Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,015 · see citing works

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235 · see citing works

Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366 · see citing works

BIOMECHANICAL AND MOLECULAR REGULATION OF BONE REMODELING

Robling, A. G., Castillo, A. B., & Turner, C. H. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095721 · Cited by 1,343 · see citing works

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147 · see citing works

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

Winkler, D. G., Sutherland, M. K., Geoghegan, J. C., Yu, C., Hayes, T., Skonier, J. E., Shpektor, D., Jonas, M., Kovacevich, B. R., Staehling‐Hampton, K., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg599 · Cited by 1,114 · see citing works

<i>Cbfa1</i>-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

Kato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086 · see citing works

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

Poole, K. E. S., Van Bezooijen, R. L., Loveridge, N., Hamersma, H., Papapoulos, S. E., Löwik, C. W., & Reeve, J. (2005) · The FASEB Journal · doi:10.1096/fj.05-4221fje · Cited by 965 · see citing works

Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.

Tatsumi, S., Ishii, K., Amizuka, N., Li, M., Kobayashi, T., Kohno, K., Ito, M., Takeshita, S., & Ikeda, K. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.001 · Cited by 848 · see citing works

[22] Detection of messenger RNA by in Situ hybridization to tissue sections and whole mounts

Wilkinson, D. G., & Nieto, M. A. (1993) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(93)25025-w · Cited by 794 · see citing works

SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor

Semënov, M., Tamai, K., & He, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504308200 · Cited by 771 · see citing works

Identification of a 52 kb deletion downstream of the <i>SOST</i> gene in patients with van Buchem disease

Balemans, W., Patel, N., Ebeling, M., Van Hul, E., Wuyts, W., Lacza, C., Dioszegi, M., Dikkers, F. G., Hildering, P., Willems, P. J., et al. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.2.91 · Cited by 698 · see citing works

Bone Loss and Bone Size after Menopause

Ahlborg, H. G., Johnell, O., Turner, C. H., Rannevik, G., & Karlsson, M. K. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022464 · Cited by 647 · see citing works

Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis

Bellido, T., Ali, A., Gubrij, I. B., Plotkin, L. I., Fu, Q., O’Brien, C. A., Manolagas, S. C., & Jilka, R. L. (2005) · Endocrinology · doi:10.1210/en.2005-0239 · Cited by 640 · see citing works

SOST is a target gene for PTH in bone

Keller, H., & Kneissel, M. (2005) · Bone · doi:10.1016/j.bone.2005.03.018 · Cited by 618 · see citing works

Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone

Robinson, J. A., Chatterjee‐Kishore, M., Yaworsky, P. J., Cullen, D. M., Zhao, W., Li, C., Kharode, Y. P., Sauter, L., Babij, P., Brown, E. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602308200 · Cited by 522 · see citing works

Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass

Morvan, F., Boulukos, K. E., Clément-Lacroix, P., Roman‐Roman, S., Suc-Royer, I., Vayssière, B., Ammann, P., Martin, P., Pinho, S., Pognonec, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060311 · Cited by 521 · see citing works

Designing Exercise Regimens to Increase Bone Strength

Turner, C. H., & Robling, A. G. (2003) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200301000-00009 · Cited by 501 · see citing works

Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.

Aguirre, J. I., Plotkin, L. I., Stewart, S. A., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C., & Bellido, T. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060107 · Cited by 494 · see citing works

Candidates for the Mechanosensory System in Bone

Cowin, S. C., Moss‐Salentijn, L., & Moss, M. L. (1991) · Journal of Biomechanical Engineering · doi:10.1115/1.2891234 · Cited by 470 · see citing works

The Wnt Antagonist Secreted Frizzled-Related Protein-1 Is a Negative Regulator of Trabecular Bone Formation in Adult Mice

Bodine, P. V. N., Zhao, W., Kharode, Y. P., Bex, F. J., Lambert, A.-J., Goad, M. B., Gaur, T., Stein, G. S., Lian, J. B., & Komm, B. S. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0498 · Cited by 450 · see citing works

Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

Loots, G. G., Kneissel, M., Keller, H., Baptist, M., Chang, J., Collette, N. M., Ovcharenko, D., Plajzer-Frick, I., & Rubin, E. M. (2005) · Genome Research · doi:10.1101/gr.3437105 · Cited by 442 · see citing works

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

Li, J., Sarosi, I., Cattley, R. C., Pretorius, J. K., Asuncion, F., Grisanti, M. S., Morony, S., Adamu, S., Geng, Z., Qiu, W., et al. (2006) · Bone · doi:10.1016/j.bone.2006.03.017 · Cited by 441 · see citing works

