The role of incretins in glucose homeostasis and diabetes treatment

Kim, Wook, Egan, Josephine M.·2008·Pharmacological Reviews

Cites (564)

Items 401–564 of 564

  1. Relation between gastric emptying of glucose and plasma concentrations of glucagon-like peptide-1
    Judith M. Wishart, Michael Horowitz, Howard A. Morris, Karen L. Jones, Michael Albrecht Nauck · 1998 · Peptides
  2. Effect of GLP-1 on glucose transport and its cell signalling in human myocytes
    González, Nieves, Acitores, Alicia, Sancho, Verónica, Valverde, Isabel, Villanueva-Peñacarrillo, María L. · 2005 · Regulatory Peptides
  3. cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in β cells
    Klaus-Peter Knoch, Ronny Meisterfeld, Stephan Kersting, Hendrik Bergert, Anke Altkrüger, Carolin Wegbrod, Melanie Jäger, Hans‐Detlev Saeger, Michele Solimena · 2006 · Cell Metabolism
  4. Glucose-Dependent Insulinotropic Polypeptide Confers Early Phase Insulin Release to Oral Glucose in Rats: Demonstration by a Receptor Antagonist1
    Jamie T. Lewis, Bama Dayanandan, Joel Francis Habener, Timothy J. Kieffer · 2000 · Endocrinology
  5. Targeted Protein Kinase A and PP-2B Regulate Insulin Secretion through Reversible Phosphorylation
    Linda B. Lester, Maree C. Faux, J. Brian Nauert, John D. Scott · 2001 · Endocrinology
  6. GLP-1 Tablet in Type 2 Diabetes in Fasting and Postprandial Conditions
    M. Gutniak, Hillevi Larsson, Steven W. Sanders, Olof T. Juneskans, Jens Juul Holst, Bo Åhrén · 1997 · Diabetes Care
  7. Role of Regulator of G Protein Signaling in Desensitization of the Glucose-Dependent Insulinotropic Peptide Receptor*1This work was supported by USPHS Grant DK-52186 (to C.-C.T.).
    Chi‐Chuan Tseng, Xiaoying Zhang · 1998 · Endocrinology
  8. Anti-proliferative effect of pro-inflammatory cytokines in cultured β cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: protective role of glucagon-like peptide -1
    Blandino-Rosano, M, Perez-Arana, G, Mellado-Gil, J M, Segundo, C, Aguilar-Diosdado, M · 2008 · Journal of Molecular Endocrinology
  9. Insulinotropic Hormone Glucagon-Like Peptide-1-(7–37) Appears Not to Augment Insulin-Mediated Glucose Uptake in Young Men during Euglycemia1
    Alice S. Ryan, Josephine Mary Egan, Joel Francis Habener, Dariush Elahi · 1998 · The Journal of Clinical Endocrinology & Metabolism
  10. Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate.
    Christian Widmann, Wanda Dolci, Bernard Thorens · 1996 · Molecular Endocrinology
  11. Insulin and C-Peptide Levels After Oral and Intravenous Glucose: Contribution of Enteroinsular Axis to Insulin Secretion
    Hampton, S M, Morgan, L M, Tredger, J A, Cramb, R, Marks, V · 1986 · Diabetes
  12. The Croonian Lectures on the Chemical Correlation of the Functions of the Body
    Ernest Henry Starling · 1968 · Harvard University Press eBooks
  13. Exendin-4 Agonist and Exendin(9-39)amide Antagonist of the GLP-1(7-36)amide Effects in Liver and Muscle
    Ana Alcántara, Mónica Morales, Elena Delgado, Marı́a I. López-Delgado, Felipe Clemente, M Luque, Willy Jean Malaisse, Isabel Valverde, María Villanueva-Peñacarrillo · 1997 · Archives of Biochemistry and Biophysics
  14. Glucagon-Like Peptide-1, But Not Glucose-Dependent Insulinotropic Peptide, Regulates Fasting Glycemia and Nonenteral Glucose Clearance in Mice
    Laurie L. Baggio, Timothy J. Kieffer, Daniel J. Drucker · 2000 · Endocrinology
  15. A Small Molecule Ligand of the Glucagon-like Peptide 1 Receptor Targets Its Amino-terminal Hormone Binding Domain
    Elmi C. Tibaduiza, Ci Chen, Martin Beinborn · 2001 · Journal of Biological Chemistry
