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Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum
Open accessAbstract
Dopamine (DA) release varies within subregions and local environments of the striatum, suggesting that controls intrinsic and extrinsic to the DA fibers and terminals regulate release. While applying fast-scan cyclic voltammetry and using tonic and phasic stimulus trains, we investigated the regulation of DA release in the dorsolateral to ventral striatum. The ratio of phasic-to-tonic-evoked DA signals varied with the average ongoing firing frequency, and the ratio was generally higher in the nucleus accumbens (NAc) compared with the dorsolateral striatum. At the normal average firing frequency, burst stimulation produces a larger increase in the DA response in the NAc than the dorsolateral striatum. This finding was comparable whether the DA measurements were made using in vitro brain slices or were recorded in vivo from freely moving rodents. Blockade of the dopamine transporters and dopamine D(2) receptors particularly enhanced the tonic DA signals. Conversely, blockade of nicotinic acetylcholine receptors (nAChRs) containing the beta(2) subunit (beta(2)(*)) predominantly suppressed tonic DA signals. The suppression of tonic DA release increased the contrast between phasic and tonic DA signals, and that made the frequency-dependent DA dynamics between the dorsolateral striatum and NAc more similar. The results indicate that intrinsic differences in the DA fibers that innervate specific regions of the striatum combine with (at least) DA transporters, DA receptors, and nAChRs to regulate the frequency dependence of DA release. A combination of mechanisms provides specific local control of DA release that underlies pathway-specific information associated with motor and reward-related functions.
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“The present study and others indicate that blockade of β2* nAChRs caused less inhibition of phasic DA signals than tonic signals (12).”
From Withdrawal from Chronic Nicotine Exposure Alters Dopamine Signaling Dynamics in the Nucleus Accumbens (2012) · cites this paper as [12]
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Glimcher, P. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014269108 · Cited by 955
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Metadata
- Authors
- Zhang, L., Doyon, W. M., Clark, J. J., Phillips, P. E. M., & Dani, J. A.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 76
- Issue
- 2
- Pages
- 396-404
- ISSN
- 0026-895X (ISSN-L)
- PMC
- PMC2713129
- OpenAlex
- W2133709709
- Cited by
- 161
- References
- 56
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 12 · 2021: 6 · 2020: 8 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 16 · 2013: 12 · 2012: 13
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Pharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diana Helis Henry Medical Research Foundation
- National Institutes of Health (NS021229)
- National Institute on Drug Abuse (F32DA024540, R01DA009411, DA009411)
- National Institute of Neurological Disorders and Stroke (NS021229, R01NS021229)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- dopamine release, phasic dopamine release, dorsal striatum, ventral striatum, nucleus accumbens, dorsolateral striatum, burst stimulation, firing rate, dopamine transporter, dopamine D2 receptor, nicotinic acetylcholine receptors, beta2 subunit, striatal subregions
- MeSH terms
- Action Potentials, Animals, Basal Ganglia, Corpus Striatum, Dopamine, Electric Stimulation, Mice, Inbred C57BL, Microelectrodes, Nucleus Accumbens, Receptors, Nicotinic, Reference Standards, Tungsten, Receptors, Dopamine D2, Mice, Knockout, Dopamine Antagonists, Area Under Curve, Mice
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