Activation of Nrf2 Reduces UVA-Mediated MMP-1 Upregulation via MAPK/AP-1 Signaling Cascades: The Photoprotective Effects of Sulforaphane and Hispidulin

Mechanisms of photoaging and chronological skin aging

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Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial

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Oxidation events and skin aging

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Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events

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Skin ageing and its treatment

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Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging

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Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

Hyeon, S., Lee, H., Yang, Y., & Jeong, W. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.005 · Cited by 313

Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase

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Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

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An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

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Protective Effects of Novel Derivatives of Vitamin D3 and Lumisterol Against UVB-Induced Damage in Human Keratinocytes Involve Activation of Nrf2 and P53 Defense Mechanisms

Chaiprasongsuk, A., Janjetovic, Z., Kim, T.-K., Jarrett, S. G., D'Orazio, J. A., Holick, M. F., Tang, E. K. Y., Tuckey, R. C., Panich, U., Li, W., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101206 · Cited by 146

Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis

An, Y., Lee, J., Son, D. U., Kang, D. H., Park, M. J., Cho, K. W., Kim, S., Kim, S., Ko, J., Jang, M.-H., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c00007 · Cited by 140

Protective Role of Melatonin and Its Metabolites in Skin Aging

Bocheva, G., Slominski, R. M., Janjetović, Z., Kim, T., Böhm, M., Steinbrink, K., Reiter, R. J., Kleszczyński, K., & Slominski, A. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031238 · Cited by 139

Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2

Chaiprasongsuk, A., & Panich, U. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.823881 · Cited by 138

The Impact of Vitamin D on Skin Aging

Bocheva, G., Slominski, R. M., & Slominski, A. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169097 · Cited by 134

The Glucosinolates: A Sulphur Glucoside Family of Mustard Anti-Tumour and Antimicrobial Phytochemicals of Potential Therapeutic Application

Melrose, J. (2019) · Biomedicines · doi:10.3390/biomedicines7030062 · Cited by 110

Chemical Characterization of Honeysuckle Polyphenols and Their Alleviating Function on Ultraviolet B-Damaged HaCaT Cells by Modulating the Nrf2/NF-κB Signaling Pathways

Zheng, S.-L., Wang, Y., Chi, C., & Wang, B. (2024) · Antioxidants · doi:10.3390/antiox13030294 · Cited by 94

Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1

Zhao, P., Alam, M. B., & Lee, S. (2018) · Nutrients · doi:10.3390/nu11010060 · Cited by 71

Role of PGE-2 and Other Inflammatory Mediators in Skin Aging and Their Inhibition by Topical Natural Anti-Inflammatories

Fuller, B. B. (2019) · Cosmetics · doi:10.3390/cosmetics6010006 · Cited by 73

Grape Peel Extract and Resveratrol Inhibit Wrinkle Formation in Mice Model Through Activation of Nrf2/HO‐1 Signaling Pathway

Kim, J., Oh, J., Averilla, J. N., Kim, H. J., Kim, J., & Kim, J. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14643 · Cited by 72

Effect of ultraviolet radiation on the Nrf2 signaling pathway in skin cells

Ryšavá, A., Vostálová, J., & Svobodová, A. R. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1962566 · Cited by 69

Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane

Habtemariam, S. (2024) · Biomedicines · doi:10.3390/biomedicines12061169 · Cited by 54

NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis

Kahremany, S., Hofmann, L., Gruzman, A., Dinkova‐Kostova, A. T., & Cohen, G. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.06.238 · Cited by 55

Research Progress in Skin Aging and Immunity

He, X., Gao, X., & Xie, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074101 · Cited by 51

Photoaging: Current Concepts on Molecular Mechanisms, Prevention, and Treatment

Kaltchenko, M. V., & Chien, A. L.-L. (2025) · American Journal of Clinical Dermatology · doi:10.1007/s40257-025-00933-z · Cited by 60