  16. Regulation of Ca2+release by cAMP-dependent protein kinase A mechanism for agonist-specific calcium signaling?
    Andrej E. Bugrim · 1999 · Cell Calcium
  17. Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats
    Sancho, Verónica, Trigo, María V, González, Nieves, Valverde, Isabel, Malaisse, Willy J, Villanueva-Peñacarrillo, María L · 2005 · Journal of Molecular Endocrinology
  18. Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes
    Juris Jendrik Meier, Baptist Gallwitz, M. Askenas, Kirsten Vollmer, Carolyn Fiona Deacon, Jens Juul Holst, Wolfgang Ekkehard Schmidt, Michael Albrecht Nauck · 2005 · Diabetologia
  19. Internalization and Homologous Desensitization of the GLP-1 Receptor Depend on Phosphorylation of the Receptor Carboxyl Tail at the Same Three Sites
    Christian Widmann, Wanda Dolci, Bernard Thorens · 1997 · Molecular Endocrinology
  20. GLP-1 amplifies insulin signaling by up-regulation of IRβ, IRS-1 and Glut4 in 3T3-L1 adipocytes
    Gao, Hong, Wang, Xinjun, Zhang, Zhiguo, Yang, Yisheng, Yang, Jun, Li, Xiaoying, Ning, Guang · 2007 · Endocrine
  21. Sur les possibilites d'un traitement du diabete par I'incretine
    J. Labarre · 1932 · Medical Entomology and Zoology
  22. Gastric inhibitory polypeptide (GIP) binding sites in rat brain
    Andrew M. Kaplan, Steven R. Vigna · 1994 · Peptides
  23. The Xenopus proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties
    David M. Irwin, Malathy Satkunarajah, Yi Wen, Patricia Lee Brubaker, Raymond A. Pederson, Michael B. Wheeler · 1997 · Proceedings of the National Academy of Sciences
  24. Processing of Mouse Proglucagon by Recombinant Prohormone Convertase 1 and Immunopurified Prohormone Convertase 2 in Vitro
    Mark E. Rothenberg, Carmen D. Eilertson, Kathy Klein, Yi Zhou, Iris Lindberg, John K. McDonald, Robert Brian Mackin, Bryan D. Noe · 1995 · Journal of Biological Chemistry
  25. Incretins and other peptides in the treatment of diabetes
    Jeannie F Todd, Stephen Robert Bloom · 2007 · Diabetic Medicine
  26. The Absolute Oral Bioavailability and??Population-Based Pharmacokinetic Modelling of a Novel Dipeptidylpeptidase-IV Inhibitor, Vildagliptin, in Healthy Volunteers
    Yanling He, Brian M Sadler, Ron Sabo, Sébastien Balez, Yibin Wang, Joelle Campestrini, Aziz L. Laurent, Monica Ligueros‐Saylan, Dan Howard · 2007 · Clinical Pharmacokinetics
  27. The elimination rates of intact GIP as well as its primary metabolite, GIP 3-42, are similar in type 2 diabetic patients and healthy subjects
    Tina Vilsbøll, Henrik Agersø, Torsten Leif Bunk Lauritsen, Carolyn Fiona Deacon, Kasper Aaboe, Sten Madsbad, Thure Krarup, Jens Juul Holst · 2006 · Regulatory Peptides
  28. Expression of glucagon‐like peptide 1 receptor in a murine C cell line Regulation of calcitonin gene by glucagon‐like peptide 1
    Lamari, Y., Boissard, C., Moukhtar, M.S., Jullienne, A., Rosselin, G., Garel, J.-M. · 1996 · FEBS Letters
  29. Reduced GLP-1 and insulin responses and glucose intolerance after gastric glucose in GRP receptor-deleted mice
    Kristin Persson, Ronald L. Gingerich, Sonali Nayak, Keiji Wada, Etsuko Wada, Bo Åhrén · 2000 · American Journal of Physiology-Endocrinology and Metabolism
  30. Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7--36) amide
    R. Scott Heller, Gregory W. Aponte · 1995 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  31. Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets
    Jie Zhou, Mauren F. A. Livak, Michel Bernier, Denis C. Muller, Olga D. Carlson, Dariush Elahi, Stuart R. Maudsley, Josephine Mary Egan · 2007 · American Journal of Physiology-Endocrinology and Metabolism
  32. Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene.
    Daisy Flamez, A Van Breusegem, Louise A. Scrocchi, Erik Quartier, DANIEL G. PIPELEERS, Daniel J. Drucker, Frans C. Schuit · 1998 · Diabetes
  33. Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): characterization of binding sites for GLP-1 on alpha-TSH cells
    Sarah A. Beak, C. J. Small, И. А. Иловайская, J D Hurley, Mohammad A. Ghatei, Stephen Robert Bloom, David M. Smith · 1996 · Endocrinology
  34. Rapid Oscillations in Plasma Glucagon-Like Peptide-1 (GLP-1) in Humans: Cholinergic Control of GLP-1 Secretion via Muscarinic Receptors
    H. J. Balks · 1997 · The Journal of Clinical Endocrinology & Metabolism
  35. Human Glucagon-Like Peptide-1 Receptor Gene: Localization to Chromosome Band 6p21 by Fluorescence In Situ Hybridization and Linkage of a Highly Polymorphic Simple Tandem Repeat DNA Polymorphism to Other Markers on Chromosome 6
    Markus Stoffel, Rafael Espinosa, Moore Michelle · 1993 · Diabetes
  36. Glucose-dependent insulinotropic peptide: structure of the precursor and tissue-specific expression in rat.
    Chi‐Chuan Tseng, Linda A. Jarboe, Steven B. Landau, Erin K. Williams, M. Michael Wolfe · 1993 · Proceedings of the National Academy of Sciences
  37. A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice
    Rhonda D. Wideman, Scott D. Covey, Gene C. Webb, Daniel J. Drucker, Timothy J. Kieffer · 2007 · Diabetes
  38. TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic β-cells
    Merewyn K. Loder, Gabriela da Silva Xavier, Angela McDonald, Guy A. Rutter · 2008 · Biochemical Society Transactions
  39. Integration of ATP, cAMP, and Ca2+ Signals in Insulin Granule Exocytosis
    Tadao Shibasaki, Yasuhiro Sunaga, Susumu Seino · 2004 · Diabetes
  40. Renal Catabolism of Truncated Glucagon-Like Peptide 1
    Carmen Ruiz-Grande, C. Alarcón, A. Alcántara, Carlos Castilla, J. López Novoa, María Luisa Villanueva‐Peñacarrillo, Isabel Valverde · 1993 · Hormone and Metabolic Research
  41. Effects of glucagon and glucagon-like peptide-1-(7-36) amide on C cells from rat thyroid and medullary thyroid carcinoma CA-77 cell line.
