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Cited by 803

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Block of Stretch-Activated Ion Channels in Xenopus Oocytes by Gadolinium and Calcium Ions

Yang, Xian-Cheng, Sachs, Frederick·1989·Science
DOI 10.1126/science.2466333
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Abstract

Gadolinium ions produce three distinct kinds of block of the stretch-activated (SA) ion channels in Xenopus oocytes: a concentration-dependent reduction in channel open time, a concentration-dependent reduction in open channel current, and a unique, steeply concentration-dependent, reversible inhibition of channel opening. This last effect reduces the probability of a channel being open from about 10 -1 at 5 μ M to less than 10 -5 at 10 μ M gadolinium. Calcium has effects on open time and current similar to that of gadolinium, but this channel is permeable to calcium and calcium does not completely inhibit channel activity. The availability of a blocker for SA ion channels may help to define their physiological function, and will simplify the use of oocytes as an expression system for ion channels.

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Cites

Show all 15 references

Research works printed but not linked: 16

  1. AUERBACH, A, SINGLE-CHANNEL CURRENTS FROM ACETYLCHOLINE-RECEPTORS IN EMBRYONIC CHICK MUSCLE - KINETIC AND CONDUCTANCE PROPERTIES OF GAPS WITHIN BURSTS, BIOPHYSICAL JOURNAL 45: 187 (1984). · doi:10.1016/s0006-3495(84)84147-8
  2. BUCCIGROSS, J.M., A FLOW-DIALYSIS METHOD FOR OBTAINING RELATIVE MEASURES OF ASSOCIATION CONSTANTS IN CALMODULIN METAL-ION SYSTEMS, BIOCHEMICAL JOURNAL 235: 677 (1986). · doi:10.1042/bj2350677
  3. COOPER, K.E., A CATION CHANNEL IN FROG LENS EPITHELIA RESPONSIVE TO PRESSURE AND CALCIUM, JOURNAL OF MEMBRANE BIOLOGY 93: 259 (1986). · doi:10.1007/bf01871180
  4. Deutsch, C., Renal Physiology and Biochemistry 11: 260 (1988).
  5. EDWARDS, K.L., CELL SURFACE SIGNAL: 41 (1987).
  6. GUHARAY, F, MECHANOTRANSDUCER ION CHANNELS IN CHICK SKELETAL-MUSCLE - THE EFFECTS OF EXTRACELLULAR PH, JOURNAL OF PHYSIOLOGY-LONDON 363: 119 (1985). · doi:10.1113/jphysiol.1985.sp015699
  7. GUSTIN, M.C., STRETCH-ACTIVATED CATION CHANNEL IN YEAST, BIOPHYSICAL JOURNAL 51: A251 (1987).
  8. KIRBER, M. T., BIOPHYSICAL JOURNAL 51: A252 (1987).
  9. KIRBER, M. T., BIOPHYSICAL JOURNAL 53: A411 (1988).
  10. MUSCHOLL, E, JOURNAL OF PHYSIOLOGY-LONDON 367: 419 (1985). · doi:10.1113/jphysiol.1985.sp015833
  11. PICKARD, B, BIOPHYS J 53: A155 (1988).
  12. PIETROBON, D, CONFORMATIONAL-CHANGES ASSOCIATED WITH ION PERMEATION IN L-TYPE CALCIUM CHANNELS, NATURE 333: 373 (1988). · doi:10.1038/333373a0
  13. SACHS, F, PFLUEGERS ARCH 395: 3331 (1982).
  14. XIANG, Z, PUERTO RICO HEALTH SCIENCES JOURNAL 7: 77 (1988).
  15. YANG, X.C., STRETCH-ACTIVATED CHANNELS IN SEVERAL TISSUES, BIOPHYSICAL JOURNAL 51: A252 (1987).
  16. YANG, X.C., STRETCH-ACTIVATED (SA) ION CHANNEL IN XENOPUS OOCYTES - PERMEATION AND BLOCK, BIOPHYSICAL JOURNAL 53: A412 (1988).

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Metadata

Authors
Yang, X.-C., & Sachs, F.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1989-02-24
Volume
243
Issue
4894
Pages
1068-1071
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.2466333
OpenAlex
W1979856671
Cited by
803
References
15
FWCI
7.56
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Block of Stretch-Activated Ion Channels in Xenopus Oocytes by Gadolinium and Calcium Ions. https://app.cochat.ai/papers/10.1126/science.2466333
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Yang, X.-C., & Sachs, F. (1989). Block of Stretch-Activated Ion Channels in Xenopus Oocytes by Gadolinium and Calcium Ions. Science. https://doi.org/10.1126/science.2466333

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