The DOI matches its Crossref record; 645 of the 645 references it cites were found in a registry or an index.
Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release
Abstract
The primary function of the presynaptic nerve terminal is to release transmitter quanta and thus activate the postsynaptic target cell. In almost every step leading to the release of transmitter quanta, there is a substantial involvement of ion channels. In this review, the multitude of ion channels in the presynaptic terminal are surveyed. There are at least 12 different major categories of ion channels representing several tens of different ion channel types; the number of different ion channel molecules at presynaptic nerve terminals is many hundreds. We describe the different ion channel molecules at the surface membrane and inside the nerve terminal in the context of their possible role in the process of transmitter release. Frequently, a number of different ion channel molecules, with the same basic function, are present at the same nerve terminal. This is especially evident in the cases of calcium channels and potassium channels. This abundance of ion channels allows for a physiological and pharmacological fine tuning of the process of transmitter release and thus of synaptic transmission.
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1 retracted
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Neurobiology and consequences of social isolation stress in animal model—A comprehensive review
Mumtaz, F., Khan, M. I., Zubair, M., & Dehpour, A. R. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.086 · Cited by 369
Calcium signaling and exocytosis in adrenal chromaffin cells
García, A. G., García-De-Diego, A. M., Gandía, L., Borges, R., & García-Sancho, J. (2006) · Physiological Reviews · doi:10.1152/physrev.00039.2005 · Cited by 349
Malhotra, J. D., Kazen-Gillespie, K., Hortsch, M., & Isom, L. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11383 · Cited by 272
The Mechanistic Classification of Addictive Drugs
Lüscher, C., & Ungless, M. A. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030437 · Cited by 255
Meinrenken, C. J., Borst, J. G. G., & Sakmann, B. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.032714 · Cited by 183
Metadata
- Authors
- Meir, A., Ginsburg, S., Butkevich, A., Kachalsky, S. G., Kaiserman, I., Ahdut, R., Demirgoren, S., & Rahamimoff, R.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1999-07-01
- Volume
- 79
- Issue
- 3
- Pages
- 1019-1088
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2154606229
- Cited by
- 300
- References
- 645
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Meir, A., Ginsburg, S., Butkevich, A., Kachalsky, S. G., Kaiserman, I., Ahdut, R., Demirgoren, S., & Rahamimoff, R. (1999). Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release. Physiological Reviews. https://doi.org/10.1152/physrev.1999.79.3.1019
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
