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Effect of Caffeine Co‐Ingested with Carbohydrate or Fat on Metabolism and Performance in Endurance‐Trained Men

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Jacobson, Talia L., Febbraio, Mark A., Arkinstall, Melissa J., Hawley, John A.·2001·Experimental Physiology
DOI 10.1113/eph8602072
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Abstract

We examined the effect of caffeine co‐ingested with either carbohydrate or fat on metabolism and performance in eight endurance‐trained subjects who performed a random order of four experimental trials consisting of 120 min of steady‐state ergometer cycling at 70% of maximal O 2 uptake (SS) followed by a time trial in which subjects completed a set amount of work (7 kJ kg−1) as quickly as possible. One hour before SS subjects ingested either 2.6 g kg−1 carbohydrate (CHO); 2.6 g kg−1 CHO + 6 mg kg−1 caffeine (CHO + CAF); 1.2 g kg−1 fat with 2000 U I.V. heparin (FAT); or 1.2 g kg−1 fat with 2000 U I.V. heparin + 6 mg kg−1 caffeine (FAT + CAF). The rate of carbohydrate oxidation was higher (μmol kg−1 min−1: CHO, 243 ± 39 and CHO + CAF, 239 ± 30 vs. FAT, 196 ± 48 and FAT + CAF, 191 ± 55; P < 0.05, values are means ± S.D.) and the rate of fat oxidation lower (μmol kg−1 min−1: CHO, 19 ± 8 and CHO + CAF, 22 ± 7 vs. FAT, 35 ± 19 and FAT + CAF, 37 ± 17; P < 0.05) with carbohydrate than fat ingestion. Yet despite lower carbohydrate use with fat feeding, the time taken to complete the time trial was less after carbohydrate than after fat ingestion (min: CHO, 30.37 ± 7.42 and CHO + CAF, 29.12 ± 5.62 vs. FAT, 33.02 ± 8.50 and FAT + CAF, 32.78 ± 7.70; P < 0.05). We conclude that (1) caffeine co‐ingested with either carbohydrate or fat meals has no additive effect on substrate utilization or exercise performance and (2) carbohydrate ingestion before exercise improves subsequent time trial performance compared with fat ingestion.

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  • The study's results are in contrast to a number of studies that have reported no effect of caffeine administration on exercise heart rate.

    “Our results are in contrast to a number of studies that have reported no effect of caffeine administration on exercise heart rate [ 13 - 28 ].”

    From Low doses of caffeine reduce heart rate during submaximal cycle ergometry (2007) · cites this paper as [21]

    The discussion accompanying Figure 4 (p. 7) reports that caffeine elevated exercise heart rate in this study. It also says there is general agreement that caffeine increases exercise heart rate, contrary to attributing a no-effect finding to this paper. (LLM, conf=0.90)

