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Candidates for the Mechanosensory System in Bone
Abstract
Some potential mechanisms by which bone cells sense mechanical loads are described and hypotheses concerning the functioning of these mechanisms are explored. It is well known that bone tissue adapts its structure to its mechanical load environment. Recent research has illuminated the biological response of bone to mechanical loading at the cellular level, but the precise mechanosensory system that signals bone cells to deposit or resorb tissue has not been identifed. The purpose of this paper is to describe the current status of this research and to suggest some possible mechanosensory systems by which bone cells might sense environmental loads.
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Citations
Cited by
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350
The aging of Wolff’s “law”: Ontogeny and responses to mechanical loading in cortical bone
Pearson, O. M., & Lieberman, D. E. (2004) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20155 · Cited by 745
Mechanosensation and transduction in osteocytes
Klein-Nulend, J., Bakker, A. D., Bacabac, R. G., Vatsa, A., & Weinbaum, S. (2013) · Bone · doi:10.1016/j.bone.2012.10.013 · Cited by 528
Modelling bone tissue fracture and healing: a review
Doblaré, M., Garcı́a, J. M., & Gómez, M. J. (2004) · Engineering Fracture Mechanics · doi:10.1016/j.engfracmech.2003.08.003 · Cited by 504
Department of Mechanical and Biomedical Engineering, N. U. O. I. G., Birmingham, E., Niebur, G., McHugh, P., Shaw, G., Barry, F., & McNamara, L. (2012) · European Cells and Materials · doi:10.22203/ecm.v023a02 · Cited by 490
Metadata
- Authors
- Cowin, S. C., Moss-Salentijn, L., & Moss, M. L.
- Venue
- Journal of Biomechanical Engineering
- Publisher
- ASME International
- Published
- 1991-05-01
- Volume
- 113
- Issue
- 2
- Pages
- 191-197
- ISSN
- 0148-0731 (ISSN-L)
- 1528-8951
- OpenAlex
- W2083049128
- Cited by
- 468
- References
- 0
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Candidates for the Mechanosensory System in Bone. https://app.cochat.ai/papers/10.1115/1.2891234
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- Cowin, S. C., Moss-Salentijn, L., & Moss, M. L. (1991). Candidates for the Mechanosensory System in Bone. Journal of Biomechanical Engineering. https://doi.org/10.1115/1.2891234
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