Effect of Fermented Fish Oil on Fine Particulate Matter-Induced Skin Aging

Hyun, Y. J., Piao, M. J., Kang, K. A., Zhen, A. X., Fernando, P. D. S. M., Kang, H. K., Ahn, Y. S., & Hyun, J. W. (2019) · Marine Drugs · doi:10.3390/md17010061 · Cited by 48

Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis

Wu, W., Peng, G., Yang, F., Zhang, Y., Mu, Z., & Han, X. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10405 · Cited by 50

CYP11A1-derived vitamin D3 products protect against UVB-induced inflammation and promote keratinocytes differentiation

Chaiprasongsuk, A., Janjetović, Z., Kim, T., Tuckey, R. C., Li, W., Raman, C., Panich, U., & Slominski, A. T. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.05.016 · Cited by 49

Extracellular Superoxide Dismutase Prevents Skin Aging by Promoting Collagen Production through the Activation of AMPK and Nrf2/HO-1 Cascades

Lee, M. J., Agrahari, G., Kim, H.-Y., An, E.-J., Chun, K., Kang, H.-G., Kim, Y.-S., Bang, C. H., Tak, L.-J., & Kim, T. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.02.757 · Cited by 47

Knockdown of nrf2 Exacerbates TNF‐ α ‐Induced Proliferation and Invasion of Rheumatoid Arthritis Fibroblast‐Like Synoviocytes through Activating JNK Pathway

Du, Y., Wang, Q., Tian, N., Lu, M., Zhang, X., & Dai, S. (2020) · Journal of Immunology Research · doi:10.1155/2020/6670464 · Cited by 43

γ-Mangosteen, an autophagy enhancer, prevents skin-aging via activating KEAP1/NRF2 signaling and downregulating MAPKs/AP-1/NF-κB-mediated MMPs

Kim, C.-W., Alam, M. B., Song, B., Lee, C. H., Kim, S. L., & Lee, S. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155815 · Cited by 43

Effect of UVA radiation on the Nrf2 signalling pathway in human skin cells

Ryšavá, A., Čížková, K., Franková, J., Roubalová, L., Ulrichová, J., Vostálová, J., Vrba, J., Zálešák, B., & Svobodová, A. R. (2020) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2020.111948 · Cited by 41

Hydroxylumisterols, Photoproducts of Pre-Vitamin D3, Protect Human Keratinocytes against UVB-Induced Damage

Chaiprasongsuk, A., Janjetović, Z., Kim, T., Schwartz, C. J., Tuckey, R. C., Tang, E. K. Y., Raman, C., Panich, U., & Slominski, A. T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249374 · Cited by 41

Air Pollution: Possible Interaction between the Immune and Nervous System?

Serafini, M. M., Maddalon, A., Iulini, M., & Galbiati, V. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192316037 · Cited by 40

The extract of buds of Chrysanthemum morifolium ramat alleviated UVB-induced skin photoaging by regulating MAPK and Nrf2/ARE pathways

Xu, S.-S., Sun, X., Zhu, Z., Xin, Y., Chen, C., & Luo, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118352 · Cited by 38

Rosmarinic acid inhibits migration, invasion, and p38/AP-1 signaling via miR-1225-5p in colorectal cancer cells

Yang, K., Shen, Z., Zou, Y., & Gao, K. (2020) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2020.1808674 · Cited by 35

The role of NRF2 transcription factor in inflammatory skin diseases

Salman, S., Paulet, V., Hardonnière, K., & Kerdine‐Römer, S. (2025) · BioFactors · doi:10.1002/biof.70013 · Cited by 43

Protective effects and mechanisms of Terminalia catappa L. methenolic extract on hydrogen-peroxide-induced oxidative stress in human skin fibroblasts

Huang, Y.-H., Wu, P., Wen, K., Lin, C., & Chiang, H. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2308-4 · Cited by 38

Hen collagen hydrolysate alleviates UVA-induced damage in human dermal fibroblasts

Wang, X., Hong, H., & Wu, J. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103574 · Cited by 32

Eriodictyol protects skin cells from UVA irradiation-induced photodamage by inhibition of the MAPK signaling pathway

