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Cited by 166Exercise and Physiological ResponsesMuscle metabolism and nutritionCardiovascular and exercise physiology

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Branched-Chain Amino Acid Supplementation Before Squat Exercise and Delayed-Onset Muscle Soreness

Shimomura, Yoshiharu, Inaguma, Asami, Watanabe, Satoko, Yamamoto, Yuko, Muramatsu, Yuji, Bajotto, Gustavo, Sato, Juichi, Shimomura, Noriko, Kobayashi, Hisamine, Mawatari, Kazunori·2010·International Journal of Sport Nutrition and Exercise Metabolism
DOI 10.1123/ijsnem.20.3.236
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Abstract

The authors examined the effect of branched-chain amino acid (BCAA) supplementation on squat-exercise-induced delayed-onset muscle soreness (DOMS) using 12 young, healthy, untrained female participants. The experiment was conducted with a crossover double-blind design. In the morning on the exercise-session day, the participants ingested either BCAA (isoleucine:leucine:valine = 1:2.3:1.2) or dextrin at 100 mg/kg body weight before the squat exercise, which consisted of 7 sets of 20 squats/set with 3-min intervals between sets. DOMS showed a peak on Days 2 and 3 in both trials, but the level of soreness was significantly lower in the BCAA trial than in the placebo. Leg-muscle force during maximal voluntary isometric contractions was measured 2 d after exercise (Day 3), and the BCAA supplementation suppressed the muscle-force decrease (to ~80% of the value recorded under the control conditions) observed in the placebo trial. Plasma BCAA concentrations, which decreased after exercise in the placebo trial, were markedly elevated during the 2 hr postexercise in the BCAA trial. Serum myoglobin concentration was increased by exercise in the placebo but not in the BCAA trial. The concentration of plasma elastase as an index of neutrophil activation appeared to increase after the squat exercise in both trials, but the change in the elastase level was significant only in the placebo trial. These results suggest that muscle damage may be suppressed by BCAA supplementation.

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Crossref · 10.1123/ijsnem.20.3.236

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Metadata

Authors
Shimomura, Y., Inaguma, A., Watanabe, S., Yamamoto, Y., Muramatsu, Y., Bajotto, G., Sato, J., Shimomura, N., Kobayashi, H., & Mawatari, K.
Affiliations
Nagoya University (JP)
ORCID
Venue
International Journal of Sport Nutrition and Exercise Metabolism
Publisher
Human Kinetics
Published
2010-06
Volume
20
Issue
3
Pages
236-244
ISSN
  • 1526-484X (ISSN-L)
  • 1543-2742
DOI
10.1123/ijsnem.20.3.236
OpenAlex
W2150326290
Cited by
166
References
45
Citations by year
2026: 1 · 2025: 5 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 12 · 2019: 7 · 2018: 12 · 2017: 31 · 2016: 12 · 2015: 8 · 2014: 6 · 2013: 15 · 2012: 12
FWCI
11.29
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Sport Nutrition and Exercise Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Uehara Memorial Foundation
  • Otsuka Pharmaceutical
Topics
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
branched-chain amino acids, delayed onset muscle soreness, squatting, muscle damage, isoleucine, leucine, valine, muscle force, serum myoglobin, neutrophil activation, plasma elastase
MeSH terms
Adult, Amino Acids, Branched-Chain, Beverages, Female, Humans, Myoglobin, Pancreatic Elastase, Exercise, Neutrophil Activation, Muscle, Skeletal, Cross-Over Studies, Dietary Supplements, Young Adult

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