Metformin prevents endotoxin-induced liver injury after partial hepatectomy

Intensive insulin therapy in critically ill patients.

Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977 · see citing works

ENDOTOXINS AND DISEASE MECHANISMS

Morrison, D. C., & Ryan, J. L. (1987) · Annual Review of Medicine · doi:10.1146/annurev.me.38.020187.002221 · Cited by 1,111 · see citing works

Physiological consequences of loss of plasminogen activator gene function in mice

Carmeliet, P., Schoonjans, L., Kieckens, L., Neugeboren, B. I., Degen, J. L., Bronson, R. T., Vos, R. D., van den Oord, J. J., Collen, D., & Mulligan, R. C. (1994) · Nature · doi:10.1038/368419a0 · Cited by 1,036 · see citing works

Experimental and surgical technique in the rat

Waynforth, H. B. (1980) · Medical Entomology and Zoology · Cited by 749 · see citing works

Metformin in non-alcoholic steatohepatitis.

Marchesini, G., Bianchi, G., Tomassetti, S., Zoli, M., & Melchionda, N. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06042-1 · Cited by 682 · see citing works

Metformin reverses fatty liver disease in obese, leptin-deficient mice.

Lin, H. Z., Yang, S. Q., Chuckaree, C., Kuhajda, F., Ronnet, G., & Diehl, A. M. (2000) · Nature Medicine · doi:10.1038/79697 · Cited by 673 · see citing works

Role of the liver in the control of carbohydrate and lipid homeostasis

Postic, C., Dentin, R., & Girard, J. R. (2004) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70133-7 · Cited by 441 · see citing works

Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta.

Sawdey, M., & Loskutoff, D. J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115440 · Cited by 413 · see citing works

Role of resistin in diet-induced hepatic insulin resistance

Muse, E. D., Obici, S., Bhanot, S., Monia, B. P., McKay, R. A., Rajala, M. W., Scherer, P. E., & Rossetti, L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21270 · Cited by 371 · see citing works

Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial

Nair, S., Diehl, A. M., Wiseman, M., Farr, G. H., & Perrillo, R. P. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02025.x · Cited by 369 · see citing works

Plasminogen Activator Inhibitors - A Review

Kruithof, E. K. O. (2017) · Enzyme · doi:10.1159/000469153 · Cited by 292 · see citing works

Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats

Satoh, H., Nguyen, M. T., Miles, P. D. G., Imamura, T., Usui, I., & Olefsky, J. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20785 · Cited by 266 · see citing works

Acute Inflammation and Microthrombosis Induced by Endotoxin, Interleukin-1, and Tumor Necrosis Factor and their Implication in Gram-Negative Infection

Cybulsky, M. I., Chan, M. K. W., & Movat, H. Z. (1989) · Humana Press eBooks · doi:10.1007/978-1-4612-4502-5_6 · Cited by 229 · see citing works

Insulin Attenuates the Systemic Inflammatory Response in Endotoxemic Rats

Jeschke, M. G., Klein, D., Bolder, U., & Einspanier, R. (2004) · Endocrinology · doi:10.1210/en.2004-0592 · Cited by 217 · see citing works

Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock

Pralong, G., Calandra, T., Glausef, M.-P., Schellekens, J. F. P., Verhoef, J., Bachmann, F., & Kruithof, E. K. O. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646614 · Cited by 199 · see citing works

Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator.

Yamamoto, K., & Loskutoff, D. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118691 · Cited by 198 · see citing works

Beneficial effects of metformin on haemostasis and vascular function in man

Grant, P. J. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(03)72787-6 · Cited by 166 · see citing works

Provocation of massive hepatic necrosis by endotoxin after partial hepatectomy in rats

Mochida, S., Ogata, I., Hirata, K., Ohta, Y., Yamada, S., & Fujiwara, K. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90967-6 · Cited by 156 · see citing works

Endotoxin induction of plasminogen activator and plasminogen activator inhibitor type 1 mRNA in rat tissues in vivo.

