Using [11C]Diprenorphine to Image Opioid Receptor Occupancy by Methadone in Opioid Addiction: Clinical and Preclinical Studies

Parametric Imaging of Ligand-Receptor Binding in PET Using a Simplified Reference Region Model

Gunn, R. N., Lammertsma, A. A., Hume, S. P., & Cunningham, V. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0303 · Cited by 1,085 · see citing works

Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.

Raynor, K., Kong, H., Chen, Y., Yasuda, K., Yu, L., Bell, G. I., & Reisine, T. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09932-8 · Cited by 672 · see citing works

Interindividual Variability of the Clinical Pharmacokinetics of Methadone: Implications for the Treatment of Opioid Dependence

Eap, C. B., Buclin, T., & Baumann, P. (2002) · Clinical Pharmacokinetics · doi:10.2165/00003088-200241140-00003 · Cited by 599 · see citing works

The efficacy of methadone maintenance interventions in reducing illicit opiate use, HIV risk behavior and criminality: a meta‐analysis

Marsch, L. A. (1998) · Addiction · doi:10.1046/j.1360-0443.1998.9345157.x · Cited by 554 · see citing works

Autoradiographic localization of the opiate receptor in rat brain

Pert, C. B., Kuhar, M. J., & Snyder, S. H. (1975) · Life Sciences · doi:10.1016/0024-3205(75)90289-1 · Cited by 388 · see citing works

Effects of Buprenorphine Maintenance Dose on μ-Opioid Receptor Availability, Plasma Concentrations, and Antagonist Blockade in Heroin-Dependent Volunteers

Greenwald, M. K., Johanson, C.-E., Moody, D. E., Woods, J. H., Kilbourn, M. R., Koeppe, R. A., Schuster, C. R., & Zubieta, J.-K. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300251 · Cited by 320 · see citing works

Opiate receptor binding sites in human brain

Pfeiffer, A. F. H., Pasi, A., Mehraein, P., & Herz, A. (1982) · Brain Research · doi:10.1016/0006-8993(82)91150-7 · Cited by 299 · see citing works

The economic costs of heroin addiction in the United States

Mark, T. L. (2001) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(00)00162-9 · Cited by 271 · see citing works

A software system for interactive and quantitative visualization of multidimensional biomedical images.

Robb, R. A., & Hanson, D. P. (1991) · PubMed · Cited by 179 · see citing works

In vivo distribution of opioid receptors in man in relation to the cortical projections of the medial and lateral pain systems measured with positron emission tomography

Jones, A. K. P., Qi, L. Y., Fujirawa, T., Luthra, S. K., Ashburner, J., Bloomfield, P., Cunningham, V. J., Itoh, M., Fukuda, H., & Jones, T. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90362-w · Cited by 166 · see citing works

Opioid Agonists Have Different Efficacy Profiles for G Protein Activation, Rapid Desensitization, and Endocytosis of Mu-opioid Receptors

Borgland, S. L., Connor, M. A., Osborne, P. B., Furness, J. B., & Christie, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300525200 · Cited by 165 · see citing works

Compartmental Analysis of Diprenorphine Binding to Opiate Receptors in the Rat in vivo and its Comparison with Equilibrium Data in vitro

Cunningham, V. J., Hume, S. P., Price, G. R., Ahier, R. G., Cremer, J. E., & Jones, A. K. P. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.1 · Cited by 136 · see citing works

Opioid Receptor Imaging with Positron Emission Tomography and [18F]Cyclofoxy in Long-Term, Methadone-Treated Former Heroin Addicts

Kling, M. A., Carson, R. E., Borg, L., Zametkin, A., Matochik, J. A., Schluger, J., Herscovitch, P., Rice, K. C., Ho, A., Eckelman, W. C., et al. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39007-x · Cited by 119 · see citing works

Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood?brain barrier of Abcb1a gene knockout mice

Wang, J.-S., Ruan, Y., Taylor, R. M., Donovan, J. L., Markowitz, J. S., & DeVane, C. L. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1718-1 · Cited by 108 · see citing works

Focal cortical release of endogenous opioids during reading induced seizures

Koepp, M. J., Richardson, M. P., Brooks, D. J., & Duncan, J. S. (1998) · The Lancet · doi:10.1016/s0140-6736(97)09077-6 · Cited by 107 · see citing works

Bupropion Treatment for Cocaine Abuse and Adult Attention-Deficit/Hyperactivity Disorder