Nisar, M. F., Liu, T., Wang, M., Chen, S., Chang, L., Karisma, V. W., Weixu, Diao, Q., Xue, M., Tang, X., et al. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112350 · Cited by 31

Mitochondria-Targeted Hydrogen Sulfide Delivery Molecules Protect Against UVA-Induced Photoaging in Human Dermal Fibroblasts, and in Mouse Skin In Vivo

Lohakul, J., Jeayeng, S., Chaiprasongsuk, A., Torregrossa, R., Wood, M. E., Saelim, M., Thangboonjit, W., Whiteman, M., & Panich, U. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8255 · Cited by 29

Corylin from Psoralea fructus ( Psoralea corylifolia L.) protects against UV ‐induced skin aging by activating Nrf2 defense mechanisms

Li, N., Liu, T., Zhu, S., Yang, Y. A., Wang, Z., Zhao, Z., Liu, T., Wang, X., Qin, W., Yan, Y., et al. (2022) · Phytotherapy Research · doi:10.1002/ptr.7501 · Cited by 30

Signaling Pathways, Chemical and Biological Modulators of Nucleotide Excision Repair: The Faithful Shield against UV Genotoxicity

Kobaisi, F., Fayyad, N., Rezvani, H. R., Fayyad‐Kazan, M., Sulpice, E., Badran, B., Fayyad‐Kazan, H., Gidrol, X., & Rachidi, W. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4654206 · Cited by 26

NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products

Frantz, M., Rozot, R., & Marrot, L. (2022) · BioFactors · doi:10.1002/biof.1907 · Cited by 30

Thai herbal antipyretic 22 formula (APF22) inhibits UVA‐mediated melanogenesis through activation of Nrf2‐regulated antioxidant defense

Onkoksoong, T., Jeayeng, S., Poungvarin, N., Limsaengurai, S., Thamsermsang, O., Tripatara, P., Akarasereenont, P., & Panich, U. (2018) · Phytotherapy Research · doi:10.1002/ptr.6083 · Cited by 25

Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway

Petkovic, M., Leal, E. C., Alves, I., Bose, C., Palade, P., Singh, P., Awasthi, S., Børsheim, E., Dalgaard, L. T., Singh, S. P., et al. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108817 · Cited by 28

Protective Effects of Ginseng Proteins on Photoaging of Mouse Fibroblasts Induced by UVA

Jiang, R., Xu, X., Sun, Z. R., Wang, F., Ma, R., Feng, K., Li, T., & Sun, L. (2019) · Photochemistry and Photobiology · doi:10.1111/php.13156 · Cited by 26

The Protective Effect of Polyherbal Formulation, Harak Formula, on UVA-Induced Photoaging of Human Dermal Fibroblasts and Mouse Skin via Promoting Nrf2-Regulated Antioxidant Defense

Lohakul, J., Chaiprasongsuk, A., Jeayeng, S., Saelim, M., Muanjumpon, P., Thanachaiphiwat, S., Tripatara, P., Soontrapa, K., Lumlerdkij, N., Akarasereenont, P., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.649820 · Cited by 26

Hispidulin Ameliorates Endotoxin-Induced Acute Kidney Injury in Mice

Kim, K., & Leem, J. (2022) · Molecules · doi:10.3390/molecules27062019 · Cited by 22

Photoprotective Properties of Isothiocyanate and Nitrile Glucosinolate Derivatives From Meadowfoam (Limnanthes alba) Against UVB Irradiation in Human Skin Equivalent

Carpenter, E. L., Le, M., Miranda, C. L., Reed, R. L., Stevens, J. F., Indra, A. K., & Ganguli‐Indra, G. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00477 · Cited by 20

Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats

Rezq, S., Alsemeh, A. E., D’Elia, L., El-Shazly, A. M., Monti, D. M., Sobeh, M., & Mahmoud, M. F. (2020) · Scientific Reports · doi:10.1038/s41598-020-77424-0 · Cited by 20