    Crespel, A, De Boisvilliers, F, Gros, L, Kervran, A · 1996 · Endocrinology
  42. β cell-specific deficiency of the stimulatory G protein α-subunit G s α leads to reduced β cell mass and insulin-deficient diabetes
    Tao Xie, Min Chen, Qinghong Zhang, Zheng Ma, Lee Scott Weinstein · 2007 · Proceedings of the National Academy of Sciences
  43. Glucagon-like peptide-1 attenuates tumour necrosis factor-α-mediated induction of plasmogen activator inhibitor-1 expression
    Hongbin Liu, Yunshan Hu, Richard W Simpson, Anthony E. Dear · 2007 · Journal of Endocrinology
  44. Interaction Between Munc13-1 and RIM Is Critical for Glucagon-Like Peptide-1–Mediated Rescue of Exocytotic Defects in Munc13-1–Deficient Pancreatic β-Cells
    Edwin P. Kwan, Li Xie, Laura Sheu, Toshihisa Ohtsuka, Herbert Y. Gaisano · 2007 · Diabetes
  45. Insulinotropic Hormone Glucagon-Like Peptide-1-(7-37) Appears Not to Augment Insulin-Mediated Glucose Uptake in Young Men during Euglycemia
    Alice S. Ryan · 1998 · The Journal of Clinical Endocrinology & Metabolism
  46. Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse
    R V Campos · 1994 · Endocrinology
  47. Pleiotropic effects of thiazolidinediones
    Christos V. Rizos, Evangelos N. Liberopoulos, Dimitri P. Mikhailidis, Moses Elisaf · 2008 · Expert Opinion on Pharmacotherapy
  48. Gastric inhibitory polypeptide: Effect on glucose-induced insulin release from isolated rat pancreatic islets in vitro
    Schauder, P., Brown, J. C., Frerichs, H., Creutzfeldt, W. · 1975 · Diabetologia
  49. Cloning and Functional Expression of a Human Glucagon-like Peptide-1 Receptor
    M P Graziano, Patricia J. Hey, D. Borkowski, Gary G. Chicchi, Catherine D. Strader · 1993 · Biochemical and Biophysical Research Communications
  50. Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.
    Daisy Flamez, Patrick Gilon, Karen Moens, A Van Breusegem, Dominique Delmeire, Louise A. Scrocchi, Jean‐Claude Henquin, Daniel J. Drucker, Frans C Schuit · 1999 · Diabetes
  51. Glucagon-Like Peptide-1 7-36 Amide and Peptide YY Have Additive Inhibitory Effect on Gastric Acid Secretion in Man
    André Wettergren, Pierre Maina, S Boesby, Jens Juul Holst · 1997 · Scandinavian Journal of Gastroenterology
  52. The effect of age, gender, and body mass index on the pharmacokinetics and pharmacodynamics of vildagliptin in healthy volunteers
    Yanling He, Ron Sabo, Joelle Campestrini, Yibin Wang, Gilles‐Jacques Rivière, Jace C. Nielsen, Mitchell A. Rosenberg, Monica Ligueros‐Saylan, Dan Howard, William P. Dole · 2007 · British Journal of Clinical Pharmacology
  53. Effects of glucose-dependent insulinotropic peptide on behavior
    Kehong Ding, Qing Zhong, Ding Xie, Huan-Xin Chen, Mary Anne Della‐Fera, Roni J. Bollag, Wendy Bollinger Bollag, Ravinder Gujral, Baolin Kang, Supriya Sridhar et al. · 2006 · Peptides
  54. Pax-6 Activates Endogenous Proglucagon Gene Expression in the Rodent Gastrointestinal Epithelium
    Denny K. Y. Trinh, Kai Zhang, Moazzem Hossain, Patricia Lee Brubaker, Daniel J. Drucker · 2003 · Diabetes
  55. The influence of hepatic impairment on the pharmacokinetics of the dipeptidyl peptidase IV (DPP-4) inhibitor vildagliptin
    Yanling He, Ron Sabo, Joelle Campestrini, Yiran Wang, Monica Ligueros‐Saylan, Kenneth C. Lasseter, Stacy C. Dilzer, D. Howard, William P. Dole · 2007 · European Journal of Clinical Pharmacology
  56. GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells
    Yihong Wang, Chahrzad Montrose‐Rafizadeh, Lisa G. Adams, Margarita J. Raygada, Orna Nadiv, Josephine Mary Egan · 1996 · Molecular and Cellular Endocrinology
  57. Osteoblast-Derived Cells Express Functional Glucose-Dependent Insulinotropic Peptide Receptors
    Roni J. Bollag · 2000 · Endocrinology
  58. Functional GIP receptors in a hamster pancreatic beta cell line, In 111: Specific binding and biological effects
    B Amiranoff, N. Vauclin-Jacques, Marc Laburthe · 1984 · Biochemical and Biophysical Research Communications
  59. The Insulinotropic Effect of Acute Exendin-4 Administered to Humans: Comparison of Nondiabetic State to Type 2 Diabetes
    Josephine Mary Egan · 2002 · The Journal of Clinical Endocrinology & Metabolism
  60. A New Pathway for Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor Signaling
    Jan A. Ehses, Shelter S.T. Lee, Raymond A. Pederson, Christopher H.S. McIntosh · 2001 · Journal of Biological Chemistry
  61. Effect of Leptin on Hypothalamic GLP-1 Peptide and Brain-Stem Pre-proglucagon mRNA
    Anthony Peter Goldstone, Irene Morgan, Julian G. Mercer, David G.A. Morgan, Kim M. Moar, Mohammad A. Ghatei, Stephen Robert Bloom · 2000 · Biochemical and Biophysical Research Communications
