Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods

Nachabe, Rami; Hendriks, Benno H.; Lucassen, Gerald W.; van der Voort, Marjolein; Evers, Daniel J.; Rutgers, Emiel J.; Peeters, Marie-Jeanne V.; Van der Hage, Jos A.; Oldenburg, Hester S.; Ruers, Theo J.; Wesseling, Jelle

doi:10.1117/1.3611010

Cited by 161Optical Imaging and Spectroscopy TechniquesSpectroscopy Techniques in Biomedical and Chemical ResearchOptical Coherence Tomography Applications

Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods

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Nachabe, Rami, Hendriks, Benno H., Lucassen, Gerald W., van der Voort, Marjolein, Evers, Daniel J., Rutgers, Emiel J., Peeters, Marie-Jeanne V., Van der Hage, Jos A. +3 more·2011·Journal of Biomedical Optics

DOI 10.1117/1.3611010

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Abstract

We report on the use of diffuse optical spectroscopy analysis of breast spectra acquired in the wavelength range from 500 to 1600 nm with a fiber optic probe. A total of 102 ex vivo samples of five different breast tissue types, namely adipose, glandular, fibroadenoma, invasive carcinoma, and ductal carcinoma in situ from 52 patients were measured. A model deriving from the diffusion theory was applied to the measured spectra in order to extract clinically relevant parameters such as blood, water, lipid, and collagen volume fractions, β-carotene concentration, average vessels radius, reduced scattering amplitude, Mie slope, and Mie-to-total scattering fraction. Based on a classification and regression tree algorithm applied to the derived parameters, a sensitivity-specificity of 98%-99%, 84%-95%, 81%-98%, 91%-95%, and 83%-99% were obtained for discrimination of adipose, glandular, fibroadenoma, invasive carcinoma, and ductal carcinoma in situ, respectively; and a multiple classes overall diagnostic performance of 94%. Sensitivity-specificity values obtained for discriminating malignant from nonmalignant tissue were compared to existing reported studies by applying the different classification methods that were used in each of these studies. Furthermore, in these reported studies, either lipid or β-carotene was considered as adipose tissue precursors. We estimate both chromophore concentrations and demonstrate that lipid is a better discriminator for adipose tissue than β-carotene.

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Collagen, predominantly found in the dermal skin layer, has absorption peaks at 1050 nm, 1200 nm, 1500 nm, and 1725 nm.
“Collagen, predominantly found in the dermal skin layer, has absorption peaks at 1050 nm, 1200 nm, 1500 nm, and 1725nm [45].”
From Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023) · cites this paper as [45]

