The DOI matches its Crossref record; 218 of the 219 references it cites were found in a registry or an index.
Organic Anion Transporters and Their Implications in Pharmacotherapy
Abstract
Organic anion transporters play an essential role in the distribution and excretion of numerous endogenous metabolic products and exogenous organic anions, including a host of widely prescribed drugs. The expression and activity of these transporters is influenced by several conditions, including transcriptional regulation, gender-dependent regulation, and genetic variation. In addition, the interaction of these transporters with several drugs and endogenous substrates has been well documented and may play a significant role in drug disposition and development of various disease states, such as nephrotoxicity and familial idiopathic hypouricemia. Members of this family of transporters have been localized mainly to the renal epithelia of various species. Much of the early research in this field has focused on their role in renal drug transport, yet increasing research on this family of transporters has localized them to various other epithelial tissues, including liver, brain, and placenta. Thus, an understanding of the role of these transporters in drug interaction and disposition in the kidney and other tissues may help in the determination of individual drug response, susceptibility to drug toxicity, and chemical carcinogenesis. This review seeks to summarize current knowledge of the molecular function and substrate profile of cloned organic anion transporters and to discuss recent progress in the understanding of the impact of interindividual variability, transcriptional regulation, and tissue distribution on individual drug response.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Organic anion transporters are highly expressed in renal epithelia (Emami Riedmaier et al., 2012).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Emami Riedmaier et al., 2012
Citations
Cites
Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
Enomoto, A., Kimura, H. J., Chairoungdua, A., Shigeta, Y., Jutabha, P., Ho, S., Hosoyamada, M., Takeda, M., Sekine, T., Igarashi, T., et al. (2002) · Nature · doi:10.1038/nature742 · Cited by 1,535
PDZ Domains: Structural Modules for Protein Complex Assembly
Hung, A. Y., & Sheng, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100065200 · Cited by 699
Kolz, M., Johnson, T., Sanna, S., Teumer, A., Vitart, V., Perola, M., Mangino, M., Albrecht, E., Wallace, C., Farrall, M., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000504 · Cited by 666
Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter
Sekine, T., Watanabe, N., Hosoyamada, M., Kanai, Y., & Endou, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18526 · Cited by 623
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
Zanger, U. M., Turpeinen, M., Klein, K., & Schwab, M. G. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2291-6 · Cited by 593
Self-citationHilgendorf, C., Ahlin, G., Seithel‐Keuth, A., Artursson, P., Ungell, A.-L. B., & Karlsson, J. E. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.014902 · Cited by 592
The SLC22 drug transporter family
Koepsell, H., & Endou, H. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1089-9 · Cited by 521
Nishizato, Y. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(03)00060-2 · Cited by 511
Ho, S., Sekine, T., Fukushima, J., Kanai, Y., Kobayashi, Y., Goya, T., & Endou, H. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.5.1277 · Cited by 508
Gene Expression Levels and Immunolocalization of Organic Ion Transporters in the Human Kidney
Motohashi, H., Sakurai, Y., Saito, H., Masuda, S., Urakami, Y., Goto, M., Fukatsu, A., Ogawa, O., & Inui, K. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v134866 · Cited by 507
Flagged first, then by citations
1 of the 219 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–129 of 129
Spearow, J. L., Gettmann, K. D., & Wade, M. (2017) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/10807039.2017.1327799 · Cited by 3
Li, J., Lu, J., Peng, Y., Xu, X., Chen, C., Gao, M., Lin, L., Guo, J., & Duan, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.577012 · Cited by 3