Osteocytes, strain detection, bone modeling and remodeling

Lanyon, L. E. (1993) · Calcified Tissue International · doi:10.1007/bf01673415 · Cited by 439 · see citing works

The Wnt Co-receptor LRP5 Is Essential for Skeletal Mechanotransduction but Not for the Anabolic Bone Response to Parathyroid Hormone Treatment

Sawakami, K., Robling, A. G., Ai, M., Pitner, N. D., Liu, D., Warden, S. J., Li, J., Maye, P. F., Rowe, D. W., Duncan, R. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601000200 · Cited by 397 · see citing works

SOST/sclerostin, an osteocyte-derived negative regulator of bone formation

van Bezooijen, R. L., ten Dijke, P., Papapoulos, S. E., & Löwik, C. W. G. M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.02.005 · Cited by 368 · see citing works

Bone Density Ligand, Sclerostin, Directly Interacts With LRP5 but Not LRP5G171V to Modulate Wnt Activity

Ellies, D. L., Viviano, B. L., McCarthy, J. J., Rey, J., Itasaki, N., Saunders, S., & Krumlauf, R. K. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060810 · Cited by 350 · see citing works

A 52‐kb deletion in the SOST‐MEOX1 intergenic region on 17q12‐q21 is associated with van Buchem disease in the Dutch population

Staehling‐Hampton, K., Proll, S. C., Paeper, B. W., Zhao, L., Charmley, P., Brown, A., Gardner, J. C., Galas, D. J., Schatzman, R. C., Beighton, P., et al. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10401 · Cited by 294 · see citing works

Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP-Stimulated Bone Formation

van Bezooijen, R. L., Svensson, J. P., Eefting, D., Visser, A., van der Horst, G., Karperien, M., Quax, P. H. A., Vrieling, H., Papapoulos, S. E., ten Dijke, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061002 · Cited by 283 · see citing works

Mechanical Loading of Diaphyseal Bone In Vivo: The Strain Threshold for an Osteogenic Response Varies with Location

Hsieh, Y., Robling, A. G., Ambrosius, W. T., Burr, D. B., & Turner, C. H. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.12.2291 · Cited by 268 · see citing works

Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation

Sutherland, M. K., Geoghegan, J. C., Yu, C., Turcott, E., Skonier, J. E., Winkler, D. G., & Latham, J. A. (2004) · Bone · doi:10.1016/j.bone.2004.05.023 · Cited by 238 · see citing works

The natural history of sclerosteosis

Hamersma, H. A., Gardner, J. C., & Beighton, P. (2003) · Clinical Genetics · doi:10.1034/j.1399-0004.2003.00036.x · Cited by 231 · see citing works

LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST

Semënov, M. V., & He, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609509200 · Cited by 222 · see citing works

Mechanotransduction in bone: genetic effects on mechanosensitivity in mice

Robling, A. G., & Turner, C. H. (2002) · Bone · doi:10.1016/s8756-3282(02)00871-2 · Cited by 208 · see citing works

TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro

Hens, J. R., Wilson, K. M., Dann, P. R., Chen, X., Horowitz, M. C., & Wysolmerski, J. J. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050210 · Cited by 185 · see citing works

Bone Mineral Density in Sclerosteosis; Affected Individuals and Gene Carriers

Gardner, J. C., van Bezooijen, R. L., Mervis, B., Hamdy, N. A. T., Löwik, C. W. G. M., Hamersma, H. A., Beighton, P., & Papapoulos, S. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1235 · Cited by 176 · see citing works

Up-regulation of the Wnt, Estrogen Receptor, Insulin-like Growth Factor-I, and Bone Morphogenetic Protein Pathways in C57BL/6J Osteoblasts as Opposed to C3H/HeJ Osteoblasts in Part Contributes to the Differential Anabolic Response to Fluid Shear

Lau, K. ‐. W., Kapur, S., Kesavan, C., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509205200 · Cited by 161 · see citing works

Mechanisms by which exercise improves bone strength

Turner, C. H., & Robling, A. G. (2005) · Journal of Bone and Mineral Metabolism · doi:10.1007/bf03026318 · Cited by 159 · see citing works

Fluid Shear Stress Induces ?-Catenin Signaling in Osteoblasts

Norvell, S. M., Alvarez, M. B., Bidwell, J. P., & Pavalko, F. M. (2004) · Calcified Tissue International · doi:10.1007/s00223-004-0213-y · Cited by 154 · see citing works

The Clinical Features of Sclerosteosis

Beighton, P., DURR, L., & HAMERSMA, H. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-4-393 · Cited by 128 · see citing works