Levin, F. R., Evans, S. M., McDowell, D. M., Brooks, D. J., & Nunes, E. (2002) · Journal of Addictive Diseases · doi:10.1300/j069v21n02_01 · Cited by 102 · see citing works

Quantification of Human Opiate Receptor Concentration and Affinity Using High and Low Specific Activity [ 11 C]Diprenorphine and Positron Emission Tomography

Sadzot, B., Price, J. C., Mayberg, H. S., Douglass, K. H., Dannals, R. F., Lever, J. R., Ravert, H. T., Wilson, A. A., Wagner, H. N., Feldman, M. A., et al. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.52 · Cited by 95 · see citing works

Replacement of (R)-methadone by a double dose of (R, S)-methadone in addicts: interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics

Eap, C. B., Finkbeiner, T., Gastpar, M., Scherbaum, N., Powell, K., & Baumann, P. (1996) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050128 · Cited by 92 · see citing works

The Orvinols and Related Opioids - High Affinity Ligands with Diverse Efficacy Profiles

Lewis, J. W., & Husbands, S. M. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043453027 · Cited by 91 · see citing works

Regional cerebral opioid receptor studies with [11C]diprenorphine in normal volunteers

Jones, A. K. P., Luthra, S. K., Maziere, B., Pike, V. W., Loc’h, C., Crouzel, C., Syrota, A., & Jones, T. (1988) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(88)90184-7 · Cited by 88 · see citing works

Optimizing Long-Term Response to Methadone Maintenance Treatment

Maxwell, S., & Shinderman, M. S. (2002) · Journal of Addictive Diseases · doi:10.1300/j069v21n03_01 · Cited by 71 · see citing works

μ-Opioid receptor and α2-adrenoceptor agonist binding sites in the postmortem brain of heroin addicts

Gabilondo, A. M., Meana, J. J., Barturen, F., Sastre, M., & Garcı́a-Sevilla, J. A. (1994) · Psychopharmacology · doi:10.1007/bf02244763 · Cited by 67 · see citing works

Subtraction autoradiography of opiate receptor subtypes in human brain

Cross, A. J., Hille, C. J., & Slater, P. (1987) · Brain Research · doi:10.1016/0006-8993(87)90101-6 · Cited by 63 · see citing works

The preparation of carbon-11 labelled diprenorphine: a new radioligand for the study of the opiate receptor system in vivo

Luthra, S. K., Pike, V. W., & Brady, F. (1985) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39850001423 · Cited by 57 · see citing works

Naloxone displacement at opioid receptor sites measured in vivo in the human brain

Melichar, J., Nutt, D., & Malizia, A. L. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02872-8 · Cited by 50 · see citing works

Quantitation of [11C]diprenorphine cerebral kinetics in man acquired by PET using presaturation, pulse-chase and tracer-only protocols

Jones, A. K. P., Cunningham, V. J., Ha-Kawa, S., Fujiwara, T., Liyi, Q., Luthra, S. K., Ashburner, J., Osman, S., & Jones, T. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90002-7 · Cited by 47 · see citing works

Regional distribution of μ, δ and κ opioid receptors in human brains from controls and parkinsonian subjects

Delay‐Goyet, P., Zajac, J., Javoy-Agid, F., Agid, Y., & Roques, B. P. (1987) · Brain Research · doi:10.1016/0006-8993(87)91321-7 · Cited by 43 · see citing works

Endogenous opioids implicated in the dynamics of experimental drug addiction: an in vivo autoradiographic analysis

Gerrits, M. A. F. M., Wiegant, V. M., & van Ree, J. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00336-4 · Cited by 38 · see citing works

Opiate Receptor Changes after Chronic Exposure to Agonists and Antagonists

Zadina, J. E., Kastin, A. J., HARRISON, L. M., Ge, L.-J., & Chang, S. L. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17493.x · Cited by 37 · see citing works

Steady-state methadone in rats does not change mRNA levels of corticotropin-releasing factor, its pituitary receptor or proopiomelanocortin

Zhou, Y., Spangler, R., Maggos, C. E., LaForge, K. S., Ho, A., & Kreek, M. J. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00672-3 · Cited by 36 · see citing works

Altered Plasma and Brain Disposition and Pharmacodynamics of Methadone in Abstinent Rats