Quax, P. H. A., van den Hoogen, C. M., Verheijen, J. H., Padró, T., Zeheb, R., GELEHRTER, T. D., van Berkel, T. J. C., Kuiper, J., & Emeis, J. J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55433-8 · Cited by 143 · see citing works

Insulin Attenuates the Systemic Inflammatory Response to Thermal Trauma

Jeschke, M. G., Einspanier, R., Klein, D., & Jauch, K. (2002) · Molecular Medicine · doi:10.1007/bf03402024 · Cited by 130 · see citing works

Increase of Plasminogen Activator Inhibitor Levels Predicts Outcome of Leukocytopenic Patients with Sepsis

Mesters, R. M., Flörke, N., Ostermann, H., & Kienast, J. (1996) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1650392 · Cited by 125 · see citing works

Activation of the fibrinolytic system and utilization of the coagulation inhibitors in sepsis: comparison with severe sepsis and septic shock

Mavrommatis, A. C., Theodoridis, T., Economou, M., Kotanidou, A. N., Ali, M. E., Christopoulou-Kokkinou, V., & Zakynthinos, S. G. (2001) · Intensive Care Medicine · doi:10.1007/s00134-001-1139-8 · Cited by 116 · see citing works

The Effect of Dimethylbiguanide on Thrombin Activity, FXIII Activation, Fibrin Polymerization, and Fibrin Clot Formation

Standeven, K. F., Ariëns, R. A. S., Whitaker, P., Ashcroft, A. E., Weisel, J. W., & Grant, P. J. (2002) · Diabetes · doi:10.2337/diabetes.51.1.189 · Cited by 106 · see citing works

Plasminogen Activators Direct Reorganization of the Liver Lobule after Acute Injury

Bezerra, J. A., Currier, A. R., Melín‐Aldana, H., Sabla, G. E., Bugge, T. H., Kombrinck, K. W., & Degen, J. L. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64039-4 · Cited by 89 · see citing works

Induction of plasminogen activator inhibitor-1 in HepG2 human hepatoma cells by mediators of the acute phase response.

Healy, A. M., & GELEHRTER, T. D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32279-2 · Cited by 80 · see citing works

Molecular mechanisms of tumor necrosis factor‐α‐mediated plasminogen activator inhibitor‐1 expression in adipocytes

Pandey, M., Loskutoff, D. J., & Samad, F. (2005) · The FASEB Journal · doi:10.1096/fj.04-3459fje · Cited by 80 · see citing works

Pirfenidone prevents endotoxin-induced liver injury after partial hepatectomy in rats

Tsuchiya, H., Kaibori, M., Yanagida, H., Yokoigawa, N., Kwon, A., Okumura, T., & Kamiyama, Y. (2003) · Journal of Hepatology · doi:10.1016/j.jhep.2003.09.023 · Cited by 71 · see citing works

Pathophysiology of impaired pulsatile insulin release

Bergsten, P. (2000) · Diabetes/Metabolism Research and Reviews · doi:10.1002/1520-7560(200005/06)16:3 · Cited by 69 · see citing works

Plasminogen activator inhibitor-1 synthesis in the human hepatoma cell line Hep G2. Metformin inhibits the stimulating effect of insulin.

Anfosso, F. J., Chomiki, N., Alessi, M., Vague, P., & Juhan-Vague, I. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116445 · Cited by 69 · see citing works

Induction of plasminogen activator inhibitor 1 gene expression in murine liver by lipopolysaccharide. Cellular localization and role of endogenous tumor necrosis factor-alpha.

