The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gating of TRP channels: a voltage connection?
Open accessAbstract
TRP channels represent the main pathways for cation influx in non‐excitable cells. Although TRP channels were for a long time considered to be voltage independent, several TRP channels now appear to be weakly voltage dependent with an activation curve extending mainly into the non‐physiological positive voltage range. In connection with this voltage dependence, there is now abundant evidence that physical stimuli, such as temperature (TRPV1, TRPM8, TRPV3), or the binding of various ligands (TRPV1, TRPV3, TRPM8, TRPM4), shift this voltage dependence towards physiologically relevant potentials, a mechanism that may represent the main functional hallmark of these TRP channels. This review discusses some features of voltage‐dependent gating of TRPV1, TRPM4 and TRPM8. A thermodynamic principle is elaborated, which predicts that the small gating charge of TRP channels is a crucial factor for the large voltage shifts induced by various stimuli. Some structural considerations will be given indicating that, although the voltage sensor is not yet known, the C‐terminus may substantially change the voltage dependence of these channels.
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Citations
Cites
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
Cited by
Trp ion channels and temperature sensation
Dhaka, A., Viswanath, V., & Patapoutian, A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112958 · Cited by 782
Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system
Romanovsky, A. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00668.2006 · Cited by 786
Metadata
- Authors
- Nilius, B., Talavera, K., Owsianik, G., Prenen, J., Droogmans, G., & Voets, T.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2005-08
- Volume
- 567
- Issue
- 1
- Pages
- 35-44
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2124873219
- Cited by
- 299
- References
- 1
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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