Concise Review: Clinical Relevance of Drug–Drug and Herb–Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P-glycoprotein)
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Learning Objectives: After completing this course, the reader will be able to: Identify important sources of variability in drug exposure caused by drug interactions mediated by P-glycoprotein.Describe how unwanted drug–drug interactions may lead to unexpected serious toxicity or undertreatment.Prevent these interactions by individualizing pharmacotherapy; this means selecting noninteracting drugs or adapting the dose of (the) interacting drug(s). CME Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com
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Lactam 4 has a further advantage over the diacetonide of 20E, namely it would likely be free from potential adverse effects and unwanted drug-drug interactions connected to P-gp inhibitors.
“this compound has a further advantage over the diacetonide of 20E, namely that it would likely be free from the potential adverse effects and unwanted drug-drug interactions”
From Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam (2018) · cites this paper as [26]
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ABC Transporters: From Microorganisms to Man
Higgins, C. F. (1992) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.08.110192.000435 · Cited by 3,985 · see citing works
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
Juliano, R. L., & Ling, V. W. T. (1976) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(76)90160-7 · Cited by 3,317 · see citing works
Thiebaut, F., TSURUO, T., Hamada, H., Gottesman, M. M., PASTAN, I., & Willingham, M. C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7735 · Cited by 2,777 · see citing works
Hoffmeyer, S., Burk, O., von Richter, O., Arnold, H., Brockmöller, J., Johne, A., Cascorbi, I., Gerloff, T., Roots, I., Eichelbaum, M. F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3473 · Cited by 2,366 · see citing works
Schinkel, A. H., Smit, J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., van der Valk, M. A., Robanus-Maandag, E. C., Riele, H. T., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90212-7 · Cited by 2,284 · see citing works
Self-citationCordon‐Cardo, C., O’Brien, J. P., Casals, D., Rittmann-Grauer, L., Biedler, J. L., Melamed, M. R., & Bertino, J. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.695 · Cited by 1,750 · see citing works
Expression of a multidrug-resistance gene in human tumors and tissues.
Fojo, A. T., Ueda, K., Slamon, D. J., Poplack, D. G., Gottesman, M. M., & Pastan, I. H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.1.265 · Cited by 1,545 · see citing works
Tsuruo, T., Iida, H., Tsukagoshi, S., & Sakurai, Y. (1981) · PubMed · Cited by 1,459 · see citing works
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
Schinkel, A. H., & Jonker, J. W. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00169-2 · Cited by 1,427 · see citing works
Induction of phase I, II and III drug metabolism/transport by xenobiotics
Xu, C., Li, C. Y.-T., & Kong, A. T. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02977789 · Cited by 1,272 · see citing works
Schinkel, A. H., Wagenaar, E., Mol, C. A. A. M., & van Deemter, L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118699 · Cited by 1,265 · see citing works
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
Schinkel, A. H., & Jonker, J. W. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.027 · Cited by 1,236 · see citing works
Schinkel, A. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., & Borst, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118214 · Cited by 1,108 · see citing works
Gros, P., Croop, J. M., & Housman, D. E. (1986) · Cell · doi:10.1016/0092-8674(86)90594-5 · Cited by 1,043 · see citing works
Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines
Kartner, N., Riordan, J. R., & Ling, V. W. T. (1983) · Science · doi:10.1126/science.6137059 · Cited by 1,005 · see citing works
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
Moore, L. B., Goodwin, B. J., Jones, S. A., Wisely, G. B., Serabjit‐Singh, C. J., Willson, T. M., Collins, J. L., & Kliewer, S. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130155097 · Cited by 946 · see citing works
Schinkel, A. H., Mayer, U., Wagenaar, E., Mol, C. A. A. M., van Deemter, L., Smit, J. J. M., van der Valk, M. A., Voordouw, A. C., Spits, H., van Tellingen, O., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4028 · Cited by 937 · see citing works
The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism
Kliewer, S. A., Goodwin, B. J., & Willson, T. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0038 · Cited by 922 · see citing works
The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
Greiner, B., Eichelbaum, M. F., Fritz, P., Kreichgauer, H. P., von Richter, O., Zundler, J., & Kroemer, H. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6663 · Cited by 917 · see citing works
Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance
Marzolini, C. (2004) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2003.09.012 · Cited by 897 · see citing works
Sparreboom, A., van Asperen, J., Mayer, U., Schinkel, A. H., Smit, J. W., Meijer, D. K. F., Borst, P., Nooijen, W. J., Beijnen, J. H., & van Tellingen, O. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.2031 · Cited by 884 · see citing works
Self-citationIndinavir concentrations and St John's wort
Piscitelli, S. C., Burstein, A. H., Chaitt, D. G., Alfaro, R. M., & Falloon, J. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05712-8 · Cited by 873 · see citing works
Wacher, V. J., Wu, C., & Benet, L. Z. (1995) · Molecular Carcinogenesis · doi:10.1002/mc.2940130302 · Cited by 862 · see citing works
Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin
Geick, A., Eichelbaum, M. F., & Burk, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010173200 · Cited by 845 · see citing works
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
Synold, T. W., Dussault, I., & FORMAN, B. M. (2001) · Nature Medicine · doi:10.1038/87912 · Cited by 840 · see citing works
A Southwest Oncology Group study
Jenkins, T. R., Tangen, C. M., Macdonald, J. S., Weiss, G. R., Chapman, R. M., & Hantel, A. (1993) · Cited by 773 · see citing works
Siddiqui, A. T. S., Kerb, R., Weale, M. E., Brinkmann, U., Smith, A. C., Goldstein, D. B., Wood, N. W., & Sisodiya, S. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021986 · Cited by 662 · see citing works
Acute heart transplant rejection due to Saint John's wort
Ruschitzka, F. T., Meier, P. J., Turina, M. I., Lüscher, T. F., & Noll, G. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05467-7 · Cited by 644 · see citing works
Johne, A. (1999) · Clinical Pharmacology & Therapeutics · doi:10.1053/cp.1999.v66.a101944 · Cited by 592 · see citing works
St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4
Dürr, D. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.112240 · Cited by 590 · see citing works
Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4
Bhardwaj, R., Glaeser, H., Becquemont, L., Klotz, U. E., Gupta, S. K., & Fromm, M. F. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034728 · Cited by 555 · see citing works
Schuetz, E. G., Beck, W. T., & Schuetz, J. D. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08713-9 · Cited by 498 · see citing works
Kruijtzer, C. M. F., Beijnen, J. H., Rosing, H., Huinink, W. W. T. B., Schot, M. E., Jewell, R. C., Paul, E. M., & Schellens, J. H. M. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.12.116 · Cited by 465 · see citing works
Self-citationEffects of St. John's wort on irinotecan metabolism.
