and Activate Thymocytes from Infants

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The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response.

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Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

Chen, Z. J., Laurence, A. D. J., Kanno, Y., Pacher-Zavisin, M. C., Zhu, B., Tato, C. M., Yoshimura, A., Hennighausen, L. G., & O’Shea, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600666103 · Cited by 648 · see citing works

SOCS regulation of the JAK/STAT signalling pathway

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Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation

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The Pathogenesis of Mycosis Fungoides

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Mycosis Fungoides

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STAT3 as a therapeutic target in head and neck cancer

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Differential hypermethylation of SOCS genes in ovarian and breast carcinomas

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Constitutive STAT3 Activation in Intestinal T Cells from Patients with Crohn's Disease

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Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma

Amin, H. M., McDonnell, T. J., Ma, Y., Lin, Q. D., Fujio, Y., Kunisada, K., Leventaki, V., Das, P., Rassidakis, G. Z., Cutler, C. S., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1207703 · Cited by 171 · see citing works

SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer

Sobah, M. L., Liongue, C., & Ward, A. C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.727987 · Cited by 171 · see citing works

Aberrant Expression of the Tyrosine Kinase Receptor EphA4 and the Transcription Factor Twist in Sezary Syndrome Identified by Gene Expression Analysis

van Doorn, R., Dijkman, R., Vermeer, M. H., Out‐Luiting, J. J., van der Raaij-Helmer, E. M. H., Willemze, R., & Tensen, C. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1253 · Cited by 163 · see citing works

Molecular cytogenetic analysis of cutaneous T-cell lymphomas: identification of common genetic alterations in Sezary syndrome and mycosis fungoides

Mao, X., Lillington, D. M., Scarisbrick, J. J., Mitchell, T. J., Czepulkowski, B. H., Russell‐Jones, R., Young, B. D., & Whittaker, S. J. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04966.x · Cited by 164 · see citing works

Signal transducer and activator of transcription (STAT) signalling and T‐cell lymphomas

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Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

Lee, J. H., Kim, C., Sethi, G., & Ahn, K. S. (2015) · Oncotarget · doi:10.18632/oncotarget.3443 · Cited by 162 · see citing works

In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3

Sommer, V. H., Clemmensen, O. J., Nielsen, O., Wasik, M. A., Lovato, P., Brender, C., Eriksen, K., Woetmann, A., Kæstel, C. G., Nissen, M. H., et al. (2004) · Leukemia · doi:10.1038/sj.leu.2403385 · Cited by 162 · see citing works

Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma

Lindahl, L. M., Willerslev-Olsen, A., Gjerdrum, L. M. R., Nielsen, P. R., Blümel, E. P., Rittig, A. H., Celis, P., Herpers, B. L., Becker, J. C., Stausbøl‐Grøn, B., et al. (2019) · Blood · doi:10.1182/blood.2018888107 · Cited by 142 · see citing works

SOCS-1 and SOCS-3 inhibit IFN-α-induced expression of the antiviral proteins 2,5-OAS and MxA

Vlotides, G., Sörensen, A. S., Kopp, F. B., Zitzmann, K., Cengic, N., Brand, S., Zachoval, R., & Auernhammer, C. J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.051 · Cited by 128 · see citing works

Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma

Willerslev-Olsen, A., Krejsgaard, T., Lindahl, L. M., Litvinov, I. V., Fredholm, S., Petersen, D. L., Nastasi, C., Gniadecki, R., Mongan, N. P., Sasseville, D., et al. (2016) · Blood · doi:10.1182/blood-2015-08-662353 · Cited by 115 · see citing works

Interleukin-7 and interleukin-15 regulate the expression of thebcl-2 and c-myb genes in cutaneous T-cell lymphoma cells

Qin, J., Zhang, C., Kamarashev, J. A., Dummer, R., Burg, G., & Döbbeling, U. (2001) · Blood · doi:10.1182/blood.v98.9.2778 · Cited by 114 · see citing works

Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome

Krejsgaard, T., Ødum, N., Geisler, C., Wasik, M. A., & Woetmann, A. (2011) · Leukemia · doi:10.1038/leu.2011.237 · Cited by 113 · see citing works

Reciprocal Regulation of SOCS 1 and SOCS3 Enhances Resistance to Ionizing Radiation in Glioblastoma Multiforme

Zhou, H., Miki, R., Eeva, M., Fike, F. M., Seligson, D. B., Yang, L., Yoshimura, A., Teitell, M. A., Jamieson, C. A. M., & Cacalano, N. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2303 · Cited by 110 · see citing works

Molecular cytogenetic characterization of Sézary syndrome

Mao, X., Lillington, D. M., Czepulkowski, B. H., Russell‐Jones, R., Young, B. D., & Whittaker, S. J. (2003) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10152 · Cited by 100 · see citing works

Lack of Suppressive CD4+CD25+FOXP3+ T Cells in Advanced Stages of Primary Cutaneous T-Cell Lymphoma

Tiemessen, M. M., Mitchell, T. J., Hendry, L., Whittaker, S. J., Taams, L. S., & John, S. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700371 · Cited by 99 · see citing works

