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Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders

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Brozovich, F.V., Nicholson, C.J., Degen, C.V., Gao, Yuan Z., Aggarwal, M., Morgan, K.G.·2016·Pharmacological Reviews

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Abstract

The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportunities for the future development of new therapeutics to regulate vascular function.

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Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Calcium's Role in Mechanotransduction during Muscle Development
Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · Nephron · doi:10.1159/000447068 · Cited by 11,717
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,630
Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction: Results of the Survival and Ventricular Enlargement Trial
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911
Long non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654
The nuclear RNase III Drosha initiates microRNA processing
Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O., Kim, S., et al. (2003) · Nature · doi:10.1038/nature01957 · Cited by 5,114
Lysine acetylation targets protein complexes and co-regulates major cellular functions
Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., & Mann, M. (2009) · Science · doi:10.1126/science.1175371 · Cited by 4,040
Genome Regulation by Long Noncoding RNAs
Rinn, J. L., & Chang, H. Y. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051410-092902 · Cited by 4,005
Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
Laurent, S., Boutouyrie, P., Asmar, R., Gautier, I., Laloux, B., Guize, L., Ducimetiere, P., & Benetos, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.5.1236 · Cited by 3,856
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
Yusuf, S., Pfeffer, M. A., Swedberg, K., Granger, C. B., Held, P., McMurray, J. J., Michelson, E. L., Olofsson, B., & Östergren, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14285-7 · Cited by 2,994
Asymmetry in the Assembly of the RNAi Enzyme Complex
Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., & Zamore, P. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00759-1 · Cited by 2,922
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M., et al. (1997) · Nature · doi:10.1038/40187 · Cited by 2,859
A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA
Hutvágner, G., McLachlan, J., Pasquinelli, A. E., Bálint, E., Tuschl, T., & Zamore, P. D. (2001) · Science · doi:10.1126/science.1062961 · Cited by 2,781
Functional siRNAs and miRNAs exhibit strand bias
Khvorova, A., Reynolds, A., & Jayasena, S. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00801-8 · Cited by 2,645
Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial
McMurray, J. J., Östergren, J., Swedberg, K., Granger, C. B., Held, P., Michelson, E. L., Olofsson, B., Yusuf, S., & Pfeffer, M. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14283-3 · Cited by 2,604
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582 · cited 1×
“gressive elevation of the proinflammatory marker TNF-a (Levine et al., 1990; Torre-Amione et al., 1996), which has been demonstrated to contribute to endothelial dysfunction and also an increase in vascular tone that is produced by a RhoA/Rho kinase-mediated inhibition of MLC phosphatase (Parris et al.”
Background
MicroRNA maturation: stepwise processing and subcellular localization
Lee, Y. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf476 · Cited by 2,478
Non-coding RNA
Mattick, J. S., & Makunin, I. V. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl046 · Cited by 2,453
Impact of Aortic Stiffness on Survival in End-Stage Renal Disease
Blacher, J., Guerin, A. P., Pannier, B., Marchais, S. J., Safar, M. E., & London, G. M. (1999) · Circulation · doi:10.1161/01.cir.99.18.2434 · Cited by 2,138
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085
Hypertension in mice lacking the gene for endothelial nitric oxide synthase
Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., & Fishman, M. C. (1995) · Nature · doi:10.1038/377239a0 · Cited by 2,070
Cerebral Blood Flow and Oxygen Consumption in Man
Lassen, N. A. (1959) · Physiological Reviews · doi:10.1152/physrev.1959.39.2.183 · Cited by 2,070
Ca2+Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase
SOMLYO, A. P., & SOMLYO, A. V. (2003) · Physiological Reviews · doi:10.1152/physrev.00023.2003 · Cited by 1,991
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II
Pitt, B., Poole-Wilson, P. A., Segal, R., Martinez, F. A., Dickstein, K., Camm, A. J., Konstam, M. A., Riegger, G., Klinger, G. H., Neaton, J., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02213-3 · Cited by 1,961
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
Mehta, P. K., & Griendling, K. K. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00287.2006 · Cited by 1,924
Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study
Mattace-Raso, F. U. S., van der Cammen, T. J. M., Hofman, A., van Popele, N. M., Bos, M. L., Schalekamp, M. A. D. H., Asmar, R., Reneman, R. S., Hoeks, A. P. G., Breteler, M. M. B., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.555235 · Cited by 1,914 · cited 1×
“…differences in the expression of contractile proteins between tonic and phasic smooth muscle (Fisher, 2010), and resistance vessels express a mixture of fast and slow contractile proteins (Fisher, 2010), as well as tonic and phasic contractile properties (Peng et al., 2001; Haddock and Hill, 2005).”
Background
Signal transduction and regulation in smooth muscle
Somlyo, A. P., & Somlyo, A. V. (1994) · Nature · doi:10.1038/372231a0 · Cited by 1,902
Prescribing Personalized Nutrition for Cardiovascular Health: Are We Ready?
Juma, S., Imrhan, V., Vijayagopal, P., & Prasad, C. (2014) · Lifestyle Genomics · doi:10.1159/000370213 · Cited by 1,891
The molecular basis of CaMKII function in synaptic and behavioural memory
Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860
Aortic Pulse Wave Velocity Improves Cardiovascular Event Prediction
