Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 444

The DOI matches its Crossref record.

Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4

Bhardwaj, Rajinder K., Glaeser, Hartmut, Becquemont, Laurent, Klotz, Ulrich, Gupta, Suresh K., Fromm, Martin F.·2002·The Journal of Pharmacology and Experimental Therapeutics
DOI 10.1124/jpet.102.034728
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1124/jpet.102.034728

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 39

  1. Ahsan, 1991, Ethnic differences in the pharmacokinetics of oral nifedipine., Br J Clin Pharmacol, 31, 399, 10.1111/j.1365-2125.1991.tb05552.x · DOI
  2. Atal, 1981, Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs., J Ethnopharmacol, 4, 229, 10.1016/0378-8741(81)90037-4 · DOI
  3. Ayrton, 2001, Role of transport proteins in drug absorption, distribution and excretion., Xenobiotica, 31, 469, 10.1080/00498250110060969 · DOI
  4. Bailey, 1998, Grapefruit juice-drug interactions., Br J Clin Pharmacol, 46, 101, 10.1046/j.1365-2125.1998.00764.x · DOI · Paper page
  5. Bano, 1987, The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers., Planta Med, 53, 568, 10.1055/s-2006-962814 · DOI
  6. Bano, 1991, Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers., Eur J Clin Pharmacol, 41, 615, 10.1007/BF00314996 · DOI · Paper page
  7. Becquemont, 2001, Effect of grapefruit juice on digoxin pharmacokinetics in humans., Clin Pharmacol Ther, 70, 311, 10.1016/S0009-9236(01)17221-8 · DOI
  8. Busse, 1995, Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans., Naunyn-Schmiedeberg’s Arch Pharmacol, 353, 116, 10.1007/BF00168924 · DOI
  9. Dalvi, 1991, Differences in the effects of piperine and piperonyl butoxide on hepatic drug-metabolizing enzyme system in rats., Drug Chem Toxicol, 14, 219, 10.3109/01480549109017878 · DOI
  10. Darbar, 1998, Modulation by dietary salt of verapamil disposition in humans., Circulation, 98, 2702, 10.1161/01.CIR.98.24.2702 · DOI
  11. Dürr, 2000, St. John’s Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4., Clin Pharmacol Ther, 68, 598, 10.1067/mcp.2000.112240 · DOI · Paper page
  12. Evans, 2000, Influence of dietary components on the gastrointestinal metabolism and transport of drugs., Ther Drug Monit, 22, 131, 10.1097/00007691-200002000-00028 · DOI
  13. Fromm, 2000, P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs., Int J Clin Pharmacol Ther, 38, 69, 10.5414/CPP38069 · DOI
  14. Fromm, 1996, Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin., Hepatology, 24, 796, 10.1002/hep.510240407 · DOI · Paper page
  15. Fromm, 1999, Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine., Circulation, 99, 552, 10.1161/01.CIR.99.4.552 · DOI
  16. Glaeser, 2002, Shed human enterocytes as a tool for the study of expression and function of intestinal drug metabolizing enzymes and transporters., Clin Pharmacol Ther, 71, 131, 10.1067/mcp.2002.121370 · DOI
  17. Greiner, 1999, The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin., J Clin Invest, 104, 147, 10.1172/JCI6663 · DOI
  18. Jensen-Jarolim, 1998, Hot spices influence permeability of human intestinal epithelial monolayers., J Nutr, 128, 577, 10.1093/jn/128.3.577 · DOI
  19. Kane, 2000, Drug-grapefruit juice interactions., Mayo Clin Proc, 75, 933, 10.4065/75.9.933 · DOI · Paper page
  20. Kim, 1998, The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors., J Clin Invest, 101, 289, 10.1172/JCI1269 · DOI
  21. Kolars, 1991, First-pass metabolism of cyclosporin by the gut., Lancet, 338, 1488, 10.1016/0140-6736(91)92302-I · DOI · Paper page
  22. Kroemer, 1992, Predictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspects., J Pharmacol Exp Ther, 260, 1052, 10.1016/S0022-3565(25)11408-0 · DOI
  23. Kroemer, 1993, Identification of P450 enzymes involved in metabolism of verapamil in humans., Naunyn-Schmiedeberg’s Arch Pharmacol, 348, 332, 10.1007/BF00169164 · DOI
  24. Lown, 1997, Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine., Clin Pharmacol Ther, 62, 248, 10.1016/S0009-9236(97)90027-8 · DOI
  25. Paine, 1996, First-pass metabolism of midazolam by the human intestine., Clin Pharmacol Ther, 60, 14
  26. Pauli-Magnus, 2000, Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein., J Pharmacol Exp Ther, 293, 376, 10.1016/S0022-3565(24)39245-6 · DOI
  27. Schinkel, 1996, P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs., J Clin Invest, 97, 2517, 10.1172/JCI118699 · DOI
  28. Schuetz, 1996, P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans., Proc Natl Acad Sci USA, 93, 4001, 10.1073/pnas.93.9.4001 · DOI · Paper page
  29. Singh, 1986, Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogenous UDP-glucuronic acid content., J Pharmacol Exp Ther, 236, 488, 10.1016/S0022-3565(25)38910-X · DOI
  30. Thummel, 1996, Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism., Clin Pharmacol Ther, 59, 491, 10.1016/S0009-9236(96)90177-0 · DOI
  31. Velpandian, 2001, Piperine in food: interference in the pharmacokinetics of phenytoin., Eur J Drug Metab Pharmacokinet, 26, 241, 10.1007/BF03226378 · DOI
  32. von Richter, 2000, Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry., J Chromatogr B Biomed Sci Appl, 738, 137, 10.1016/S0378-4347(99)00508-3 · DOI
  33. Wacher, 2001, Active secretion and enterocytic drug metabolism barriers to drug absorption., Adv Drug Deliv Rev, 46, 89, 10.1016/S0169-409X(00)00126-5 · DOI
  34. Walter-Sack, 1996, Influence of diet and nutritional status on drug metabolism., Clin Pharmacokinet, 31, 47, 10.2165/00003088-199631010-00004 · DOI
  35. Watkins, 1997, The barrier function of CYP3A4 and P-glycoprotein in the small bowel., Adv Drug Deliv Rev, 27, 161, 10.1016/S0169-409X(97)00041-0 · DOI
  36. Watkins, 1987, Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man., J Clin Invest, 80, 1029, 10.1172/JCI113156 · DOI · Paper page
  37. Westphal, 2000, Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction., Clin Pharmacol Ther, 68, 345, 10.1067/mcp.2000.109797 · DOI · Paper page
  38. Wilkinson, 1997, The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans., Adv Drug Deliv Rev, 27, 129, 10.1016/S0169-409X(97)00040-9 · DOI
  39. Zutshi, 1985, Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis., J Assoc Physicians India, 33, 223

Cited by

Metadata

Authors
Bhardwaj, R. K., Glaeser, H., Becquemont, L., Klotz, U., Gupta, S. K., & Fromm, M. F.
Venue
The Journal of Pharmacology and Experimental Therapeutics
Publisher
Elsevier BV
Published
2002-08
Volume
302
Issue
2
Pages
645-650
ISSN
0022-3565
DOI
10.1124/jpet.102.034728
Cited by
444
References
0
Language
en
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.