Fearns, C., & Loskutoff, D. J. (1997) · Europe PMC (PubMed Central) · Cited by 67 · see citing works

Insulin Resistance in Burns and Trauma

Carter, E. A. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01636.x · Cited by 53 · see citing works

Metformin, but not Thiazolidinediones, Inhibits Plasminogen Activator Inhibitor-1 Production in Human Adipose Tissuein Vitro

He, G., Pedersen, S. B., Bruun, J. M., Lihn, A. S., & Richelsen, B. (2003) · Hormone and Metabolic Research · doi:10.1055/s-2003-38386 · Cited by 43 · see citing works

Sepsis: current concepts in intracellular signaling

Strassheim, D., Park, J. S., & Abraham, E. H. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00049-3 · Cited by 39 · see citing works

Coagulation in Sepsis

Jagneaux, T., Taylor, D. E., & Kantrow, S. P. (2004) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200410000-00002 · Cited by 35 · see citing works

Insulin Resistance in Experimental Shock

Chaudry, I. H. (1974) · Archives of Surgery · doi:10.1001/archsurg.1974.01360030064017 · Cited by 34 · see citing works

The role of hepatic type 1 plasminogen activator inhibitor (PAI‐1) during murine hemorrhagic shock†

Lagoa, C. E., Yoram Vodovotz, B., Stolz, D. B., Lhuillier, F., McCloskey, C. A., Gallo, D. J., Yang, R., Ustinova, E. E., Fink, M. P., Billiar, T. R., et al. (2005) · Hepatology · doi:10.1002/hep.20797 · Cited by 30 · see citing works

Changes in the reticuloendothelial phagocytic function after partial hepatectomy.

Arii, S., Shibagaki, M., Takahashi, S., Taki, Y., Yokoo, N., JIKKO, A., Tanaka, J., Kamiyama, Y., Takasan, H., & Ozawa, K. (1985) · PubMed · Cited by 29 · see citing works

What the physician needs to know for correct management of gastro‐oesophageal reflux disease and dyspepsia

Talley, N. J. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02043.x · Cited by 19 · see citing works

Impact of Severe Infections on the Outcome of Major Liver Surgery: a Pathophysiologic and Clinical Analysis

D'Amico, D. F., & Cillo, U. (1999) · Journal of Chemotherapy · doi:10.1179/joc.1999.11.6.513 · Cited by 8 · see citing works

Untitled work

Good (1996) · doi:10.1002/(sici)1097-4652(199609)168:3

AMPK, Mitochondrial Function, and Cardiovascular Disease

Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286 · see citing works

Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase

Park, C. S., Bang, B., Kwon, H., Moon, K., Kim, T., Lee, K., Moon, H., & Cho, Y. S. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.09.025 · Cited by 208 · see citing works

Metformin Prevents Alcohol-Induced Liver Injury in the Mouse: Critical Role of Plasminogen Activator Inhibitor-1

Bergheim, I., Guo, L., Davis, M. A., Lambert, J. C., Beier, J. I., Duveau, I., Luyendyk, J. P., Roth, R. A., & Arteel, G. E. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.020 · Cited by 204 · see citing works

Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function

Spruss, A., Kanuri, G., Stahl, C., Bischoff, S. C., & Bergheim, I. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.75 · Cited by 168 · see citing works

Mitochondrial Respiratory Complex I Regulates Neutrophil Activation and Severity of Lung Injury

Żmijewski, J. W., Lorne, E., Zhao, X., Tsuruta, Y., Sha, Y., Liu, G., Siegal, G. P., & Abraham, E. H. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200710-1602oc · Cited by 167 · see citing works

Metformin inhibits HMGB1 release in LPS‐treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

Tsoyi, K., Jang, H. J., Nizamutdinova, I. T., Kim, Y. M., Lee, Y. S., Kim, H. J., Seo, H. G., Lee, J. H., & Chang, K. C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01126.x · Cited by 158 · see citing works

Synergistic drug–cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

Cosgrove, B. D., King, B. M., Hasan, M. A., Alexopoulos, L. G., Farazi, P. A., Hendriks, B. S., Griffith, L. G., Sorger, P. K., Tidor, B., Xu, J. J., et al. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.04.002 · Cited by 133 · see citing works

REVIEW ARTICLE: Immunological Modes of Pregnancy Loss

Kwak-Kim, J. Y.-H., Park, J. C., Ahn, H. K., Kim, J. W., & Gilman‐Sachs, A. (2010) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2010.00847.x · Cited by 122 · see citing works

