Brain uptake kinetics of nicotine and cotinine after chronic nicotine exposure

Role of dopamine in the behavioural actions of nicotine related to addiction

Chiara, G. D. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00122-9 · Cited by 680 · see citing works

A Major Role for CYP2A6 in Nicotine C-Oxidation by Human Liver Microsomes

Messina, E. S., Tyndale, R. F., & Sellers, E. M. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36947-2 · Cited by 455 · see citing works

Structural and functional aspects of the blood-brain barrier

Begley, D. J., & Brightman, M. (2003) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8049-7_2 · Cited by 452 · see citing works

Smokers of Low-Yield Cigarettes Do Not Consume Less Nicotine

Benowttz, N. L., Hall, S. M., Herning, R. I., Jacob, P., Jones, R. T., & Osman, A.-L. (1983) · New England Journal of Medicine · doi:10.1056/nejm198307213090303 · Cited by 442 · see citing works

Absorption and metabolism of nicotine from cigarettes.

ARMITAGE, A. K., Dollery, C. T., George, C. F., Houseman, T. H., Lewis, P. J., & Turner, D. M. (1975) · BMJ · doi:10.1136/bmj.4.5992.313 · Cited by 293 · see citing works

Circadian blood nicotine concentrations during cigarette smoking

Benowitz, N. L., Kuyt, F., & Jacob, P. (1982) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1982.233 · Cited by 292 · see citing works

Cigarette Smoking and Plasma Levels of Nicotine

ISAAC, P. F., & RAND, M. J. (1972) · Nature · doi:10.1038/236308a0 · Cited by 257 · see citing works

Cigarette Smoking: A Dependence on High-Nicotine Boli

Russell, M. A. H., & Feyerabend, C. (1978) · Drug Metabolism Reviews · doi:10.3109/03602537808993776 · Cited by 253 · see citing works

Nicotine increases in vivo blood–brain barrier permeability and alters cerebral microvascular tight junction protein distribution

Hawkins, B. T., Abbruscato, T. J., Egleton, R. D., Brown, R. C., Huber, J. D., Campos, C. R., & Davis, T. P. (2004) · Brain Research · doi:10.1016/j.brainres.2004.08.043 · Cited by 227 · see citing works

In Situ Blood–Brain Barrier Transport of Nanoparticles

Koziara, J. M., Lockman, P. R., Allen, D. D., & Mumper, R. J. (2003) · Pharmaceutical Research · doi:10.1023/b:pham.0000003374.58641.62 · Cited by 182 · see citing works

Nicotine and Cotinine Modulate Cerebral Microvascular Permeability and Protein Expression of ZO-1 through Nicotinic Acetylcholine Receptors Expressed on Brain Endothelial Cells

Abbruscato, T. J., Lopez, S. P., Mark, K. S., Hawkins, B. T., & Davis, T. P. (2002) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10256 · Cited by 182 · see citing works

Cigarette smoking decreases cerebral blood flow suggesting increased risk for stroke.

Rogers, R. L., Meyer, J. S., Shaw, T. G., Mortel, K. F., Hardenberg, J. P., & Zaid, R. R. (1983) · PubMed · Cited by 116 · see citing works

Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment

Miksys, S. L., Hoffmann, E. B., & Tyndale, R. F. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00281-1 · Cited by 114 · see citing works

A Review of Blood–Brain Barrier Transport Techniques

Smith, Q. R. (2003) · Humana Press eBooks · doi:10.1385/1-59259-419-0:193 · Cited by 113 · see citing works

Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2'-(14)C]nicotine.

Ghosheh, O. A., Dwoskin, L. P., Miller, D. K., & Crooks, P. A. (2001) · PubMed · Cited by 111 · see citing works

Local cerebral blood flow in the conscious rat as measured with 14C-antipyrine, 14C-iodoantipyrine and 3H-nicotine.

Ohno, K., Pettigrew, K. D., & Рапопорт, С. И. (1979) · Stroke · doi:10.1161/01.str.10.1.62 · Cited by 111 · see citing works

Comparative Effects of Propofol, Pentobarbital, and Isoflurane on Cerebral Blood Flow and Blood Volume

Todd, M. M., & Weeks, J. B. (1996) · Journal of Neurosurgical Anesthesiology · doi:10.1097/00008506-199610000-00007 · Cited by 109 · see citing works

Effects of chronic oral consumption of nicotine on the rabbit aortic endothelium.