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Engineering Approaches for Breast Cancer Diagnosis: A Review
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Noninvasive evaluation of collagen and hemoglobin contents and scattering property of in vivo keloid scars and normal skin using diffuse reflectance spectroscopy: pilot study
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Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes
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Biophotonic technologies for assessment of breast tumor surgical margins—A review
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Broadband Time Domain Diffuse Optical Reflectance Spectroscopy: A Review of Systems, Methods, and Applications
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Toward Noninvasive Characterization of Breast Cancer and Cancer Metabolism with Diffuse Optics
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In vivo tumor identification of colorectal liver metastases with diffuse reflectance and fluorescence spectroscopy
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Photoacoustic imaging of the uterine cervix to assess collagen and water content changes in murine pregnancy
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Advancing Optical Imaging for Breast Margin Assessment: An Analysis of Excisional Time, Cautery, and Patent Blue Dye on Underlying Sources of Contrast
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Diffuse reflectance spectroscopy to quantify the met-myoglobin proportion and meat oxygenation inside of pork and beef
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Spectrally encoded confocal microscopy for diagnosing breast cancer in excision and margin specimens
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Diffuse Reflectance Spectroscopy for Surface Measurement of Liver Pathology
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Diffuse reflectance spectroscopy: toward real-time quantification of steatosis in liver
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Impact of contact pressure–induced spectral changes on soft-tissue classification in diffuse reflectance spectroscopy: problems and solutions
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Development and Testing of an LED-Based Near-Infrared Sensor for Human Kidney Tumor Diagnostics
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Fourth near-infrared optical window for assessment of bone and other tissues
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Label-free imaging of fibroblast membrane interfaces and protein signatures with vibrational infrared photothermal and phase signals
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Variations in tissue optical parameters with the incident power of an infrared laser
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Prostate cancer detection using combined auto-fluorescence and light reflectance spectroscopy: ex vivo study of human prostates
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Methods of biomedical optical imaging: from subcellular structures to tissues and organs
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Accurate extraction of optical properties and top layer thickness of two-layered mucosal tissue phantoms from spatially resolved reflectance spectra
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Tissue-mimicking phantom materials with tunable optical properties suitable for assessment of diffuse reflectance spectroscopy during electrosurgery
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Optimizing algorithm development for tissue classification in colorectal cancer based on diffuse reflectance spectra
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Monitoring of Tumor Response to Cisplatin Using Optical Spectroscopy
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Spectroscopic photoacoustic imaging of cervical tissue composition in excised human samples
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Tunable blood oxygenation in the vascular anatomy of a semi-anthropomorphic photoacoustic breast phantom
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Nerve detection using optical spectroscopy, an evaluation in four different models: In human and swine, in‐vivo, and post mortem
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Machine Learning-Assisted Short-Wave InfraRed (SWIR) Techniques for Biomedical Applications: Towards Personalized Medicine
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Detection of Breast Diseases using Numerical Study of Light Propagation
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Mechanisms of laser activation of chondrocytes in osteoarthritis healing
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Intraoperative liver steatosis characterization using diffuse reflectance spectroscopy
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Application of optical spectroscopy in diagnosing and monitoring breast cancers: A technical review
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Nerve detection during surgery: optical spectroscopy for peripheral nerve localization
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Development of simple diffuse optical metabolic spectroscopy for tissue metabolism measurement
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Detection of canine skin and subcutaneous tumors by visible and near-infrared diffuse reflectance spectroscopy
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Diffuse reflectance spectroscopy accurately quantifies various degrees of liver steatosis in murine models of fatty liver disease
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Diffuse reflectance spectroscopy sensor to differentiate between glial tumor and healthy brain tissue: a proof-of-concept study
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Narrowband diffuse reflectance spectroscopy in the 900–1000 nm wavelength region to quantify water and lipid content of turbid media
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Near-infrared excitation/emission microscopy with lanthanide-based nanoparticles
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Feasibility of Ex Vivo Margin Assessment with Hyperspectral Imaging during Breast-Conserving Surgery: From Imaging Tissue Slices to Imaging Lumpectomy Specimen
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A modified source-detector configuration for the discrimination between normal and diseased human breast based on the continuous-wave diffuse optical imaging approach: a simulation study
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Objective determination of peripheral edema in heart failure patients using short-wave infrared molecular chemical imaging
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Diffuse reflectance spectroscopy of the cartilage tissue in the fourth optical window
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Diffuse reflectance spectroscopy for accurate margin assessment in breast-conserving surgeries: importance of an optimal number of fibers
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The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging
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Real-time tracking of a diffuse reflectance spectroscopy probe used to aid histological validation of margin assessment in upper gastrointestinal cancer resection surgery
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Review of shortwave infrared imaging and spectroscopy in tissue [Invited]
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In vivo nerve identification in head and neck surgery using diffuse reflectance spectroscopy
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Perspective Chapter: Hyperspectral Imaging for the Analysis of Seafood
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Optical spectroscopy and chemometrics in intraoperative tumor margin assessment
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Diffuse Reflectance Spectroscopy as a Possible Tool to Complement Liver Biopsy for Grading Hepatic Fibrosis in Paraffin-Preserved Human Liver Specimens
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Optical fluorescence imaging with shortwave infrared light emitter nanomaterials for in vivo cell tracking in regenerative medicine
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Machine learning applications to diffuse reflectance spectroscopy in optical diagnosis: a systematic review
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The design and implementation of a low-cost multispectral endoscopy through galvo scanning of a fiber bundle
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Numerical analysis of the optical fluence rate at the scalp for noninvasive brain tumor detection
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LED-based near infrared sensor for cancer diagnostics
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Towards Development of LED-Based Time-Domain Near-IR Spectroscopy System for Delineating Breast Cancer From Adjacent Normal Tissue
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A Comparison of Spectroscopy and Imaging Techniques Utilizing Spectrally Resolved Diffusely Reflected Light for Intraoperative Margin Assessment in Breast-Conserving Surgery: A Systematic Review and Meta-Analysis
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Optical Emission Spectroscopy for the Real-Time Identification of Malignant Breast Tissue
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Analyzing acoustoelastic effect of shear wave elastography data for perfused and hydrated soft tissues using a macromolecular network inspired model
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Toward the development of portable light emitting diode‐based polarization spectroscopy tools for breast cancer diagnosis
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Intraoperative tumor margin assessment using diffuse reflectance spectroscopy: the effect of electrosurgery on tissue discrimination using ex vivo animal tissue models
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Breast tissue analysis using a clinically compatible combined time‐resolved fluorescence and diffuse reflectance (TRF‐DR) system
Dao, E., Gohla, G., Williams, P., Lovrics, P. J., Badr, F., Fang, Q., Farrell, T. J., & Farquharson, M. (2023) · Lasers in Surgery and Medicine · doi:10.1002/lsm.23710 · Cited by 7 · see citing works
Hyperspectral dark-field microscopy of human breast lumpectomy samples for tumor margin detection in breast-conserving surgery
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Monitoring of neoadjuvant chemotherapy through time domain diffuse optics: breast tissue composition changes and collagen discriminative potential
Mule, N., Maffeis, G., Cubeddu, R., Santangelo, C., Bianchini, G., Panizza, P., & Taroni, P. (2024) · Biomedical Optics Express · doi:10.1364/boe.527968 · Cited by 7 · see citing works