Mathijssen, R. H. J. (2002) · CancerSpectrum Knowledge Environment · doi:10.1093/jnci/94.16.1247 · Cited by 457 · see citing works
Kroetz, D., Pauli-Magnus, C., Hodges, L. M., Huang, C. C., Kawamoto, M., Johns, S., Stryke, D., Ferrin, T., Deyoung, J., Taylor, T. R., et al. (2003) · Pharmacogenetics (London) · doi:10.1097/00008571-200308000-00006 · Cited by 438 · see citing works
Increased drug delivery to the brain by P-glycoprotein inhibition
Sadeque, A. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.109156 · Cited by 426 · see citing works
Kempf, D. J., Marsh, K. C., Kumar, G. N., et al. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.3.654 · Cited by 422 · see citing works
List, A. F., Kopecky, K. J., Willman, C. L., Head, D. R., Persons, D. L., Slovak, M. L., Dorr, R. T., Karanes, C., Hynes, H. E., Doroshow, J. H., et al. (2001) · Blood · doi:10.1182/blood.v98.12.3212 · Cited by 418 · see citing works
Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer
Rogan, A. M., Hamilton, T. C., Young, R. C., Klecker, R. W., & Ozols, R. F. (1984) · Science · doi:10.1126/science.6372095 · Cited by 396 · see citing works
The barrier function of CYP3A4 and P-glycoprotein in the small bowel
Watkins, P. B. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00041-0 · Cited by 395 · see citing works
Herbal Modulation of P‐Glycoprotein
Zhou, S., Lim, L. Y., & Chowbay, B. (2004) · Drug Metabolism Reviews · doi:10.1081/dmr-120028427 · Cited by 375 · see citing works
Hunter, J., Jepson, M. A., TSURUO, T., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82429-2 · Cited by 370 · see citing works
Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo
Fellner, S., Bauer, B., Miller, D. S., Schaffrik, M., Fankhänel, M., Spruß, T., Bernhardt, G., Graeff, C., Färber, L., Gschaidmeier, H., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15451 · Cited by 359 · see citing works
Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo
Fellner, S., Bauer, B., Miller, D. S., Schaffrik, M., Fankhänel, M., Spruß, T., Bernhardt, G., Graeff, C., Färber, L., Gschaidmeier, H., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215451 · Cited by 359 · see citing works
Smit, J. W., Huisman, M. T., van Tellingen, O., WILTSHIRE, H. R., & Schinkel, A. H. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7963 · Cited by 352 · see citing works
Breedveld, P., Pluim, D., Cipriani, G., Wielinga, P. R., van Tellingen, O., Schinkel, A. H., & Schellens, J. H. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2416 · Cited by 352 · see citing works
Self-citationHébert, M. F., Roberts, J. P., Prueksaritanont, T., & Benet, L. Z. (1992) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1992.171 · Cited by 337 · see citing works
Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis
Schwab, M. G., Schaeffeler, E., Marx, C., Fromm, M. F., Kaskas, B., Metzler, J., Stange, E. F., Herfarth, H. H., Schöelmerich, J., Gregor, M., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50010 · Cited by 323 · see citing works
Breedveld, P., Beijnen, J. H., & Schellens, J. H. M. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.11.009 · Cited by 323 · see citing works
Self-citationLankas, G. R., Wise, L. D., Cartwright, M. E., Pippert, T. R., & Umbenhauer, D. R. (1998) · Reproductive Toxicology · doi:10.1016/s0890-6238(98)00027-6 · Cited by 314 · see citing works
Zhang, S., & Morris, M. E. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.044412 · Cited by 311 · see citing works
Genetic Polymorphisms of the HumanMDR1Drug Transporter
Schwab, M. G., Eichelbaum, M. F., & Fromm, M. F. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140233 · Cited by 310 · see citing works
Kilic, T., Alberta, J. A., Zdunek, P. R., Acar, M., Iannarelli, P., O'Reilly, T., Buchdunger, E., Black, P. M., & Stiles, C. D. (2000) · PubMed · Cited by 310 · see citing works
Contribution of adverse drug reactions to hospital admission of older patients
Mannesse, C. K. (2000) · Age and Ageing · doi:10.1093/ageing/29.1.35 · Cited by 304 · see citing works
Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols
Jodoin, J., Demeule, M., & Béliveau, R. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(01)00175-6 · Cited by 300 · see citing works
Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR
de Bruin, M., Miyake, K., Litman, T., Robey, R. W., & Bates, S. E. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00182-2 · Cited by 298 · see citing works
Fattinger, K. E., Roos, M., Vergères, P., Holenstein, C., Kind, B., Masche, U., Stocker, D., Braunschweig, S., Kullak-Ublick, G. A., Galeazzi, R. L., et al. (2000) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2000.00132.x · Cited by 296 · see citing works
Anuchapreeda, S., Leechanachai, P., Smith, M. M., Ambudkar, S. V., & Limtrakul, P. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01224-8 · Cited by 291 · see citing works
The interaction between St John's wort and an oral contraceptive
Hall, S. D. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2003.08.009 · Cited by 286 · see citing works
Westphal, K. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.109797 · Cited by 285 · see citing works
Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia.
