A Hypomorphic Allele of Aryl Hydrocarbon Receptor-Associated Protein-9 Produces a Phenocopy of the Ahr-Null Mouse
Open accessAbstract
The aryl hydrocarbon receptor-associated protein-9 (ARA9) is a chaperone of the aryl hydrocarbon receptor (AHR). The AHR has been shown to play a late developmental role in the normal closure of a fetal hepatovascular shunt known as the ductus venosus (DV). Given that Ara9-null mice display early embryonic lethality, we generated a hypomorphic Ara9 allele (designated Ara9(fxneo)) that displays reduced ARA9 protein expression. In an effort to demonstrate the role of ARA9 protein in AHR-mediated DV closure, we used combinations of Ara9 wild-type [Ara9(+/+)], null [Ara9(-/-)], and hypomorphic [Ara9(fxneo/fxneo)] alleles to produce mice with a graded expression of the ARA9 protein. Liver perfusion studies demonstrated that although none of the Ara9(+/+) mice displayed a patent DV, the shunt was observed in 10% of the Ara9(+/fxneo) mice, 55% of the Ara9(+/-) mice, and 83% of the Ara9(fxneo/fxneo) mice. That expression level of ARA9 correlates with the frequency of a phenocopy of the Ahr-null allele supports the conclusion that the ARA9 protein is essential for AHR signaling during development.
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Preliminary evidence from the authors' laboratory suggests that the NeoPGK transgene reduces RNA expression from multiple loci independent of its direction or position.
“While extensive studies to explain how the presence of the NeoPGK cassette leads to hypomorphism are lacking, preliminary evidence from multiple alleles in our own laboratory suggest that the presence of the NeoPGK transgene reduces RNA expression from multiple loci, independent of direction or position (Bunger et al., 2008; Bunger et al., 2003; Lin et al., 2008; Walisser, Bunger, Glover, & Brad”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Lin et al., 2008
The Discussion says targeted Neo insertion frequently produces a hypomorphic allele, and the Results report markedly reduced ARA9 protein expression in mice carrying the Ara9fxneo allele (page not provided). The paper does not establish reduced RNA expression across multiple loci or show that the effect is independent of cassette direction or position. (LLM, conf=0.83)
Experimental — accuracy not yet measuredThe Ara9 hypomorph (Ara9fxneo) expresses limited amounts of ARA9.
“The ARA9 hypomorph (Ara9fxneo) is a mouse model that expresses limited amounts of the chaperone protein, Ah receptor associated 9 (ARA9) (also known as Ah Receptor interacting protein, AIP, or Hepatitis B Virus X associated protein, XAP2) (Figure 7) (LaPres et al., 2000; Lin et al., 2008).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Lin et al., 2008
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Cites
Poland, A., & Knutson, J. C. (1982) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.22.040182.002505 · Cited by 2,515 · see citing works
Schmidt, J. V., Su, G. H., Reddy, J., Simon, M., & Bradfield, C. (1996) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.93.13.6731 · Cited by 932 · see citing works
Self-citationFernández‐Salguero, P. M., Hilbert, D. M., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1996) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.0210 · Cited by 835 · see citing works
Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A., & Simon, M. C. (1997) · Nature · doi:10.1038/386403a0 · Cited by 781 · see citing works
Self-citationReyes, H., Reisz‐Porszasz, S., & Hankinson, O. (1992) · Science · doi:10.1126/science.256.5060.1193 · Cited by 777 · see citing works
Statistics: The Exploration and Analysis of Data
Kotnour, K. D., Devore, J. L., & Peck, R. (1988) · Technometrics · doi:10.2307/1269820 · Cited by 639 · see citing works
Biochemical actions of hormones
(1987) · General and Comparative Endocrinology · doi:10.1016/0016-6480(87)90137-7 · Cited by 576 · see citing works
Carver, L. A., & Bradfield, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11452 · Cited by 428 · see citing works
Self-citationMa, Q., & Whitlock, J. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.8878 · Cited by 426 · see citing works
Lahvis, G. P., Lindell, S. L., Thomas, R. S., McCuskey, R. S., Murphy, C., Glover, E., Bentz, M., Southard, J., & Bradfield, C. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190256997 · Cited by 377 · see citing works
Self-citationDymecki, S. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.6191 · Cited by 361 · see citing works
Meyer, B. K., & Perdew, G. H. (1999) · Biochemistry · doi:10.1021/bi982223w · Cited by 232 · see citing works
Cross-talk between the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor Signaling Pathways
Chan, W. K., Yao, G., Gu, Y.-Z., & Bradfield, C. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.12115 · Cited by 221 · see citing works
Self-citationLahvis, G. P., Pyzalski, R. W., Glover, E., Pitot, H. C., McElwee, M. K., & Bradfield, C. A. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.008888 · Cited by 168 · see citing works
Self-citationGestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development
Walisser, J. A., Bunger, M. K., Glover, E. A., & Bradfield, C. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404379101 · Cited by 133 · see citing works
Self-citationPatent Ductus Venosus and Dioxin Resistance in Mice Harboring a Hypomorphic Arnt Allele
Walisser, J. A., Bunger, M. K., Glover, E. A., Harstad, E. B., & Bradfield, C. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400784200 · Cited by 121 · see citing works
Self-citationHord, N. G., & Perdew, G. H. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09792-5 · Cited by 111 · see citing works