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

Corominas-Faja, B., Quirantes‐Piné, R., Oliveras‐Ferraros, C., Vázquez‐Martín, A., Cufí, S., Martı́n-Castillo, B., Micol, V., Joven, J., Segura‐Carretero, A., & Menéndez, J. A. (2012) · Aging · doi:10.18632/aging.100472 · Cited by 118 · see citing works

Metformin Suppresses Interleukin (IL)-1β-Induced IL-8 Production, Aromatase Activation, and Proliferation of Endometriotic Stromal Cells

Takemura, Y., Osuga, Y., Yoshino, O., Hasegawa, A., Hirata, T., Hirota, Y., Nose, E., Morimoto, C., Harada, M., Koga, K., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2486 · Cited by 102 · see citing works

Activation of AMPK Enhances Neutrophil Chemotaxis and Bacterial Killing

Park, D. W., Jiang, S., Tadié, J., Stigler, W. S., Gao, Y., Deshane, J. S., Abraham, E. H., & Zmijewski, J. W. (2013) · Molecular Medicine · doi:10.2119/molmed.2013.00065 · Cited by 94 · see citing works

Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice #

Beier, J. I., Luyendyk, J. P., Guo, L., von Montfort, C., Staunton, D. E., & Arteel, G. E. (2009) · Hepatology · doi:10.1002/hep.22847 · Cited by 91 · see citing works

Is metformin poised for a second career as an antimicrobial?

Malik, F. R., Mehdi, S. F., Ali, H., Patel, P., Basharat, A., Kumar, A., Ashok, F., Stein, J., Brima, W., Malhotra, P., et al. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2975 · Cited by 87 · see citing works

AMP-Activated Protein Kinase and Host Defense against Infection

Silwal, P., Kim, J. K., Yuk, J., & Jo, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113495 · Cited by 81 · see citing works

GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury

Park, D. W., Jiang, S., Liu, Y., Siegal, G. P., Inoki, K., Abraham, E. H., & Zmijewski, J. W. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00165.2014 · Cited by 84 · see citing works

Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice

Tan, M., Schmidt, R. H., Beier, J. I., Watson, W. H., Zhong, H., States, J. C., & Arteel, G. E. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.09.019 · Cited by 81 · see citing works

Asthma Therapy and Its Effect on Airway Remodelling

Berair, R., & Brightling, C. E. (2014) · Drugs · doi:10.1007/s40265-014-0250-4 · Cited by 80 · see citing works

Caloric restriction and chronic inflammatory diseases

González, O. A., Tobia, C. M., Ebersole, J. L., & Novak, M. J. (2011) · Oral Diseases · doi:10.1111/j.1601-0825.2011.01830.x · Cited by 76 · see citing works

Metformin protects primary rat hepatocytes against oxidative stress‐induced apoptosis

de la Rosa, L. C., Vrenken, T. E., Buist‐Homan, M., Faber, K. N., & Moshage, H. J. (2015) · Pharmacology Research & Perspectives · doi:10.1002/prp2.125 · Cited by 67 · see citing works

Metformin inhibits inflammatory angiogenesis in a murine sponge model

Xavier, D. O., Amaral, L. S. D. B., Gomes, M. A., Rocha, M. A., Campos, P. R., Cota, B. D. C. V., Tafuri, L., Paiva, A., Silva, J. H., Andrade, S. P., et al. (2009) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2009.08.004 · Cited by 67 · see citing works

Mitochondria and AMP-activated Protein Kinase-dependent Mechanism of Efferocytosis

Jiang, S., Park, D. W., Stigler, W. S., Creighton, J. R., Ravi, S., Darley-Usmar, V. M., & Żmijewski, J. W. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.489468 · Cited by 66 · see citing works

Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury

Zmijewski, J. W., Lorne, E., Banerjee, S., & Abraham, E. H. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90522.2008 · Cited by 66 · see citing works

AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6

Gongol, B., Marin, T., Peng, I.-C., Woo, B., Martin, M., King, S., Sun, W., Johnson, D. A., Chien, S., & Shyy, J. Y.-J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222051110 · Cited by 61 · see citing works