  62. Gene therapy using SV40-derived vectors: What does the future hold?
    David S. Strayer · 1999 · Journal of Cellular Physiology
  63. Exendin-4 induction of cyclin D1 expression in INS-1 β-cells: involvement of cAMP-responsive element
    Myeong‐Jin Kim, J-H Kang, Y G Park, Gyeong Ryul Ryu, Seung‐Hyun Ko, I-K Jeong, K-H Koh, D.-J. Rhie, Seokjeong Yoon, Sang June Hahn et al. · 2006 · Journal of Endocrinology
  64. Heterodimeric Pbx-Prep1 Homeodomain Protein Binding to the Glucagon Gene Restricting Transcription in a Cell Type-dependent Manner
    Stephan Herzig, LASZLO FÜZESI, Willhart Knepel · 2000 · Journal of Biological Chemistry
  65. Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development
    Nadja Herbach, Burkhard Göke, Marlon Roberto Schneider, Walter Hermanns, Eckhard Wolf, Rüdiger Wanke · 2004 · Regulatory Peptides
  66. Identification of Specific Binding Sites for Glucagon-Like Peptide-1 on the Posterior Lobe of the Rat Pituitary
    Rüdiger Göke, Philip Just Larsen, Jens D. Mikkelsen, Søren Paludan Sheikh · 2008 · Neuroendocrinology
  67. Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells
    Yukihiro Fujita, Jeannie W. Y. Chui, David King, Tianjiao Zhang, Jochen Seufert, Scott Pownall, Anthony T. Cheung, Timothy J. Kieffer · 2008 · American Journal of Physiology-Endocrinology and Metabolism
  68. Orexin-A Inhibits Glucagon Secretion and Gene Expression through a Foxo1-Dependent Pathway
    Eva Göncz, Mathias Z. Strowski, Carsten Grötzinger, Krzysztof W. Nowak, Przemek Kaczmarek, Maciej Sassek, Stefan Mergler, Bilal Farouk El-Zayat, Marily Theodoropoulou, Günter Karl Stalla et al. · 2007 · Endocrinology
  69. Chronic desensitization of the glucose-dependent insulinotropic polypeptide receptor in diabetic rats
    Chi‐Chuan Tseng, M O Boylan, Linda A. Jarboe, Ted Björn Usdin, M. Michael Wolfe · 1996 · American Journal of Physiology-Endocrinology and Metabolism
  70. Elevated Plasma Glucose-Dependent Insulinotropic Polypeptide Associates With Hyperinsulinemia in Impaired Glucose Tolerance
    Michael J. Theodorakis, Olga D. Carlson, Denis C. Muller, Josephine Mary Egan · 2004 · Diabetes Care
  71. Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle
    Alicia Acitores, Nieves González, Verónica Sancho, Isabel Valverde, ML Villanueva-Penacarrillo · 2004 · Journal of Endocrinology
  72. Lack of Effect of Synthetic Human Gastric Inhibitory Polypeptide and Glucagon-LikePeptide 1 [7-36 Amide] Infused at Near-Physiological Concentrations on Pentagastrin-Stimulated Gastric Acid Secretion in Normal Human Subjects
    Michael Albrecht Nauck, Eckart Bartels, Cathrine Ørskov, Reinhold Ebert, W. Creutzfeldt · 2009 · Digestion
  73. Reaction of trans-Chlorocarbonylbis(triphenylphosphine) Iridium(I) and its Analogues with Oxidizing Metal Salts
    D. N. Cash, R. O. Harris · 1971 · Canadian Journal of Chemistry
  74. Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions
    Y Wang, Kole Hk, Chahrzad Montrose‐Rafizadeh, Riccardo Perfetti, Michel Bernier, JM Egan · 1997 · Journal of Molecular Endocrinology
  75. Regulation of glucose-dependent insulinotropic peptide gene expression by a glucose meal
    C. C. Tseng, Linda A. Jarboe, M. Michael Wolfe · 1994 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  76. Cell-Specific Expression of Glucose-Dependent-Insulinotropic Polypeptide Is Regulated by the Transcription Factor PDX-1
    Lisa I. Jepeal, Yoshio Fujitani, M O Boylan, Cherrell N. Wilson, Christopher V.E. Wright, M. Michael Wolfe · 2004 · Endocrinology
  77. Glucagon-Like Peptide 1 and its Potential in the Treatment of Non-Insulin-Dependent Diabetes Mellitus
    Michael Albrecht Nauck, Jens Juul Holst, B. Willms · 1997 · Hormone and Metabolic Research
  78. Localization of the Domains Involved in Ligand Binding and Activation of the Glucose-Dependent Insulinotropic Polypeptide Receptor
    Richard W. Gelling, Michael B. Wheeler, Jiaping Xue, Sandor Gyomorey, Cuilan Nian, Raymond A. Pederson, Christopher H.S. McIntosh · 1997 · Endocrinology
  79. Role of the Exchange Protein Directly Activated by Cyclic Adenosine 5′-Monophosphate (Epac) Pathway in Regulating Proglucagon Gene Expression in Intestinal Endocrine L Cells
    Shamim Lotfi, LI Zhi-hong, Jane Sun, Yang Zuo, Patrick P. L. Lam, Youhou Kang, Mehdi Rahimi, Diana Islam, Peixiang Wang, Herbert Y. Gaisano et al. · 2006 · Endocrinology
  80. Ghrelin Attenuates the Inhibitory Effects of Glucagon-Like Peptide-1 and Peptide YY(3-36) on Food Intake and Gastric Emptying in Rats
    Prasanth K. Chelikani, Alvin C. Haver, Roger D. Reidelberger · 2006 · Diabetes
  81. Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1
    Albert A. Salehi, Sandra Meidute Abaraviciene, Javier Jimenez‐Feltström, Claes‐Göran Östenson, Suad Efendić, Ingmar Lundquist · 2008 · PLoS ONE
  82. Glucose-dependent insulinotropic polypeptide and insulin-like immunoreactivity in saliva following sham-fed and swallowed meals
    Beatrice. Messenger, Michael Newton Clifford, LM Morgan · 2003 · Journal of Endocrinology
  83. Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamus
    P. J. Shughrue · 1996 · Endocrinology
  84. Oxygen free radical scavenger properties of dehydroepiandrosterone
    Elena Tamagno, Manuela Aragno, Giuseppe Boccuzzi, Marco Gallo, Silvia Parola, Bice Fubini, Giuseppe Poli, Oliviero Danni · 1998 · Cell Biochemistry and Function
  85. Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action.