Garrido, M. J., Valle, M., Calvo, R., & Trocóniz, I. F. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37940-6 · Cited by 29 · see citing works

Human spinal fluid methadone levels

Rubenstein, R. B., Kreek, M. J., Mbawa, N., Wolff, W. I., Korn, R., & Gutjahr, C. L. (1978) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(78)90022-4 · Cited by 21 · see citing works

Divers pathways mediate δ-opioid receptor down regulation within the same cell

Shapira, M., Keren, O., Gafni, M., & Sarne, Y. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00283-2 · Cited by 20 · see citing works

The Neurochemistry of Addiction

Nutt, D. (1997) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/(sici)1099-1077(199706)12:2+ · Cited by 19 · see citing works

Evaluation of S-[11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites

Hume, S. P., Lammertsma, A. A., Bench, C. J., Pike, V. W., Pascali, C., Cremer, J. E., & Dolan, R. J. (1992) · International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology · doi:10.1016/0883-2897(92)90171-t · Cited by 18 · see citing works

Apparent thermodynamic parameters of ligand binding to the cloned rat μ-opioid receptor

Li, J.-G., Raffa, R. B., Cheung, P., Tzeng, T., & Liu‐Chen, L. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00444-0 · Cited by 16 · see citing works

Using saccadic eye movements as objective measures of tolerance in methadone dependent individuals during the hydromorphone challenge test

Melichar, J., MYLES, J., Eap, C. B., & Nutt, D. (2003) · Addiction Biology · doi:10.1080/1355621031000069891 · Cited by 15 · see citing works

Dynamic monitoring of [11C]diprenorphine in rat brain using a prototype positron imaging device

Rajeswaran, S., Hume, S. P., Cremer, J. E., Young, J., Bailey, D. L., Ashburner, J., Luthra, S. K., Jones, A. K. P., & Jones, T. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90071-7 · Cited by 14 · see citing works

Imaging of opioid receptors in the central nervous system

Henriksen, G., & Willoch, F. (2008) · Brain · doi:10.1093/brain/awm255 · Cited by 214 · see citing works

The Neuropsychology of Amphetamine and Opiate Dependence: Implications for Treatment

Ersche, K. D., & Sahakian, B. J. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9033-y · Cited by 166 · see citing works

The Development, Past Achievements, and Future Directions of Brain PET

Jones, T., & Rabiner, E. (2012) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2012.20 · Cited by 128 · see citing works

Target site occupancy: emerging generalizations from clinical and preclinical studies.

Grimwood, S., & Hartig, P. (2009) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2009.03.002 · Cited by 124 · see citing works

PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users

Shi, J., Zhao, L.-Y., Copersino, M. L., Fang, Y.-X., Chen, Y., Tian, J., Deng, Y., Shuai, Y., Jin, J., & Lu, L. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.042 · Cited by 108 · see citing works

Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat

Thompson, S. J., Pitcher, M. H., Stone, L. S., Tarum, F., Niu, G., Chen, X. S., Kiesewetter, D. O., Schweinhardt, P., & Bushnell, M. C. (2018) · Pain · doi:10.1097/j.pain.0000000000001282 · Cited by 95 · see citing works

Endogenous opiates and behavior: 2005

Bodnar, R. J., & Klein, G. E. (2006) · Peptides · doi:10.1016/j.peptides.2006.07.011 · Cited by 85 · see citing works

Differential Involvement of P-Glycoprotein (ABCB1) in Permeability, Tissue Distribution, and Antinociceptive Activity of Methadone, Buprenorphine, and Diprenorphine: In Vitro and In Vivo Evaluation

Hassan, H. E., Myers, A. L., Coop, A., & Eddington, N. D. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21770 · Cited by 86 · see citing works

Prolonged Central μ-Opioid Receptor Occupancy after Single and Repeated Nalmefene Dosing

Ingman, K., Hagelberg, N. M., Aalto, S., Någren, K., Juhakoski, A., Karhuvaara, S., Kallio, A., Oikonen, V., Hietala, J. A., & Scheinin, H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300790 · Cited by 82 · see citing works

Imaging opioid analgesia in the human brain and its potential relevance for understanding opioid use in chronic pain.

Lee, M. C., Wanigasekera, V., & Tracey, I. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.035 · Cited by 56 · see citing works

Brain opioid receptor binding in early abstinence from opioid dependence: positron emission tomography study.