New role of plasminogen activator inhibitor‐1 in alcohol‐induced liver injury

Arteel, G. E. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05285.x · Cited by 61 · see citing works

Metformin inhibits hepatitis B virus protein production and replication in human hepatoma cells

Xun, Y. ‐., Zhang, Y. ‐., Pan, Q. ‐., Mao, R., Qin, Y., Liu, H., Zhang, Y., Yu, Y., Tang, Z. ‐., Lu, M., et al. (2013) · Journal of Viral Hepatitis · doi:10.1111/jvh.12187 · Cited by 56 · see citing works

Alcoholic liver disease and the potential role of plasminogen activator inhibitor-1 and fibrin metabolism

Beier, J. I., & Arteel, G. E. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011255 · Cited by 56 · see citing works

Context-Dependent Pharmacological Effects of Metformin on the Immune System

Marcucci, F., Romeo, E. L., Caserta, C. A., Rumio, C., & Lefoulon, F. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.01.003 · Cited by 55 · see citing works

Frontline Science: D1 dopaminergic receptor signaling activates the AMPK-bioenergetic pathway in macrophages and alveolar epithelial cells and reduces endotoxin-induced ALI

Bone, N. B., Liu, Z., Pittet, J., & Zmijewski, J. W. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3hi0216-068rr · Cited by 54 · see citing works

Treatment with Metformin and Combination of Metformin Plus Pioglitazone on Serum Levels of IL-6 and IL-8 in Polycystic Ovary Syndrome: A Randomized Clinical Trial

Ali, D.-E.-S., Shah, M., Ali, A., Malik, M. O., Rehman, F., Badshah, H., Ehtesham, E., & Vitale, S. G. (2019) · Hormone and Metabolic Research · doi:10.1055/a-1018-9606 · Cited by 53 · see citing works

Camel milk inhibits inflammatory angiogenesis via downregulation of proangiogenic and proinflammatory cytokines in mice

Alhaider, A. A., Gader, A. G. M. A., Almeshaal, N., & Saraswati, S. (2013) · Apmis · doi:10.1111/apm.12199 · Cited by 49 · see citing works

New Role of Resistin in Lipopolysaccharide-Induced Liver Damage in Mice

Beier, J. I., Guo, L., von Montfort, C., Kaiser, J. P., Joshi‐Barve, S., & Arteel, G. E. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.136721 · Cited by 48 · see citing works

A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure.

Hassan, F. I., Didari, T., Khan, F., Niaz, K., Mojtahedzadeh, M., & Abdollahi, M. R. (2020) · PubMed Central · doi:10.22074/cellj.2020.6286 · Cited by 48 · see citing works

γδT Cells Initiate Acute Inflammation and Injury in Adenovirus-Infected Liver via Cytokine-Chemokine Cross Talk

Ajuebor, M. N., Jin, Y., Gremillion, G., Strieter, R. M., Chen, Q., & Adegboyega, P. A. (2008) · Journal of Virology · doi:10.1128/jvi.00927-08 · Cited by 46 · see citing works

Pharmaceutical Impact of Houttuynia Cordata and Metformin Combination on High-Fat-Diet-Induced Metabolic Disorders: Link to Intestinal Microbiota and Metabolic Endotoxemia

Wang, J., Bose, S., Shin, N. R., Chin, Y., Choi, Y. H., & Kim, H. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00620 · Cited by 45 · see citing works

Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP‐9 expression but not direct TJ proteins expression regulation

Zhang, D., Tang, Q., Zheng, G., Wang, C., Zhou, Y., Wu, Y., Xuan, J., Tian, N., Wang, X., Wu, Y., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13235 · Cited by 44 · see citing works

How does blood glucose control with metformin influence intensive insulin protocols? Evidence for involvement of oxidative stress and inflammatory cytokines

