The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance
Open accessAbstract
We asked whether the central effects of fatiguing locomotor muscle fatigue exert an inhibitory influence on central motor drive to regulate the total degree of peripheral fatigue development. Eight cyclists performed constant‐workload prefatigue trials (a) to exhaustion (83% of peak power output (Wpeak), 10 ± 1 min; PFT 83%), and (b) for an identical duration but at 67%Wpeak (PFT 67%). Exercise‐induced peripheral quadriceps fatigue was assessed via changes in potentiated quadriceps twitch force (Δ Qtw,pot) from pre‐ to post‐exercise in response to supra‐maximal femoral nerve stimulation (Δ Qtw,pot). On different days, each subject randomly performed three 5 km time trials (TTs). First, subjects repeated PFT 83% and the TT was started 4 min later with a known level of pre‐existing locomotor muscle fatigue (Δ Qtw,pot−36%) (PFT 83%‐TT). Second, subjects repeated PFT 67% and the TT was started 4 min later with a known level of pre‐existing locomotor muscle fatigue (Δ Qtw,pot−20%) (PFT 67%‐TT). Finally, a control TT was performed without any pre‐existing level of fatigue. Central neural drive during the three TTs was estimated via quadriceps EMG. Increases in pre‐existing locomotor muscle fatigue from control TT to PFT 83%‐TT resulted in significant dose‐dependent changes in central motor drive (−23%), power output (−14%), and performance time (+6%) during the TTs. However, the magnitude of locomotor muscle fatigue following various TTs was not different (Δ Qtw,pot of −35 to −37%, P= 0.35). We suggest that feedback from fatiguing muscle plays an important role in the determination of central motor drive and force output, so that the development of peripheral muscle fatigue is confined to a certain level.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reward prediction in primate basal ganglia and frontal cortex
Schultz, W., Tremblay, L., & Hollerman, J. R. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00071-9 · Cited by 318
Muscle metabolites and performance during high-intensity, intermittent exercise
Hargreaves, M., McKenna, M. J., Jenkins, D. G., Warmington, S. A., Li, J. L., Snow, R. J., & Febbraio, M. A. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.5.1687 · Cited by 173
Branched-Chain Amino Acids and Central Fatigue
Newsholme, E. A., & Blomstrand, E. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.1.274s · Cited by 150
CAQUELARD, F., BURNET, H., TAGLIARINI, F., CAUCHY, E., RICHALET, J. P., & JAMMES, Y. (2000) · Clinical Science · doi:10.1042/cs0980329 · Cited by 70
Cited by
Repeated-Sprint Ability – Part I: Factors Contributing to Fatigue
Girard, O., Mendez-Villanueva, A., & Bishop, D. (2011) · Sports Medicine · doi:10.2165/11590550-000000000-00000 · Cited by 916
Froyd, C., Millet, G. Y., & Noakes, T. D. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.245316 · Cited by 176
Impact of pulmonary system limitations on locomotor muscle fatigue in patients with COPD
Amann, M., Regan, M. S., Kobitary, M., Eldridge, M. W., Boutellier, U., Pegelow, D. F., & Dempsey, J. A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00183.2010 · Cited by 150
Self-citationMendez-Villanueva, A., Edge, J., Suriano, R., Hamer, P., & Bishop, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051977 · Cited by 135
The Positive Consequences of Pain: A Biopsychosocial Approach
Bastian, B., Jetten, J., Hornsey, M. J., & Leknes, S. (2014) · Personality and Social Psychology Review · doi:10.1177/1088868314527831 · Cited by 91
Hollingsworth, K. G., Newton, J. L., Taylor, R., McDonald, C., Palmer, J. M., Blamire, A. M., & Jones, D. E. J. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.04.013 · Cited by 89
Muddle, T. W. D., Colquhoun, R. J., Magrini, M. A., Luera, M. J., DeFreitas, J. M., & Jenkins, N. D. M. (2018) · Physiological Reports · doi:10.14814/phy2.13675 · Cited by 41
Gelabert-Rebato, M., Wiebe, J. C., Martin-Rincon, M., Gericke, N., Perez-Valera, M., Curtelin, D., Galvan-Alvarez, V., Lopez-Rios, L., Morales-Alamo, D., & Calbet, J. A. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00740 · Cited by 33
Thurston, T. S., Weavil, J. C., Hureau, T. J., Gifford, J. R., Georgescu, V. P., Wan, H.-Y., La Salle, D. T., Richardson, R. S., & Amann, M. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00400.2021 · Cited by 16
Self-citation
Metadata
- Authors
- Amann, M., & Dempsey, J. A.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2008-01
- Volume
- 586
- Issue
- 1
- Pages
- 161-173
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2098977319
- Cited by
- 374
- References
- 4
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
