Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance

Wenner, Megan M.; Taylor, Hugh S.; Stachenfeld, Nina S.

doi:10.1113/jphysiol.2010.194563

Cited by 41Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlAdrenal Hormones and Disorders

Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance

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Wenner, Megan M., Taylor, Hugh S., Stachenfeld, Nina S.·2011·The Journal of Physiology

DOI 10.1113/jphysiol.2010.194563PMC PMC3060374

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Abstract

Non‐technical summary Women experience orthostatic intolerance (the inability to maintain blood pressure during postural changes) more frequently than men. This difference between men and women may in part be related to how oestradiol and progesterone influence dilatation and constriction of blood vessels. We show that progesterone enhances vasoconstriction in women who have a higher tolerance to orthostatic stress, but not in women with low tolerance. The increase in vasoconstriction with progesterone administration in women with high tolerance appears to be mediated by prostaglandins (hormone‐like substances that assist in maintaining bodily functions). These results show that progesterone alters blood vessel constriction and can help us understand blood pressure regulation in women.

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Progesterone seems to promote vasoconstriction by enhancing α-adrenergic responsiveness, mediated by cyclooxygenase.
“The peripheral effect of progesterone is less clear although it seems to promote vasoconstriction by enhancing α-adrenergic responsiveness, mediated by cyclooxygenase [172].”
From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [172]

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Authors: Wenner, M. M., Taylor, H. S., & Stachenfeld, N. S.
Affiliations: John B. Pierce Laboratory (US)
Yale University (US)
ORCID: Wenner, Megan M.
Taylor, Hugh S.
Stachenfeld, Nina S.
Venue: The Journal of Physiology
Publisher: Wiley
Published: 2011-02-15
Volume: 589
Issue: 4
Pages: 975-986
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jphysiol.2010.194563
PMC: PMC3060374
OpenAlex: W1834727479
Cited by: 41
References: 51
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 5 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 3
FWCI: 2.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3 d)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL071159)
Topics: Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: progesterone, orthostatic intolerance, orthostatic tolerance, skin blood flow, estradiol, sex hormones, norepinephrine, cyclooxygenase pathway, nitric oxide synthase, ketorolac, lower body negative pressure, women, GnRH antagonist, L-NMMA
MeSH terms: Blood Flow Velocity, Dose-Response Relationship, Drug, Female, Hemodynamics, Humans, Gonadotropin-Releasing Hormone, Norepinephrine, Progesterone, Skin, Adrenergic Agents, Orthostatic Intolerance, Young Adult

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Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance

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