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Cited by 43Thermoregulation and physiological responsesCardiovascular and exercise physiologyMuscle metabolism and nutrition

Increase in Skeletal-Muscle Glycogenolysis and Perceived Exertion With Progressive Dehydration During Cycling in Hydrated Men

Logan-Sprenger, Heather M., Heigenhauser, George J. F., Jones, Graham L., Spriet, Lawrence L.·2013·International Journal of Sport Nutrition and Exercise Metabolism
DOI 10.1123/ijsnem.23.3.220
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Abstract

This study investigated the effects of progressive mild dehydration during cycling on whole-body substrate oxidation and skeletal-muscle metabolism in recreationally active men. Subjects ( N = 9) cycled for 120 min at ~65% peak oxygen uptake (VO 2peak 22.7 °C, 32% relative humidity) with water to replace sweat losses (HYD) or without fluid (DEH). Blood samples were taken at rest and every 20 min, and muscle biopsies were taken at rest and at 40, 80, and 120 min of exercise. Subjects lost 0.8%, 1.8%, and 2.7% body mass (BM) after 40, 80, and 120 min of cycling in the DEH trial while sweat loss was not significantly different between trials. Heart rate was greater in the DEH trial from 60 to 120 min, and core temperature was greater from 75 to 120 min. Rating of perceived exertion was higher in the DEH trial from 30 to 120 min. There were no differences in VO 2, respiratory-exchange ratio, total carbohydrate (CHO) oxidation (HYD 312 ± 9 vs. DEH 307 ± 10 g), or sweat rate between trials. Blood lactate was significantly greater in the DEH trial from 20 to 120 min with no difference in plasma free fatty acids or epinephrine. Glycogenolysis was significantly greater (24%) over the entire DEH vs. HYD trial (433 ± 44 vs. 349 ± 27 mmol · kg −1 · dm −1 ). In conclusion, dehydration of <2% BM elevated physiological parameters and perceived exertion, as well as muscle glycogenolysis, during exercise without affecting whole-body CHO oxidation.

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  • There appears to be equivalent losses of plasma volume between the sexes under similar exercise conditions potentially representing sex differences in the compartmentalization of fluids.

    “there appears to be equivalent losses of plasma volume between the sexes under similar exercise conditions [272,273] potentially representing sex differences in the compartmentalization of fluids.”

    From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [272]

  • Other factors may impact the degradation of muscle glycogen, such as dehydration and hyperthermia.

    “Other factors may impact the degradation of muscle glycogen, such as dehydration and hyperthermia [36,95,96,97].”

    From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [95]

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Authors
Logan-Sprenger, H. M., Heigenhauser, G. J. F., Jones, G. L., & Spriet, L. L.
Affiliations
University of Guelph (CA)
ORCID
Venue
International Journal of Sport Nutrition and Exercise Metabolism
Publisher
Human Kinetics
Published
2013-06
Volume
23
Issue
3
Pages
220-229
ISSN
  • 1526-484X (ISSN-L)
  • 1543-2742
DOI
10.1123/ijsnem.23.3.220
OpenAlex
W2128172872
Cited by
43
References
33
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 9 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 1
FWCI
1.39
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Sport Nutrition and Exercise Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
dehydration, perceived exertion, cycling exercise, carbohydrate oxidation, substrate oxidation, blood lactate, sweat loss, core body temperature, heart rate, free fatty acids, epinephrine, muscle metabolism
MeSH terms
Bicycling, Dehydration, Energy Metabolism, Fatty Acids, Nonesterified, Heart Rate, Humans, Male, Oxygen Consumption, Sweat, Sweating, Exercise, Body Mass Index, Muscle, Skeletal, Lactic Acid, Glycogenolysis, Young Adult

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