Ansari, G., Mojtahedzadeh, M., Kajbaf, F., Najafi, A., Khajavi, M. R., Khalili, H., Rouini, M. R., Ahmadi, H., & Abdollahi, M. R. (2008) · Advances in Therapy · doi:10.1007/s12325-008-0075-1 · Cited by 43 · see citing works

Changes in peripheral mitochondrial DNA copy number in metformin-treated women with polycystic ovary syndrome: a longitudinal study

Yang, P.-K., Chou, C.-H., Chang, C., Chen, S., Ho, H., & Chen, M. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00629-5 · Cited by 43 · see citing works

Sex-Specific Differences in the Development of Acute Alcohol-Induced Liver Steatosis in Mice

Wagnerberger, S., Fiederlein, L., Kanuri, G., Stahl, C., Millonig, G., Mueller, S., Bischoff, S. C., & Bergheim, I. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt138 · Cited by 42 · see citing works

Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity†

Wang, H., Park, O., Lafdil, F., Shen, K., Horiguchi, N., Yin, S., Fu, X.-Y., Kunos, G., & Gao, B. (2009) · Hepatology · doi:10.1002/hep.23430 · Cited by 41 · see citing works

Metformin attenuated the inflammation after renal ischemia/reperfusion and suppressed apoptosis of renal tubular epithelial cell in rats

Wang, Z., Liu, X., Wang, M., Jiang, G., Qiu, T., Chen, Z.-Y., & Wang, L. (2015) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-865020150090000006 · Cited by 38 · see citing works

Houttuynia cordata Facilitates Metformin on Ameliorating Insulin Resistance Associated with Gut Microbiota Alteration in OLETF Rats

Wang, J., Bose, S., Lim, S.-K., Ansari, A., Chin, Y., Choi, H. S., & Kim, H. (2017) · Genes · doi:10.3390/genes8100239 · Cited by 36 · see citing works

Strychnine inhibits inflammatory angiogenesis in mice via down regulation of VEGF, TNF-α and TGF-β

Saraswati, S., & Agarwal, S. S. (2013) · Microvascular Research · doi:10.1016/j.mvr.2013.01.003 · Cited by 31 · see citing works

Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway

Wei, Y., Gao, C., Wang, H.-R., Zhang, Y.-N., Gu, J.-H., Zhang, X.-Y., Gong, X.-H., & Hao, Z.-H. (2023) · Journal of Animal Science and Biotechnology · doi:10.1186/s40104-023-00845-0 · Cited by 27 · see citing works

AMPK activation improves recovery from pneumonia-induced lung injury via reduction of er-stress and apoptosis in alveolar epithelial cells

Becker, E., Husain, M., Bone, N. B., Smith, S., Morris, P. E., & Zmijewski, J. W. (2023) · Respiratory Research · doi:10.1186/s12931-023-02483-6 · Cited by 29 · see citing works

Metformin as a Potential Treatment Option for Endometriosis

Kimber-Trojnar, Ż., Dłuski, D. F., Wierzchowska-Opoka, M., Ruszała, M., & Leszczyńska‐Gorzelak, B. (2022) · Cancers · doi:10.3390/cancers14030577 · Cited by 31 · see citing works

Metformin Suppresses Prostaglandin E2-Induced Cytochrome P450 Aromatase Gene Expression and Activity via Stimulation of AMP-Activated Protein Kinase in Human Endometriotic Stromal Cells

Zhou, Y., Xu, J., Zeng, C., Li, X., Zhou, Y., Qi, Y., & Xue, Q. (2015) · Reproductive Sciences · doi:10.1177/1933719115590664 · Cited by 27 · see citing works

Focal liver necrosis appears early after partial hepatectomy and is dependent on T cells and antigen delivery from the gut

Rudich, N., Zamir, G. A., Pappo, O., Shlomai, Z., Faroja, M., Weiss, I. D., Wald, H., Galun, E., Peled, A., & Wald, O. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02048.x · Cited by 25 · see citing works

Brucine, a plant derived alkaloid inhibits inflammatory angiogenesis in a murine sponge model