Global gene profiling reveals a downregulation of BMP gene expression in experimental atrophic nonunions compared to standard healing fractures

Niikura, T., Hak, D. J., & Reddi, A. H. (2006) · Journal of Orthopaedic Research® · doi:10.1002/jor.20182 · Cited by 113 · see citing works

Rat tail suspension reduces messenger RNA level for growth factors and osteopontin and decreases the osteoblastic differentiation of bone marrow stromal cells

Zhang, R., Supowit, S. C., Klein, G. L., Lu, Z., Christensen, M. D., Lozano, R., & Simmons, D. J. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100312 · Cited by 102 · see citing works

Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice

Xing, W., Baylink, D. J., Kesavan, C., Hu, Y., Kapoor, S., Chadwick, R. B., & Mohan, S. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20606 · Cited by 95 · see citing works

Optimal compressive force induces bone formation via increasing bone morphogenetic proteins production and decreasing their antagonists production by Saos-2 cells

Mitsui, N., Suzuki, N., Maeno, M., Yanagisawa, M., Koyama, Y., Otsuka, K., & Shimizu, N. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.10.024 · Cited by 92 · see citing works

Skeletal unloading induces osteoblast apoptosis and targets α5β1-PI3K-Bcl-2 signaling in rat bone

Dufour, C., Holy, X., & Marie, P. J. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.10.021 · Cited by 75 · see citing works

Rat hindlimb unloading by tail suspension reduces osteoblast differentiation, induces IL-6 secretion, and increases bone resorption in ex vivo cultures.

Grano, M., Mori, G., Minielli, V., Barou, O., Colucci, S., Giannelli, G., Alexandre, C., Zallone, A. Z., & Vico, L. (2002) · Calcified Tissue International · doi:10.1007/s00223-001-2034-6 · Cited by 61 · see citing works

Bone morphogenetic protein-7 selectively enhances mechanically induced bone formation

Cheline, A. J., Reddi, A. H., & Martin, R. B. (2002) · Bone · doi:10.1016/s8756-3282(02)00865-7 · Cited by 20 · see citing works

Sclerosing bone dysplasias: neurologic assessment and management

Hofmeyr, L. M., & Hamersma, H. A. (2004) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/01.moo.0000134441.84110.9e · Cited by 11 · see citing works

The amazing osteocyte

Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287 · see citing works

WNT signaling in bone homeostasis and disease: From human mutations to treatments

Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093 · see citing works

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works

The Osteocyte: An Endocrine Cell … and More

Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042 · see citing works

Estrogens and androgens in skeletal physiology and pathophysiology

Almeida, M., Laurent, M. R., Dubois, V., Claessens, F., O'Brien, C. A., Bouillon, R., Vanderschueren, D., & Manolagas, S. C. (2017) · Physiological Reviews · doi:10.1152/physrev.00033.2015 · Cited by 860 · see citing works

Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms

Booth, F. W., Roberts, C. K., Thyfault, J. P., Ruegsegger, G. N., & Toedebusch, R. G. (2017) · Physiological Reviews · doi:10.1152/physrev.00019.2016 · Cited by 696 · see citing works

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

Pederson, L., Ruan, M., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805133106 · Cited by 556 · see citing works

The Osteocyte: New Insights

Robling, A. G., & Bonewald, L. F. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034332 · Cited by 539 · see citing works

Osteocytes: master orchestrators of bone

Schaffler, M. B., Cheung, W.-Y., Majeska, R., & Kennedy, O. (2014) · Calcified Tissue International · doi:10.1007/s00223-013-9790-y · Cited by 514 · see citing works

Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway

Wijenayaka, A. R., Kogawa, M., Lim, H. P., Bonewald, L. F., Findlay, D. M., & Atkins, G. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025900 · Cited by 503 · see citing works

Molecular mechanosensors in osteocytes

Qin, L., Liu, W., Cao, H., & Xiao, G. (2020) · Bone Research · doi:10.1038/s41413-020-0099-y · Cited by 484 · see citing works

Transforming growth factor‐β in stem cells and tissue homeostasis

Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414 · see citing works

Osteocyte-Driven Bone Remodeling

Bellido, T. (2014) · Calcified Tissue International · doi:10.1007/s00223-013-9774-y · Cited by 384 · see citing works

Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

Hu, L., Chen, W., Qian, A., & Li, Y.-P. (2024) · Bone Research · doi:10.1038/s41413-024-00342-8 · Cited by 359 · see citing works

Increased Sclerostin Serum Levels Associated with Bone Formation and Resorption Markers in Patients with Immobilization-Induced Bone Loss

