The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The Solid Mechanics of Cancer and Strategies for Improved Therapy
Open accessAbstract
Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can regulate fluid stresses by compressing intratumoral blood and lymphatic vessels. Blood vessel compression reduces tumor perfusion, while compression of lymphatic vessels hinders the ability of the tumor to drain excessive fluid from its interstitial space contributing to the uniform elevation of the interstitial fluid pressure. Hypoperfusion and interstitial hypertension pose major barriers to the systemic administration of chemotherapeutic agents and nanomedicines to tumors, reducing treatment efficacies. Hypoperfusion can also create a hypoxic and acidic tumor microenvironment that promotes tumor progression and metastasis. Hence, alleviation of intratumoral solid stress levels can decompress tumor vessels and restore perfusion and interstitial fluid pressure. In this review, three major types of tissue level solid stresses involved in tumor growth, namely stress exerted externally on the tumor by the host tissue, swelling stress, and residual stress, are discussed separately and details are provided regarding their causes, magnitudes, and remedies. Subsequently, evidence of how stress-alleviating drugs could be used in combination with chemotherapy to improve treatment efficacy is presented, highlighting the potential of stress-alleviation strategies to enhance cancer therapy. Finally, a continuum-level, mathematical framework to incorporate these types of solid stress is outlined.
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1 retracted
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Self-citationThe Role of Mechanical Forces in Tumor Growth and Therapy
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“In this sense, solid tumors comprise an interesting and complex mechanical system that involves both solid and fluid mechanics in which the stresses originating from the solid phase of a tumor determine, in large part, both the fluid stresses and cancer progression [3,4].”
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Self-citationSolid stress inhibits the growth of multicellular tumor spheroids
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Cited by
Role of Extracellular Matrix in Development and Cancer Progression
Walker, C., Mojares, E., & Del Río Hernández, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,084
El-Sawy, H. S., Al-Abd, A. M., Ahmed, T. A., El-Say, K. M., & Torchilin, V. P. (2018) · ACS Nano · doi:10.1021/acsnano.8b06104 · Cited by 431
Jiang, X., Xu, S., Miao, Y., Huang, K., Wang, B., Ding, B., Zhang, Z., Zhao, Z., Zhang, X., Shi, X., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2319880121 · Cited by 57
Metadata
- Authors
- Stylianopoulos, T.
- Venue
- Journal of Biomechanical Engineering
- Publisher
- ASME International
- Published
- 2017-01-19
- Volume
- 139
- Issue
- 2
- ISSN
- 0148-0731 (ISSN-L)
- 1528-8951
- OpenAlex
- W2536034592
- Cited by
- 169
- References
- 18
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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