Vo, D.-K., Nguyen, T., Joo, S.-A., & Maeng, H. (2026) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2026.107454 · Cited by 2
Ianus Bifrons: The Two Faces of Metformin
Goglia, U., Hasballa, I., Teti, C., Boschetti, M., Ferone, D., & Albertelli, M. (2024) · Cancers · doi:10.3390/cancers16071287 · Cited by 2
Ichimura, Y., Kudoh, N., Ito, S., Oda, M., & Saitoh, H. (2021) · BPB Reports · doi:10.1248/bpbreports.4.1_36 · Cited by 2
Ichimura, Y., Kudoh, N., Murabe, T., Akao, T., Watanuki, S., Suzuki, T., Saito, T., Oda, M., & Saitoh, H. (2021) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2021.100406 · Cited by 2
Plant Pharmacogenomics: From Drug Discovery to Personalized Ethnomedicine
Babar, M. M., Zaidi, N. U. S. S., & Gul, A. (2015) · Springer eBooks · doi:10.1007/978-81-322-2172-2_25 · Cited by 2
Effects of Hydrochlorothiazide on Tenofovir Disoproxil Fumarate-Induced Nephrotoxicity in Rats
G.Al-Rakhat, I., & Al-Shawi, N. N. (2019) · Iraqi Journal of Pharmaceutical Sciences · doi:10.31351/vol28iss2pp58-64 · Cited by 2
Verpooten, G. A. (2014) · doi:10.1002/9781118820186.ch37 · Cited by 2
Marchetti, S., & Schellens, J. H. M. (2014) · doi:10.1002/9781118705308.ch22 · Cited by 2
Qusa, M. H., Qosa, H., & Volpe, D. A. (2024) · Pharmaceutical Research · doi:10.1007/s11095-024-03746-7 · Cited by 1
Bridging structure and function: artificial intelligence-based modelling of kidney proteins
Wu, S., Wang, W., Zhou, Z. H., Scalzo, F., & Kurtz, I. (2026) · Nature Reviews Nephrology · doi:10.1038/s41581-026-01060-6 · Cited by 1
Andrographolide is neither a human organic anion transporter 1 (hOAT1) substrate nor inhibitor
Chong, Y. M., Kaur, G., & Tan, M. (2019) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2018.1520704 · Cited by 1
Interactions of bioflavonoids and other polyphenolic-type nutraceuticals with drugs
Télessy, I. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819815-5.00046-x · Cited by 1
Effect of Sulfhydryl Modification on Rat Kidney Basolateral Plasma Membrane Transport Function
Ansari, R. A., Rizvi, S. A. A., Husain, K. M., Lymperopoulos, A., & Berndt, W. O. (2012) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-012-0756-y
Sattler, W., Palmer, J. H., Bridges, C. C., Joshee, L., Zalups, R. K., & Parkin, G. (2013) · Polyhedron · doi:10.1016/j.poly.2013.05.012
Vildhede, A. M. (2015) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
ORGANIC ANION TRANSPORTERS (OATs)
Granados, J. C., Zhang, J., You, G., & Nigám, S. K. (2022) · doi:10.1002/9781119739883.ch4
Nies, A. T. (2014) · Springer eBooks · doi:10.1007/978-3-642-27841-9_3628-5
Self-citationNies, A. T. (2014) · Springer eBooks · doi:10.1007/978-3-662-46875-3_3628
Self-citationJacqueroux, E. (2019) · theses.fr (ABES) · doi:10.70675/efb81441zf7d4z462ezb119z2027e0f494bc
Drug transporters in drug disposition – highlights from the year 2025
Sandoval, P., Mitra, P., Nakakariya, M., Ramsden, D., Rotter, C. J., Ding, N., & Chothe, P. P. (2026) · Drug Metabolism Reviews · doi:10.1080/03602532.2026.2690529
Metadata
- Authors
- Emami Riedmaier, A., Nies, A. T., Schaeffeler, E., & Schwab, M.
- Affiliations
- Universitätsklinikum Tübingen (DE)
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 64
- Issue
- 3
- Pages
- 421-449
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2114622644
- Cited by
- 128
- References
- 219
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 11 · 2018: 6 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 18 · 2013: 8 · 2012: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- organic anion transporters, renal drug transport, drug disposition, drug-drug interactions, nephrotoxicity, transcriptional regulation, interindividual variability, genetic variation, tissue distribution, drug toxicity, chemical carcinogenesis, substrate specificity
- MeSH terms
- Animals, Biological Transport, Drug Interactions, Drug Therapy, Pharmaceutical Preparations, Female, Gene Expression Regulation, Humans, Male, Organ Specificity, Sex Characteristics, Substrate Specificity, Tissue Distribution, Xenobiotics, Organic Anion Transporters, Drug-Related Side Effects and Adverse Reactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