    C. Montrose-Rafizadeh, J. Egan, J. Roth · 1994 · Endocrinology
  86. Heterologous Desensitization of the Glucagon-like Peptide-1 Receptor by Phorbol Esters Requires Phosphorylation of the Cytoplasmic Tail at Four Different Sites
    Christian Widmann, Wanda Dolci, Bernard Thorens · 1996 · Journal of Biological Chemistry
  87. Dose Proportionality and the Effect of Food on Vildagliptin, a Novel Dipeptidyl Peptidase IV Inhibitor, in Healthy Volunteers
    Gangadhar Sunkara, Ron Sabo, Yibin Wang, Yanling He, Joelle Campestrini, Mitchell A. Rosenberg, Dan Howard, William P. Dole · 2007 · The Journal of Clinical Pharmacology
  88. Effects of exendin‐4 on islets from type 2 diabetes patients
    Roberto Lupi, Rita Mancarella, Silvia Del Guerra, Marco Bugliani, Stefano Del Prato, Ugo Boggi, Franco Mosca, Franco Filipponi, Piero Marchetti · 2008 · Diabetes Obesity and Metabolism
  89. Exendin-4 as a Stimulator of Rat Insulin I Gene Promoter Activity via bZIP/CRE Interactions Sensitive to Serine/Threonine Protein Kinase Inhibitor Ro 31-8220
    Oleg G. Chepurny, Mehboob Ali Hussain, George G. Holz · 2002 · Endocrinology
  90. Hamster Gastric Inhibitory Polypeptide Receptor Expressed in Pancreatic Islets and Clonal Insulin-Secreting Cells: Its Structure and Functional Properties
    Koichiro Yasuda, Nobuya Inagaki, Yuichiro Yamada, Akira Kubota, Susumu Seino, Yutaka Seino · 1994 · Biochemical and Biophysical Research Communications
  91. Signalling pathways activated by glucagon-like peptide-1 (7-36) amide in the rat heart and their role in protection against ischaemia.
    Barbara Huisamen, Sonia Genade, Amanda Lochner · 2008 · Europe PMC (PubMed Central)
  92. The proglucagon gene upstream enhancer contains positive and negative domains important for tissue-specific proglucagon gene transcription.
    Tianru Jin, Daniel J. Drucker · 1995 · Molecular Endocrinology
  93. Diabetes Outfoxed by GLP-1?
    George G. Holz, Oleg G. Chepurny · 2005 · Science s STKE
  94. Glucagonlike Peptide-I-(7–36)-Amide Receptors Only in Islets of Langerhans: Autoradiographic Survey of Extracerebral Tissues in Rats
    Cathrine Ørskov, Steen Seier Poulsen · 1991 · Diabetes
  95. Involvement of PDX-1 in activation of human insulin gene transcription
    John Le Lay, Roland W. Stein · 2006 · Journal of Endocrinology
  96. A Novel Mechanism for the Suppression of a Voltage-gated Potassium Channel by Glucose-dependent Insulinotropic Polypeptide
    Sujin Kim, Woo Sung Choi, John Song Mou Han, Garth L. Warnock, David Fedida, Christopher H.S. McIntosh · 2005 · Journal of Biological Chemistry
  97. Inhibitory effect of GLP-1 on gastric motility persists after vagal deafferentation in pigs
    Carl Frederik Nagell, André Wettergren, Cathrine Ørskov, Jens Juul Holst · 2006 · Scandinavian Journal of Gastroenterology
  98. Divergent regulation of human and rat proglucagon gene promoters in vivo.
    Nian Min, D. Drucker, D. Irwin · 1999 · American Journal of Physiology
  99. Evidence for and Characterization of Specific High Affinity Binding Sites for the Gastric Inhibitory Polypeptide in Pancreaticβ-Cells*
    M. Maletti, Bernard Portha, Mats Carlquist, Micheline Kergoat, Marc Laburthe, Jean Claude Marie, G Rosselin · 1984 · Endocrinology
  100. Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP- 1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate
    Christian Widmann · 1996 · Molecular Endocrinology
  101. Response of gastric inhibitory polypeptide (GIF) to test meal in chronic pancreatitis ? Relationship to endocrine and exocrine insufficiency
    Reinhold Ebert, W. Creutzfeldt, John Canvin Brown, H. Frerichs, R. Arnold · 1976 · Diabetologia
  102. Enhanced Protection against Cytokine- and Fatty Acid-induced Apoptosis in Pancreatic Beta Cells by Combined Treatment with Glucagon-like Peptide-1 Receptor Agonists and Insulin Analogues
    Daniel Tews, U. Werner, Jürgen Eckel · 2008 · Hormone and Metabolic Research
  103. Effects of antibodies to gastric inhibitory peptide on gastric acid secretion and gastrin release in the dog
    M. Michael Wolfe, Michael P. Hocking, Daniel G. Maico · 1983 · Gastroenterology
  104. Muscarinic Receptors Control Postprandial Release of Glucagon-Like Peptide-1: In Vivo and in Vitro Studies in Rats
    Y. Anini · 2002 · Endocrinology
  105. Constitution of a biphasic insulin response to glucose in human fetal pancreatic beta-cells with glucagon-like peptide 1.
