Commentary: Update on Animal Models for NTP Studies
Open accessAbstract
Based on recommendations of participants at the National Toxicology Program (NTP) workshop ‘‘Animal Models for the NTP Cancer Bioassay: Strains and Stocks—Should We Switch?’’ some modifications to the NTP rodent cancer bioassay were made. The B6C3F1 remains the mouse model used in the cancer bioassay. The use of multiple strains of mice will be explored through a new branch within the NTP, the Host Susceptibility Branch. Several rat models were evaluated; the Harlan Sprague Dawley rat is currently being used in the NTP studies.
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We used the Sprague-Dawley strain of rat, as recommended for chronic toxicology tests by the National Toxicology Program in the USA, and as used by Monsanto in its 90-day study.
“We used the Sprague-Dawley strain of rat, as recommended for chronic toxicology tests by the National Toxicology Program in the USA [31], and as used by Monsanto in its 90-day study [3].”
From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [31]
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- Authors
- King-Herbert, A. P., Sills, R. C., & Bucher, J. R.
- Affiliations
- National Institute of Environmental Health Sciences (US)
- National Institutes of Health (US)
- ORCID
- Bucher, John R.
- Venue
- Toxicologic Pathology
- Publisher
- SAGE Publications
- Published
- 2009-12-17
- Volume
- 38
- Issue
- 1
- Pages
- 180-181
- ISSN
- 0192-6233 (ISSN-L)
- 1533-1601
- OpenAlex
- W2155830966
- Cited by
- 49
- References
- 4
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 10 · 2013: 5 · 2012: 7
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Toxicologic Pathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- animal models, National Toxicology Program, B6C3F1 mice, mouse strains, host susceptibility, Sprague-Dawley rats, carcinogenicity testing
- MeSH terms
- Animals, Disease Models, Animal, Rats, Inbred F344, Carcinogenicity Tests, Rats, Sprague-Dawley, Mice, Rats
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