Relationship between reflection spectra of breast adipose tissue with histologic grade
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Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy
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SPETTROSCOPIA E IMAGING IN OTTICA DIFFUSA: FOCUS SUL TUMORE DELLA MAMMELLA
Taroni, P. (2020) · Istituto Lombardo - Accademia di Scienze e Lettere - Rendiconti di Scienze · doi:10.4081/scie.2019.693

Authors: Nachabe, R., Hendriks, B. H., Lucassen, G. W., van der Voort, M., Evers, D. J., Rutgers, E. J., Peeters, M.-J. V., Van der Hage, J. A., Oldenburg, H. S., Ruers, T. J., & Wesseling, J.
Affiliations: Philips (Netherlands) (NL)
The Netherlands Cancer Institute (NL)
Philips Research Nederland B.V.
The Netherlands Cancer Institute
ORCID: Hendriks, Benno H.
Lucassen, Gerald W.
Evers, Daniel J.
Rutgers, Emiel J.
Oldenburg, Hester S.
Ruers, Theo J.
Venue: Journal of Biomedical Optics
Publisher: SPIE-Intl Soc Optical Eng
Published: 2011-08-01
Volume: 16
Issue: 08
Pages: 1-13
ISSN: 1083-3668 (ISSN-L)
1560-2281
DOI: 10.1117/1.3611010
OpenAlex: W2122745779
Cited by: 161
References: 45
Citations by year: 2026: 4 · 2025: 9 · 2024: 14 · 2023: 8 · 2022: 14 · 2021: 12 · 2020: 7 · 2019: 17 · 2018: 18 · 2017: 7 · 2016: 12 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 13
FWCI: 7.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Biomedical Optics (publishedVersion)
PubMed (publishedVersion)
University of Twente Research Information (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
University of Twente Research Information (submittedVersion)
Funders: European Commission (MEST-CT-2004-007832)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
Keywords: breast cancer diagnosis, diffuse optical spectroscopy, breast tissue classification, fibroadenoma, ductal carcinoma in situ, invasive breast cancer, adipose tissue, glandular tissue, chromophore concentration, lipid concentration, beta-carotene, classification and regression trees, diffusion theory, Mie scattering, optical fiber probe, ex vivo breast tissue
MeSH terms: Algorithms, Breast Neoplasms, Collagen, Diffusion, Female, Hemoglobins, Humans, Lipids, Oxyhemoglobins, Regression Analysis, Spectrum Analysis, Water, Statistics, Nonparametric, beta Carotene

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Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods

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