Point Mutation in Intron Sequence Causes Altered Carboxyl-Terminal Structure in the Aryl Hydrocarbon Receptor of the Most 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Resistant Rat Strain
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The rat splice donor mutation produces three alternative splice variants and two truncated protein products.
“The result is the generation of three alternative splice variants and two truncated protein products (Moffat et al., 2007; Okey et al., 2005; Pohjanvirta et al., 1998).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Pohjanvirta et al., 1998
Cites
AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899 · see citing works
Analysis of the four alleles of the murine aryl hydrocarbon receptor
Poland, A., Palen, D., & Glover, E. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09833-5 · Cited by 303 · see citing works
In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.
Dolwick, K. M., Swanson, H. I., & Bradfield, C. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8566 · Cited by 239 · see citing works
Mapping the 90 kDa heat shock protein binding region of the Ah receptor
Perdew, G. H., & Bradfield, C. A. (1996) · IUBMB Life · doi:10.1080/15216549600201651 · Cited by 63 · cited 2× · see citing works
“c-Src is usually bound to hsp90 (Pratt, 1997), which makes contact with the AhR at two distinct sites within the bHLH and PAS domains (Perdew and Bradfield, 1996).”
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Aryl hydrocarbon receptors: diversity and evolution
Hahn, M. E. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00070-4 · Cited by 642 · see citing works
CYP induction-mediated drug interactions: in vitro assessment and clinical implications
Lin, J. H. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-0277-7 · Cited by 264 · see citing works
Karchner, S. I., Franks, D. G., Kennedy, S. W., & Hahn, M. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509950103 · Cited by 207 · see citing works
Hahn, M. E., Karchner, S. I., Franks, D. G., & Merson, R. R. (2004) · Pharmacogenetics · doi:10.1097/00008571-200402000-00007 · Cited by 71 · see citing works
Commentary: Update on Animal Models for NTP Studies
King-Herbert, A. P., Sills, R. C., & Bucher, J. R. (2010) · Toxicologic Pathology · doi:10.1177/0192623309356450 · Cited by 49 · see citing works
Jensen, B. A., & Hahn, M. E. (2001) · Toxicological Sciences · doi:10.1093/toxsci/64.1.41 · Cited by 44 · see citing works
Celius, T., & Matthews, J. (2010) · Toxicology · doi:10.1016/j.tox.2010.08.015 · Cited by 34 · see citing works
Kim, E.-Y., & Hahn, M. E. (2002) · Aquatic Toxicology · doi:10.1016/s0166-445x(01)00221-1 · Cited by 22 · see citing works
Rodent Genetic Models of Ah Receptor Signaling
Wilson, R. H., & Bradfield, C. A. (2021) · Drug Metabolism Reviews · doi:10.1080/03602532.2021.1955916 · Cited by 16 · see citing works
“The result is the generation of three alternative splice variants and two truncated protein products (Pohjanvirta et al. 1998; Okey et al. 2005; Moffat et al. Figure 8.”
BackgroundInfluential
- Authors
- Pohjanvirta, R., Wong, J. M. Y., Li, W., Harper, P. A., Tuomisto, J., & Okey, A. B.
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 54
- Issue
- 1
- Pages
- 86-93
- ISSN
- 0026-895X
- Cited by
- 137
- References
- 4
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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