Booyse, F. M., Osikowicz, G., & Quarfoot, A. J. (1981) · PubMed · Cited by 108 · see citing works

Activation and inhibition of the human α7 nicotinic acetylcholine receptor by agonists

Briggs, C. A., & McKenna, D. G. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00110-5 · Cited by 108 · see citing works

Importance of baseline cotinine plasma values in smoking cessation: results from a double-blind study with nicotine patch

Paoletti, P., Fornai, E., Maggiorelli, F., Puntoni, R., Viegi, G., Carrozzi, L., Corlando, A., GUSTAVSSON, G., Säwe, U., & Giuntini, C. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09040643 · Cited by 108 · see citing works

In Vivo and in Vitro Assessment of Baseline Blood-Brain Barrier Parameters in the Presence of Novel Nanoparticles

Lockman, P. R., Koziara, J. M., Roder, K. E., Paulson, J. R., Abbruscato, T. J., Mumper, R. J., & Allen, D. D. (2003) · Pharmaceutical Research · doi:10.1023/a:1023492015851 · Cited by 92 · see citing works

Metabolites of nicotine in rat brain after peripheral nicotine administration. Cotinine, nornicotine, and norcotinine.

Crooks, P. A., Li, M., & Dwoskin, L. P. (1997) · PubMed · Cited by 92 · see citing works

Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted

Yamanaka, H., Nakajima, M., Nishimura, K., Yoshida, R., Fukami, T., Katoh, M., & Yokoi, T. (2004) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2004.04.012 · Cited by 85 · see citing works

Regulation of Blood-Brain Barrier Na,K,2Cl-Cotransporter through Phosphorylation during in Vitro Stroke Conditions and Nicotine Exposure

Abbruscato, T., Lopez, S. P., Roder, K. E., & Paulson, J. R. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.066274 · Cited by 81 · see citing works

Nicotine metabolism by rat hepatic cytochrome P450s

Nakayama, H., Okuda, H., Nakashima, T., Imaoka, S., & Funae, Y. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90238-r · Cited by 73 · see citing works

The potential role of cotinine in the cognitive and neuroprotective actions of nicotine

Buccafusco, J. J., & Terry, A. V. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00226-1 · Cited by 62 · see citing works

Cerebral Blood Flow During Hemodilution and Hypoxia in Rats

Tomiyama, Y., Brian, J. E., & Todd, M. M. (1999) · Stroke · doi:10.1161/01.str.30.9.1942 · Cited by 62 · see citing works

(S)- and (R)-[11C]nicotine and the metabolite ()-[11C]cotinine. preparation, metabolite studies and in vivo distribution in the human brain using PET

Halldin, C., Någren, K., Swahn, C., et al. (1992) · International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology · doi:10.1016/0883-2897(92)90173-v · Cited by 61 · see citing works

The effect of cigarette smoke, nicotine, and carbon monoxide on the permeability of the arterial wall

Allen, D. R., BROWSE, N. L., Rutt, D. L., Butler, L., & Fletcher, C. L. (1988) · Journal of Vascular Surgery · doi:10.1016/0741-5214(88)90387-4 · Cited by 55 · see citing works

Nicotinic agonists modulate basal forebrain control of cortical cerebral blood flow in anesthetized rats.

Linville, D. G., Williams, S., Raszkiewicz, J. L., et al. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39506-6 · Cited by 51 · see citing works

Regional Changes in Cerebral Blood Flow and Blood — Brain Barrier Permeability during Epileptiform Seizures and in Acute Hypertension in Rabbits

Suzuki, R., Nitsch, C., Fujiwara, K., et al. (1984) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1984.12 · Cited by 50 · see citing works

Metabolism of nicotine by rat liver cytochromes P-450. Assessment utilizing monoclonal antibodies to nicotine and cotinine.