Williams, T., Daglish, M., Lingford-Hughes, A., Taylor, L., Hammers, A., Brooks, D., Grasby, P., Myles, J., & Nutt, D. (2007) · The British journal of psychiatry : the journal of mental science · doi:10.1192/bjp.bp.106.031120 · Cited by 54 · see citing works

Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding

Deen, M., Hougaard, A., Hansen, H. D., Schain, M., Dyssegaard, A., Knudsen, G. M., & Ashina, M. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.0755 · Cited by 46 · see citing works

Advances in simultaneous PET/MR for imaging neuroreceptor function

Sander, C. Y. M., Hansen, H. D., & Wey, H. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20910038 · Cited by 46 · see citing works

Addiction: the clinical interface

Nutt, D., & Lingford-Hughes, A. R. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.101 · Cited by 45 · see citing works

A Survey of Molecular Imaging of Opioid Receptors

Cumming, P. D., Marton, J., Lilius, T. O., Olberg, D. E., & Rominger, A. (2019) · Molecules · doi:10.3390/molecules24224190 · Cited by 44 · see citing works

Modeling of PET data in CNS drug discovery and development

Varnäs, K., Varrone, A., & Farde, L. (2013) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-013-9320-6 · Cited by 44 · see citing works

Neuropharmacology of addiction and how it informs treatment

Lingford-Hughes, A. R., Watson, B. J., Kalk, N. J., & Reid, A. G. (2010) · British Medical Bulletin · doi:10.1093/bmb/ldq032 · Cited by 40 · see citing works

The delta opioid receptor tool box

Vicente‐Sánchez, A., Segura, L., & Pradhan, A. A. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.028 · Cited by 39 · see citing works

Imaging Endogenous Opioid Peptide Release with [ 11 C]Carfentanil and [ 3 H]Diprenorphine: Influence of Agonist-Induced Internalization

Quelch, D. R., Katsouri, L., Nutt, D., Parker, C. A., & Tyacke, R. J. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.117 · Cited by 35 · see citing works

Human brain imaging and substance abuse

Lingford-Hughes, A. R. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.10.002 · Cited by 34 · see citing works

Substance abuse disorders

Reid, A. G., Lingford-Hughes, A. R., Cancela, L. M., & Kalivas, P. W. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00024-3 · Cited by 33 · see citing works

Low Sensitivity of the Positron Emission Tomography Ligand [11C]Diprenorphine to Agonist Opiates

Hume, S. P., Lingford-Hughes, A. R., Nataf, V., Hirani, E., Ahmad, R., Davies, A. N., & Nutt, D. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.121749 · Cited by 32 · see citing works

Insights from recent positron emission tomographic studies of drug abuse and dependence

Chang, L., & Haning, W. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000218594.46431.2f · Cited by 28 · see citing works

A PET study with [ 11 C]AZ10419369 to determine brain 5-HT 1B receptor occupancy of zolmitriptan in healthy male volunteers

Varnäs, K., Jučaitė, A., McCarthy, D. J., Stenkrona, P., Nord, M., Halldin, C., Farde, L., & Kanes, S. (2013) · Cephalalgia · doi:10.1177/0333102413476372 · Cited by 25 · see citing works

Medications Development for Treatment of Opioid Use DisorderPreprint

Townsend, E. A., Negus, S. S., & Banks, M. L. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039263 · Cited by 25 · see citing works

Hunting for the high‐affinity state of G‐protein‐coupled receptors with agonist tracers: Theoretical and practical considerations for positron emission tomography imaging

Shalgunov, V., van Waarde, A., Booij, J., Michel, M. C., Dierckx, R., & Elsinga, P. H. (2018) · Medicinal Research Reviews · doi:10.1002/med.21552 · Cited by 24 · see citing works

Cardiac and mortality outcome differences between methadone, buprenorphine and naltrexone prescriptions in patients with an opioid use disorder

Wang, L., Volkow, N. D., Berger, N. A., Davis, P. B., Kaelber, D. C., & Xu, R. (2023) · Journal of Clinical Psychology · doi:10.1002/jclp.23582 · Cited by 24 · see citing works

Synthesis and Evaluation of a Full-Agonist Orvinol for PET-Imaging of Opioid Receptors: [11C]PEO

Marton, J., Schoultz, B. W., Hjørnevik, T., Drzezga, A. E., Yousefi, B. H., Wester, H., Willoch, F., & Henriksen, G. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900892x · Cited by 24 · see citing works

Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R‐[125/131I]AM2233

Dhawan, J., Deng, H., Gatley, S. J., Makriyannis, A., Akinfeleye, T., Bruneus, M., Dimaio, A. A., & Gifford, A. N. (2006) · Synapse · doi:10.1002/syn.20277 · Cited by 23 · see citing works

Opioid Imaging

Hammers, A., & Lingford-Hughes, A. R. (2006) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2006.06.004 · Cited by 22 · see citing works

Metabolic and toxicological considerations of the opioid replacement therapy and analgesic drugs: methadone and buprenorphine

Moody, D. E. (2013) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2013.783567 · Cited by 21 · see citing works

Positron Emission Tomography Molecular Imaging of Dopaminergic System in Drug Addiction

Hou, H., Tian, M., & Zhang, H. (2012) · The Anatomical Record · doi:10.1002/ar.22457 · Cited by 20 · see citing works

Data collection and analysis strategies for phMRI

Mandeville, J. B., Liu, C. H., Vanduffel, W., Marota, J. J. A., & Jenkins, B. G. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.02.018 · Cited by 19 · see citing works

Synthesis and Evaluation of Three Structurally Related18F-Labeled Orvinols of Different Intrinsic Activities: 6-O-[18F]Fluoroethyl-diprenorphine ([18F]FDPN), 6-O-[18F]Fluoroethyl-buprenorphine ([18F]FBPN), and 6-O-[18F]Fluoroethyl-phenethyl-orvinol ([18F]FPEO)

Schoultz, B. W., Hjørnevik, T., Reed, B. J., Marton, J., Coello, C. S., Willoch, F., & Henriksen, G. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm500503k · Cited by 18 · see citing works

Imaging metabotropic glutamate receptor system: Application of positron emission tomography technology in drug development

Xu, Y., & Li, Z. (2019) · Medicinal Research Reviews · doi:10.1002/med.21566 · Cited by 15 · see citing works

Time‐dependent regional brain distribution of methadone and naltrexone in the treatment of opioid addiction

Teklezgi, B. G., Pamreddy, A., Baijnath, S., Kruger, H. G., Naicker, T., Gopal, N. D., & Govender, T. (2018) · Addiction Biology · doi:10.1111/adb.12609 · Cited by 16 · see citing works

Reaching out for Sensitive Evaluation of the Mu Opioid Receptor in Vivo: Positron Emission Tomography Imaging of the Agonist [11C]AH7921

Rafique, W., Khanapur, S., Spilhaug, M. M., & Riss, P. J. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00075 · Cited by 14 · see citing works

Role of Nuclear Imaging to Understand the Neural Substrates of Brain Disorders in Laboratory Animals: Current Status and Future Prospects

D’Elia, A., Schiavi, S., Soluri, A., Massari, R., Soluri, A., & Trezza, V. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.596509 · Cited by 14 · see citing works

Effects of Buprenorphine/Naloxone and Methadone on Depressive Symptoms in People with Prescription Opioid Use Disorder: A Pragmatic Randomised Controlled Trial

Bastien, G., McAnulty, C., Ledjiar, O., Socias, M. E., Foll, B. L., Lim, R., Hassan, A. N., Brissette, S., Marsan, S., Talbot, A., et al. (2022) · The Canadian Journal of Psychiatry · doi:10.1177/07067437221145013 · Cited by 14 · see citing works

Imaging addiction with PET: is insight in sight?

Schiffer, W. K., Lee, D. E., Brodie, J. D., & Dewey, S. L. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03412-4 · Cited by 13 · see citing works

Divided Doses for Methadone Maintenance

Adinoff, B. H. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07121944 · Cited by 11 · see citing works

Recent development and potential use of µ‐ and κ‐opioid receptor ligands in positron emission tomography studies

Henriksen, G., Willoch, F., Talbot, P. S., & Wester, H. (2006) · Drug Development Research · doi:10.1002/ddr.20161 · Cited by 9 · see citing works

The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review

Jegede, O. O., Aquino, J. P. D., Hsaio, C., Caldwell, E., Funaro, M. C., Petrakis, I. L., & Muvvala, S. B. (2024) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000001356 · Cited by 8 · see citing works

Physical Considerations for Treatment Complications of Alcohol and Drug Use and Misuse

Addolorato, G., Leggio, L., D’Angelo, C., Ferrulli, A., Mirijello, A., Cardone, S., Leso, V., Malandrino, N., Capristo, E., Landolfi, R., et al. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0338-9_56 · Cited by 8 · see citing works

Imaging opioid analgesia in the human brain

Lee, M., Wanigasekera, V., & Tracey, I. (2012) · Trends in Anaesthesia and Critical Care · doi:10.1016/j.tacc.2012.07.002 · Cited by 6 · see citing works

Antagonist—agonist combinations as therapies for heroin addiction: back to the future?