Agrawal, S. S., Saraswati, S., Mathur, R., & Pandey, M. (2011) · Biomedicine & Preventive Nutrition · doi:10.1016/j.bionut.2011.06.014 · Cited by 24 · see citing works

Boswellic acid inhibits inflammatory angiogenesis in a murine sponge model

Saraswati, S., Pandey, M., Mathur, R., & Agrawal, S. S. (2011) · Microvascular Research · doi:10.1016/j.mvr.2011.08.002 · Cited by 24 · see citing works

Costunolide suppresses an inflammatory angiogenic response in a subcutaneous murine sponge model

Saraswati, S., Alhaider, A. A., & Abdelgadir, A. M. (2018) · Apmis · doi:10.1111/apm.12808 · Cited by 19 · see citing works

Metformin-attenuated sepsis-induced oxidative damages: a novel role for metformin.

Ghavimi, H., Sheidaei, S., Vaez, H., Zolali, E., Asgharian, P., & Hamishehkar, H. (2018) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2018.24610.6126 · Cited by 19 · see citing works

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Wang, Y., Li, J., Wang, D., Jin, K., Hui, J., & Xu, H. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s360348 · Cited by 17 · see citing works

Camel urine inhibits inflammatory angiogenesis in murine sponge implant angiogenesis model

Alhaider, A. A., Gader, A. G. M. A., Almeshal, N., & Saraswati, S. (2013) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2013.10.003 · Cited by 17 · see citing works

Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury

Feng, D., Wang, Y., Mei, Y., Xu, Y., Xu, H. Y., Lu, Y., Luo, Q., Zhou, S., Kong, X., & Xu, L. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.105 · Cited by 16 · see citing works

CXCL13 and CXCR5 are upregulated in PCOS mice ovaries but downregulated following metformin administration

Ullah, A., Pervaz, S., Adu‐Gyamfi, E. A., Czika, A., Guo, M., Wang, M., & Wang, Y. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111730 · Cited by 15 · see citing works

Repurposing of metformin and colchicine reveals differential modulation of acute and chronic kidney injury

El‐Rashid, M., Nguyen-Ngo, D., Minhas, N., Meijles, D. N., Li, J. S. Y., Ghimire, K., Julovi, S. M., & Rogers, N. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-78936-5 · Cited by 15 · see citing works

Effects of glycemic control on glucose utilization and mitochondrial respiration during resuscitated murine septic shock

Vogt, J. A., Wachter, U. A., Wagner, K., Calzia, E., Gröger, M., Weber, S., Stahl, B., Georgieff, M., Asfar, P., Fontaine, E. M., et al. (2014) · Intensive Care Medicine Experimental · doi:10.1186/2197-425x-2-19 · Cited by 15 · see citing works

Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy

Slotta, J. E., Laschke, M. W., Menger, M. D., & Thorlacius, H. (2008) · British journal of surgery · doi:10.1002/bjs.6082 · Cited by 14 · see citing works

Ameliorative role of metformin on lipopolysaccharide-mediated liver malfunction through suppression of inflammation and oxidative stress in rats

Beheshti, F., Hosseini, M., Arab, Z., Asghari, A., & Anaeigoudari, A. (2020) · Toxin Reviews · doi:10.1080/15569543.2020.1833037 · Cited by 13 · see citing works

Inflammation and Hepatotoxicity

Luyendyk, J. P., Roth, R. A., & Ganey, P. E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.01031-9 · Cited by 8 · see citing works

Inflammation and Hepatotoxicity

Luyendyk, J. P., Ganey, P. E., Fullerton, A. M., & Roth, R. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95664-2 · Cited by 5 · see citing works

Effect of nutritional support on glucose control

Seematter, G., & Tappy, L. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3280147711 · Cited by 5 · see citing works

Plasminogen Activator Inhibitor-1 is Regulated Through Dietary Fat Intake and Heritability: Studies in Twins

Engstler, A. J., Frahnow, T., Kruse, M., Pfeiffer, A. F. H., & Bergheim, I. (2017) · Twin Research and Human Genetics · doi:10.1017/thg.2017.36 · Cited by 5 · see citing works

