Health benefits of resveratrol: Evidence from clinical studies
Abstract
Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in over 244 clinical trials, with an additional 27 clinical trials currently ongoing. Resveretrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis. The polyphenol is reported to be safe at doses up to 5 g/d, when used either alone or as a combination therapy. The molecular basis for the pleiotropic activities of resveratrol are based on its ability to modulate multiple cell signaling molecules such as cytokines, caspases, matrix metalloproteinases, Wnt, nuclear factor‐κB, Notch, 5′‐AMP‐activated protein kinase, intercellular adhesion molecule, vascular cell adhesion molecule, sirtuin type 1, peroxisome proliferator‐activated receptor‐γ coactivator 1α, insulin‐like growth factor 1, insulin‐like growth factor‐binding protein 3, Ras association domain family 1α, pAkt, vascular endothelial growth factor, cyclooxygenase 2, nuclear factor erythroid 2 like 2, and Kelch‐like ECH–associated protein 1. Although the clinical utility of resveratrol is well documented, the rapid metabolism and poor bioavailability have limited its therapeutic use. In this regard, the recently produced micronized resveratrol formulation called SRT501, shows promise. This review discusses the currently available clinical data on resveratrol in the prevention, management, and treatment of various diseases and disorders. Based on the current evidence, the potential utility of this molecule in the clinic is discussed.
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Clinical trials have proved the safety of resveratrol in the human body.
“Although clinical trials have proved the safety of resveratrol in the human body, further in vivo research on its use for the treatment of fungal infections is still needed (66).”
From Recent Progress in Research on Mitochondrion-Targeted Antifungal Drugs: a Review (2023) · cites this paper as [66]
Resveratrol administration appears to improve the metabolic profile in obese and/or insulin-resistant patients.
“Administration of resveratrol appears to improve the metabolic profile in obese and/or insulin-resistant patients.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [5]
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Insulin and Glucagon: Partners for Life
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Maia, H., Haddad, Pinheiro, & Casoy, J. (2012) · International Journal of Women s Health · doi:10.2147/ijwh.s36825 · Cited by 87 · see citing works
Matrix effects on the bioavailability of resveratrol in humans
Ortuño, J., Covas, M., Farré, M., Pujadas, M., Fitó, M., Khymenets, O., Andrés‐Lacueva, C., Roset, P. N., Joglar, J., Lamuela-Raventós, R. M., et al. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.11.032 · Cited by 87 · see citing works
Kjær, T. N., Ørnstrup, M. J., Poulsen, M. M., et al. (2015) · The Prostate · doi:10.1002/pros.23006 · Cited by 86 · see citing works
Obesidad, síndrome metabólico y diabetes: implicaciones cardiovasculares y actuación terapéutica
Ezquerra, E. A., Castellano, J. M., & Barrero, A. A. (2008) · Revista Española de Cardiología · doi:10.1157/13123996 · Cited by 85 · see citing works
Resveratrol-induced autophagy promotes survival and attenuates doxorubicin-induced cardiotoxicity
Gu, J. F., Hu, W. G., Song, Z., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.01.002 · Cited by 83 · see citing works
Resveratrol: From Basic Studies to Bedside
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Antioxidant Properties of Resveratrol and its Protective Effects in Neurodegenerative Diseases
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The effect of resveratrol on hypertension: A clinical trial
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Potential Adverse Effects of Resveratrol: A Literature Review
Shaito, A., Posadino, A. M., Younes, N., Hasan, H., Halabi, S., Alhababi, D., Al-Mohannadi, A., Abdel-Rahman, W. M., Eid, A. H., Nasrallah, G. K., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062084 · Cited by 716 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
The Role of Resveratrol Administration in Human Obesity
Mongioì, L. M., La Vignera, S., Cannarella, R., Cimino, L., Compagnone, M., Condorelli, R. A., & Calogero, A. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094362 · Cited by 71 · see citing works
Miguel, C. A., Noya-Riobó, M. V., Mazzone, G. L., Villar, M. J., & Coronel, M. F. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105188 · Cited by 70 · see citing works
Zhang, X., Chen, S., Luo, D., Chen, D., Zhou, H., Zhang, S., Chen, X., Lu, W., & Liu, W. (2023) · Molecules · doi:10.3390/molecules28062738 · Cited by 60 · see citing works
Zhang, B., Zhang, Y., Liu, X., Zhao, C., Yin, J., Li, X., Zhang, X., Wang, J., & Wang, S. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2022.133904 · Cited by 47 · see citing works
Recent Progress in Research on Mitochondrion-Targeted Antifungal Drugs: a Review
Qin, Y., Wang, J., Lv, Q., & Han, B. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00003-23 · Cited by 38 · see citing works
“Although clinical trials have proved the safety of resveratrol in the human body, further in vivo research on its use for the treatment of fungal infections is still needed (66).”
BackgroundThe synergistic antifungal activity of resveratrol with azoles against <i>Candida albicans</i>
Wang, J., Zhang, X., Gao, L., Wang, L., Song, F., Zhang, L., & Wan, Y. (2021) · Letters in Applied Microbiology · doi:10.1111/lam.13458 · Cited by 29 · see citing works
- Authors
- Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C.
- Affiliations
- Indian Institute of Technology BHU (IN)
- Banaras Hindu University (IN)
- Stellenbosch University (ZA)
- Corresponding author
- Maiti, Pralay
- Gupta, Subash Chandra
- ORCID
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2019-02-11
- Volume
- 39
- Issue
- 5
- Pages
- 1851-1891
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W2913875557
- Cited by
- 523
- References
- 263
- Citations by year
- 2026: 40 · 2025: 80 · 2024: 88 · 2023: 85 · 2022: 86 · 2021: 74 · 2020: 53 · 2019: 17
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicinal Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science and Engineering Research Board (ECR/2016/000034, PDF/2016/004063)
- University Grants Commission (No. F.30‐112/2015 (BSR))
- Department of Biotechnology, Government of West Bengal (DBT/2017/BHU/786)
- Indian Council of Medical Research (3/2/2/43/2018/Online Onco Fship/NCD‐III)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- resveratrol, polyphenols, nutraceuticals, health benefits, diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular disease, kidney disease, inflammatory diseases, rhinopharyngitis, drug safety, pharmacokinetics, bioavailability, signal transduction, SIRT1, AMPK, NF-κB, NF-E2-related factor 2, disease prevention
- MeSH terms
- Resveratrol, Animals, Antioxidants, Diabetes Mellitus, Humans, Neoplasms, Obesity, Metabolic Syndrome
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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