Hispidulin Attenuates Cardiac Hypertrophy by Improving Mitochondrial Dysfunction

Wang, Y., Xie, Z., Jiang, N., Wu, Z., Xue, R., Dong, B., Fan, W., Dai, G., Chen, C., Li, J., et al. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.582890 · Cited by 22

Long-Term Intake of Glucoraphanin-Enriched Kale Suppresses Skin Aging via Activating Nrf2 and the TβRII/Smad Pathway in SAMP1 Mice

Chawalitpong, S., Ichikawa, S., Uchibori, Y., Nakamura, S., & Katayama, S. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02725 · Cited by 19

Free Radicals in Health and Disease

Dai, X., Huang, Z., & Lyu, R. (2025) · MedComm · doi:10.1002/mco2.70396 · Cited by 24

Hispidulin alleviates 2,4-dinitrochlorobenzene and house dust mite extract-induced atopic dermatitis-like skin inflammation

Kang, J., Lee, S., Kim, N.-K., Dhakal, H., Choi, Y., Kwon, T. K., Khang, D., & Kim, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111359 · Cited by 18

The Combination of Sulforaphane and Fernblock® XP Improves Individual Beneficial Effects in Normal and Neoplastic Human Skin Cell Lines

Serini, S., Guarino, R., Vasconcelos, R. O., Celleno, L., & Calviello, G. (2020) · Nutrients · doi:10.3390/nu12061608 · Cited by 18

Bletilla striata polysaccharide protects against UVA-induced skin damage by activating Nrf2/HO-1 signaling and inhibiting ferroptosis

Wang, M., Zhang, Y., Jiao, J., Pourzand, C., Lin, Y., Lin, C., Cui, J., Zhang, Z., & Zhong, J. L. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124360 · Cited by 18

Anti-Proliferative and Anti-Migratory Activities of Hispidulin on Human Melanoma A2058 Cells

Chang, C.-J., Hung, Y.-L., Chen, T.-C., Li, H., Lo, Y., Wu, N., Chang, D., & Hung, C. (2021) · Biomolecules · doi:10.3390/biom11071039 · Cited by 17

Activation of SIRT-1 Signalling in the Prevention of Bipolar Disorder and Related Neurocomplications: Target Activators and Influences on Neurological Dysfunctions

Rajkhowa, B., Mehan, S., Sethi, P., & Prajapati, A. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00480-z · Cited by 18

Protection against Ultraviolet A-Induced Skin Apoptosis and Carcinogenesis through the Oxidative Stress Reduction Effects of N-(4-bromophenethyl) Caffeamide, A Propolis Derivative

Kuo, Y., Chiang, H., Wu, P.-Y., Chu, Y., Chang, Q.-X., Wen, K., Lin, C., & Chiang, H. (2020) · Antioxidants · doi:10.3390/antiox9040335 · Cited by 17

Melatonin attenuates the detrimental effects of UVA irradiation in human dermal fibroblasts by suppressing oxidative damage and MAPK / AP ‐1 signal pathway in vitro

Koçtürk, S., Eğrilmez, M. Y., Aktan, Ş., Oktay, G., Resmi, H., Şimşek, H., Serdar, B. S., Erkmen, T., Güner, G., & Özkan, Ş. (2019) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12456 · Cited by 16

Ethyl Acetate Extract of Marine Algae, Halymenia durvillei, Provides Photoprotection against UV-Exposure in L929 and HaCaT Cells

Kraokaew, P., Manohong, P., Prasertsuksri, P., Jattujan, P., Niamnont, N., Tamtin, M., Sobhon, P., & Meemon, K. (2022) · Marine Drugs · doi:10.3390/md20110707 · Cited by 15

Protective effect of sucupira oil nanoemulsion against oxidative stress in UVA-irradiated HaCaT cells

Pacheco, M. T., da Silva, A. C. G., Nascimento, T. L., Diniz, D. G. A., Valadares, M. C., & Lima, E. M. (2019) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13148 · Cited by 14

Astragaloside IV and ferulic acid synergistically promote neurite outgrowth through Nrf2 activation

Liang, Y., Zou, Y. S., Niu, C., & Niu, Y. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.04.002 · Cited by 14

