The electrical activity of mouse pancreatic beta‐cells recorded in vivo shows glucose‐dependent oscillations.
Open accessAbstract
1. The characteristics of the electrical activity of beta‐cells from islets of Langerhans recorded in vivo are described. For blood glucose concentrations from 4 to 11 mM, the electrical activity of pancreatic beta‐cells is oscillatory, with alternating depolarized and hyperpolarized phases. During the depolarized phases, action potentials are triggered. 2. The main effect of increasing glucose concentration consists of an increase in the duration of the depolarized phase. The relationship between blood glucose concentration and the percentage of time in the depolarized phase can be described by a sigmoidal function with half‐activation at 6.8 mM glucose. The equivalent value obtained in parallel experiments in vitro is 13.3 mM, a significant rightward shift in the activation curve that suggests a role for other neural or humoral factors in determining the islet sensitivity to glucose. 3. The injection of glucose into the bloodstream produces a transitory phase of continuous electrical activity that is recorded within seconds after the change and that leads to a decrease of the glycaemia to the prestimulatory value. 4. The results demonstrate that under physiological conditions the electrical response of beta‐cells to glucose consists of membrane potential oscillations, validating previous data obtained with isolated preparations. Furthermore, the electrical response occurs at lower levels of glycaemia than those predicted from recordings in isolated preparations and is maximal within the physiological range of blood glucose.
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In vivo membrane potential recordings demonstrate transition from oscillatory electrical activity to continuous action potential firing at glucose concentrations as low as 10 mM.
“Although it is questionable whether such high concentrations are attained physiologically, it is notable that in vivo membrane potential recordings also demonstrate the transition from oscillatory electrical activity to continuous action potential firing with the latter occurring at glucose concentrations as low as 10 mM (587).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [587]
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Cites
Intracellular ATP directly blocks K+ channels in pancreatic B-cells
Cook, D. L., & Hales, N. (1984) · Nature · doi:10.1038/311271a0 · Cited by 1,208 · see citing works
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- the pancreatic f-cell. In Molecular and Cellular Biology of Diabetes Mellitus, vol. 1, ed. DRAZNIN, B., MELMED, S. & LEROITH, D., pp. 49-68.
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Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
Oscillation of gap junction electrical coupling in the mouse pancreatic islets of Langerhans.
Andreu, E., Soria, B., & Sanchez-Andres, J. V. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021899 · Cited by 58 · see citing works
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- Authors
- Sánchez-Andrés, J. V., Gomis, A., & Valdeolmillos, M.
- Affiliations
- University of Alicante (ES)
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1995-07
- Volume
- 486
- Issue
- 1
- Pages
- 223-228
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC1156510
- OpenAlex
- W1984995573
- Cited by
- 78
- References
- 1
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Keywords
- pancreatic beta cells, pancreatic islets, membrane potential oscillations, action potential, glucose sensitivity, blood glucose, hyperpolarization, glucose injection
- MeSH terms
- Animals, Blood Glucose, Electrophysiology, Glucose, Islets of Langerhans, Membrane Potentials, Patch-Clamp Techniques, Mice, In Vitro Techniques
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