The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
The mechanism of excitation by acetylcholine in the cerebral cortex
Open accessAbstract
1. The muscarinic depolarizing action of ACh on cortical neurones is associated with an increase in membrane resistance (mean Δ V/Δ R = 3·16 mV/MΩ). 2. ACh also promotes repetitive firing by slowing repolarization after spikes. 3. The depolarizing effect has a mean reversal level of −86·7 mV (with mean resting potential −56 mV). 4. It is concluded that as a muscarinic excitatory agent, ACh probably acts by reducing the resting K+ conductance of cortical neurones, and also the delayed K+ current of the action potential. 5. These results are discussed in relation to the possible role of ACh in cortical function.
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Cites
Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004764 · Cited by 23,191
The influence of potassium and chloride ions on the membrane potential of single muscle fibres
Hodgkin, A. L., & Horowicz, P. (1959) · The Journal of Physiology · doi:10.1113/jphysiol.1959.sp006278 · Cited by 1,456
The histochemical localization of cholinesterases in the central nervous system of the rat
Koelle, G. B. (1954) · Journal of Comparative Neurology · doi:10.1002/cne.901000108 · Cited by 559
The physiology of neuroglial cells
Kuffler, S. W., & Nicholls, J. G. (2007) · Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie · doi:10.1007/bfb0116991 · Cited by 416
Responses of Human Somatosensory Cortex to Stimuli below Threshold for Conscious Sensation
Libet, B., Alberts, W. W., Wright, E. W., & Feinstein, B. (1967) · Science · doi:10.1126/science.158.3808.1597 · Cited by 374
SLOW AND FAST GROUPS OF PYRAMIDAL TRACT CELLS AND THEIR RESPECTIVE MEMBRANE PROPERTIES
Takahashi, K. (1965) · Journal of Neurophysiology · doi:10.1152/jn.1965.28.5.908 · Cited by 345
ACTIONS OF ANTIDROMIC PYRAMIDAL VOLLEYS ON SINGLE BETZ CELLS IN THE CAT
Phillips, C. G. (1959) · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · doi:10.1113/expphysiol.1959.sp001364 · Cited by 327
Pharmacological properties of acetylcholine‐sensitive cells in the cerebral cortex
Krnjević, K., & Phillis, J. W. (1963) · The Journal of Physiology · doi:10.1113/jphysiol.1963.sp007107 · Cited by 321
Self-citationThe potassium and chloride conductance of frog muscle membrane
Adrian, R. H., & Freygang, W. H. (1962) · The Journal of Physiology · doi:10.1113/jphysiol.1962.sp006959 · Cited by 308
Cortical inhibition and γ-aminobutyric acid
Dreifuss, J. J., Kelly, J. S., & Krnjević, K. (1969) · Experimental Brain Research · doi:10.1007/bf00238327 · Cited by 219
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Cited by
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4<347::aid-hipo1>3.0.co;2-i · Cited by 3,441
Alzheimer's disease: Targeting the Cholinergic System
H. Ferreira-Vieira, T., M. Guimaraes, I., R. Silva, F., & M. Ribeiro, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x13666150716165726 · Cited by 1,551
Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone
Brown, D. A., & Adams, P. R. (1980) · Nature · doi:10.1038/283673a0 · Cited by 1,444
McCormick, D. A. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90012-4 · Cited by 1,117
Voltage-clamp analysis of muscarinic excitation in hippocampal neurons
Halliwell, J. V., & Adams, P. R. (1982) · Brain Research · doi:10.1016/0006-8993(82)90954-4 · Cited by 1,041
Metadata
- Authors
- Krnjević, K., Pumain, R., & Renaud, L.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1971-05
- Volume
- 215
- Issue
- 1
- Pages
- 247-268
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2038328684
- Cited by
- 708
- References
- 32
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.