    Timo Otonkoski, Alberto Hayek · 1995 · The Journal of Clinical Endocrinology & Metabolism
  106. The action of GLP-1 and exendins upon glucose transport in normal human adipocytes, and on kinase activity as compared to morbidly obese patients
    Verónica Sancho, Bernardo Nuche, Luís Arnes, Jesús Cancelas, Nieves Gonz ́lez, Mariano Díaz-Miguel, Antonio Martín‐Duce, Isabel Valverde, María Villanueva-Peñacarrillo · 2007 · International Journal of Molecular Medicine
  107. Preserved GLP-I Effects on Glycogen Synthase a Activity and Glucose Metabolism in Isolated Hepatocytes and Skeletal Muscle From Diabetic Rats
    Mónica Morales, Marı́a I. López-Delgado, Ana Alcántara, M Luque, Felipe Clemente, Luis Márquez, Jesús Puente, Concepción Viñmbres, Willy Jean Malaisse, María L Wlanueva-Peñacarrillo et al. · 1997 · Diabetes
  108. Cross-talk between Bone Morphogenetic Protein and Transforming Growth Factor-β Signaling Is Essential for Exendin-4-induced Insulin-positive Differentiation of AR42J Cells
    Kok-Hooi Yew, Mark J. Hembree, Krishna L. Prasadan, Barry L. Preuett, Christopher R. McFall, Christina L. Benjes, Amanda R. Crowley, Susan W. Sharp, Sidhartha Tulachan, Sheilendra S. Mehta et al. · 2005 · Journal of Biological Chemistry
  109. FoxO1 Is Required for the Regulation of Preproglucagon Gene Expression by Insulin in Pancreatic αTC1-9 Cells
    Caroline M. McKinnon, Magalie A. Ravier, Guy A. Rutter · 2006 · Journal of Biological Chemistry
  110. Glycosylation of the GLP-1 receptor is a prerequisite for regular receptor function
    Rüdiger Göke, Roland Just, Brigitte Lankat–Buttgereit · 1994 · Peptides
  111. Insulinotropic Hormone Glucagon-Like Peptide 1 (GLP-1) Activation of Insulin Gene Promoter Inhibited by p38 Mitogen-Activated Protein Kinase
    Daniel M. Kemp, Joel Francis Habener · 2001 · Endocrinology
  112. Biosynthesis of Peptide Hormones Derived from Precursor Sequences
    Regula von Eggelkraut‐Gottanka, Annette G. Beck‐Sickinger · 2004 · Current Medicinal Chemistry
  113. Cell-specific Expression of the Glucose-dependent Insulinotropic Polypeptide Gene in a Mouse Neuroendocrine Tumor Cell Line
    M O Boylan, Lisa I. Jepeal, Linda A. Jarboe, M. Michael Wolfe · 1997 · Journal of Biological Chemistry
  114. Role of the Glucagon Receptor COOH-Terminal Domain in Glucagon-Mediated Signaling and Receptor Internalization
    Joseph J. Buggy, Rainer O. Heurich, Margit L. MacDougall · 1997 · Diabetes
  115. Treatment of type 2 diabetes with incretin-based therapies
    Sten Madsbad · 2008 · The Lancet
  116. Characterization of the Carboxyl-terminal Domain of the Rat Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor
    Michael B. Wheeler, Richard W. Gelling, Simon A. Hinke, Ba Tu, Raymond A. Pederson, Francis C. Lynn, Jan A. Ehses, Christopher H.S. McIntosh · 1999 · Journal of Biological Chemistry
  117. Gastric inhibitory polypeptide release from a tumor-derived cell line
    Timothy J. Kieffer, Zhihong Huang, Christopher H.S. McIntosh, Alison M. J. Buchan, John Canvin Brown, Raymond A. Pederson · 1995 · American Journal of Physiology-Endocrinology and Metabolism
  118. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
    Hiroshi Yamamoto, Charlotte E. Lee, Jacob Marcus, Todd D. Williams, J. M. Overton, Marisol E. Lopez, Anthony Neil Hollenberg, Laurie L. Baggio, Clifford B. Saper, Daniel J. Drucker et al. · 2002 · Journal of Clinical Investigation
  119. cDNA array reveals increased expression of glucose-dependent insulinotropic polypeptide following chronic clozapine treatment: role in atypical antipsychotic drug-induced adverse metabolic effects
    S Sondhi, Juan Manuel Castellano, Victor Z. Chong, Raina M. Rogoza, Kevin J. Skoblenick, Bailee A. Dyck, Joseph P. Gabriele, N Thomas, K Ki, Zdenek B. Pristupa et al. · 2005 · The Pharmacogenomics Journal
  120. Protein Kinase B Activity Is Sufficient to Mimic the Effect of Insulin on Glucagon Gene Transcription
    Sven Schinner, Andreas Barthel, Claudia Dellas, Rafal Grzeskowiak, Sanjeev K. Sharma, Elke Oetjen, Roland Blume, Willhart Knepel · 2004 · Journal of Biological Chemistry
  121. Role of Regulator of G Protein Signaling in Desensitization of the Glucose-Dependent Insulinotropic Peptide Receptor
    C.-C. Tseng · 1998 · Endocrinology
  122. Neuroendocrine Function and Response to Stress in Mice with Complete Disruption of Glucagon-Like Peptide-1 Receptor Signaling
    Neil James MacLusky · 2000 · Endocrinology
  123. Potential Role for a Regulator of G Protein Signaling (RGS3) in Gonadotropin-Releasing Hormone (GnRH) Stimulated Desensitization
    Jimmy D. Neill · 1997 · Endocrinology
  124. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression
    Daniel F. Boyer, Yoshio Fujitani, MAUREEN A. GANNON, Alvin C. Powers, Roland W. Stein, Christopher V.E. Wright · 2006 · Developmental Biology