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  1. Angus, D. J., Hargreaves, M., Dancey, J. &amp; Febbraio, M. A. (2000 ). Effect of carbohydrate or carbohydrate plus medium-chain triglyceride ingestion on cycling time trial performance. Journal of Applied Physiology 88 , 113-119.
  2. Borg, G. (1975 ). Simple rating method for estimation of perceived exertion. In Physical Work and Effort, ed. Borg, G., pp. 39-46. Pergamon, New York.
  3. Coggan, A. R. &amp; Coyle, E. F. (1991 ). Carbohydrate ingestion during prolonged exercise: effects on metabolism and performance. In Exercise and Sport Sciences Reviews, ed. Holloszy, J. O., pp. 1-40. Williams and Wilkins, Baltimore.
  4. Cole, K. J., Costill, D. L., Starling, R. D., Goodpaster, B. H., Trappe, S. W. &amp; Fink, W. J. (1996 ). Effect of caffeine on perception of effort and subsequent work production. International Journal of Sports Nutrition 6 , 14-23.
  5. Coyle, E. F., Coggan, A. R., Hemmert, M. K. &amp; Ivy, J. L. (1986 ). Muscle glycogen utilisation utilization during prolonged strenuous exercise when fed carbohydrate. Journal of Applied Physiology 61 , 165-172.
  6. Essig, D., Costill, D. L. &amp; Van Handel, P. J. (1980 ). Effects of caffeine ingestion on utilisation of muscle glycogen and lipid during leg ergometer exercise. International Journal of Sports Medicine 1 , 86-90.
  7. Graham, T. E. &amp; Spriet, L. L. (1991 ). Performance and metabolic responses to a high caffeine dose during prolonged exercise. Journal of Applied Physiology 71 , 2292-2298.
  8. Graham, T. E. &amp; Spriet, L. L. (1995 ). Metabolic, catecholamine, and exercise performance responses to various doses of caffeine. Journal of Applied Physiology 78 , 867-874.
  9. Hawley, J. A. &amp; Burke, L. M. (1997 ). Effect of meal frequency and timing on physical performance. British Journal of Nutrition 77 , S91-103.
  10. Hawley, J. A., Burke, L. M., Angus, D. J., Fallon, K. E., Martin, D. T. &amp; Febbraio, M. A. (2000 ). Effect of altering substrate availability on metabolism and performance during intense exercise. British Journal of Nutrition 84 , 1-10.
  11. Hawley, J. A. &amp; Noakes, T. D. (1992 ). Peak sustained power output predicts VO 2max and performance time in trained cyclists. European Journal of Applied Physiology and Occupational Physiology 65 , 79-83.
  12. Hawley, J. A., Palmer, G. S. &amp; Noakes, T. D. (1997 ). Effect of 3 days of carbohydrate supplementation on muscle glycogen content and utilisation during a 1-h cycling performance. European Journal of Applied Physiology 75 , 407-412.
  13. Horowitz, J. F., Mora-Rodriguez, R., Byerley, L. O. &amp; Coyle, E. F. (1997 ). Lipolytic suppression following carbohydrate ingestion limits fat oxidation during exercise. American Journal of Physiology 273 , E768-775.
  14. Horowitz, J. F., Mora-Rodriguez, R., Byerley, L. O. &amp; Coyle, E. F. (2000 ). Preexercise medium-chain triglyceride ingestion does not alter muscle glycogen use during exercise. Journal of Applied Physiology 88 , 219-225.
  15. Jackman, M., Wendling, P., Friars, D. &amp; Graham, T. E (1996 ). Metabolic, catecholamine, and endurance responses to caffeine ingestion during intense exercise. Journal of Applied Physiology 81 , 1658-1663.
  16. Jeukendrup, A. E., Saris, W. H. M., V an Diesen, R., Brouns, F. &amp; Wagenmakers, A. J. M. (1996 ). Effect of endogenous carbohydrate availability on oral medium-chain triglyceride oxidation during prolonged exercise. Journal of Applied Physiology 80 , 949-954.
  17. Jeukendrup, A. E., Thielen, J. J. H. C., Wagenmakers, A. J. M., Brouns, F. &amp; Saris, W. H. M. (1998 ). Effect of medium-chain triacylglycerol and carbohydrate ingestion during exercise on substrate utilization and subsequent cycling performance. American Journal of Clinical Nutrition 67 , 397-404.
  18. Kalmar, J. M. &amp; Cafarelli, E. (1999 ). Effects of caffeine on neuromuscular function. Journal of Applied Physiology 87 , 801-808.
  19. Kovacs, E. M. R., Stegen, J. H. C. H. &amp; Brouns, F. (1998 ). Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance. Journal of Applied Physiology 85 , 709-715.
  20. McConell, G., Fabris, S., Proietto, J. &amp; Hargreaves, M. (1994 ). Effect of carbohydrate ingestion on glucose kinetics during exercise. Journal of Applied Physiology 77 , 1537-1541.
  21. Okano, G., Sato, Y., Takumi, Y. &amp; Sugawara, M. (1996 ). Effect of 4h pre-exercise high carbohydrate and high fat meal ingestion on endurance performance and metabolism. International Journal of Sports Medicine 17 , 530-534.
  22. Pasman, W. J., van Baak, M. A., Jeukendrup, A. E. &amp; de Haan, A. (1995 ). The effect of different dosages of caffeine on endurance performance time. International Journal of Sports Medicine 16 , 225-230.
  23. Spriet, L. L., Maclean, D. A., Dyck, D. J., Hultman, E., Cederblad, G. &amp; Graham, T. E. (1992 ). Caffeine ingestion and muscle metabolism during prolonged exercise in humans. American Journal of Physiology 262 , E891-898.
  24. Tsintzas, O. K., Williams, C., Boobis, L. &amp; Greenhaff, P. (1995 ). Carbohydrate ingestion and glycogen utilization on different muscle fibre types in man. Journal of Physiology 489 , 243-250.
  25. Van Zyl, C. G., Lambert, E. V., Hawley, J. A., Noakes, T. D. &amp; Dennis, S. C. (1996 ). Effects of medium chain triglyceride ingestion on fuel metabolism and cycling performance. Journal of Applied Physiology 80 , 2217-2225.
  26. Waldeck, B. (1973 ). Sensitisation by caffeine of central catecholamine receptors. Journal of Neural Transmission 34 , 61-72.
  27. Whitley, H. A., Humphreys, S. M., Cambpell, I. T., Keegan, M. A., Jayanetti, T. D., Sperry, D. A., MacLaren, D. P., Reilly, T. &amp; Frayn, K. N. (1998 ). Metabolic and performance responses during endurance exercise after high-fat and high-carbohydrate meals. Journal of Applied Physiology 85 , 418-424.

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Authors
Jacobson, T. L., Febbraio, M. A., Arkinstall, M. J., & Hawley, J. A.
Affiliations
The University of Melbourne (AU)
Corresponding author
Hawley, John A.
ORCID
Venue
Experimental Physiology
Publisher
Wiley
Published
2001-01
Volume
86
Issue
1
Pages
137-144
ISSN
  • 0958-0670 (ISSN-L)
  • 1469-445X
DOI
10.1113/eph8602072
OpenAlex
W2163917569
Cited by
73
References
0
Citations by year
2024: 2 · 2022: 5 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 1 · 2012: 6
FWCI
1.55
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1220 d)
Locations
  • Experimental Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
caffeine, carbohydrate intake, dietary fat intake, substrate oxidation, carbohydrate oxidation, fat oxidation, endurance performance, time trial performance, endurance-trained men, heparin, cycle ergometry, exercise metabolism, dietary fat
MeSH terms
Adult, Blood, Caffeine, Dietary Carbohydrates, Dietary Fats, Energy Metabolism, Physical Exertion, Heart Rate, Homeostasis, Humans, Male, Metabolism, Oxidation-Reduction, Physical Education and Training, Physical Endurance, Time Factors

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