Hammond, D. K., Bjercke, R. J., Langone, J. J., & Strobel, H. W. (1991) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)08898-1 · Cited by 50 · see citing works

Studies on the interactions of tobacco leaf and tobacco smoke constituents and monoamine oxidase

Castagnoli, K., Steyn, S. J., Magnin, G., der Schyf, C. J. V., Fourie, I., Khalil, A. A., & Castagnoli, N. (2002) · Neurotoxicity Research · doi:10.1080/10298420290015854 · Cited by 46 · see citing works

Chronic nicotine exposure alters blood–brain barrier permeability and diminishes brain uptake of methyllycaconitine

Lockman, P. R., der Schyf, C. J. V., Abbruscato, T. J., & Allen, D. D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03162.x · Cited by 41 · see citing works

The Effect of Nicotine on Pulmonary Epithelial Permeability in Man

Minty, B. D., Royston, D., Jones, J. G., et al. (1984) · CHEST Journal · doi:10.1378/chest.86.1.72 · Cited by 37 · see citing works

Nicotine Is More Efficient than Cotinine at Passing the Blood–Brain Barrier in Rats

Riah, O., Courriére, P., Dousset, J.-C., et al. (1998) · Cellular and Molecular Neurobiology · doi:10.1023/a:1022501131709 · Cited by 33 · see citing works

Nicotine Downregulates α2 Isoform of Na,K-ATPase at the Blood-Brain Barrier and Brain in Rats

Wang, L., McComb, J. G., Weiss, M. H., McDonough, A. A., & Zloković, B. V. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1389 · Cited by 33 · see citing works

Metabolism of (−)-(S)-nicotine by guinea pig and rat brain: identification of cotinine

Jacob, P., Ülgen, M., & Gorrod, J. W. (1997) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03190975 · Cited by 27 · see citing works

Cigarette smoking decreases cerebral blood flow suggesting increased risk for stroke

Rogers, R. (1983) · JAMA · doi:10.1001/jama.250.20.2796 · Cited by 17 · see citing works

Effects of nicotine on cortical high voltage spindles in rats

Radek, R. J. (1993) · Brain Research · doi:10.1016/0006-8993(93)90133-8 · Cited by 16 · see citing works

The effect of cigarette smoke, nicotine, and carbon monoxide on the permeability of the arterial wall

Allen, D. R., BROWSE, N. L., Rutt, D. L., et al. (1988) · Journal of Vascular Surgery · doi:10.1067/mva.1988.avs0070139 · Cited by 13 · see citing works

Extravasation of macromolecules and vascular reactivity of microvessels in response to nicotine in the hamster.

To, M., Wl, J., & Jp, G. (1988) · PubMed · Cited by 12 · see citing works

Effects of cotinine at cholinergic nicotinic receptors of the sympathetic superior cervical ganglion of the mouse

Schroff, K.-C., Lovich, P., Schmitz, O. J., Aschhoff, S., Richter, E., & Remien, J. (2000) · Toxicology · doi:10.1016/s0300-483x(99)00195-x · Cited by 11 · see citing works

Nicotinic receptor-mediated reduction in l-DOPA-induced dyskinesias may occur via desensitization

Bordia, T., Campos, C., McIntosh, J. M., & Quik, M. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.162396 · Cited by 82 · see citing works

Urinary levels of nicotine & cotinine in tobacco users.

Behera, D., Uppal, R., & Majumdar, S. (2003) · PubMed · Cited by 53 · see citing works

Biomarkers Derived from Nicotine and its Metabolites: A Review

Tricker, A. R. (2006) · Contributions to Tobacco & Nicotine Research · doi:10.2478/cttr-2013-0825 · Cited by 39 · see citing works

Cotinine antagonizes the behavioral effects of nicotine exposure in the planarian Girardia tigrina

Bach, D., Tenaglia, M., Baker, D. L., et al. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.09.005 · Cited by 16 · see citing works

Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine

Tang, Y., Bryant, M., Li, M., Min, S., Pellar, G., Wu, Q., Yang, D.-J., Kang, H.-K., Sepehr, E., He, X., et al. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae120 · Cited by 11 · see citing works

Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2′-14C]nicotine

Ghosheh, O., Dwoskin, L. P., Li, W.-K., & Crooks, P. A. (1999) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)14955-0 · Cited by 108 · see citing works