The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
A novel excitatory network for the control of breathing
Open accessAbstract
Breathing must be tightly coordinated with other behaviours such as vocalization, swallowing, and coughing. These behaviours occur after inspiration, during a respiratory phase termed postinspiration. Failure to coordinate postinspiration with inspiration can result in aspiration pneumonia, the leading cause of death in Alzheimer’s disease, Parkinson’s disease, dementia, and other neurodegenerative diseases. Here we describe an excitatory network that generates the neuronal correlate of postinspiratory activity in mice. Glutamatergic–cholinergic neurons form the basis of this network, and GABA (γ-aminobutyric acid)-mediated inhibition establishes the timing and coordination relative to inspiration. We refer to this network as the postinspiratory complex (PiCo). The PiCo has autonomous rhythm-generating properties and is necessary and sufficient for postinspiratory activity in vivo. The PiCo also shows distinct responses to neuromodulators when compared to other excitatory brainstem networks. On the basis of the discovery of the PiCo, we propose that each of the three phases of breathing is generated by a distinct excitatory network: the preBötzinger complex, which has been linked to inspiration; the PiCo, as described here for the neuronal control of postinspiration; and the lateral parafacial region (pFL), which has been associated with active expiration, a respiratory phase that is recruited during high metabolic demand.
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Cites
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Pre-Bötzinger Complex: a Brainstem Region that May Generate Respiratory Rhythm in Mammals
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A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
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Self-citationLOCOMOTOR CIRCUITS IN THE MAMMALIAN SPINAL CORD
Kiehn, O. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112910 · Cited by 882
The motor infrastructure: from ion channels to neuronal networks
Grillner, S. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1137 · Cited by 839
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Self-citationSmith, J. C., Abdala, A. P. L., Koizumi, H., Rybak, I. A., & Paton, J. F. R. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00985.2007 · Cited by 463
Distinct rhythm generators for inspiration and expiration in the juvenile rat
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Silencing preBötzinger Complex somatostatin-expressing neurons induces persistent apnea in awake rat
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Structural and functional architecture of respiratory networks in the mammalian brainstem
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Cited by
Del Negro, C. A., Funk, G. D., & Feldman, J. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0003-6 · Cited by 663
Efferent projections of excitatory and inhibitory preBötzinger Complex neurons
Yang, C. F., & Feldman, J. L. (2018) · Journal of Comparative Neurology · doi:10.1002/cne.24415 · Cited by 167
Breathing Rhythm and Pattern and Their Influence on Emotion
Ashhad, S., Kam, K., Del Negro, C. A., & Feldman, J. L. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-090121-014424 · Cited by 161
Circuits in the rodent brainstem that control whisking in concert with other orofacial motor actions
McElvain, L. E., Friedman, B., Karten, H. J., Svoboda, K., Wang, F., Deschênes, M., & Kleinfeld, D. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.034 · Cited by 82
Baldo, B. A. (2025) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00314.2024 · Cited by 25
Metadata
- Authors
- Anderson, T. M., Garcia, A. J., Baertsch, N. A., Pollak, J., Bloom, J. C., Wei, A. D., Rai, K. G., & Ramirez, J.-M.
- Venue
- Nature
- Published
- 2016-07-27
- Volume
- 536
- Issue
- 7614
- Pages
- 76-80
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2505292440
- Cited by
- 283
- References
- 26
- FWCI
- 17.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Anderson, T. M., Garcia, A. J., Baertsch, N. A., Pollak, J., Bloom, J. C., Wei, A. D., Rai, K. G., & Ramirez, J.-M. (2016). A novel excitatory network for the control of breathing. Nature. https://doi.org/10.1038/nature18944
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