List, A. F., Spier, C. M., Greer, J. P., et al. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.9.1652 · Cited by 280 · see citing works
Beijnen, J. H., & Schellens, J. H. M. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01528-1 · Cited by 278 · see citing works
Self-citationDistribution of STI-571 to the Brain Is Limited by P-Glycoprotein-Mediated Efflux
Dai, H. I., Marbach, P., Lemaire, M., Hayes, M., & Elmquist, W. F. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.045260 · Cited by 274 · see citing works
Kurata, Y., Ieiri, I., Kimura, M., et al. (2002) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2002.126177 · Cited by 270 · see citing works
Arceci, R. J., Croop, J. M., Horwitz, S. B., & Housman, D. E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4350 · Cited by 265 · see citing works
Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects
Dresser, G. K., Schwarz, U. I., Wilkinson, G. R., & Kim, R. B. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2003.10 · Cited by 261 · see citing works
Irinotecan pathway genotype analysis to predict pharmacokinetics.
Mathijssen, R. H. J., Marsh, S., Karlsson, M. O., Xie, R., Baker, S. D., Verweij, J., Sparreboom, A., & McLeod, H. L. (2003) · PubMed · Cited by 258 · see citing works
Effect of St John's wort on imatinib mesylate pharmacokinetics
Frye, R. F., Fitzgerald, S. M., Lagattuta, T. F., Hruska, M. W., & Egorin, M. J. (2004) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2004.06.007 · Cited by 258 · see citing works
Pharmacokinetic Interactions of Drugs with St John’s Wort
Zhou, S., Chan, E., Pan, S. Q., Huang, M., & Lee, E. J. D. (2004) · Journal of Psychopharmacology · doi:10.1177/0269881104042632 · Cited by 256 · see citing works
MDR1 gene polymorphisms and disposition of the P‐glycoprotein substrate fexofenadine
Drescher, S., Schaeffeler, E., Hitzl, M., Hofmann, U., Schwab, M. G., Brinkmann, U., Eichelbaum, M. F., & Fromm, M. F. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01591.x · Cited by 249 · see citing works
MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients.
Illmer, T., Schuler, U. S., Thiede, C., Schwarz, U. I., Kim, R. B., Gotthard, S., Freund, D., Schäkel, U., Ehninger, G., & Schaich, M. A. (2002) · PubMed · Cited by 248 · see citing works
Doering, W. (1979) · New England Journal of Medicine · doi:10.1056/nejm197908233010803 · Cited by 247 · see citing works
Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.
Kemper, E. M., van Zandbergen, A. E., Cleypool, C. G. J., Mos, H. A., Boogerd, W. J., Beijnen, J. H., & van Tellingen, O. (2003) · PubMed · Cited by 243 · see citing works
Self-citationSiegsmund, M. J., Brinkmann, U., Accent]ffeler, E. S. A., Weirich, G., Schwab, M. G., Eichelbaum, M. F., Fritz, P., Burk, O., Decker, J., Alken, P. M., et al. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000019412.87412.bc · Cited by 243 · see citing works
Herb–Drug Interactions in Oncology: Focus on Mechanisms of Induction
Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2006) · The Oncologist · doi:10.1634/theoncologist.11-7-742 · Cited by 236 · see citing works
Self-citationGreenberg, P. L., Lee, S. J., Advani, R. H., Tallman, M. S., Sikic, B. I., Letendre, L., Dugan, K., Lum, B. L., Chin, D. L., Dewald, G. W., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.07.048 · Cited by 234 · see citing works
Reversal of multidrug resistance by surfactants
Woodcock, D., Linsenmeyer, M. E., Chojnowski, G. M., Kriegler, A., Nink, V., Webster, L., & Sawyer, W. (1992) · British Journal of Cancer · doi:10.1038/bjc.1992.217 · Cited by 233 · see citing works
Mechanism of the Pharmacokinetic Interaction between Methotrexate and Benzimidazoles
Breedveld, P., Zelcer, N., Pluim, D., Sönmezer, Ö., Tibben, M. M., Beijnen, J. H., Schinkel, A. H., van Tellingen, O., Borst, P., & Schellens, J. H. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-4062 · Cited by 230 · see citing works
Self-citationInteraction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein
Pauli‐Magnus, C., Rekersbrink, S., Klotz, U. E., et al. (2001) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-001-0489-7 · Cited by 230 · see citing works
Variable modulation of opioid brain uptake by P-glycoprotein in mice
Dagenais, C., Graff, C. L., & Pollack, G. M. (2003) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.08.027 · Cited by 220 · see citing works
Effect of St John's wort on the pharmacokinetics of fexofenadine
Wang, Z., Hamman, M. A., Huang, S. M., Lesko, L. J., & Hall, S. D. (2002) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2002.124080 · Cited by 214 · see citing works
The influence of verapamil on serum digoxin concentration.
