Cited by 115Osteoarthritis Treatment and MechanismsProteoglycans and glycosaminoglycans researchHip disorders and treatments

Physical activity ameliorates cartilage degeneration in a rat model of aging: a study on lubricin expression

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Musumeci, G., Castrogiovanni, P., Trovato, F. M., Imbesi, R., Giunta, S., Szychlinska, M. A., Loreto, C., Castorina, S. +1 more·2015·Scandinavian Journal of Medicine & Science in Sports

Abstract

Osteoarthritis (OA) is a common musculoskeletal disorder characterized by slow progression and joint tissue degeneration. Aging is one of the most prominent risk factors for the development and progression of OA. OA is not, however, an inevitable consequence of aging and age-related changes in the joint can be distinguished from those that are the result of joint injury or inflammatory disease. The question that remains is whether OA can be prevented by undertaking regular physical activity. Would moderate physical activity in the elderly cartilage (and lubricin expression) comparable to a sedentary healthy adult? In this study we used physical exercise in healthy young, adult, and aged rats to evaluate the expression of lubricin as a novel biomarker of chondrocyte senescence. Immunohistochemistry and western blotting were used to evaluate the expression of lubricin in articular cartilage, while enzyme-linked immunosorbent assay was used to quantify lubricin in synovial fluid. Morphological evaluation was done by histology to monitor possible tissue alterations. Our data suggest that moderate physical activity and normal mechanical joint loading in elderly rats improve tribology and lubricative properties of articular cartilage, promoting lubricin synthesis and its elevation in synovial fluid, thus preventing cartilage degradation compared with unexercised adult rats.

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  • Physical activity intervention in rats ameliorates the deleterious effects of chondrocyte senescence and ageing, indicating that cartilage degeneration responds to environmental signals.

    “Physical activity intervention in rats ameliorates the deleterious effects of chondrocyte senescence and ageing [15], indicating that cartilage degeneration responds to environmental signals.”

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Authors
Musumeci, G., Castrogiovanni, P., Trovato, F. M., Imbesi, R., Giunta, S., Szychlinska, M. A., Loreto, C., Castorina, S., & Mobasheri, A.
Affiliations
  • University of Catania (IT)
  • University of Nottingham (GB)
Corresponding author
Musumeci, G.
Venue
Scandinavian Journal of Medicine & Science in Sports
Publisher
Wiley
Published
2014-07-09
Volume
25
Issue
2
Pages
e222-30
ISSN
  • 0905-7188 (ISSN-L)
  • 1600-0838
OpenAlex
W2125680519
Cited by
115
References
35
Citations by year
2025: 3 · 2024: 2 · 2023: 14 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 28 · 2018: 12 · 2017: 15 · 2016: 12 · 2015: 10 · 2014: 2
FWCI
10.79
Type
journal article
Language
en
Open access
Locations
  • Scandinavian Journal of Medicine and Science in Sports (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
  • Open Research (University of Surrey) (submittedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Health Sciences › Medicine › Surgery › Hip disorders and treatments
Keywords
osteoarthritis, physical activity, aging, lubricin, articular cartilage degeneration, chondrocyte senescence, synovial fluid, cartilage lubrication, biomarkers, rat model
MeSH terms
Proteoglycan 4, Aging, Animals, Cartilage, Articular, Glycoproteins, Immunohistochemistry, Male, Motor Activity, Synovial Fluid, Blotting, Western, Biomarkers, Rats, Wistar, Chondrocytes, Rats

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