Nutt, D. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109356129 · Cited by 6 · see citing works

PET imaging of the opioid system using radioligands: Synthetic approaches and translational applications

Reale, C., Costanzo, G., Cosentino, G., Parenti, C., & Pasquinucci, L. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117865 · Cited by 5 · see citing works

Neuroimaging

Garavan, H., Lingford-Hughes, A. R., Jones, T., Morris, P. G., Rothwell, J. C., & Williams, S. (2007) · Elsevier eBooks · doi:10.1016/b978-012370624-9/50012-8 · Cited by 5 · see citing works

Rapid uptake of sumatriptan into the brain: An ongoing question of blood-brain barrier permeability

Holland, P. R., Sureda-Gibert, P., & Vila‐Pueyo, M. (2020) · Cephalalgia · doi:10.1177/0333102420905131 · Cited by 5 · see citing works

Selective Mu-Opioid Receptor Imaging Using 18F-Labeled Carfentanils

Lee, S. J., Pearson, T. D., Dhaynaut, M., MacDonagh, A. C., Wey, H., Wilks, M. Q., Roth, B. L., Hooker, J. M., & Normandin, M. D. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02287 · Cited by 4 · see citing works

Opioid Imaging

Hammers, A., & Lingford-Hughes, A. R. (2007) · PET Clinics · doi:10.1016/j.cpet.2007.09.006 · Cited by 4 · see citing works

Positron Emission Tomography (PET) Imaging of Opioid Receptors

van Waarde, A., Absalom, A. R., Visser, A. K. D., & Dierckx, R. (2014) · Springer eBooks · doi:10.1007/978-3-642-42014-6_20 · Cited by 3 · see citing works

Imaging Human Brain Opioid Receptors: Applications to Substance Use Disorders

Greenwald, M. K., & Steinmiller, C. L. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-197-0_3 · Cited by 3 · see citing works

Abnormalities of Neurotransmission in Drug Addiction

Trick, L., Butler, K., Chukwueke, C. C., Ciano, P. D., Ibrahim, C., Rubin-Kahana, D. S., Boileau, I., & Foll, B. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_21 · Cited by 4 · see citing works

Experiments with cocaine and heroin addicts—are they predictive?

Bye, A. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.11.012 · Cited by 2 · see citing works

Substitution treatment in addiction: there is more than one way…

Lingford-Hughes, A. R. (2016) · Addiction · doi:10.1111/add.13288 · Cited by 2 · see citing works

An Integrated Framework for Human Neuroimaging Studies of Addiction from a Preclinical Perspective

Ersche, K. D., & Robbins, T. W. (2011) · Wiley eBooks · doi:10.1002/9781119998938.ch2 · Cited by 2 · see citing works

Some controversies related to questionable clinical uses of methadone for chronic non-cancer pain and in palliative care

Butler, S. H. (2021) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2020-0178 · Cited by 1 · see citing works

Opioid Use Disorder Treatment Gaps and Emerging Therapeutics to Address Them

Banks, M. L. (2026) · CNS Drugs · doi:10.1007/s40263-026-01300-0 · Cited by 1 · see citing works

Neurocognitive Functions in Opioid Dependence: Comparisons Between Opioid Categories

Ghosh, A., Shaktan, A., Verma, A., Nehra, R., Basu, D., Rana, D. K., Ahuja, C. K., Modi, M., & Singh, P. (2023) · Journal of Drug Issues · doi:10.1177/00220426231179208 · Cited by 1 · see citing works

Neurobiological Research on Addiction

Carter, A., Hall, W., Capps, B., & Daglish, M. R. C. (2009) · Cited by 1 · see citing works

Positron Emission Tomography (PET) Imaging of Opioid Receptors

van Waarde, A., Absalom, A. R., Visser, A. K. D., & Dierckx, R. (2020) · Springer eBooks · doi:10.1007/978-3-030-53176-8_21 · Cited by 1 · see citing works

