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Cited by 102Attention Deficit Hyperactivity DisorderSubstance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Bupropion Treatment for Cocaine Abuse and Adult Attention-Deficit/Hyperactivity Disorder

Levin, Frances R., Evans, Suzette M., McDowell, David M., Brooks, Daniel J., Nunes, Edward·2002·Journal of Addictive Diseases
DOI 10.1300/j069v21n02_01
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Abstract

There are few published studies assessing the efficacy of pharmacologic treatments for attention-deficit hyperactivity disorder (ADHD) among substance abusers seeking treatment. Eleven patients who met DSM-IV diagnostic criteria for cocaine dependence and adult ADHD were entered into a 12-week single-blind trial of divided daily doses of bupropion (BPR). All patients received weekly individual standardized relapse prevention therapy. Treatment compliance and retention were good. Patients reported significant reductions in attention difficulties, hyperactivity and impulsivity. Self-reported cocaine use, cocaine craving, and cocaine positive toxicologies, also decreased significantly. In a previously published trial, 12 patients who met similar diagnostic criteria for adult ADHD and cocaine dependence were entered into a 12-week trial of divided daily doses of sustained-release methylphenidate (MPH). Improvements observed on BPR were similar to, and did not differ from those previously observed with MPH. These preliminary data suggest that BPR may be as effective as sustained-release MPH, when combined with relapse prevention therapy, for cocaine abusers with adult ADHD. However, a future study directly comparing BPR to MPH in a double-blind placebo-controlled trial is needed.

Integrity signals

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Crossref · 10.1300/j069v21n02_01

Cites

39 of 39 references verified0 citation errors · 0 not checkable

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  • Effective treatment of ADHD has been shown to improve comorbid disorders including SUD, bipolar disorder, depression, and anxiety disorders.

    “Effective treatment of ADHD has been shown to improve comorbid disorders including SUD [69,95,132], bipolar disorder [17], depression [69], and anxiety disorders [114,133].”

    From Adult ADHD and comorbid disorders: clinical implications of a dimensional approach (2017) · cites this paper as [132]

  • Bupropion has a lower abuse potential and has effectively been used in patients with ADHD, cocaine use, and comorbid depression.

    “Another alternative to stimulants is bupropion, which has a lower abuse potential, and has effectively been used in patients with ADHD, cocaine use, and comorbid depression [132].”

    From Adult ADHD and comorbid disorders: clinical implications of a dimensional approach (2017) · cites this paper as [132]

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Related

Authors
Levin, F. R., Evans, S. M., McDowell, D. M., Brooks, D. J., & Nunes, E.
Affiliations
New York State Psychiatric Institute (US)
ORCID
Venue
Journal of Addictive Diseases
Publisher
Informa UK Limited
Published
2002-02-27
Volume
21
Issue
2
Pages
1-16
ISSN
  • 1055-0887 (ISSN-L)
  • 1545-0848
DOI
10.1300/j069v21n02_01
OpenAlex
W1994589145
Cited by
102
References
40
Citations by year
2025: 3 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 2 · 2018: 1 · 2017: 4 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 10
FWCI
4.71
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Addictive Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k20da000214-05)
  • National Institute on Drug Abuse (K20 DA-00214, P50 DA-09236, P50DA009236)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
bupropion, cocaine dependence, adult ADHD, methylphenidate, cocaine craving, impulsivity, hyperactivity, addiction treatment, pharmacotherapy
MeSH terms
Adult, Attention Deficit Disorder with Hyperactivity, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Male, Methylphenidate, Comorbidity, Single-Blind Method, Bupropion, Treatment Outcome, Cocaine-Related Disorders

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