  125. Comparison of GLP-1 (7-36amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas.
    Roland M. Schmid, Volker Schusdziarra, Richard Aulehner · 1990 · PubMed
  126. Ligand-specificity of the rat GLP-I receptor recombinantly expressed in Chinese hamster ovary (CHO-) cells.
    Hans Christoph Fehmann, J Jiang, Johannes Schweinfurth, Karola Dorsch, Michael B. Wheeler, A E Boyd, Burkhard Göke · 1994 · PubMed
  127. Interplay of Glucagon-Like Peptide-1 and Transforming Growth Factor-β Signaling in Insulin-Positive Differentiation of AR42J Cells
    Kok-Hooi Yew, Krishna L. Prasadan, Barry L. Preuett et al. · 2004 · Diabetes
  128. Autonomic nervous system‐dependent and ‐independent cardiovascular effects of exendin‐4 infusion in conscious rats
    Sheila Margaret Gardiner, Julie E. March, P.A. Kemp, Thomas M. Bennett · 2008 · British Journal of Pharmacology
  129. Inositolphosphoglycans and diacylglycerol are possible mediators in the glycogenic effect of GLP-1(7-36)amide in BC3H-1 myocytes
    C. Galera, Felipe Clemente, A. Alcántara, M. A. Trapote, Almudena Perea, Marı́a I. López-Delgado, María Luisa Villanueva‐Peñacarrillo, Isabel Valverde · 1996 · Cell Biochemistry and Function
  130. Differential Gene Expression in the Lens Epithelial Cells from Selenite Injected Rats
    Takeshi Nakajima, Emi Nakajima, Chiho Fukiage, Mitsuyoshi Azuma, Thomas R. Shearer · 2002 · Experimental Eye Research
  131. Stimulation of Glucagon Secretion by Gastric Inhibitory Polypeptide in Patients with Hepatic Cirrhosis and Hyperglucagonemia
    J. DUPRE, Yves Caussignac, Timothy James McDonald, S. VAN VLIET · 1991 · The Journal of Clinical Endocrinology & Metabolism
  132. Internalization and Homologous Desensitization of the GLP-1 Receptor Depend on Phosphorylation of the Receptor Carboxyl Tail at the Same Three Sites
    Christian Widmann · 1997 · Molecular Endocrinology
  133. Dietary regulation of glucose-dependent insulinotropic peptide (GIP) gene expression in rat small intestine
    Yoshifumi Higashimoto, Emmanuel C. Opara, Rodger A. Liddle · 1995 · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology
  134. Interaction of gastric inhibitory polypeptide (GIP) with the insulin-secreting pancreatic beta cell line, in 111: Characteristics of GIP binding sites
    B Amiranoff, N. Vauclin-Jacques, Marc Laburthe · 1985 · Life Sciences
  135. Inositolphosphoglycans are possible mediators of the glucagon-like peptide 1 (7–36)amide action in the liver
    M. A. Trapote, Felipe Clemente, C. Galera · 1996 · Journal of Endocrinological Investigation
  136. GIP receptors and signal‐transduction mechanisms
    Christopher H.S. McIntosh, Michael B. Wheeler, Richard W. Gelling, John Canvin Brown, Raymond A. Pederson · 1996 · Acta Physiologica Scandinavica