A Negative Feedback Loop in Ultraviolet A-Induced Senescence in Human Dermal Fibroblasts Formed by SPCA1 and MAPK

Xie, H., Xiao, X., Yi, Y., Deng, M., Li, P., Jian, D., Deng, Z., & Li, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.597993 · Cited by 12

Sulforaphane and bladder cancer: a potential novel antitumor compound

Zuo, M., Chen, H., Liao, Y., He, P., Xu, T., Tang, J., & Zhang, N. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1254236 · Cited by 13

Human Serum Albumin/Selenium Complex Nanoparticles Protect the Skin from Photoaging Injury

Yao, K., Peng, Y., Tang, Q., Liu, K., & Peng, C. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s446090 · Cited by 14

Immunosuppressive effect of hispidulin in allergic contact dermatitis

Thitilertdecha, P., Pluangnooch, P., Timalsena, S., & Soontrapa, K. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2689-z · Cited by 13

Metabolic activation of lumisterol to biologically active metabolites and their mechanism of action

Slominski, A. T., Kim, T., Janjetović, Z., Ravichandran, S., Song, Y., Podgórska, E., Slominski, R. M., Ewendt, F., Song, Y., Szpotan, J., et al. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.117711 · Cited by 11

Liquiritigenin reverses skin aging by inhibiting UV‐induced mitochondrial uncoupling and excessive energy consumption

Lu, Q., Zou, L., Gao, Y.-Z., Ye, T., Li, M., Zhang, Y.-K. J., Liang, B., Sun, W., & Xing, D. (2022) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15506 · Cited by 11

Neuroprotective effect of whey protein hydrolysate containing leucine-aspartate-isoleucine-glutamine-lysine on HT22 cells in hydrogen peroxide–induced oxidative stress

Chang, Y. B., Jung, E.-J., Jo, K., Suh, H. J., & Choi, H. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-24284 · Cited by 11

Single-Walled Carbon Nanotube-Guided Topical Skin Delivery of Tyrosinase to Prevent Photoinduced Damage

Ko, J., Lee, M. J., Jeong, W., Choi, S., Shin, E., An, Y., Kim, H., Lee, U., Kim, B., Kwak, S., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c06846 · Cited by 10

Calcitriol/vitamin D receptor system alleviates PM2.5-induced human bronchial epithelial damage through upregulating mitochondrial bioenergetics in association with regulation of HIF-1α/PGC-1α signaling

Chatsirisupachai, A., Muanjumpon, P., Jeayeng, S., Onkoksoong, T., Pluempreecha, M., Soingam, T., & Panich, U. (2024) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2024.104568 · Cited by 9

Botanical and Upcycled Bioactives for Advanced Topical Formulations: Mechanistic Pathways, Cutaneous Delivery, and Sustainability-by-Design

Panza, S., Pellegrini, B., Fiore, D., Tarsitano, M., Mancuso, A., Cristiano, M. C., & Paolino, D. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18030375 · Cited by 11

Anemopsis californica Attenuates Photoaging by Regulating MAPK, NRF2, and NFATc1 Signaling Pathways

Nguyen, Q. T. N., Fang, M., Quynh, N., Jeong, J., Oh, S., Zheng, S., Kim, M., Choi, J., Lim, S., & Yi, T. (2021) · Antioxidants · doi:10.3390/antiox10121882 · Cited by 9

Attenuating UVA-induced oxidative stress of human skin fibroblasts by enhancing bioactive components of Armillaria luteo-virens by Lactobacillus delbrueckii subsp. Bulgaricus fermentation

Zhao, J., You, S., Wang, D., Su, N., Li, Y., Zhao, D., Zhang, J., Li, M., & Wang, C. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102899 · Cited by 8

Comparison of the Regenerative Metabolic Efficiency of Lipid Extracts from Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis on Fibroblasts

Jastrząb, A., Conde, T., Domingues, M. R., Domingues, P. M., Biernacki, M., & Skrzydlewska, E. (2024) · Antioxidants · doi:10.3390/antiox13030276 · Cited by 9

Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts

Liu, P., Liu, Y., Zheng, H., Zheng, X.-S., Yang, X., Zhao, X., Chen, L., & Liu, Y. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11633 · Cited by 8

Mitigating PM2.5-induced skin injury and aging: botanical strategies targeting redox and inflammatory pathways

Maunjumpon, P., Thamsermsang, O., & Panich, U. (2026) · Redox Report · doi:10.1080/13510002.2026.2629079 · Cited by 7

Selenium-Containing Compound Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Regulating the MAPK/AP-1 Pathway

Jia, W., Ding, W., Chen, X., Xu, Z., Tang, Y., Wang, M., Zheng, B., Zhang, Y., Wei, T., & Zhu, Z. (2021) · Inflammation · doi:10.1007/s10753-021-01521-z · Cited by 7

Hispidulin exerts a protective effect against oleic acid induced-ARDS in the rat via inhibition of ACE activity and MAPK pathway

Koç, K., Özek, N. Ş., Aysin, F., Demir, Ö., Yilmaz, A., Yılmaz, M., Geyikoğlu, F., & Erol, H. S. (2023) · International Journal of Environmental Health Research · doi:10.1080/09603123.2023.2166023 · Cited by 5

Live-cell imaging Unveils stimulus-specific dynamics of Nrf2 activation in UV-exposed melanoma cells: Implications for antioxidant compound screening

Htut, N. W., Onkoksoong, T., Saelim, M., Kueanjinda, P., Sampattavanich, S., & Panich, U. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.12.007 · Cited by 5

Editorial: Redox Biology of Skin Aging and Carcinogenesis: the Role of Natural Antioxidants as Potential Protective Agents

Panich, U., & Slominski, A. T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00249 · Cited by 5

Protective Effects of Keratinocyte-Derived GCSF and CCL20 on UVB-Induced Melanocyte Damage

Jeayeng, S., Saelim, M., Muanjumpon, P., Buraphat, P., Kanchanapiboon, P., Sampattavanich, S., & Panich, U. (2024) · Cells · doi:10.3390/cells13191661 · Cited by 4

Tannic acid prevents UVB-induced skin photoaging by regulating ferroptosis through NRF2/SLC7A11/GPX4 signaling

Chen, Z., Ye, L., Zhu, L., Zhou, L., Chen, C., Wang, Q., Meng, Y., Chen, X., Zheng, G., Hu, J., et al. (2025) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2025.113309 · Cited by 6

Protective effect of a novel metal-phenolic network composite against ultraviolet-induced skin damage by modulating MAPK/AP-1/NF-κB signaling pathways and attenuating oxidative stress in human keratinocytes

Shin, M. H., Kwon, Y., Lee, S. H., Kim, H., Kim, H., Jeong, S., Yun, S., Park, C. H., & Kwon, O. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118874 · Cited by 4

Neuroprotective roles of flavonoid "hispidulin" in the central nervous system: A review.

Mustapha, S., Magaji, R. A., Magaji, M. G., Bako, I. G., Umar, B., Yusha’u, Y., Daku, A. B., Chiroma, S. M., Jaafar, A., Mehat, M. Z., et al. (2024) · PubMed Central · doi:10.22038/ijbms.2024.76605.16573 · Cited by 4

Lentinula edodes extract inhibits matrix metalloproteinase expression and increases type I procollagen expression via the p38 MAPK/c-Fos signaling pathway in ultraviolet A and B-irradiated HaCaT keratinocytes

Lee, J. I., Oh, J. H., Karadeniz, F., Park, S., Kim, H. R., Jo, H. J., Jung, K. I., Jeon, B.-J., & Kong, C. (2021) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/2221-1691.310203 · Cited by 4

Screening the active ingredients of plants via molecular docking technology and evaluating their ability to reduce skin photoaging

Zheng, S., Deng, R., Huang, G., Ou, Z., & Shen, Z. (2024) · Biogerontology · doi:10.1007/s10522-024-10125-7 · Cited by 3