Klein, H. O., Lang, R. M., Weiss, E. M., Segni, E. D., Libhaber, C. D., Guerrero, J., & Kaplinsky, E. (1982) · Circulation · doi:10.1161/01.cir.65.5.998 · Cited by 208 · see citing works
Polymorphism in the P-glycoprotein drug transporter MDR1 gene
Droździk, M., Białecka, M. A., liwiec, K. M., Honczarenko, K., Stankiewicz, J., & Sych, Z. (2003) · Pharmacogenetics · doi:10.1097/00008571-200305000-00004 · Cited by 207 · see citing works
Coadministration of oral cyclosporin A enables oral therapy with paclitaxel.
Terwogt, J. M. M., Malingré, M. M., Beijnen, J. H., Huinink, W. W. T. B., Rosing, H., Koopman, F. J., van Tellingen, O., Swart, M., & Schellens, J. H. M. (1999) · PubMed · Cited by 205 · see citing works
Self-citationThe effect of rifampin administration on the disposition of fexofenadine
Hamman, M. A. (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.113697 · Cited by 204 · see citing works
van Asperen, J., van Tellingen, O., Sparreboom, A., et al. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.530 · Cited by 203 · see citing works
Roberts, R. L., Joyce, P. R., Mulder, R., Begg, E., & Kennedy, M. A. (2002) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500099 · Cited by 201 · see citing works
Effect of clarithromycin on renal excretion of digoxin: Interaction with P-glycoprotein*
若杉, 博., Yano, I., Ito, T., et al. (1998) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(98)90030-3 · Cited by 200 · see citing works
Coadministration of Cyclosporine Strongly Enhances the Oral Bioavailability of Docetaxel
Malingré, M. M., Richel, D. J., Beijnen, J. H., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.4.1160 · Cited by 199 · see citing works
Self-citationDroździk, M., Białecka, M. A., Myśliwiec, K., Honczarenko, K., Stankiewicz, J., & Sych, Z. (2003) · PubMed · doi:10.1097/01.fpc.0000054087.48725.d9 · Cited by 189 · see citing works
Association ofCYP2C8, CYP3A4, CYP3A5, andABCB1Polymorphisms with the Pharmacokinetics of Paclitaxel
Henningsson, A., Marsh, S., Loos, W. J., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1152 · Cited by 189 · see citing works
Bauer, S., Störmer, E., Johne, A., Krüger, H., Budde, K., Neumayer, H.-H., Roots, I., & Mai, I. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.01759.x · Cited by 187 · see citing works
Eagling, Profit, & Back (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00052.x · Cited by 182 · see citing works
Effects of dietary chemopreventive phytochemicals on P-glycoprotein function
Nabekura, T., Kamiyama, S., & Kitagawa, S. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.081 · Cited by 180 · see citing works
Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors
Huisman, M. T., Smit, J. W., & Schinkel, A. H. (2000) · AIDS · doi:10.1097/00002030-200002180-00005 · Cited by 180 · see citing works
Furuno, T., Landi, M.-T., Ceroni, M., Caporaso, N., Bernucci, I., Nappi, G., Martignoni, E., Schaeffeler, E., Eichelbaum, M., Schwab, M., et al. (2002) · Pharmacogenetics · doi:10.1097/00008571-200210000-00004 · Cited by 178 · see citing works
Kemper, E. M., Boogerd, W. J., Thuis, I., Beijnen, J. H., & van Tellingen, O. (2004) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2004.04.001 · Cited by 177 · see citing works
Self-citationWestphal, K. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.107579 · Cited by 177 · see citing works
Itraconazole Decreases Renal Clearance of Digoxin
Jalava, K.-M., Partanen, J., & Neuvonen, P. J. (1997) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199712000-00001 · Cited by 176 · see citing works
Takanaga, H., Ohnishi, A., Matsuo, H., et al. (1998) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.21.1062 · Cited by 169 · see citing works
Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers*1
DING, R. (2004) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2004.02.008 · Cited by 169 · see citing works
Mai, I., Störmer, E., Bauer, S., Krüger, H., Budde, K., & Roots, I. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg002 · Cited by 169 · see citing works
Digoxin pharmacokinetics and MDR1 genetic polymorphisms
Verstuyft, C., Schwab, M. G., Schaeffeler, E., et al. (2003) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-003-0567-5 · Cited by 167 · see citing works
Hsu, A., Granneman, G. R., Cao, G., et al. (1998) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(98)90041-8 · Cited by 164 · see citing works
Clinical Studies with Modulators of Multidrug Resistance
Fisher, G. A., & Sikic, B. I. (1995) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30099-6 · Cited by 164 · see citing works
P-GLYCOPROTEIN SYSTEM AS A DETERMINANT OF DRUG INTERACTIONS: THE CASE OF DIGOXIN–VERAPAMIL
Verschraagen, M., Koks, C. H. W., Schellens, J. H. M., & Beijnen, J. H. (1999) · Pharmacological Research · doi:10.1006/phrs.1999.0535 · Cited by 159 · see citing works
Self-citationOhnishi, A., Matsuo, H., Yamada, S., et al. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703433 · Cited by 158 · see citing works
Interaction between digoxin and calcium antagonists and antiarrhythmic drugs
Belz, G. G., Doering, W., Munkes, R., et al. (1983) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1983.55 · Cited by 157 · see citing works
