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Cited by 119Protein Kinase Regulation and GTPase SignalingLipid Membrane Structure and BehaviorCellular transport and secretion

Target‐specific PIP2signalling: how might it work?

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Gamper, Nikita, Shapiro, Mark S.·2007·The Journal of Physiology
DOI 10.1113/jphysiol.2007.132787PMC PMC2075238
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Abstract

Phosphatidylinositol 4,5‐bisphosphate (PIP 2)‐mediated signalling is a new and rapidly developing area in the field of cellular signal transduction. With the extensive and growing list of PIP 2‐sensitive membrane proteins (many of which are ion channels and transporters) and multiple signals affecting plasma membrane PIP 2 levels, the question arises as to the cellular mechanisms that confer specificity to PIP 2‐mediated signalling. In this review we critically consider two major hypotheses for such possible mechanisms: (i) clustering of PIP 2 in membrane microdomains with restricted lateral diffusion, a hypothesis providing a mechanism for spatial segregation of PIP 2 signals and (ii) receptor‐specific buffering of the global plasma membrane PIP 2 pool via Ca 2+‐mediated stimulation of PIP 2 synthesis or release, a concept allowing for receptor‐specific signalling with free lateral diffusion of PIP 2. We also discuss several other technical and conceptual intricacies of PIP 2‐mediated signalling.

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  • Our results are consistent with the 'buffering' of global plasma membrane PIP2 pool hypothesis, which proposes that stimulation of PIP2 hydrolysis occurs concurrently with an activation of PIP2 synthesis via Ca2+-sensitive stimulation of PI4-kinase.

    “Our results are consistent with the ‘buffering’ of global plasma membrane PIP2 pool hypothesis(31), which proposes that stimulation of PIP2 hydrolysis (e.g. via PLCγ2) occurs concurrently with an activation of PIP2 synthesis via Ca2+-sensitive stimulation of PI4-kinase(32).”

    From Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain (2023) · cites this paper as [31]

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References 74 · Cited by 119

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Authors
Gamper, N., & Shapiro, M. S.
Affiliations
  • University of Leeds (GB)
  • The University of Texas at San Antonio Health Science Center (US)
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
2007-07-21
Volume
582
Issue
3
Pages
967-975
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2007.132787
PMC
PMC2075238
OpenAlex
W1512892368
Cited by
119
References
74
Citations by year
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FWCI
5.29
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust (080593/Z/06/Z)
  • National Institute of Neurological Disorders and Stroke (NS043394, R01NS043394)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
phosphatidylinositol 4,5-bisphosphate, signal transduction, lipid rafts, lateral diffusion, calcium signaling, ion channels, membrane transporters, receptor specificity, plasma membrane
MeSH terms
Myristoylated Alanine-Rich C Kinase Substrate, Animals, Cell Membrane, Cell Physiological Phenomena, Membrane Proteins, Signal Transduction, Phosphatidylinositol 4,5-Diphosphate, Intracellular Signaling Peptides and Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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