Loss of CDKC ; 2 increases both cell division and drought tolerance in Arabidopsis thaliana
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Summary: Drought stress is one of the abiotic stresses that limit plant growth and agricultural productivity. To further understand the mechanism of drought tolerance and identify the genes involved in this process, a genetic screen for altered drought response was conducted in Arabidopsis. One mutant with enhanced drought tolerance was isolated and named Arabidopsis drought tolerance mutant 1 ( atdtm1 ), which has larger lateral organs, prolonged growth duration, increased relative water content and a reduced leaf stomatal density compared with the wild type. The loss of At DTM 1 increases cell division during leaf development. The phenotype is caused by the loss of a T‐ DNA tagged gene encoding CYCLIN ‐ DEPENDENT KINASE C;2 ( CDKC ;2), which functions in the regulation of transcription by influencing the phosphorylation status of RNA polymerase II (Pol II ). Here, we show that CDKC ;2 affects the transcription of downstream genes such as cell cycle genes and genes involved in stomatal development, resulting in altered plant organ size as well as drought tolerance of the plant. These results reveal the crucial role of CDKC ;2 in modulating both cell division and the drought response in Arabidopsis.
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Zhao et al. showed that CDK;2 increases both cell division and drought tolerance in Arabidopsis through the regulations of cycle genes and those involved in stomatal development.
“In recent studies, Zhao et al. [24] showed that CDK;2 increases both cell division and drought tolerance in Arabidopsis through the regulations of cycle genes and those involved in stomatal development.”
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Magwanga, R. O., Lu, P., Kirungu, J. N., Cai, X., Zhou, Z., Wang, X., Diouf, L., Xu, Y., Hou, Y., Hu, Y., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092625 · Cited by 88 · see citing works
- Authors
- Zhao, L., Li, Y., Xie, Q., & Wu, Y.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Xie, Qi
- Wu, Yaorong
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2017-07-13
- Volume
- 91
- Issue
- 5
- Pages
- 816-828
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W2626705723
- Cited by
- 50
- References
- 69
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 7 · 2023: 13 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 1
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Plant Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (NSFC 31270301)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Physical Sciences › Environmental Science › Global and Planetary Change › Plant Water Relations and Carbon Dynamics
- Keywords
- drought tolerance, cell division, stomatal development, leaf development, RNA polymerase II phosphorylation, transcriptional regulation, abiotic stress response, Arabidopsis thaliana, mutant screen
- MeSH terms
- Adaptation, Physiological, Cell Division, Models, Biological, Phenotype, Stress, Physiological, Mutagenesis, Insertional, Arabidopsis, Gene Expression Regulation, Plant, Cyclin-Dependent Kinases, Arabidopsis Proteins, Plants, Genetically Modified, Plant Stomata, Droughts
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