Dalton, W. S., Crowley, J. J., Salmon, S., Grogan, T. M., Laufman, L. R., Weiss, G. R., & Bonnet, J. D. (1995) · Cancer · doi:10.1002/1097-0142(19950201)75:3 · Cited by 156 · see citing works
Gréen, H., Söderkvist, P., Rosenberg, P., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0950 · Cited by 156 · see citing works
Reversal of P-glycoprotein-mediated multidrug resistance by ginsenoside Rg3
Kim, S., Kwon, H., Chi, D.-W., et al. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01446-6 · Cited by 155 · see citing works
Malingré, M. M., Beijnen, J. H., Rosing, H., et al. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1543 · Cited by 153 · see citing works
Self-citationTakayama, N., Sato, N., O’Brien, S. G., Ikeda, Y., & Okamoto, S. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03881.x · Cited by 152 · see citing works
Honda, Y., Ushigome, F., Koyabu, N., et al. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706008 · Cited by 151 · see citing works
The Influence of St. John's Wort on the Pharmacokinetics and Protein Binding of Imatinib Mesylate
Smith, P. F., Bullock, J. M., Booker, B. M., Haas, C. E., Berenson, C. S., & Jusko, W. J. (2004) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.24.16.1508.50958 · Cited by 151 · see citing works
Grapefruit juice ingestion significantly reduces talinolol bioavailability
Schwarz, U. I., SEEMANN, D., Oertel, R., et al. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2004.11.111 · Cited by 149 · see citing works
Drug Interactions Between Antiretroviral Drugs and Comedicated Agents
de Maat, M. M. R., Ekhart, G. C., Huitema, A. D. R., Koks, C. H. W., Mulder, J. W., & Beijnen, J. H. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342030-00002 · Cited by 148 · see citing works
Self-citationP-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans
Schwarz, U. I., Gramatté, T., Krappweis, J., et al. (2000) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp38161 · Cited by 146 · see citing works
Friedenberg, W. R., Rué, M., Blood, E., et al. (2006) · Cancer · doi:10.1002/cncr.21666 · Cited by 146 · see citing works
Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids
Limtrakul, P., Anuchapreeda, S., & Buddhasukh, D. (2004) · BMC Cancer · doi:10.1186/1471-2407-4-13 · Cited by 145 · see citing works
Effects of Rifampin on Tacrolimus Pharmacokinetics in Healthy Volunteers
Hébert, M. F., Fisher, R. M., Marsh, C. L., et al. (1999) · The Journal of Clinical Pharmacology · doi:10.1177/00912709922007499 · Cited by 144 · see citing works
Unwanted pregnancy on self‐medication with St John's wort despite hormonal contraception
Schwarz, U. I., Büschel, B., & Kirch, W. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.01716.x · Cited by 142 · see citing works
van Asperen, J., van Tellingen, O., van der Valk, M. A., et al. (1998) · PubMed · Cited by 140 · see citing works
Chan, H. S. L., Deboer, G., Thiessen, J. J., et al. (1996) · PubMed · Cited by 138 · see citing works
TANNERGREN, C. (2004) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2003.12.012 · Cited by 138 · see citing works
The Functional Role of P-Glycoprotein in the Blood–Brain Barrier
van Asperen, J., Mayer, U., van Tellingen, O., & Beijnen, J. H. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js9701364 · Cited by 138 · see citing works
Self-citationBardelmeijer, H. A., Ouwehand, M., Buckle, T., et al. (2002) · PubMed · Cited by 135 · see citing works
Active Transport of Fentanyl by the Blood-Brain Barrier
Henthorn, T. K., Liu, Y., Mahapatro, M., & Ng, K. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38239-4 · Cited by 135 · see citing works
Takanaga, H., Ohnishi, A., Yamada, S., et al. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39224-9 · Cited by 133 · see citing works
Functional role of P-glycoprotein in the human blood-placental barrier
Molsa, M., HEIKKINEN, T., Hakkola, J., HAKALA, K., Wallerman, O., Wadelius, M., Wadelius, C., & LAINE, K. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.04.014 · Cited by 132 · see citing works
Co-administration of cyclosporin enables oral therapy with paclitaxel
Terwogt, J. M. M., Beijnen, J. H., Huinink, W. W. T. B., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)24030-x · Cited by 129 · see citing works
Self-citationGrapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol
Spahn-Langguth, H., & Langguth, P. (2001) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00191-3 · Cited by 124 · see citing works
Kemper, E. M., Verheij, M., Boogerd, W. J., Beijnen, J. H., & van Tellingen, O. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.01.024 · Cited by 123 · see citing works
Self-citationKafka, A., Sauer, G., Jaeger, C., et al. (2003) · International Journal of Oncology · doi:10.3892/ijo.22.5.1117 · Cited by 121 · see citing works
Bardelmeijer, H. A., Beijnen, J. H., Brouwer, K. R., Rosing, H., Nooijen, W. J., Schellens, J. H. M., & van Tellingen, O. (2000) · PubMed · Cited by 121 · see citing works
Self-citationBelpomme, D., Gauthier, S., Pujade-Lauraine, É., Facchini, T., Goudier, M.-J., Krakowski, I., Netter-Pinon, G., Frénay, M., Gousset, C., MARIE, F.-N., et al. (2000) · Annals of Oncology · doi:10.1023/a:1026556119020 · Cited by 118 · see citing works
Pharmacologic approaches to reversing multidrug resistance.
