Daily patterns of secretion of neurohypophysial hormones in man: effect of age
Open accessAbstract
The neurohypophysial hormone vasopressin contributes to control of urine output and, while urine flow shows a clear daily rhythm, there has been debate as to whether this is true of neurohypophysial hormones. A study was performed on fifteen adult males, with a mean age of 25 years, over a 24 h period, nine blood samples being taken at regular intervals for the determination of neurohypophysial hormones and indices of fluid balance. Samples were taken via an indwelling cannula so that sleep was undisturbed. A daily variation in the plasma concentrations of oxytocin and vasopressin was demonstrated with concentrations reaching a nadir in the late afternoon. Concentrations of both hormones peaked at 02.00 h. Vasopressin concentrations were inversely correlated with packed cell volume, indicating that the altered hormone release was affecting fluid retention. Consistent with this was the observation that the relationship of plasma osmolality to vasopressin depended on the time of day. To determine the effect of ageing, a similar study was performed on nine healthy elderly subjects with a mean age of 70 years. The nocturnal peak of vasopressin was markedly attenuated, while oxytocin release was similar to that in the younger group. These observations confirm the existence of a daily rhythm in the plasma concentrations of neurohypophysial hormones and indicate that the amplitude of the vasopressin change decreases with age.
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Plasma oxytocin has stability in its diurnal cycle during afternoon and evening hours.
“Experiments were conducted in a comfortable laboratory during the mid-afternoon hours, in light of previous research suggesting stability in the diurnal cycle of plasma OT in the afternoon and evening hours (Forsling et al., 1998).”
From Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity (2012) · cites this paper as Forsling et al., 1998
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- Authors
- Forsling, M., Montgomery, H., Halpin, D., Windle, R., & Treacher, D.
- ORCID
- Montgomery, H
- Venue
- Experimental Physiology
- Publisher
- Wiley
- Published
- 1998-05
- Volume
- 83
- Issue
- 3
- Pages
- 409-418
- ISSN
- 0958-0670 (ISSN-L)
- 1469-445X
- OpenAlex
- W2128580090
- Cited by
- 93
- References
- 9
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 5 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 5
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Experimental Physiology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- vasopressin, oxytocin, neurohypophyseal hormones, circadian rhythm, diurnal variation, aging, plasma osmolality, fluid balance, fluid retention, hematocrit, older men
- MeSH terms
- Adult, Aged, Aging, Body Fluids, Circadian Rhythm, Humans, Male, Middle Aged, Osmolar Concentration, Pituitary Hormones, Posterior
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