Gastric inhibitory polypeptide: Effect on glucose-induced insulin release from isolated rat pancreatic islets in vitro
Open accessAbstract
Gastric Inhibitory Polypeptide (GIP; 1 or 10 mug/ml) potentiated glucose-induced (8 or 16.6 mM) insulin (IRI) release from isolated rat pancreatic islets. Basal release was unaffected. The threshold concentration of glucose necessary for GIP to modulate IRI release was between 6 and 8 mM. GIP had no effect on IRI release from islets submitted to a maximal glucose stimulus (25 mM).
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The incretin effect describes that orally, but not intravenously, administered glucose enhances insulin secretion by triggering GLP-1 and GIP secretion, and the resulting potentiation may account for up to 50% of total insulin release.
“This effect describes the observation that orally, but not intravenously, administered glucose enhances insulin secretion by triggering GLP-1 and GIP secretion;73, 74, 75 the resulting potentiation of insulin secretion may account for up to 50% of the total release.”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [73]
The Discussion reports that oral glucose produces a greater rise in serum insulin than intravenous glucose and identifies GIP as a possible contributor. The Results show that GIP potentiated glucose-induced insulin release from isolated rat islets, but the paper does not establish that oral glucose acts through both GIP and GLP-1. The 50% estimate follows the citation in the citing sentence and is not treated as attributed to this source. (LLM, conf=0.87)
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Cites
Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas
Lacy, P. E., & Kostianovsky, M. (1967) · Diabetes · doi:10.2337/diab.16.1.35 · Cited by 2,775 · see citing works
STIMULATION OF INSULIN SECRETION BY GASTRIC INHIBITORY POLYPEPTIDE IN MAN. <sup>1</sup>
Dupre, J., Ross, S. A., Watson, D., & Brown, J. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-5-826 · Cited by 860 · see citing works
Self-citationPlasma Insulin Response to Oral and Intravenous Glucose Administration1
ELRICK, H., STIMMLER, L., HLAD, C. J., & ARAI, Y. (1964) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-24-10-1076 · Cited by 857 · see citing works
Intestinal Factors in the Control of Insulin Secretion
McIntyre, N. R., Holdsworth, C. D., & Turner, D. S. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-10-1317 · Cited by 387 · see citing works
A Gastric Inhibitory Polypeptide II: The Complete Amino Acid Sequence
Brown, J. C., & Dryburgh, J. R. (1971) · Canadian Journal of Biochemistry · doi:10.1139/o71-122 · Cited by 344 · see citing works
Self-citationRadioimmunoassay for Gastric Inhibitory Polypeptide
Kuzio, M. D., Dryburgh, J. R., Malloy, K. M., & Brown, J. C. (1974) · Gastroenterology · doi:10.1016/s0016-5085(74)80134-4 · Cited by 241 · see citing works
Self-citationGastric Inhibitory Polypeptide (GIP) Stimulation by Oral Glucose in Man
Cataland, S., Crockett, S. E., Brown, J. C., & Mazzaferri, E. L. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-2-223 · Cited by 227 · see citing works
Self-citationÜber die radioimmunologische Bestimmung von Insulin im Blut
Melani, F., DITSCHUNEIT, H. H., Bartelt, K. M., Friedrich, H., & Pfeiffer, E. F. (1965) · Journal of Molecular Medicine · doi:10.1007/bf01747863 · Cited by 178 · see citing works
Adenylate Cyclase in Islets of Langerhans
Kuo, W., Hodgins, D. S., & Kuo, J. F. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44063-5 · Cited by 177 · see citing works
Pederson, R. A., & Brown, J. C. (1972) · Gastroenterology · doi:10.1016/s0016-5085(72)80144-6 · Cited by 164 · see citing works
Self-citationA Gastric Inhibitory Polypeptide. I. The Amino Acid Composition and the Tryptic Peptides
Brown, J. C. (1971) · Canadian Journal of Biochemistry · doi:10.1139/o71-037 · Cited by 123 · see citing works
Self-citationTurner, D. S., Etheridge, L., Marks, V., Brown, J. C., & Mutt, V. (1974) · Diabetologia · doi:10.1007/bf01221638 · Cited by 37 · see citing works
Self-citationCreutzfeldt, M. (1974) · PubMed · Cited by 33 · see citing works
Cytochalasin B: Inhibition of glucose-induced insulin release from isolated rat pancreatic islets
SCHAUDER, P., & Frerichs, H. (1974) · Diabetologia · doi:10.1007/bf00421418 · Cited by 21 · see citing works
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Glucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868 · see citing works
Pancreatic regulation of glucose homeostasis.
Röder, P. V., Wu, B., Liu, Y., & Han, W. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.6 · Cited by 985 · see citing works
The role of incretins in glucose homeostasis and diabetes treatment
Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824 · see citing works
Creutzfeldt, W. (1979) · Diabetologia · doi:10.1007/bf01225454 · Cited by 731 · see citing works
Self-citationPEDERSON, R. A., & BROWN, J. C. (1978) · Endocrinology · doi:10.1210/endo-103-2-610 · Cited by 156 · see citing works
Self-citationEbert, R., Unger, H., & Creutzfeldt, W. (1983) · Diabetologia · doi:10.1007/bf00257346 · Cited by 120 · see citing works
Self-citationCircadian rhythm of gastric inhibitory polypeptide (GIP) in man
Salera, M., Giacomoni, P., Pironi, L., Ustra, C., Capelli, M., Giorgi, A., Miglioli, M., & Barbara, L. (1983) · Metabolism · doi:10.1016/0026-0495(83)90150-6 · Cited by 23 · see citing works
- Authors
- Schauder, P., Brown, J. C., Frerichs, H., & Creutzfeldt, W.
- Affiliations
- University of Göttingen (DE)
- ORCID
- Brown, J. C.
- Venue
- Diabetologia
- Published
- 1975-10
- Volume
- 11
- Issue
- 5
- Pages
- 483-484
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1976973369
- Cited by
- 65
- References
- 14
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2019: 1 · 2016: 2 · 2012: 1
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (Fr 264/4)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- glucose-dependent insulinotropic polypeptide, insulin secretion, glucose-stimulated insulin secretion, pancreatic islets, incretins, glucose threshold, rats
- MeSH terms
- Insulin Secretion, Animals, Gastrointestinal Hormones, Glucose, Insulin, Islets of Langerhans, Male, Peptides, Stimulation, Chemical, Rats, In Vitro Techniques
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