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The charge carried by single‐channel currents of rat cultured muscle cells in the presence of local anaesthetics.
Open accessAbstract
Acetylcholine‐induced single‐channel currents were measured in the presence of the lignocaine derivative QX222. Unit responses appeared as bursts of short current pulses as a result of the fast blocking action of the drug (QX222). The amplitude of the individual current pulses was not changed by the presence of the drug up to a concentration of 250 microM. The time integral of current during a burst, which for a sequential blocking model should be independent of drug concentration, decreased at concentrations of QX222 higher than 40 microM. The distribution of gap times within a burst could not be fitted by a single exponential for high concentrations of QX222. It is concluded that the simple sequential model of channel blockade does not apply for concentrations of QX222 higher than 40 microM.
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Citations
Cited by
Ascher, P., & Nowak, L. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017078 · Cited by 819
Block of Stretch-Activated Ion Channels in Xenopus Oocytes by Gadolinium and Calcium Ions
Yang, X.-C., & Sachs, F. (1989) · Science · doi:10.1126/science.2466333 · Cited by 803
Acetylcholine Receptor: An Allosteric Protein
Changeux, J.-P., Devillers-Thiéry, A., & Chemouilli, P. (1984) · Science · doi:10.1126/science.6382611 · Cited by 623
On the stochastic properties of bursts of single ion channel openings and of clusters of bursts
Colquhoun, D., & Hawkes, A. G. (1982) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1982.0156 · Cited by 567
Wilson, G. G., & Karlin, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1241 · Cited by 138
Metadata
- Authors
- Neher, E.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1983-06
- Volume
- 339
- Issue
- 1
- Pages
- 663-678
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1990594499
- Cited by
- 210
- References
- 0
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- green
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