Effects of a 10-day oxytocin trial in older adults on health and well-being
Abstract
The neuropeptide oxytocin (OT) modulates functioning of the hypothalamic-pituitary-adrenal (HPA) axis and regulates a range of social processes. Clinical studies have used intranasal OT administration to treat symptoms arising from a number of psychiatric disorders including autism, schizophrenia, and depression. Most of this research, however, has been based on single dose treatments of OT in younger adult populations. The present study examined the impact on the health and psychological well-being of a 10-day OT administration in an older adult population. Residentially housed older adults (N = 41, mean age of 80) were enrolled in a randomized, double-blind, placebo-controlled study. Participants received 40 IU intranasal OT or placebo for 10 consecutive days. No changes in mood or cardiovascular states were observed across the 10-day period. Repeated-measures ANOVAs showed that dispositional gratitude improved for the OT infused participants, although gratitude declined for placebo controls over the 10 days (p = .015). Those in the OT condition did not report a decline in physical functioning over time as was observed in the placebo condition (p = .05), and also reported less fatigue compared with controls (p = .03). No significant adverse events were reported throughout the entirety of the study, indicating that OT can be safely used with older adults.
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Early studies of oxytocin in human aging suggest that higher oxytocin levels reduce age-related physical decline and fatigue.
“on oxytocin administration in human aging provide first evidence that increased oxytocin levels ameliorate age-related physical decline and reduce fatigue (Barraza, Grewal, Ropacki, Perez, Gonzalez, and Zak 2013)”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Barraza, Grewal, Ropacki, Perez, Gonzalez, and Zak 2013
In humans, intranasal oxytocin treatment over 10 days in elderly subjects produced no significant effects on mood or cardiovascular indices but yielded positive changes in psychological well-being and physical functioning.
“In humans, OXT IN treatment over 10 days in elderly subjects produced no significant effects on mood or the cardiovascular indices but yielded positive changes in psychological well-being and physical functioning (141).”
From Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships (2016) · cites this paper as [141]
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Self-citation
- Authors
- Barraza, J. A., Grewal, N. S., Ropacki, S., Perez, P., Gonzalez, A., & Zak, P. J.
- Affiliations
- Claremont Graduate University (US)
- Venue
- Experimental and Clinical Psychopharmacology
- Published
- 2013-04
- Volume
- 21
- Issue
- 2
- Pages
- 85-92
- ISSN
- 1064-1297 (ISSN-L)
- 1936-2293
- OpenAlex
- W2321799382
- Semantic Scholar
- 8f89ca9b7a1a6fc0aa6c541d6b813e9334d1e1d6
- Cited by
- 61
- References
- 68
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 4 · 2013: 4
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental and Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (1R21AG029871-01A2)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, older adults, intranasal administration, dispositional gratitude, well-being, physical function, fatigue, hypothalamic-pituitary-adrenal axis, placebo effect, adverse events
- MeSH terms
- Aged, Aged, 80 and over, Analysis of Variance, Double-Blind Method, Humans, Middle Aged, Oxytocin, Placebos, Quality of Life
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