Sikic, B. I. (1997) · PubMed · Cited by 117 · see citing works
de Castro, W. V., Mertens‐Talcott, S. U., Rubner, A., et al. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0516944 · Cited by 116 · see citing works
Choi, C.-H., Kang, G. J., & Min, Y. (2003) · Planta Medica · doi:10.1055/s-2003-38483 · Cited by 113 · see citing works
Hébert, M. F., Park, J. M., Chen, Y., Akhtar, S., & Larson, A. M. (2003) · The Journal of Clinical Pharmacology · doi:10.1177/0091270003261078 · Cited by 113 · see citing works
Kruijtzer, C. M. F., Beijnen, J. H., & Schellens, J. H. M. (2002) · The Oncologist · doi:10.1634/theoncologist.7-6-516 · Cited by 110 · see citing works
Self-citationRole of pharmacogenetics in irinotecan therapy
de Jong, F. A., de Jonge, M. J. A., Verweij, J., & Mathijssen, R. H. J. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.04.040 · Cited by 109 · see citing works
Joerger, M., Huitema, A. D. R., van den Bongard, H. J. G. D., et al. (2005) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2005.02513.x · Cited by 107 · see citing works
Wishart, G. C., Bissett, D., Paul, J., Jodrell, D. I., Harnett, A. N., Habeshaw, T., Kerr, D. J., Macham, M. A., Soukop, M., & Leonard, R. C. (1994) · Journal of Clinical Oncology · doi:10.1200/jco.1994.12.9.1771 · Cited by 102 · see citing works
Ikegawa, T., Ushigome, F., Koyabu, N., et al. (2000) · Cancer Letters · doi:10.1016/s0304-3835(00)00549-8 · Cited by 101 · see citing works
Sadzuka, Y., Sugiyama, T., & Sonobe, T. (2000) · Toxicology Letters · doi:10.1016/s0378-4274(99)00290-8 · Cited by 99 · see citing works
Effects of curcumin on P-glycoprotein in primary cultures of rat hepatocytes
Romiti, N., Tongiani, R., Cervelli, F., et al. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00216-1 · Cited by 98 · see citing works
Low concentrations of STI571 in the cerebrospinal fluid: a case report
Petzer, A. L., Gunsilius, E., Hayes, M., et al. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03523.x · Cited by 98 · see citing works
Pharmacokinetic and pharmaceutic interaction between digoxin and Cremophor RH40
Tayrouz, Y., Ding, R., Burhenne, J., et al. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(03)00059-6 · Cited by 95 · see citing works
Diltiazem Increases Tacrolimus Concentrations
Hébert, M. F., & Lam, A. Y. (1999) · Annals of Pharmacotherapy · doi:10.1345/aph.18356 · Cited by 95 · see citing works
Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer
Zhou, Q. S., Sparreboom, A., Tan, E.-H., Cheung, Y., Lee, A., Poon, D. Y. H., Lee, E. J. D., & Chowbay, B. (2005) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2004.02330.x · Cited by 94 · see citing works
Sonneveld, P., Suciu, S., Weijermans, P., Beksaç, M., Neuwirtová, R., Solbu, G., Lokhorst, H. M., der Lelie, J. V., Döhner, H., Gerhartz, H., et al. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.03171.x · Cited by 93 · see citing works
Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study
Millward, M. J., Cantwell, B. M. J., Munro, N. C., Robinson, A. G., Corris, P. A., & Harris, A. L. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.189 · Cited by 91 · see citing works
Phase I Study of Infusional Paclitaxel in Combination With the P-Glycoprotein Antagonist PSC 833
Chico, I. M., Kang, M. H., Bergan, R. C., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.3.832 · Cited by 90 · see citing works
Inhibition of P-Glycoprotein Transport Function by Grapefruit Juice Psoralen
Wang, E., Casciano, C. N., Clement, R. P., et al. (2001) · Pharmaceutical Research · doi:10.1023/a:1011089924099 · Cited by 89 · see citing works
Solary, É., Drénou, B., Campos, L., de Crémoux, P., Mugneret, F., Moreau, P., Lioure, B., Falkenrodt, A., Witz, B., Bernard, M., et al. (2003) · Blood · doi:10.1182/blood-2002-11-3419 · Cited by 87 · see citing works
Jamroziak, K., & Robak, T. (2004) · Hematology · doi:10.1080/10245330310001638974 · Cited by 86 · see citing works
Dose‐dependent increase of saquinavir bioavailability by the pharmaceutic aid cremophor EL
Martin‐Facklam, M., Burhenne, J., Ding, R., et al. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01595.x · Cited by 86 · see citing works
The Role of P-Glycoprotein and Organic Anion-Transporting Polypeptides in Drug Interactions
DuBuske, L. M. (2005) · Drug Safety · doi:10.2165/00002018-200528090-00004 · Cited by 84 · see citing works
P Glycoprotein in Human Immunodeficiency Virus Type 1 Infection and Therapy
Sankatsing, S. U. C., Beijnen, J. H., Schinkel, A. H., Lange, J. M. A., & Prins, J. M. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.4.1073-1081.2004 · Cited by 83 · see citing works
Self-citationCyclosporin‐erythromycin interaction in renal transplant patients.
