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Cited by 33Exercise and Physiological ResponsesMangiferin and Mango ExtractsSports Performance and Training

Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans

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Gelabert-Rebato, Miriam, Wiebe, Julia C., Martin-Rincon, Marcos, Gericke, Nigel, Perez-Valera, Mario, Curtelin, David, Galvan-Alvarez, Victor, Lopez-Rios, Laura +2 more·2018·Frontiers in Physiology
DOI 10.3389/fphys.2018.00740PMC PMC6002676
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Abstract

It remains unknown whether polyphenols such as luteolin (Lut), mangiferin and quercetin (Q) have ergogenic effects during repeated all-out prolonged sprints. Here we tested the effect of Mangifera indica L. leaf extract (MLE) rich in mangiferin (Zynamite®) administered with either quercetin (Q) and tiger nut extract (TNE), or with luteolin (Lut) on sprint performance and recovery from ischemia-reperfusion. Thirty young volunteers were randomly assigned to three treatments 48h before exercise. Treatment A: placebo (500 mg of maltodextrin/day); B: 140 mg of MLE (60% mangiferin) and 50 mg of Lut/day; and C: 140 mg of MLE, 600 mg of Q and 350 mg of TNE/day. After warm-up, subjects performed two 30s Wingate tests and a 60s all-out sprint interspaced by 4-min recovery periods. At the end of the 60-s sprint the circulation of both legs was instantaneously occluded for 20s. Then, the circulation was re-opened and a 15-s sprint performed, followed by 10 s recovery with open circulation, and another 15-s final sprint. MLE supplements enhanced peak (Wpeak) and mean (Wmean) power output by 5.0-7.0% (P<0.01). After ischemia, MLE+Q+TNE increased Wpeak by 19.4 and 10.2% compared with the placebo (P<0.001) and MLE+Lut (P<0.05), respectively. MLE+Q+TNE increased Wmean post-ischemia by 11.2 and 6.7% compared with the placebo (P<0.001) and MLE+Lut (P=0.012). Mean VO2 during the sprints was unchanged, suggesting increased efficiency or recruitment of the anaerobic capacity after MLE ingestion. In women, peak VO2 during the repeated sprints was 5.8% greater after the administration of MLE, coinciding with better brain oxygenation. MLE attenuated the metaboreflex hyperpneic response post-ischemia, may have improved O2 extraction by the vastus lateralis (MLE+Q+TNE vs placebo, P=0.056), and reduced pain during ischemia (P=0.068). Blood lactate, acid-base balance and plasma electrolytes responses were not altered by the supplements. In conclusion, a MLE extract rich in mangiferin combined with either quercetin and tiger nut extract or luteolin exerts a remarkable ergogenic effect, increasing muscle power in fatigued subjects and enhancing peak VO2 and brain oxygenation in women during prolonged sprinting. Importantly, the combination of MLE+Q+TNE improves skeletal muscle contractile function during ischemia/reperfusion.

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  • Under the reported analytical conditions, MGF is not detected in brain tissue, consistent with limited penetration across the blood-brain barrier in this model.

    “Under the reported analytical conditions, MGF is not detected in brain tissue, which is consistent with limited penetration across the blood-brain barrier in this model (19).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [19]

    The Materials and methods section describes measurements of cerebral oxygenation and blood velocity, not an assay for mangiferin (MGF) in brain tissue. The Introduction says mangiferin can traverse the blood-brain barrier, but the paper reports no brain-tissue detection result or analytical conditions that could establish the claimed limited penetration. Searches for brain-tissue detection and blood-brain-barrier penetration found no such result. (LLM, conf=0.77)

    Experimental — accuracy not yet measured

  • In rats administered oral MGF, peak concentrations in the plasma, lungs and kidneys occur 4-6 h after dosing.

    “In rats administered oral MGF, peak concentrations in the plasma, lungs and kidneys have been reported to occur 4-6 h after dosing.”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [19]

    The Materials and methods > Main experiment passage describes oral mangiferin absorption and a mean residence time near 7 hours, citing a human-plasma pharmacokinetic study; it does not give peak concentrations in rats. Searches for rat plasma, lung and kidney concentrations and a 4–6-hour peak found no passage addressing that claim. Page numbers were not available in our copy. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Gelabert-Rebato, M., Wiebe, J. C., Martin-Rincon, M., Gericke, N., Perez-Valera, M., Curtelin, D., Galvan-Alvarez, V., Lopez-Rios, L., Morales-Alamo, D., & Calbet, J. A. L.
ORCID
Venue
Frontiers in Physiology
Publisher
Frontiers Media SA
Published
2018-06-08
Volume
9
Pages
740-740
ISSN
1664-042X (ISSN-L)
DOI
10.3389/fphys.2018.00740
PMC
PMC6002676
OpenAlex
W2805786573
Cited by
33
References
8
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 4 · 2017: 1
FWCI
3.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
Funders
Ministerio de Economía y Competitividad (DEP2017-86409-C2-1-P)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
mangiferin, luteolin, quercetin, polyphenols, ergogenic aids, repeated sprint performance, ischemia-reperfusion, skeletal muscle function, oxygen consumption, peak power, Wingate test, cerebral oxygenation, anaerobic capacity, post-exercise recovery, female athletes, dietary supplementation, oxidative stress

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