Prevention strategies for vasovagal reaction in whole blood donors: A Quadri-armed randomised control trial
Open accessAbstract
Introduction: Vasovagal reaction (VVR) is a frequently encountered generalised donor adverse reaction, associated with donor deterrence towards future donation. Several mitigation strategies for prevention of VVR were tried but still not standardised. This quadri‐armed randomised study evaluated the utility of water ingestion, applied muscle tension (AMT) and combination of both in preventing the VVR among blood donors. Methods: A quadri‐armed randomised controlled trial was performed on 4320 whole blood donors. Blood donors of 18–65 years of age were randomised into four groups based on the interventions performed i.e., control with no intervention (Group 1, n = 1081), water ingestion (Group 2, n = 1082), AMT (Group 3, n = 1070) and combined intervention (Group 4, n = 1087). VVR during and immediately after blood donation were observed along with assessment of risk factors in blood donors and the effectiveness of interventions were analysed. Results: The incidence of VVR observed 1.6% in our study, with the highest occurrence in the control group (2.5%) and the lowest in the combined intervention group (0.9%). Multivariable logistic regression revealed that the control group donors faced a 1.38‐fold greater risk of VVR compared to those receiving interventions (OR: 1.38, 95% CI: 1.10–1.75). Other risk factors included younger age (OR: 1.5, 95% CI: 1.05–2.17), first‐time donation (OR: 5.7, 95% CI: 1.66–5.74), prior history of VVR (OR: 2.5, 95% CI: 10.4–101.52). Discussion/Conclusion: The combined approach of water ingestion and AMT proved significantly more effective in VVR prevention compared to individual interventions.
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Solanki, A., Singh, A., Sonker, A., & Agarwal, P. (2026) · Asian Journal of Transfusion Science · doi:10.4103/ajts.ajts_101_25
“[18,19] This comprehensive and large‑scale study of 5003 blood donors provides crucial insights into the predictors of adverse reactions in northern India, a region where replacement donations are the most common form and healthcare resources are often limited.”
- Authors
- Meher, R., Patidar, G. K., Chaurasia, R., Pandey, H. C., & Hazarika, A.
- Affiliations
- All India Institute of Medical Sciences (IN)
- Corresponding author
- Patidar, Gopal Kumar
- Venue
- Transfusion Medicine
- Publisher
- Wiley
- Published
- 2024-01-02
- Volume
- 34
- Issue
- 1
- Pages
- 20-29
- ISSN
- 0958-7578 (ISSN-L)
- 1365-3148
- OpenAlex
- W4390508138
- Semantic Scholar
- 8b4bd147c92d9813b5ffe1c9735161fba1244dde
- Cited by
- 10
- References
- 29
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 1
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Transfusion Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Business, Management and Accounting › Management of Technology and Innovation › Blood donation and transfusion practices
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Keywords
- vasovagal reaction, whole blood donors, prevention, water intake, combined intervention, risk factors
- MeSH terms
- Strobilurins, Blood Donors, Humans, Pyrimidines, Risk Factors, Water, Syncope, Vasovagal
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