Trp ion channels and temperature sensation
Abstract
The abilities to sense environmental and internal temperatures are required for survival, both for maintenance of homeostasis and for avoidance of tissue-damaging noxious temperatures. Vertebrates can sense external physical stimuli via specialized classes of neurons in the peripheral nervous system that project to the skin. Temperature-sensitive neurons can be divided into two classes: innocuous thermosensors (warm or cool) and noxious thermonociceptors (hot or cold). ThermoTRPs, a subset of the transient receptor potential family of ion channels, which are expressed in sensory nerve endings and in skin, respond to distinct thermal thresholds. In this review, we examine the extent to which thermoTRPs are responsible for providing a molecular basis for thermal sensation.
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The temperatures used (44.3-49.3°C) are all in a range that activates TRPV1 nociceptive ion channels.
“These temperatures are all in a range that activates TRPV1 nociceptive ion channels [43].”
From Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain (2015) · cites this paper as [43]
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- Authors
- Dhaka, A., Viswanath, V., & Patapoutian, A.
- Affiliations
- Scripps Research Institute (US)
- Genomics Institute of the Novartis Research Foundation (US)
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2006-07-21
- Volume
- 29
- Issue
- 1
- Pages
- 135-161
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2106207830
- Cited by
- 782
- References
- 151
- Citations by year
- 2026: 22 · 2025: 31 · 2024: 32 · 2023: 36 · 2022: 43 · 2021: 45 · 2020: 26 · 2019: 40 · 2018: 32 · 2017: 26 · 2016: 31 · 2015: 33 · 2014: 48 · 2013: 35 · 2012: 39
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32ns048654-03)
- National Institute of Neurological Disorders and Stroke (R01NS042822, 1F32NS048654, NS046303, NS42822, NS04910, R01NS046303)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- TRP channels, thermosensation, temperature thresholds, peripheral sensory neurons, skin, homeostasis, nociception
- MeSH terms
- Animals, Humans, Models, Biological, Neurons, Afferent, Thermosensing, Keratinocytes, Phosphatidylinositol 4,5-Diphosphate, Transient Receptor Potential Channels
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