Constitutive expression of SOCS3 confers resistance to IFN-α in chronic myelogenous leukemia cells

Sakai, I., Takeuchi, K., Yamauchi, H., Narumi, H., & Fujita, S. (2002) · Blood · doi:10.1182/blood-2002-01-0073 · Cited by 97 · see citing works

Bacterial Toxins Fuel Disease Progression in Cutaneous T-Cell Lymphoma

Willerslev-Olsen, A., Krejsgaard, T., Lindahl, L. M., Bonefeld, C. M., Wasik, M. A., Koralov, S. B., Geisler, C., Kilian, M., Iversen, L., Woetmann, A., et al. (2013) · Toxins · doi:10.3390/toxins5081402 · Cited by 92 · see citing works

STAT3 Polymorphism Predicts Interferon-Alfa Response in Patients With Metastatic Renal Cell Carcinoma

Ito, N., Eto, M., Nakamura, E., Takahashi, A., Tsukamoto, T., Toma, H., Nakazawa, H., Hirao, Y., Uemura, H., Kagawa, S., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.8897 · Cited by 91 · see citing works

Malignant Tregs express low molecular splice forms of FOXP3 in Sézary syndrome

Krejsgaard, T., Gjerdrum, L. M. R., Ralfkiaer, E. M., Lauenborg, B. T., Eriksen, K., Mathiesen, A.-M., Bovin, L. F., Gniadecki, R., Geisler, C., Ryder, L. P., et al. (2008) · Leukemia · doi:10.1038/leu.2008.224 · Cited by 87 · see citing works

Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma

Sibbesen, N. A., Kopp, K., Litvinov, I. V., Jønson, L., Willerslev-Olsen, A., Fredholm, S., Petersen, D. L., Nastasi, C., Krejsgaard, T., Lindahl, L. M., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4111 · Cited by 86 · see citing works

Increased Expression of CTLA-4 in Malignant T Cells from Patients with Mycosis Fungoides – Cutaneous T-Cell Lymphoma

Wong, H. K., Wilson, A. J., Gibson, H. M., Hafner, M. S., Hedgcock, C. J., Berger, C. L., Edelson, R. L., & Lim, H. W. (2005) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700029 · Cited by 82 · see citing works

Suppressor of cytokine signalling gene expression is elevated in breast carcinoma

Raccurt, M., Tam, S. P., Lau, P., Mertani, H. C., Lambert, A., García‐Caballero, T., Li, H., Brown, R. J. P., McGuckin, M. A., Morel, G., et al. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601115 · Cited by 84 · see citing works

The emerging roles of GPRC5A in diseases

Zhou, H., & Rigoutsos, I. (2014) · Oncoscience · doi:10.18632/oncoscience.104 · Cited by 82 · see citing works

Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNα

Brender, C., Lovato, P., Sommer, V. H., Woetmann, A., Mathiesen, A.-M., Geisler, C., Wasik, M. A., & Ødum, N. (2004) · Leukemia · doi:10.1038/sj.leu.2403610 · Cited by 78 · see citing works

Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways

Patil, K., Kuttikrishnan, S., Khan, A. Q., Ahmad, F., Alam, M. A., Buddenkotte, J., Ahmad, A., Steinhoff, M. S., & Shahab Uddin, M. S. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.12.003 · Cited by 72 · see citing works

Constitutive and Interleukin-7- and Interleukin-15-Stimulated DNA Binding of STAT and Novel Factors in Cutaneous T Cell Lymphoma Cells

Qin, J., Kamarashev, J. A., Zhang, C.-L., Dummer, R., Burg, G., & Döbbeling, U. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01436.x · Cited by 71 · see citing works

SOCS3 is an endogenous inhibitor of pathologic angiogenesis

Stahl, A., Joyal, J., Chen, J., Sapieha, P. S., Juan, A. M., Hatton, C. J., Pei, D. T., Hurst, C. G., Seaward, M. R., Krah, N. M., et al. (2012) · Blood · doi:10.1182/blood-2012-04-422527 · Cited by 70 · see citing works

Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes

Barton, B. E. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.4.737 · Cited by 69 · see citing works

Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

Nielsen, M., Nissen, M. H., Gerwien, J. G., Zocca, M.-B., Rasmussen, H. M., Nakajima, K., Röpke, C., Geisler, C., Kaltoft, K., & Ødum, N. (2002) · Blood · doi:10.1182/blood.v99.3.973 · Cited by 67 · see citing works

Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication

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Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients

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IFN-α-Induced Signal Transduction, Gene Expression, and Antitumor Activity of Immune Effector Cells Are Negatively Regulated by Suppressor of Cytokine Signaling Proteins

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Effects of Cardiotrophin on Adipocytes

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IL-6/STAT3 Plays a Regulatory Role in the Interaction Between Pancreatic Stellate Cells and Cancer Cells

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The Role of Suppressors of Cytokine Signalling in Human Neoplasms

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Constitutive Suppressor of Cytokine Signaling 3 Expression Confers a Growth Advantage to a Human Melanoma Cell Line

