The DOI matches its Crossref record.
On the mechanism by which calcium and magnesium affect the release of transmitter by nerve impulses
Open accessAbstract
1. The relationship between the quantal content of end‐plate potentials (e.p.p.s) and the bathing [Ca] and [Mg] was determined at neuromuscular junctions in the rat diaphragm in vitro. 2. E.p.p.s were recorded intracellularly from preparations exposed to solutions with [Ca] between 0·05 and 10 m M and [Mg] between 0·1 and 12·5 m M. The quantal content of e.p.p.s was increased by raising the [Ca] over this range and decreased by raising the [Mg]. There appeared to be competition of Mg with Ca at three sites in the nerve terminal membrane. 3. A kinetic scheme based on competition of Ca and Mg at three sites could quantitatively explain the effects of Ca and Mg upon the quantal content of e.p.p.s and also the effects of these ions upon miniature end‐plate potential frequency.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Tetrodotoxin‐resistant electric activity in presynaptic terminals
Katz, B., & Miledi, R. (1969) · The Journal of Physiology · doi:10.1113/jphysiol.1969.sp008875 · Cited by 615
The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat
Ginsborg, B. L., & Hirst, G. D. S. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp009916 · Cited by 367
Calcium signaling and exocytosis in adrenal chromaffin cells
García, A. G., García-De-Diego, A. M., Gandía, L., Borges, R., & García-Sancho, J. (2006) · Physiological Reviews · doi:10.1152/physrev.00039.2005 · Cited by 349
Organization and synaptic physiology of crustacean neuromuscular systems
Atwood, H. L. (1976) · Progress in Neurobiology · doi:10.1016/0301-0082(76)90009-5 · Cited by 317
Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release
Meir, A., Ginsburg, S., Butkevich, A., Kachalsky, S. G., Kaiserman, I., Ahdut, R., Demirgoren, S., & Rahamimoff, R. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.3.1019 · Cited by 300
Metadata
- Authors
- Hubbard, J. I., Jones, S. F., & Landau, E. M.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1968-05
- Volume
- 196
- Issue
- 1
- Pages
- 75-86
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2041853397
- Cited by
- 210
- References
- 0
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: On the mechanism by which calcium and magnesium affect the release of transmitter by nerve impulses. https://app.cochat.ai/papers/10.1113/jphysiol.1968.sp008495
- The paper
- Hubbard, J. I., Jones, S. F., & Landau, E. M. (1968). On the mechanism by which calcium and magnesium affect the release of transmitter by nerve impulses. The Journal of Physiology. https://doi.org/10.1113/jphysiol.1968.sp008495
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
