The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Activation of Nrf2 Reduces UVA-Mediated MMP-1 Upregulation via MAPK/AP-1 Signaling Cascades: The Photoprotective Effects of Sulforaphane and Hispidulin
Open accessAbstract
UVA irradiation plays a role in premature aging of the skin through triggering oxidative stress-associated stimulation of matrix metalloproteinase-1 (MMP-1) responsible for collagen degradation, a hallmark of photoaged skin. Compounds that can activate nuclear factor E2-related factor 2 (Nrf2), a transcription factor regulating antioxidant gene expression, should therefore serve as effective antiphotoaging agents. We investigated whether genetic silencing of Nrf2 could relieve UVA-mediated MMP-1 upregulation via activation of mitogen-activated protein kinase (MAPK)/activator protein 1 (AP-1) signaling using human keratinocyte cell line (HaCaT). Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation. Our findings suggested that depletion of Nrf2 promoted both mRNA expression and activity of MMP-1 in the UVA-irradiated HaCaT cells. Treatment of Nrf2 knocked-down HaCaT cells with MAPK inhibitors significantly suppressed UVA-induced MMP-1 and AP-1 activities. Moreover, pretreatment of the mouse skin with HPD and SFN, which could activate Nrf2, provided protective effects against UVA-mediated MMP-1 induction and collagen depletion in correlation with the decreased levels of phosphorylated MAPKs, c-Jun, and c-Fos in the mouse skin. In conclusion, Nrf2 could influence UVA-mediated MMP-1 upregulation through the MAPK/AP-1 signaling cascades. HPD and SFN may therefore represent promising antiphotoaging candidates.
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“Our previous study revealed that UV significantly decreased Nrf2 protein expression, the transcription factor mediating antioxidant responses, 1 h post-irradiation [57].”
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1 retracted
Jung, Y. R., Kim, D. H., Kim, S. R., An, H. J., Lee, E. K., Tanaka, T., Kim, N. D., Yokozawa, T., Park, J. N., & Chung, H. Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102689 · Cited by 57
RetractedMechanisms of photoaging and chronological skin aging
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Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events
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“Introduction Exposure of the skin to ultraviolet (UV) radiation is the primary cause of premature skin aging, which is a multifactorial process involving various molecular pathways (Baumann, 2007; Hwang et al., 2011; Panich et al., 2016).”
BackgroundSelf-citationNrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation
Hyeon, S., Lee, H., Yang, Y., & Jeong, W. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.005 · Cited by 313
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Saha, S., Buttari, B., Panieri, E., Profumo, E., & Saso, L. (2020) · Molecules · doi:10.3390/molecules25225474 · Cited by 1,460
Chaiprasongsuk, A., Janjetovic, Z., Kim, T.-K., Jarrett, S. G., D'Orazio, J. A., Holick, M. F., Tang, E. K. Y., Tuckey, R. C., Panich, U., Li, W., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101206 · Cited by 146
Self-citationAn, Y., Lee, J., Son, D. U., Kang, D. H., Park, M. J., Cho, K. W., Kim, S., Kim, S., Ko, J., Jang, M.-H., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c00007 · Cited by 140
Protective Role of Melatonin and Its Metabolites in Skin Aging
Bocheva, G., Slominski, R. M., Janjetović, Z., Kim, T., Böhm, M., Steinbrink, K., Reiter, R. J., Kleszczyński, K., & Slominski, A. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031238 · Cited by 139
Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2
Chaiprasongsuk, A., & Panich, U. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.823881 · Cited by 138
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Metadata
- Authors
- Chaiprasongsuk, A., Lohakul, J., Soontrapa, K., Sampattavanich, S., Akarasereenont, P., & Panich, U.
- Affiliations
- Siriraj Hospital (TH)
- Corresponding author
- Panich, Uraiwan
- ORCID
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 360
- Issue
- 3
- Pages
- 388-398
- ISSN
- 0022-3565 (ISSN-L)
- PMC
- PMC5325073
- OpenAlex
- W2563575197
- Cited by
- 101
- References
- 54
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 13 · 2023: 7 · 2022: 12 · 2021: 14 · 2020: 15 · 2019: 15 · 2018: 4
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mahidol University
- Thailand Research Fund (RSA5980066)
- National Research Council of Thailand
- Faculty of Medicine Siriraj Hospital, Mahidol University
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- Nrf2, UVA irradiation, MMP-1, MAPK signaling, AP-1, hispidulin, sulforaphane, photoaging, skin aging, collagen degradation, keratinocytes, c-Jun, c-fos, oxidative stress, photoprotection
- MeSH terms
- Animals, Cell Line, Collagen, Enzyme Activation, Humans, Skin, Sulfoxides, Ultraviolet Rays, Skin Aging, Keratinocytes, Up-Regulation, Antimutagenic Agents, Isothiocyanates, Oxidative Stress, Transcription Factor AP-1, Aging, Premature, Matrix Metalloproteinase 1, MAP Kinase Signaling System, Flavones, NF-E2-Related Factor 2, Mice
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