Gaudio, A., Pennisi, P., Bratengeier, C., Torrisi, V., Lindner, B., Mangiafico, R. A., Pulvirenti, I., Hawa, G., Tringali, G., & Fiore, C. E. (2010) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2010-0067 · Cited by 315 · see citing works

A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis

Shen, B., Tasdogan, A., Ubellacker, J. M., Zhang, J., Nosyreva, E. D., Du, L., Murphy, M. M., Hu, S., Yi, Y., Kara, N., et al. (2021) · Nature · doi:10.1038/s41586-021-03298-5 · Cited by 310 · see citing works

Sclerostin and Its Association with Physical Activity, Age, Gender, Body Composition, and Bone Mineral Content in Healthy Adults

Amrein, K., Amrein, S., Drexler, C., Dimai, H. P., Dobnig, H., Pfeifer, K., Tomaschitz, A., Pieber, T. R., & Fahrleitner-Pammer, A. (2012) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2011-2152 · Cited by 277 · see citing works

Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

Bivi, N., Condon, K. W., Allen, M. R., Farlow, N., Passeri, G., Brun, L. R., Rhee, Y., Bellido, T., & Plotkin, L. I. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.548 · Cited by 261 · see citing works

Osteocyte: the unrecognized side of bone tissue

Rochefort, G. Y., Pallu, S., & Benhamou, C. L. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1194-5 · Cited by 268 · see citing works

The endothelium–bone axis in development, homeostasis and bone and joint disease

Tuckermann, J., & Adams, R. H. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00682-3 · Cited by 258 · see citing works

Osteocytic signalling pathways as therapeutic targets for bone fragility

Plotkin, L. I., & Bellido, T. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.71 · Cited by 206 · see citing works

Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation

Morrell, A. E., Brown, G. N., Robinson, S. T., Sattler, R. L., Baik, A. D., Zhen, G., Cao, X., Bonewald, L. F., Jin, W., Kam, L. C., et al. (2018) · Bone Research · doi:10.1038/s41413-018-0007-x · Cited by 184 · see citing works

Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

Sims, N. A., & Martin, T. J. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00041 · Cited by 184 · see citing works

Tissue-level mechanisms responsible for the increase in bone formation and bone volume by sclerostin antibody

Ominsky, M. S., Niu, Q.-T., Li, C., Li, X., & Ke, H. Z. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2152 · Cited by 167 · see citing works

Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis

Li, G., Zhang, L., Wang, D., AIQudsy, L., Jiang, J. X., Xu, H., & Shang, P. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28946 · Cited by 166 · see citing works

Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training

Armamento-Villareal, R., Sadler, C., Napoli, N., Shah, K., Chode, S., Sinacore, D. R., Qualls, C., & Villareal, D. T. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1560 · Cited by 158 · see citing works

HDAC5 Controls MEF2C-Driven Sclerostin Expression in Osteocytes

Wein, M. N., Spatz, J., Nishimori, S., Doench, J., Root, D., Babij, P., Nagano, K., Baron, R., Brooks, D., Bouxsein, M., et al. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2381 · Cited by 158 · see citing works

Enhanced Osteoclastic Resorption and Responsiveness to Mechanical Load in Gap Junction Deficient Bone

Zhang, Y., Paul, E. M., Sathyendra, V., Davison, A., Sharkey, N., Bronson, S., Srinivasan, S., Gross, T. S., & Donahue, H. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023516 · Cited by 148 · see citing works

Spaceflight-induced Bone Loss: Is there an Osteoporosis Risk?

Sibonga, J. D. (2013) · Current Osteoporosis Reports · doi:10.1007/s11914-013-0136-5 · Cited by 147 · see citing works

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin

Stegen, S., Stockmans, I., Moermans, K., Thienpont, B., Maxwell, P. H., Carmeliet, P., & Carmeliet, G. (2018) · Nature Communications · doi:10.1038/s41467-018-04679-7 · Cited by 126 · see citing works

Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor

Delgado-Calle, J., Tu, X., Pacheco-Costa, R., McAndrews, K., Edwards, R., Pellegrini, G. G., Kuhlenschmidt, K., Olivos, N., Robling, A., Peacock, M., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3011 · Cited by 114 · see citing works

Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats

Taylor, S., Ominsky, M. S., Hu, R., Pacheco, E., He, Y. D., Brown, D. L., Aguirre, J. I., Wronski, T. J., Buntich, S., Afshari, C. A., et al. (2016) · Bone · doi:10.1016/j.bone.2015.12.013 · Cited by 106 · see citing works

Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes

Lyons, J. S., Joca, H. C., Law, R. A., Williams, K. M., Kerr, J. P., Shi, G., Khairallah, R. J., Martin, S. S., Konstantopoulos, K., Ward, C. W., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aan5748 · Cited by 106 · see citing works

Osteocyte Network; a Negative Regulatory System for Bone Mass Augmented by the Induction of Rankl in Osteoblasts and Sost in Osteocytes at Unloading

Moriishi, T., Fukuyama, R., Ito, M., Miyazaki, T., Maeno, T., Kawai, Y., Komori, H., & Komori, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040143 · Cited by 105 · see citing works

Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity

William Lau, K.-H., Baylink, D. J., Zhou, X.-D., Rodriguez, D., Bonewald, L. F., Li, Z., Ruffoni, D., Müller, R., Kesavan, C., & Sheng, M. H.-C. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00092.2013 · Cited by 94 · see citing works

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

Sato, T., Verma, S., Andrade, C. D. C., Omeara, M., Campbell, N., Wang, J. S., Cetinbas, M., Lang, A., Ausk, B. J., Brooks, D. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17099-3 · Cited by 86 · see citing works

Hormonal and systemic regulation of sclerostin

Drake, M. T., & Khosla, S. (2017) · Bone · doi:10.1016/j.bone.2016.12.004 · Cited by 77 · see citing works

Weight loss-induced reduction of bone mineral density in older adults with obesity

Jiang, B. C., & Villareal, D. T. (2019) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2018.1564721 · Cited by 50 · see citing works

Effect of liver dysfunction on circulating sclerostin

Rhee, Y., Kim, W. J., Han, K. J., Lim, S. K., & Kim, S. H. (2014) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-013-0524-z · Cited by 42 · see citing works

Serum sclerostin in alcoholics: a pilot study

González-Reimers, E., Martín-González, C., de la Vega-Prieto, M. J., Pelazas-González, R., Fernández-Rodríguez, C., López-Prieto, J., Alvisa-Negrín, J., & Santolaria-Fernández, F. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/ags136 · Cited by 41 · see citing works

On the combined effects of normobaric hypoxia and bed rest upon bone and mineral metabolism: Results from the PlanHab study

Rittweger, J., Debevec, T., Frings-Meuthen, P., Lau, P., Mittag, U., Ganse, B., Ferstl, P. G., Simpson, E. J., Macdonald, I. A., Eiken, O., et al. (2016) · Bone · doi:10.1016/j.bone.2016.07.013 · Cited by 35 · see citing works

Future directions for new medical entities in osteoporosis

Ferrari, S. (2014) · Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism · doi:10.1016/j.beem.2014.08.002 · Cited by 34 · see citing works

Active vitamin D and vitamin D analogs stimulate fibroblast growth factor 23 production in osteocyte-like cells via the vitamin D receptor

Yashiro, M., Ohya, M., Mima, T., Nakashima, Y., Kawakami, K., Yamamoto, S., Kobayashi, S., Yano, T., Tanaka, Y., Sonou, T., et al. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113139 · Cited by 18 · see citing works

Osteocyte Wnt/β-catenin pathway activation upon mechanical loading is altered in ovariectomized mice

Jackson, E., Lara-Castillo, N., Akhter, M. P., Dallas, M., Scott, J. M., Ganesh, T., & Johnson, M. L. (2021) · Bone Reports · doi:10.1016/j.bonr.2021.101129 · Cited by 13 · see citing works

Osteocyte Deficiency in Hip Fractures

Delgado‐Calle, J., Arozamena, J., García-Renedo, R. J., García‐Ibarbia, C., Pascual-Carra, M. A., González-Macı́as, J., & Riancho, J. A. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9522-0 · Cited by 43 · see citing works

Osteocyte — A new target for the treatment of osteoporosis

Wu, X., Wu, X., & Yuan, L. (2013) · Zhonghua neifenmi daixie zazhi · doi:10.3760/cma.j.issn.1000-6699.2013.07.023

Faculty Opinions recommendation of Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin.

Ott, S. M. (2008) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1103314.559346

Does Osteocyte Sclerostin Response to Unloading and Exercise Vary across Bone Compartments?

Metzger, C. E., Lee, T. V., McBurnett, P. K., et al. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000493280.92872.3e

Sclerostin Inhibition Reverses Skeletal Fragility in an Lrp5-Deficient Mouse Model of OPPG Syndrome

Kedlaya, R., Veera, S. S., Horan, D. J., Moss, R. E., Ayturk, U. M., Jacobsen, C. M., Bowen, M. E., Pászty, C., Warman, M. L., & Robling, A. G. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006627 · Cited by 77 · see citing works