Cited by 782Ion Channels and ReceptorsPain Mechanisms and TreatmentsBiochemical Analysis and Sensing Techniques

Trp ion channels and temperature sensation

Dhaka, Ajay, Viswanath, Veena, Patapoutian, Ardem·2006·Annual Review of Neuroscience

Abstract

The abilities to sense environmental and internal temperatures are required for survival, both for maintenance of homeostasis and for avoidance of tissue-damaging noxious temperatures. Vertebrates can sense external physical stimuli via specialized classes of neurons in the peripheral nervous system that project to the skin. Temperature-sensitive neurons can be divided into two classes: innocuous thermosensors (warm or cool) and noxious thermonociceptors (hot or cold). ThermoTRPs, a subset of the transient receptor potential family of ion channels, which are expressed in sensory nerve endings and in skin, respond to distinct thermal thresholds. In this review, we examine the extent to which thermoTRPs are responsible for providing a molecular basis for thermal sensation.

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Crossref · 10.1146/annurev.neuro.29.051605.112958

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151 of 151 references verified0 citation errors · 0 not checkable

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Authors
Dhaka, A., Viswanath, V., & Patapoutian, A.
Affiliations
  • Scripps Research Institute (US)
  • Genomics Institute of the Novartis Research Foundation (US)
Venue
Annual Review of Neuroscience
Published
2006-07-21
Volume
29
Issue
1
Pages
135-161
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
OpenAlex
W2106207830
Cited by
782
References
151
Citations by year
2026: 22 · 2025: 31 · 2024: 32 · 2023: 36 · 2022: 43 · 2021: 45 · 2020: 26 · 2019: 40 · 2018: 32 · 2017: 26 · 2016: 31 · 2015: 33 · 2014: 48 · 2013: 35 · 2012: 39
FWCI
7.03
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5f32ns048654-03)
  • National Institute of Neurological Disorders and Stroke (R01NS042822, 1F32NS048654, NS046303, NS42822, NS04910, R01NS046303)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords
TRP channels, thermosensation, temperature thresholds, peripheral sensory neurons, skin, homeostasis, nociception
MeSH terms
Animals, Humans, Models, Biological, Neurons, Afferent, Thermosensing, Keratinocytes, Phosphatidylinositol 4,5-Diphosphate, Transient Receptor Potential Channels

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