The Pharmacological Spectrum of Hispidulin: A Thorough Systematic Review and Meta-analysis

Singh, A., Chaitanya, M., Tatiparthi, R., Arya Lakshmi, M., Dwarampudi, L. P., Ramaswamy, S., Mazumder, A., Singh, A., & Kumar, S. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01871-7 · Cited by 2

Sustained Activation of Nrf2 Antioxidant Pathway by Flexible Liposome Based on Low Phase Transition Temperature to Delay Skin Aging

Liu, H., Hu, Y., Ji, W., Wang, S., Zhu, Y., Lin, Q., Zhao, X., Zhou, H., Guo, X., Liu, Y., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501696 · Cited by 2

Quantitative analysis of the 2D tissue skin layer with fluorescent dyes

Chaiprasongsuk, R., Achararit, P., Jarutatsanangkoon, P., Nonthasaen, P., Mahikul, W., Chaiprasongsuk, A., Panich, U., & Prombut, P. (2022) · International Joint Conference on Computer Science and Software Engineering · doi:10.1109/jcsse54890.2022.9836243 · Cited by 2

Chemical Composition, Antioxidant Activity, Anti-Fatigue Function and Mechanism of Pomegranate Peel Polyphenols on Exercise-Induced Fatigue in Mice

Ma, X.-Y., Wang, Y.-M., Hu, Y.-D., Wang, B., & Xu, L. (2026) · Foods · doi:10.3390/foods15091576 · Cited by 1

UV-induced Photodamage - attenuating Properties of Water Extract from Lentinuls edodes

Lee, J. I., Oh, J. H., Park, S. Y., Kim, H. R., Jung, K. I., Jeon, B.-J., Kim, D., & Kong, C. (2020) · JoLS Journal of Life Sciences · doi:10.5352/jls.2020.30.10.877 · Cited by 1

Santamarine Isolated from Artemisia scoparia Inhibits UVB-induced Matrix Metalloproteinase Expression via Repression of MAPK/AP-1 Pathway in Human Keratinocytes

Oh, J. H., Karadeniz, F., Kim, H. R., Kong, C. S., & Seo, Y. W. (2022) · Korean Journal of Medicinal Crop Science · doi:10.7783/kjmcs.2022.30.5.366 · Cited by 1

Keratinocyte-derived paracrine factors regulate stress response of melanocytes to UVBPreprint

Jeayeng, S., Saelim, M., Muanjumpon, P., Buraphat, P., Kanchanapiboon, P., Sampattavanich, S., & Panich, U. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.13.523939

Screening active ingredients of traditional Chinese medicine by molecular docking technology and evaluating their reduce skin photoaging activitiesPreprint

Zheng, S., Deng, R., Huang, G., Ou, Z., & Shen, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-3992726/v1

Gamma ray‐irradiated fibroin protein from Bombyx mori protects against TNF‐ α ‐induced oxidative stress and inflammation in human skin keratinocytes through NF‐ κ B and Nrf2 signaling pathways

Park, H., Kwon, M., Lee, G. W., & Cho, Y. H. (2024) · Entomological Research · doi:10.1111/1748-5967.12719

Selaginella Tamariscina extract reduces UVA-induced skin photodamage via regulating apoptosis and autophagy by AKT phosphorylation

Zhao, N., Zhou, X., Li, Z., Liang, L., Bao, J., Chen, X., Shu, P., & Zhong, J. (2025) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2025.113343

Korean black ginseng extract protects against UV-induced skin damage through antioxidant activity and inhibition of elastase, tyrosinase, and hyaluronidase

Lyu, S. (2025) · Food Science and Preservation · doi:10.11002/fsp.2025.32.6.1210

Anti-Photoaging Activity of a Structurally Optimized Curcumin Analogue (THHGV-5) in UV-B-Irradiated Human Dermal Fibroblasts: An Integrated In Silico and In Vitro Study

Murwanti, R., Arifka, V. I., Anargya, R. D. P., Marbun, P., DAMAYANTI, A. N., SYAHPUTRA, A., Prinanda, H. H., & Ritmaleni, R. (2026) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-026-02044-w