Lin, B. C., Sullivan, R., Lee, Y., Moran, S. M., Glover, E. A., & Bradfield, C. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705471200 · Cited by 97 · see citing works
Self-citationCharacterization of Hepatoportal Microvascular Dysplasia in a Kindred of Cairn Terriers
Schermerhorn, T., Dykes, N. L., Rowland, P. H., Yeager, A. E., Erb, H. N., Oberhansley, K., & Bonda, M. (1996) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1996.tb02053.x · Cited by 71 · see citing works
Induction of the Drug-Metabolizing Enzymes
Parke, D. V. (1975) · Springer eBooks · doi:10.1007/978-1-4615-8954-9_8 · Cited by 68 · see citing works
Eisen, H. J., Hannah, R. R., Legraverend, C., Okey, A. B., & Nebert, D. W. (1983) · Biochemical Actions of Hormones · doi:10.1016/b978-0-12-452810-9.50012-7 · Cited by 65 · see citing works
Henry, E. C., & Gasiewicz, T. A. (1993) · Biochemical Journal · doi:10.1042/bj2940095 · Cited by 60 · see citing works
Hollingshead, B. D., Petrulis, J. R., & Perdew, G. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407840200 · Cited by 55 · see citing works
p23 enhances the formation of the aryl hydrocarbon receptor–DNA complex
Shetty, P. V., Bhagwat, B., & Chan, W. K. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01650-7 · Cited by 51 · see citing works
Host Factors in Human Carcinogenesis
(1984) · Food and Chemical Toxicology · doi:10.1016/0278-6915(84)90064-4 · Cited by 34 · see citing works
A Maternal Ahr Null Genotype Sensitizes Embryos to Chemical Teratogenesis
Thomae, T. L., Glover, E. A., & Bradfield, C. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403690200 · Cited by 30 · see citing works
Self-citationNiwa‐Kawakita, M., Abramowski, V., Kalamarides, M., Thomas, G. D., & Giovannini, M. (2000) · genesis · doi:10.1002/(sici)1526-968x(200002)26:2 · Cited by 22 · see citing works
Induction of the drug-metabolizing enzymes.
Poland, A. (1982) · PubMed · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 29 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Hollingshead BD Petrulis JR Perdew GH The Ah receptor transcriptional regulator XAP2 antagonizes p23 binding to Ah receptor/Hsp90 complexes and is dispensable for receptor function J Biol Chem 2004 15322122
- Kellendonk C Opherk C Anlag K Schutz G Tronche F Hepatocyte-specific expression of Cre recombinase Genesis 2000 26 2 151 153 10686615
- Lahvis G Lindell S Thomas R McCuskey R Murphy C Glover E Bentz M Southard J Bradfield C Portosystemic shunts and persistent fetal vascular structures in Ah-receptor deficient mice Proc Natl Acad Sci U S A 2000 97 10442 10447 10973493 PMC27043
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Stevens, E. A., Mezrich, J. D., & Bradfield, C. A. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03054.x · Cited by 415 · see citing works
Self-citationDaly, A., Tichomirowa, M. A., Pétrossians, P., Heliövaara, E., Jaffrain‐Rea, M., Barlier, A., Naves, L. A., Ebeling, T., Karhu, A., Raappana, A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2556 · Cited by 384 · see citing works
Beckers, A. M., Aaltonen, L. A., Daly, A., & Karhu, A. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1013 · Cited by 356 · see citing works
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Chahal, H., Chapple, J. P., Frohman, L. A., Grossman, A. B., & Korbonits, M. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.02.007 · Cited by 118 · see citing works
Nukaya, M., Moran, S. M., & Bradfield, C. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809613106 · Cited by 95 · see citing works
Self-citationRaitila, A., Lehtonen, H. J., Arola, J. T., Heliövaara, E., Ahlsten, M., Georgitsi, M., Jalanko, A., Paetau, A. E., Aaltonen, L. A., & Karhu, A. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100138 · Cited by 80 · see citing works
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Wells, P. G., Lee, C. J. J., McCallum, G. P., Perstin, J., & Harper, P. A. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-00663-0_6 · Cited by 68 · see citing works
Relevance of the Aryl Hydrocarbon Receptor (AhR) for Clinical Toxicology
Bradshaw, T. D., & Bell, D. R. (2009) · Clinical Toxicology · doi:10.1080/15563650903140423 · Cited by 62 · see citing works
Nukaya, M., Lin, B. C., Glover, E. A., Moran, S. M., Kennedy, G. D., & Bradfield, C. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.132043 · Cited by 60 · see citing works
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Marques, P., & Korbonits, M. (2017) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.01.004 · Cited by 59 · see citing works
Boutros, P. C., Bielefeld, K. A., Pohjanvirta, R., & Harper, P. A. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp191 · Cited by 58 · see citing works
Vandeva, S., Vasilev, V., Vroonen, L., Naves, L. A., Jaffrain‐Rea, M., Daly, A., Zacharieva, S., & Beckers, A. M. (2010) · Annales d Endocrinologie · doi:10.1016/j.ando.2010.08.005 · Cited by 55 · see citing works
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- Authors
- Lin, B. C., Nguyen, L. P., Walisser, J. A., & Bradfield, C. A.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 74
- Issue
- 5
- Pages
- 1367-1371
- ISSN
- 0026-895X (ISSN-L)
- PMC
- PMC2909677
- OpenAlex
- W2131995035
- Cited by
- 48
- References
- 29
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2021: 5 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (T32CA009135, P30CA014520)
- National Institute of Environmental Health Sciences (R01ES006883)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Keywords
- aryl hydrocarbon receptor, hypomorphic allele, AhR signaling, embryonic lethality, liver perfusion
- MeSH terms
- Alleles, Animals, Organ Size, Veins, Blotting, Southern, Blotting, Western, Receptors, Aryl Hydrocarbon, Mice, Knockout, Intracellular Signaling Peptides and Proteins, Mice
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