Tapering and withdrawing opioids: guidance informed by fundamental principles to minimise withdrawal symptoms

Abie Horowitz, M., Framer, A., Strang, J., & Taylor, D. (2025) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253251371504

IMAGING DRUG DELIVERY TO THE CNS USING TRANSLATIONAL POSITRON EMISSION TOMOGRAPHY STUDIES

Lee, C., Varnäs, K., & Farde, L. (2013) · doi:10.1002/9781118356845.ch20

PET IMAGING OF THE PHARMACOKINETICS OF SMALL MOLECULAR‐WEIGHT DRUGS

Moerlein, S. M., & Tu, Z. (2013) · doi:10.1002/9781118356845.ch7

Bridging the preclinical - clinical gap

Nutt, D., Lingford-Hughes, A. R., Daglish, M. R. C., Tm, W., Taylor, L., Wilson, S., Davies, S., Melichar, J., & Myles, J. S. (2005) · Bristol Research (University of Bristol)

Drug dependence study

Miyawaki, I. (2007) · Folia Pharmacologica Japonica · doi:10.1254/fpj.130.211

(20R)-4,5-α-Epoxy-6-(2-[18F])fluoroethoxy)-3-hydroxy-α,17-dimethyl-α-(2-phenyleth-1-yl)-6,14-ethenomorphinan-7-methanol

Leung, K. (2013)

(20R)-4,5-α-Epoxy-17-methyl-3-hydroxy-6-[11C]methoxy-α,17-dimethyl-α-(2-phenylethyl)-6,14-ethenomorphinan-7-methanol

Leung, K. (2010) · National Center for Biotechnology Information (US) eBooks

Imagerie cérébrale et addictions

Weinstein, A. M., & Potenza, M. N. (2023) · Elsevier eBooks · doi:10.1016/b978-2-294-77934-3.00004-4

Total-body [11C]carfentanil PET: Liver-brain axis in methadone vs. buprenorphine treatment

Li, E. J., Wiers, C. E., Hsieh, C., Lee, H., Schmitz, A., Young, A. J., Pond, T., Chang, J., Schubert, E. K., Mach, R. H., et al. (2026) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-026-08144-2

BindingDB Entry 50030714: Synthesis and evaluation of a full-agonist orvinol for PET-imaging of opioid receptors: [11C]PEO.

BindingDB (2010) · UC San Diego · doi:10.7270/q2sq90f7

BindingDB Entry 50044557: Synthesis and evaluation of three structurally related¹8F-labeled orvinols of different intrinsic activities: 6-O-[¹8F]fluoroethyl-diprenorphine ([¹8F]FDPN), 6-O-[¹8F]fluoroethyl-buprenorphine ([¹8F]FBPN), and 6-O-[¹8F]fluoroethyl-phenethyl-orvinol ([¹8F]FPEO).

BindingDB (2015) · UC San Diego · doi:10.7270/q2rb764t

Low Sensitivity of the Positron Emission Tomography Ligand [11C]Diprenorphine to Agonist Opiates

Hume, S. P., Lingford-Hughes, A. R., Nataf, V., Hirani, E., Ahmad, R., Davies, A. N., & Nutt, D. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.121749 · Cited by 32 · see citing works

Regional cerebral opioid receptor studies with [11C]diprenorphine in normal volunteers

Jones, A. K. P., Luthra, S. K., Maziere, B., Pike, V. W., Loc’h, C., Crouzel, C., Syrota, A., & Jones, T. (1988) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(88)90184-7 · Cited by 88 · see citing works

C-11-diprenorphine PET imaging of opioid binding during chronic methadone treatment and early abstinence

Daglish, M. R. C., Melichar, J., Lingford-Hughes, A. R., Brooks, D. J., Myles, J. S., & Nutt, D. J. (2000) · Journal of Nuclear Medicine · Cited by 1 · see citing works

Total-body [11C]carfentanil PET: Liver-brain axis in methadone vs. buprenorphine treatment

Li, E. J., Wiers, C. E., Hsieh, C., Lee, H., Schmitz, A., Young, A. J., Pond, T., Chang, J., Schubert, E. K., Mach, R. H., et al. (2026) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-026-08144-2

Naloxone displacement at opioid receptor sites measured in vivo in the human brain

Melichar, J., Nutt, D., & Malizia, A. L. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02872-8 · Cited by 50 · see citing works