  137. SUDDEN INSENSIBILITY FOLLOWING THE DRINKING OF A COLD FLUID.
    ArthurT. Cridland · 1843 · The Lancet
  138. Regulation of Glucagon-Like Peptide-1 Synthesis and Secretion in the GLUTag Enteroendocrine Cell Line
    P. L. Brubaker · 1998 · Endocrinology
  139. Molecular cloning of rat glucose-dependent insulinotropic peptide (GIP)
    Yoshifumi Higashimoto, Jenny Simchock, Rodger A. Liddle · 1992 · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
  140. Glucagon-Like Peptide-1 Causes Pancreatic Duodenal Homeobox-1 Protein Translocation from the Cytoplasm to the Nucleus of Pancreatic -Cells by a Cyclic Adenosine Monophosphate/Protein Kinase A-Dependent Mechanism
    Xueyuying Wang · 2001 · Endocrinology
  141. Structure of the rat glucose-dependent insulinotropic polypeptide receptor gene
    M O Boylan, Lisa I. Jepeal, M. Michael Wolfe · 1999 · Peptides
  142. Contraction induced by glicentin on smooth muscle cells from the human colon is abolished by exendin (9–39)
    Soulaf El Ayachi, F. Borie, Richard Magous, Koichi Sasaki, D. Le Nguyen, Jean Pierre Bali, Bertrand Millat, C. Jarrousse · 2005 · Neurogastroenterology & Motility
  143. Cell-specific expression of the glucose-dependent insulinotropic polypeptide gene functions through a GATA and an ISL-1 motif in a mouse neuroendocrine tumor cell line
    Lisa I. Jepeal, M O Boylan, M. Michael Wolfe · 2003 · Regulatory Peptides
  144. Role of GIP and insulin in glucose-induced changes in intestinal motility patterns
    Peter Thor, J Laskiewicz, Jan W. Konturek, Stanisław J. Konturek, W. Creutzfeldt · 1987 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  145. GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage
    Lisa I. Jepeal, M O Boylan, M. Michael Wolfe · 2008 · Molecular and Cellular Endocrinology
  146. Glucose-Dependent Insulinotropic Polypeptide Confers Early Phase Insulin Release to Oral Glucose in Rats: Demonstration by a Receptor Antagonist
    J. T. Lewis · 2000 · Endocrinology
  147. The cytoplasmic domain close to the transmembrane region of the glucagon-like peptide-1 receptor contains sequence elements that regulate agonist-dependent internalisation
    Patricia Vázquez, Isabel Roncero, Enrique Blázquez, Elvira Álvarez · 2005 · Journal of Endocrinology
  148. Stimulation of Gastric Inhibitory Polypeptide Release in ob/ob Mice by Oral Administration of Sugars and Their Analogues
    Peter R. Flatt, Piotr Kwasowski, Clifford J. Bailey · 1989 · Journal of Nutrition
  149. Substitution of the cysteine 438 residue in the cytoplasmic tail of the glucagon-like peptide-1 receptor alters signal transduction activity
    Patricia Vázquez, Isabel Roncero, Enrique Blázquez, Elvira Álvarez · 2005 · Journal of Endocrinology
  150. Two 3',5'‐cyclic‐adenosine monophosphate response elements in the promoter region of the human gastric inhibitory polypeptide gene
    Yoshimichi Someya, Nobuya Inagaki, Toshio Maekawa, Yutaka Seino, Shunsuke Ishii · 1993 · FEBS Letters
  151. Upregulation of glucose-dependent insulinotropic polypeptide and its receptor in the retina of streptozotocin-induced diabetic rats
    Gyeong Jae Cho, Sun Youl Ryu, Young Hee Kim, Yoon Sook Kim, Eun Woo Cheon, Jong Moon Park, Hyun Joon Kim, Sang Soo Kang, Wan Sung Choi · 2002 · Current Eye Research
  152. Synergistic Endocrine Induction by GLP-1 and TGF-?? in the Developing Pancreas
    Eri Tei, Sheilendra S. Mehta, Sidhartha Tulachan, Hooi Yew, Mark J. Hembree, Barry L. Preuett, Charles L. Snyder, Atsuyuki Yamataka, Takeshi Miyano, George K. Gittes · 2005 · Pancreas
  153. Genetic variation inGlp1rexpression influences the rate of gastric emptying in mice
    K. Ganesh Kumar, Lauri O. Byerley, Júlia Vólaufová, Daniel J. Drucker, Gary A. Churchill, Renhua Li, Barbara York, Aamir R. Zuberi, Brenda K. Smith Richards · 2007 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  154. The proglucagon gene upstream enhancer contains positive and negative domains important for tissue-specific proglucagon gene transcription
    Tianru Jin · 1995 · Molecular Endocrinology
  155. The Recombinant Rat Glucagon-Like Peptide-1 Receptor, Expressed in an α-Cell Line, Is Coupled to Adenylyl Cyclase Activation and Intracellular Calcium Release
    Joseph Stephen Dillon, M. Lu, S. Bowen · 2005 · Experimental and Clinical Endocrinology & Diabetes
  156. LAF-237 (Novartis).
    Daniela Barlocco · 2004 · PubMed
  157. Constitution of a biphasic insulin response to glucose in human fetal pancreatic beta-cells with glucagon-like peptide 1
    T. Otonkoski · 1995 · The Journal of Clinical Endocrinology & Metabolism
  158. Efficacy and Safety of Incretin Therapy in Type 2 Diabetes: Systematic Review and Meta-analysis
    Amori, Renee E., Lau, Joseph, Pittas, Anastassios G. · 2007 · JAMA
  159. Regulation of l-pyruvate kinase activity by insulin and glycolytic intermediates
    Osamu MIYANAGA, Claudia T. Evans, G.Larry Cottam · 1984 · Biochemical and Biophysical Research Communications
  160. Sp1/Sp3 binding is associated with cell-specific expression of the glucose-dependent insulinotropic polypeptide receptor gene
    M O Boylan, Lisa I. Jepeal, M. Michael Wolfe · 2006 · American Journal of Physiology-Endocrinology and Metabolism
  161. Adrenergic modulation of interdigestive pancreatic secretion in humans
    Peter Layer, Albert Chan, Vay Liang W. Go · 1992 · Gastroenterology
  162. Durable islet effects on insulin secretion and protein kinase A expression following exendin-4 treatment of high-fat diet-fed mice
    Maria Sörhede Winzell, Bo Åhrén · 2007 · Journal of Molecular Endocrinology
  163. Synergistic endocrine induction by GLP-1 and TGF-β in the developing pancreas
    英里 鄭 · 2006 · Medical Entomology and Zoology
  164. EFFECT OF GLUCAGON‐LIKE PEPTIDE‐1 ON THE β CELL RESPONSE TO GLUCOSE‐DEPENDENT INSULINOTROPIC POLYPEPTIDE IN ELDERLY PATIENTS WITH DIABETES MELLITUS
    Graydon S. Meneilly, Dariush Elahi · 2006 · Journal of the American Geriatrics Society