The DOI matches its Crossref record; 341 of the 341 references it cites were found in a registry or an index.
Stimuli-Responsive Nano-Architecture Drug-Delivery Systems to Solid Tumor Micromilieu: Past, Present, and Future Perspectives
Abstract
The microenvironment characteristics of solid tumors, renowned as barriers that harshly impeded many drug-delivery approaches, were precisely studied, investigated, categorized, divided, and subdivided into a complex diverse of barriers. These categories were further studied with a particular perspective, which makes all barriers found in solid-tumor micromilieu turn into different types of stimuli, and were considered triggers that can increase and hasten drug-release targeting efficacy. This review gathers data concerning the nature of solid-tumor micromilieu. Past research focused on the treatment of such tumors, the recent efforts employed for engineering smart nanoarchitectures with the utilization of the specified stimuli categories, the possibility of combining more than one stimuli for much-greater targeting enhancement, examples of the approved nanoarchitectures that already translated clinically as well as the obstacles faced by the use of these nanostructures, and, finally, an overview of the possible future implementations of smart-chemical engineering for the design of more-efficient drug delivery and theranostic systems and for making nanosystems with a much-higher level of specificity and penetrability features.
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Cites
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Cited by
Rahim, M. A., Jan, N., Khan, S., Shah, H., Madni, A., Khan, A., Jabar, A., Khan, S., Elhissi, A., Hussain, Z., et al. (2021) · Cancers · doi:10.3390/cancers13040670 · Cited by 323
Li, J., & Kataoka, K. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.0c09029 · Cited by 281
Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy
Zhan, Q., Yi, K., Qi, H., Li, S., Li, X., Wang, Q., Wang, Y., Liu, C., Qiu, M., Yuan, X., et al. (2020) · Theranostics · doi:10.7150/thno.45028 · Cited by 168
Liu, T., Zhu, M., Chang, X., Tang, X., Yuan, P., Tian, R., Zhu, Z., Zhang, Y., & Chen, X. (2023) · Advanced Materials · doi:10.1002/adma.202300086 · Cited by 98
Ma, X., Chen, X., Yi, Z., Deng, Z., Su, W., Chen, G., Ma, L., Ran, Y., Tong, Q., & Li, X. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c04698 · Cited by 36
Metadata
- Authors
- El-Sawy, H. S., Al-Abd, A. M., Ahmed, T. A., El-Say, K. M., & Torchilin, V. P.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-10-17
- Volume
- 12
- Issue
- 11
- Pages
- 10636-10664
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2896523722
- Cited by
- 431
- References
- 341
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- El-Sawy, H. S., Al-Abd, A. M., Ahmed, T. A., El-Say, K. M., & Torchilin, V. P. (2018). Stimuli-Responsive Nano-Architecture Drug-Delivery Systems to Solid Tumor Micromilieu: Past, Present, and Future Perspectives. ACS Nano. https://doi.org/10.1021/acsnano.8b06104
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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