The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs
Open accessAbstract
Transient receptor potential (TRP) A1 and TRPM8 are ion channels that have been localized to afferent nociceptive nerves. These TRP channels may be of particular relevance to respiratory nociceptors in that they can be activated by various inhaled irritants and/or cold air. We addressed the hypothesis that mouse vagal sensory nerves projecting to the airways express TRPA1 and TRPM8 and that they can be activated via these receptors. Single cell RT‐PCR analysis revealed that TRPA1 mRNA, but not TRPM8, is uniformly expressed in lung‐labelled TRPV1‐expressing vagal sensory neurons. Neither TRPA1 nor TRPM8 mRNA was expressed in TRPV1‐negative neurons. Capsaicin‐sensitive, but not capsaicin‐insensitive, lung‐specific neurons responded to cinnamaldehyde, a TRPA1 agonist, with increases in intracellular calcium. Menthol, a TRPM8 agonist, was ineffective at increasing cellular calcium in lung‐specific vagal sensory neurons. Cinnamaldehyde also induced TRPA1‐like inward currents (as measured by means of whole cell patch clamp recordings) in capsaicin‐sensitive neurons. In an ex vivo vagal innervated mouse lung preparation, cinnamaldehyde evoked action potential discharge in mouse vagal C‐fibres with a peak frequency similar to that observed with capsaicin. Cinnamaldehyde inhalation in vivo mimicked capsaicin in eliciting strong central‐reflex changes in breathing pattern. Taken together, our results support the hypothesis that TRPA1, but not TRPM8, is expressed in vagal sensory nerves innervating the airways. TRPA1 activation provides a mechanism by which certain environmental stimuli may elicit action potential discharge in airway afferent C‐fibres and the consequent nocifensor reflexes.
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Citations
Cites
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
McKemy, D. D., Neuhausser, W. M., & Julius, D. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,709
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T. R., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,486
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Bautista, D. M., Jordt, S.-E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. (2006) · Cell · doi:10.1016/j.cell.2006.02.023 · Cited by 1,932
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt, S.-E., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,899
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., & Patapoutian, A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00150-3 · Cited by 1,827
Kwan, K. Y., Allchorne, A. J., Vollrath, M. A., Christensen, A. P., Zhang, D.-S., Woolf, C. J., & Corey, D. P. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.042 · Cited by 1,267
Trp ion channels and temperature sensation
Dhaka, A., Viswanath, V., & Patapoutian, A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112958 · Cited by 782
Pedersen, S. F., Owsianik, G., & Nilius, B. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.028 · Cited by 774
Trevisani, M., Siemens, J., Materazzi, S., Bautista, D. M., Nassini, R., Campi, B., Imamachi, N., Andrè, E., Patacchini, R., Cottrell, G. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705923104 · Cited by 770
Kobayashi, K., Fukuoka, T., Obata, K., Yamanaka, H., Dai, Y., Tokunaga, A., & Noguchi, K. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20794 · Cited by 729
Cited by
Molecular and functional neuroscience in immunity
Pavlov, V. A., Chavan, S. S., & Tracey, K. J. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053158 · Cited by 444
Chemosensory properties of the trigeminal system
Viana, F. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn100102c · Cited by 196
Kim, S.-H., Patil, M. J., Hadley, S. H., Bahia, P. K., Butler, S. G., Madaram, M., & Taylor-Clark, T. E. (2022) · eneuro · doi:10.1523/eneuro.0026-22.2022 · Cited by 56
Self-citation
Metadata
- Authors
- Nassenstein, C., Kwong, K., Taylor‐Clark, T., Kollarik, M., MacGlashan, D. M., Braun, A., & Undem, B. J.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2008-03-15
- Volume
- 586
- Issue
- 6
- Pages
- 1595-1604
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1543856987
- Cited by
- 349
- References
- 37
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- green
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