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Current Status of HDAC Inhibitors in Cutaneous T-cell Lymphoma

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STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides

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Sle1ab Mediates the Aberrant Activation of STAT3 and Ras-ERK Signaling Pathways in B Lymphocytes

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t(8;9)(p22;p24)/PCM1-JAK2 Activates SOCS2 and SOCS3 via STAT5

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MicroRNAs in the Pathogenesis, Diagnosis, Prognosis and Targeted Treatment of Cutaneous T-Cell Lymphomas

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STAT3 Dysregulation in Mature T and NK Cell Lymphomas

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Type 1 Diabetes in STAT Protein Family Mutations: Regulating the Th17/Treg Equilibrium and Beyond

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Interferon-Alpha Induces Transient Suppressors of Cytokine Signalling Expression in Human T Cells

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Loss of Expression and Function of SOCS3 Is an Early Event in HNSCC: Altered Subcellular Localization as a Possible Mechanism Involved in Proliferation, Migration and Invasion

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Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma

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Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma

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Increased Twist expression in advanced stage of mycosis fungoides and Sézary syndrome

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SOCS3 was induced by hypoxia and suppressed STAT3 phosphorylation in pulmonary arterial smooth muscle cells

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Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1

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Protein Phosphatase 2A (PP2A) Regulates Interleukin-4-mediated STAT6 Signaling

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Pharmacologic rationale for early G-CSF prophylaxis in cancer patients and role of pharmacogenetics in treatment optimization

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Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis

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Psoralen plus ultraviolet A ± interferon-α treatment resistance in mycosis fungoides: the role of tumour microenvironment, nuclear transcription factor-κB and T-cell receptor pathways

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Immunohistochemical Analysis of IL-6, IL-8/CXCR2 Axis, Tyrp -STAT-3, and SOCS-3 in Lymph Nodes from Patients with Chronic Lymphocytic Leukemia: Correlation between Microvascular Characteristics and Prognostic Significance

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Transcriptional Activation of the Suppressor of Cytokine Signaling-3 (SOCS-3) Gene via STAT3 Is Increased in F9 REX1 (ZFP-42) Knockout Teratocarcinoma Stem Cells Relative to Wild-type Cells

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Bcl-2 Overexpression Leads to Increases in Suppressor of Cytokine Signaling-3 Expression in B Cells and De novo Follicular Lymphoma

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SHP-1 expression in peripheral T cells from patients with Sezary syndrome and in the T cell line HUT-78: implications in JAK3-mediated signaling

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Clinical significance of mucosal suppressors of cytokine signaling 3 expression in ulcerative colitis

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KIR3DL2/CpG ODN Interaction Mediates Sézary Syndrome Malignant T Cell Apoptosis

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STAT3 signaling pathway is involved in decitabine induced biological phenotype regulation of acute myeloid leukemia cells.

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Cross-Inhibition of Interferon-Induced Signals by GM-CSF Through a Block in Stat1 Activation

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Tyrosine-phosphorylated SOCS3 Interacts with the Nck and Crk-L Adapter Proteins and Regulates Nck Activation

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Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia

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Reduced liver injury in the interleukin‐6 knockout mice by chronic carbon tetrachloride administration

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Silencing SOCS3 could inhibit TNF-α induced apoptosis in 3T3-L1 and mouse preadipocytes

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Heme oxygenase‐1 alleviates eosinophilic inflammation by inhibiting STAT3‐SOCS3 signaling

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Sezary Syndrome Cells Unlike Normal Circulating T Lymphocytes Fail to Migrate Following Engagement of NT1 Receptor

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Expression of Interleukin-8 Receptor CXCR2 and Suppressor of Cytokine Signaling-3 in Astrocytic Tumors

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Induction of SOCS-3 is insufficient to confer IRS-1 protein degradation in 3T3-L1 adipocytes

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SHP2 REGULATES IL-2 INDUCED MAPK ACTIVATION, BUT NOT Stat3 OR Stat5 TYROSINE PHOSPHORYLATION, IN CUTANEOUS T CELL LYMPHOMA CELLS

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Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy

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IFN-α-2b–Induced Signal Transduction and Gene Regulation in Patient Peripheral Blood Mononuclear Cells Is Not Enhanced by a Dose Increase from 5 to 10 Megaunits/m2

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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function

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Hematopathology in Oncology

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Cutaneous T-Cell Lymphomas: A Review of New Discoveries and Treatments

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Platelet Factor 4 Limits Th17 Differentiation and Ischaemia–Reperfusion Injury After Liver Transplantation in Mice

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Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells

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LncRNA PPM1A-AS Regulate Tumor Development Through Multiple Signal Pathways in T-Cell Acute Lymphoblastic Leukemia

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Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNα

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In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3

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Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

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O18 Molecular crosstalk between PLCγ1 and STAT3 in cutaneous T-cell lymphoma

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The Suppressor of Cytokine Signaling-3 Gene Is Overexpressed in Human De Novo Follicular Lymphomas and Promotes IL-3-Independent Proliferation of the BaF3 Pro-B Cell Line.

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