Gupta, S., Bakran, A., Johnson, R. W. G., et al. (1989) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1989.tb05396.x · Cited by 81 · see citing works
Kharasch, E. D., Hoffer, C., Altuntas, T. G., et al. (2004) · The Journal of Clinical Pharmacology · doi:10.1177/0091270003262075 · Cited by 80 · see citing works
Babaoglu, M. O., Bayar, B., AYNACIOGLU, A., et al. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.08.015 · Cited by 79 · see citing works
Effect of grapefruit juice intake on etoposide bioavailability
Reif, S., Nicolson, M. C., Bisset, D., et al. (2002) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-002-0495-9 · Cited by 79 · see citing works
Enhanced Cardiac Effect of Digoxin During Quinidine Treatment
Leahey, E. B. (1979) · Archives of Internal Medicine · doi:10.1001/archinte.1979.03630420015008 · Cited by 78 · see citing works
Reversal of cancer multidrug resistance by green tea polyphenols
Mei, Y., Qian, F., Wei, D., et al. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357044364 · Cited by 74 · see citing works
Fracasso, P. M., Goldstein, L. J., de Alwis, D. P., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0452 · Cited by 70 · see citing works
Milroy, R. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.433 · Cited by 68 · see citing works
EFFECT OF PROTOTYPICAL INDUCING AGENTS ON P-GLYCOPROTEIN AND CYP3A EXPRESSION IN MOUSE TISSUES
Matheny, C. J., Ali, R. Y., Yang, X., et al. (2004) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)02985-4 · Cited by 68 · see citing works
Kruijtzer, C. M. F., Schellens, J. H. M., Mezger, J. M., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.04.058 · Cited by 59 · see citing works
Self-citationImpact of omeprazole on the plasma clearance of methotrexate
Reid, T., Yuen, A. R., Catolico, M., et al. (1993) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00686028 · Cited by 56 · see citing works
Severe myalgia from an interaction between treatments with pantoprazole and methotrexate
Tröger, U., Stötzel, B., Martens-Lobenhoffer, J., et al. (2002) · BMJ · doi:10.1136/bmj.324.7352.1497 · Cited by 53 · see citing works
Erythromycin enhances the absorption of cyclosporin.
Gupta, S. K., Bakran, A., Johnson, R. W. G., & Rowland, M. (1988) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1988.tb03320.x · Cited by 53 · see citing works
Digoxin toxicity due to interaction of digoxin with erythromycin.
Maxwell, D. L., Gilmour-White, S. K., & Hall, M. R. (1989) · BMJ · doi:10.1136/bmj.298.6673.572 · Cited by 53 · see citing works
A Model for the Prediction of Digoxin-Drug Interactions at the Renal Tubular Cell Level
Woodland, C., Ito, S., & Koren, G. (1998) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199804000-00002 · Cited by 49 · see citing works
Xu, J., Go, M., & Lim, L. Y. (2003) · Pharmaceutical Research · doi:10.1023/a:1022254617664 · Cited by 48 · see citing works
�, R. R., Sczech, R., Landes�, N., et al. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0475-1 · Cited by 47 · see citing works
Quinidine and Digoxin An Important Interaction
Bigger, J. T., & Leahey, E. B. (1982) · Drugs · doi:10.2165/00003495-198224030-00003 · Cited by 47 · see citing works
Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer
Kruijtzer, C. M. F., Boot, H., Beijnen, J. H., et al. (2003) · Annals of Oncology · doi:10.1093/annonc/mdg078 · Cited by 47 · see citing works
Self-citationNew approaches in cancer treatment
Sikic, B. I. (1999) · Annals of Oncology · doi:10.1093/annonc/10.suppl_6.s149 · Cited by 46 · see citing works
Multidrug resistance: clinical relevance in acute leukemia.