The antioxidant transcription factor NRF2 as a new regulator of the extracellular matrix in human skin fibroblasts

Salamito, M. (2020) · theses.fr (ABES) · doi:10.70675/06c757bdz04c8z4119za1e4z46921f1528b1

RNAi and Chemical-Based High Content Screening for the Normalization of XPC Phenotyope

Kobaisi, F. (2021) · theses.fr (ABES) · doi:10.70675/e34b8c43z081az4c41zad64z8e0c753e5c20

Rosemary (Rosmarinus officinalis) Phytochemicals as Prevention of Collagen Degradation and Wrinkle Formation: a Literature Review

Parimartha, N. L. T., & Laksemi, D. A. A. S. (2026) · Journal of Pharmaceutical And Sciences · doi:10.36490/journal-jps.com.v9i2.1486

Sulforaphane as a Photoprotective Agent Against UV-Induced Skin Damage and Carcinogenesis: A Scoping Review

Filippo, M. D., Paolino, G., Nicola, M. R. D., Kiss, N., Bánvölgyi, A., Bortone, G., Nisticò, S. P., Zampini, E., Pellacani, G., & Cantisani, C. (2026) · Journal of Personalized Medicine · doi:10.3390/jpm16060319

Photoprotective effects of Caulerpa lentillifera extract against UV-induced cellular damage via Nrf2 activation and MMP inhibition

Kraokaew, P., Manohong, P., Niamnont, N., Tamtin, M., Suriyonplengsaeng, C., Sobhon, P., & Meemon, K. (2026) · Free Radical Research · doi:10.1080/10715762.2026.2694113

Ameliorating effects and mechanisms of tuna peptides on UVB-induced photoaging and melanogenesis targeting oxidative stress, apoptosis, and tyrosinase inactivation

Wang, Y.-M., Zeng, Y.-H., Zheng, S.-L., Wang, B., Chi, C., & Zeng, Q. (2026) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2026.113572

Fermentocosmetology: Integrating Fermentation Science, Microbiome Research, and Dermocosmetic Innovation for Skin Health

Uçar, R. A., & Şimşek, Ö. (2026) · Fermentation · doi:10.3390/fermentation12100448

Photoprotective Role of Nrf2 in UVA-Mediated MMP-1 Via MAPK/AP-1 Signaling in Keratinocyte HaCaT Cells and Mouse Skin: The Photoprotective Effects of Sulforaphane

Panich, U., Chaiprasongsuk, A., Lohakul, J., Soontrapa, K., & Sampattavanich, S. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.115 · Cited by 2

The protective effect of hesperetin on UVA-induced matrix metalloproteinase-1 (MMP-1) in primary human dermal fibroblasts and mouse skin through modulation of nuclear factor erythroid 2- related factor 2 (NRF2)-regulated antioxidant defenses

Chaiprasongsuk, A., Lohakul, J., & Panich, U. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.127 · Cited by 1

The novel mitochondria-targeted hydrogen sulfide donors AP39 and AP123 exert anti-photoaging effects on primary dermal fibroblasts and mouse skin exposed to UVA in association with activation of Nrf2-mediated antioxidant response

Panich, U., Lohakul, J., & Whiteman, M. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.311 · Cited by 2

The protective effects of hispidulin and sulforaphane on UVA-induced photoaging through Nrf2 activation in mouse skin

Lohakul, J., Chaiprasongsuk, A., & Panich, U. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.138

The Protective Effect of Polyherbal Formulation, Harak Formula, on UVA-Induced Photoaging of Human Dermal Fibroblasts and Mouse Skin via Promoting Nrf2-Regulated Antioxidant Defense

Lohakul, J., Chaiprasongsuk, A., Jeayeng, S., Saelim, M., Muanjumpon, P., Thanachaiphiwat, S., Tripatara, P., Soontrapa, K., Lumlerdkij, N., Akarasereenont, P., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.649820 · Cited by 26