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Effects of Resveratrol in Patients with Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure
Abstract
OBJECTIVES: The primary aims of the study were to examine the effect of resveratrol on skeletal muscle SIRT1 expression and energy expenditure in subjects with Type 2 diabetes mellitus (T2DM). BACKGROUND: Animal and in vivo studies indicate that resveratrol increases SIRT1 expression that stimulates PGC1α activity. Subsequent upregulation of AMPK and GLUT4 expression are associated with improved insulin sensitivity in peripheral tissues. METHODS: Ten subjects with T2DM were randomized in a double-blind fashion to receive 3g resveratrol or placebo daily for 12 weeks. Secondary outcomes include measures of AMPK, p-AMPK and GLUT4 expression levels, energy expenditure, physical activity levels, distribution of abdominal adipose tissue and skeletal muscle fiber type composition, body weight, HbA1c, plasma lipid subfraction, adiponectin levels, and insulin sensitivity. RESULTS: There was a significant increase in both SIRT1 expression (2.01 vs. 0.86 arbitrary units [AU], p = .016) and p-AMPK to AMPK expression ratio (2.04 vs. 0.79 AU, p = .032) in the resveratrol group compared with the placebo group. Although the percentage of absolute change (8.6 vs. -13.9%, p = .033) and percentage of predicted resting metabolic rate (RMR; 7.8 vs. -13.9%, p = .013) were increased following resveratrol, there was a significant reduction in average daily activity (-38 vs. 43.2%, p = .028) and step counts (-39.5 vs. 11.8%, p = .047) when compared with placebo. CONCLUSIONS: In patients with T2DM, treatment with resveratrol regulates energy expenditure through increased skeletal muscle SIRT1 and AMPK expression. These findings indicate that resveratrol may have beneficial exercise-mimetic effects in patients with T2DM.
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“In these studies, treatment with resveratrol has proved to activate both fuel-sensors AMPK and sirtuin 1 in insulin-sensitive peripheral tissues, especially skeletal muscles.”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [150]
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Antioxidant effects of resveratrol in the cardiovascular system
Xia, N., Daiber, A., Förstermann, U., & Li, H. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13492 · Cited by 583
Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523
“In one patient, mild elevation in ALT was reported while in other, mild hypoglycemia and diarrhea were observed.(253) In addition, bleeding and bruising effects may be seen due to antiplatelet effects of resveratrol, especially, in the patients using blood anticoagulants such as clopidogrel (Plavix), enoxaparin (Loven…”
BackgroundResveratrol and diabetes: from animal to human studies
Szkudelski, T., & Szkudelska, K. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.013 · Cited by 364
Sirtuins Link Inflammation and Metabolism
Vachharajani, V., Liu, T., Wang, X., Hoth, J. J., Yoza, B. K., & McCall, C. E. (2016) · Journal of Immunology Research · doi:10.1155/2016/8167273 · Cited by 333
“In animalmodels of diabetes, SIRT1 activation increases energy expenditure and improves insulin sensitivity [49, 50].”
Dietary polyphenols as antidiabetic agents: Advances and opportunities
Sun, C., Zhao, C., Çapanoğlu, E., Paoli, P., Simal‐Gándara, J., Ramkumar, K. M., Wang, S., Buleu, F. N., Pah, A.-M., Turi, V., et al. (2020) · Food Frontiers · doi:10.1002/fft2.15 · Cited by 309
“Upregulation of GLUT4 by AMPK phosphorylation in skeletal muscle has also been observed in a clinical trial carried out in a cohort of diabetic subjects (Goh et al., 2014).”
Background
Metadata
- Authors
- Goh, K. P., Lee, H. Y., Lau, D. P., Supaat, W., Chan, Y. H., & Koh, A. F. Y.
- Affiliations
- Khoo Teck Puat Hospital (SG)
- Venue
- International Journal of Sport Nutrition and Exercise Metabolism
- Publisher
- Human Kinetics
- Published
- 2014-02
- Volume
- 24
- Issue
- 1
- Pages
- 2-13
- ISSN
- 1526-484X (ISSN-L)
- 1543-2742
- OpenAlex
- W2103667012
- Cited by
- 187
- References
- 0
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 12 · 2023: 20 · 2022: 15 · 2021: 24 · 2020: 22 · 2019: 9 · 2018: 17 · 2017: 17 · 2016: 9 · 2015: 10 · 2014: 10
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Sport Nutrition and Exercise Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- resveratrol, type 2 diabetes, SIRT1, AMPK, skeletal muscle, energy expenditure, resting metabolic rate, insulin sensitivity, GLUT4, PGC-1α, physical activity, adiponectin, HbA1c
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Resveratrol, Basal Metabolism, Diabetes Mellitus, Type 2, Double-Blind Method, Energy Metabolism, Physical Exertion, Humans, Insulin Resistance, Male, Middle Aged, Plant Extracts, Rest, Stilbenes, Transcription Factors, Exercise, Muscle, Skeletal, Vitis, Glucose Transporter Type 4, AMP-Activated Protein Kinases, Sirtuin 1
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