Ethanol-Induced Hepatotoxicity

Beier, J. I., & Arteel, G. E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.01017-4 · Cited by 4 · see citing works

Hepatotoxicity

Arteel, G. E. (2015) · doi:10.1002/9781118876992.ch11 · Cited by 3 · see citing works

Hyperglycemia in sepsis

Wang, T., Gong, B., Shi, K., Hu, G., Sun, L., & Xu, Y. (2025) · Clinica Chimica Acta · doi:10.1016/j.cca.2025.120702 · Cited by 3 · see citing works

EFFECTS OF METFORMIN ON TNF-α RELEASE IN LIPOPOLYSACCHARIDE-INDUCED MONOCYTES IN RATS

Gedikli, E., Parlak, M., & Soydan, A. S. (2024) · Cumhuriyet Tıp Dergisi/Cumhuriyet Üniversitesi Tıp Fakültesi dergisi · doi:10.7197/cmj.1413260 · Cited by 2 · see citing works

Lipopolysaccharides-Induced Inflammatory Response in White Blood Cells Is Associated with Alterations in Senescence Mediators: Modulation by Metformin

Aljada, A. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2014.0168 · Cited by 2 · see citing works

In Vitro Models for the Prediction of Drug‐Induced Liver Injury in Lead Discovery

Moulin, F., & Flint, O. P. (2015) · Methods and principles in medicinal chemistry · doi:10.1002/9783527673643.ch07 · Cited by 1 · see citing works

AMPK Mediates Endothelial Function Through the Phosphorylation of Nucleolin and PARP-1

Gongol, B. (2013) · eScholarship (California Digital Library) · Cited by 1 · see citing works

Development and analysis of an in vitro model of inflammatory cytokine-mediated idiosyncratic drug hepatotoxicity

Hasan, M. A. (2007) · DSpace@MIT (Massachusetts Institute of Technology)

Airway structural remodelling in asthma: Functional relevance and suitability as a target for therapy

Berair, R. (2018) · Leicester Research Archive (University of Leicester)

Inflammation and Hepatotoxicity

Luyendyk, J. P., Ganey, P. E., Fullerton, A. M., & Roth, R. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00211-4

Additional file 1 of Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway

Wei, Y., Gao, C., Wang, H., Zhang, Y., Gu, J., Zhang, X., Gong, X., & Hao, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26581190

Additional file 1 of AMPK activation improves recovery from pneumonia-induced lung injury via reduction of er-stress and apoptosis in alveolar epithelial cells

Becker, E., Husain, M., Bone, N. B., Smith, S., Morris, P. E., & Zmijewski, J. W. (2023) · Figshare · doi:10.6084/m9.figshare.23672621

Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice

Yuan, H., Li, L., Zheng, W., Wan, J., Ge, P., Li, H., & Zhang, L. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.01.015 · Cited by 59 · see citing works

Metformin attenuated sepsis-associated liver injury and inflammatory response in aged mice

Song, H., Zhang, X., Zhai, R., Liang, H., Song, G., Yuan, Y., Xu, Y., Yan, Y., Qiu, L., & Sun, T. (2022) · Bioengineered · doi:10.1080/21655979.2022.2036305 · Cited by 52 · see citing works

Early Treatment with Metformin Decreases Pancreatic Damage in Rats with LPS Induced Sepsis

Kar, E., Alataş, İ. Ö., Şahıntürk, V., & Öz, S. (2018) · DergiPark (Istanbul University) · Cited by 2 · see citing works

Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D-galactosamine-induced fulminant hepatitis

Gong, X., Duan, R., Ao, J.-E., Ai, Q., Ge, P., LIN, L., & Zhang, L. R. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4206 · Cited by 10 · see citing works

Effects of metformin on lipopolysaccharide induced inflammation by activating fibroblast growth factor 21

Kar, E., Alataş, Ö., Şahıntürk, V., & ÖZ, S. (2021) · Biotechnic & Histochemistry · doi:10.1080/10520295.2021.1894353 · Cited by 10 · see citing works