List, A. F. (1993) · PubMed · Cited by 46 · see citing works
Yamaguchi, H., Hishinuma, T., Endo, N., Tsukamoto, H., Kishikawa, Y., Masugi, S. A. T. O., MURAI, Y., Hiratsuka, M., Ito, K., Okamura, C., et al. (2006) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2006.00593.x · Cited by 45 · see citing works
Differential Bidirectional Transfer of Indinavir in the Isolated Perfused Human Placenta
Sudhakaran, S. S., Ghabrial, H., Nation, R. L., Kong, D. C. M., Gude, N. M., Angus, P., & Rayner, C. R. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.3.1023-1028.2005 · Cited by 44 · see citing works
Zoppi, M., Braunschweig, S., Kuenzi, U. P., et al. (2000) · European Journal of Clinical Pharmacology · doi:10.1007/s002280000158 · Cited by 40 · see citing works
Antineoplastic Agents Drug Interactions of Clinical Significance
van Meerten, E., Verweij, J., & Schellens, J. H. M. (1995) · Drug Safety · doi:10.2165/00002018-199512030-00003 · Cited by 38 · see citing works
Self-citationInteraction Between Digoxin and Propafenone
Calvo, M. V. M., Martín‐Suárez, A., Luengo, C. M., et al. (1989) · Therapeutic Drug Monitoring · doi:10.1097/00007691-198901000-00003 · Cited by 38 · see citing works
Woodland, C., Verjee, Z. H., Giesbrecht, E. E., et al. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37024-7 · Cited by 38 · see citing works
Helgason, H. H., Kruijtzer, C. M. F., Huitema, A. D. R., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603332 · Cited by 38 · see citing works
St. John’s Wort Modulates the Toxicities and Pharmacokinetics of CPT-11 (Irinotecan) in Rats
Hu, Z., Yang, X., Ho, P. C., Chan, E., Chan, S. Y., Xu, C., Li, X., Zhu, Y. Z., Duan, W., Chen, X., et al. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-4585-0 · Cited by 37 · see citing works
Wada, M. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.06.050 · Cited by 35 · see citing works
Erythromycin-Induced Digoxin Toxicity
Morton, M. R., & Cooper, J. W. (1989) · DICP · doi:10.1177/106002808902300908 · Cited by 31 · see citing works
Carlson, R. W., O’Neill, A., Goldstein, L. J., et al. (2006) · Cancer Investigation · doi:10.1080/07357900600981349 · Cited by 29 · see citing works
Горева, О. Б., Grishanova, A. Y., Mukhin, O. V., et al. (2003) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1026331326648 · Cited by 28 · see citing works
Multi-drug transporter MDR1 gene polymorphism and prognosis in adult acute lymphoblastic leukemia.
Jamroziak, K., Balcerczak, E., Cebula‐Obrzut, B., et al. (2006) · PubMed · Cited by 27 · see citing works
Yamaguchi, H., Hishinuma, T., Endo, N., et al. (2006) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-00009577-200605000-00004 · Cited by 23 · see citing works
Digoxin toxicity and ritonavir
Phillips, E. J., Rachlis, A., & Ito, S. (2003) · AIDS · doi:10.1097/00002030-200307040-00026 · Cited by 17 · see citing works
Digoxin toxicity and ritonavir: a drug interaction mediated through p-glycoprotein?
Phillips, E. J., Rachlis, A., & Ito, S. (2003) · PubMed · doi:10.1097/01.aids.0000072673.21517.d6 · Cited by 14 · see citing works
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- Henningsson A, Marsh S, Loos WJ et al. Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with the pharmacoki- netics of paclitaxel. Clin Cancer Res 2005;11:8097-8104.
- Dresser G, Schwartz U, Wilkinson G et al. Fexofenadine bio-availability modulated by dietary salt [abstract]. Clin Pharmacol Ther 2001;69:P23.
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Vágvölgyi, M., Martins, A., Kulmány, Á., Zupkó, I., Gáti, T., Simon, A., Tóth, G., & Hunyadi, A. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.12.032 · Cited by 37 · see citing works
Melatonin Interaction Resulting in Severe Sedation
Foster, B. C., Cvijovic, K., Boon, H. S., Tam, T. W., Liu, R., Murty, M., Vu, D., Jaeger, W., Tsuyuki, R. T., Barnes, J., et al. (2015) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3ss35 · Cited by 17 · see citing works
- Authors
- Marchetti, S., Mazzanti, R., Beijnen, J. H., & Schellens, J. H. M.
- Affiliations
- The Netherlands Cancer Institute (NL)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Utrecht University (NL)
- Venue
- The Oncologist
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-08-01
- Volume
- 12
- Issue
- 8
- Pages
- 927-941
- ISSN
- 1083-7159 (ISSN-L)
- 1549-490X
- OpenAlex
- W2108525782
- Cited by
- 284
- References
- 197
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 3 · 2023: 8 · 2022: 8 · 2021: 9 · 2020: 7 · 2019: 14 · 2018: 19 · 2017: 11 · 2016: 17 · 2015: 19 · 2014: 26 · 2013: 24 · 2012: 19
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Oncologist (publishedVersion)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Keywords
- P-glycoprotein, drug-drug interactions, herb-drug interactions, food-drug interactions, pharmacokinetic interactions, multidrug resistance 1 gene, genetic variation, complementary and alternative medicine, Hypericum perforatum, grapefruit juice, anticancer agents, drug safety, individualized drug therapy
- MeSH terms
- Drug Interactions, Humans, ATP Binding Cassette Transporter, Subfamily B, ATP Binding Cassette Transporter, Subfamily B, Member 1, Herb-Drug Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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