Ben-Shlomo, Y., Spears, M., Boustred, C., May, M., Anderson, S. G., Benjamin, E. J., Boutouyrie, P., Cameron, J., Chen, C.-H., Cruickshank, J. K., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.09.063 · Cited by 1,835
Sirtuins in mammals: insights into their biological function
Michan, S., & Sinclair, D. (2007) · Biochemical Journal · doi:10.1042/bj20070140 · Cited by 1,718
Molecular Mechanisms of Human Hypertension
Lifton, R. P., Gharavi, A. G., & Geller, D. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00241-0 · Cited by 1,686
Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial
Granger, C. B., McMurray, J. J., Yusuf, S., Held, P., Michelson, E. L., Olofsson, B., Östergren, J., Pfeffer, M. A., & Swedberg, K. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14284-5 · Cited by 1,686
Cellular mechanotransduction: putting all the pieces together again
Ingber, D. E. (2006) · The FASEB Journal · doi:10.1096/fj.05-5424rev · Cited by 1,627
Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi
Hammond, S. M., Boettcher, S., Caudy, A. A., Kobayashi, R., & Hannon, G. J. (2001) · Science · doi:10.1126/science.1064023 · Cited by 1,580
Nanoscale architecture of integrin-based cell adhesions
Kanchanawong, P., Shtengel, G., Pasapera, A. M., Ramko, E. B., Davidson, M. W., Hess, H. F., & Waterman, C. M. (2010) · Nature · doi:10.1038/nature09621 · Cited by 1,567
Aortic Pulse-Wave Velocity and Its Relationship to Mortality in Diabetes and Glucose Intolerance: An Integrated Index of Vascular Function?
Cruickshank, K., Riste, L., Anderson, S. G., Wright, J. S., Dunn, G., & Gosling, R. G. (2002) · Circulation · doi:10.1161/01.cir.0000033824.02722.f7 · Cited by 1,531
On the local reactions of the arterial wall to changes of internal pressure
Bayliss, W. M. (1902) · The Journal of Physiology · doi:10.1113/jphysiol.1902.sp000911 · Cited by 1,519
Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population
Willum Hansen, T., Staessen, J. A., Torp-Pedersen, C., Rasmussen, S., Thijs, L., Ibsen, H., & Jeppesen, J. (2006) · Circulation · doi:10.1161/circulationaha.105.579342 · Cited by 1,515
Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey
Kim, S. C., Sprung, R., Chen, Y., Xu, Y., Ball, H., Pei, J., Cheng, T., Kho, Y., Xiao, H., Xiao, L., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.026 · Cited by 1,487
MicroRNAs and other non-coding RNAs as targets for anticancer drug development
Ling, H., Fabbri, M., & Calin, G. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4140 · Cited by 1,465
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor
Straight, A. F., Cheung, A., Limouze, J., Chen, I., Westwood, N. J., Sellers, J. R., & Mitchison, T. J. (2003) · Science · doi:10.1126/science.1081412 · Cited by 1,412
Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension
Ghofrani, H.-A., D'Armini, A. M., Grimminger, F., Hoeper, M. M., Jansa, P., Kim, N. H., Mayer, E., Simonneau, G., Wilkins, M. R., Fritsch, A., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209657 · Cited by 1,401
Relaxation of Arterial Smooth Muscle by Calcium Sparks
Nelson, M. T., Cheng, H., Rubart, M., Santana, L. F., Bonev, A. D., Knot, H. J., & Lederer, W. J. (1995) · Science · doi:10.1126/science.270.5236.633 · Cited by 1,396
Riociguat for the treatment of pulmonary arterial hypertension
Ghofrani, H.-A., Galiè, N., Grimminger, F., Grünig, E., Humbert, M., Jing, Z.-C., Keogh, A. M., Langleben, D., Kilama, M. O., Fritsch, A., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209655 · Cited by 1,346
Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual Care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT)
The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.23.2998 · Cited by 1,331
Eph-Ephrin Bidirectional Signaling in Physiology and Disease
Pasquale, E. B. (2008) · Cell · doi:10.1016/j.cell.2008.03.011 · Cited by 1,252
Inositol Trisphosphate Receptor Ca2+Release Channels
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188
Diversifying microRNA sequence and function
Ameres, S. L., & Zamore, P. D. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3611 · Cited by 1,175
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111 · cited 1×
“(SIRT2), or mitochondria sirtuins (SIRT3, 4, and 5) (Michishita et al., 2008).”
Background
Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone
Nelson, M. T., Patlak, J. B., Worley, J. F., & Standen, N. B. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.259.1.c3 · Cited by 1,096
Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
Chu, T. F., Rupnick, M. A., Kerkela, R., Dallabrida, S. M., Zurakowski, D., Nguyen, L., Woulfe, K., Pravda, E., Cassiola, F., Desai, J., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61865-0 · Cited by 1,083
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
Kolch, W. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1743 · Cited by 1,070
Impact of Aortic Stiffness Attenuation on Survival of Patients in End-Stage Renal Failure
Guerin, A. P., Blacher, J., Pannier, B., Marchais, S. J., Safar, M. E., & London, G. M. (2001) · Circulation · doi:10.1161/01.cir.103.7.987 · Cited by 1,040
Recent insights into the cellular biology of atherosclerosis
Tabas, I., García-Cardeña, G., & Owens, G. K. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201412052 · Cited by 1,016 · cited 4×
“Recent Direct Confirmation of Changes in Vascular Tone/Resistance Related to Changes in Systemic Vascular Resistance and Blood Pressure and the Importance of Vascular Smooth Muscle Contraction in both Normal Physiology and Pathophysiology—Hypertension.”
BackgroundInfluential
Hypoxia-Induced Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms
Stenmark, K. R., Fagan, K. A., & Frid, M. G. (2006) · Circulation Research · doi:10.1161/01.res.0000243584.45145.3f · Cited by 1,006
Diagnosis and differential assessment of pulmonary arterial hypertension
Barst, R. J., McGoon, M., Torbicki, A., Sitbon, O., Krowka, M. J., Olschewski, H., & Gaine, S. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.02.032 · Cited by 992
Signaling Mechanisms Underlying the Vascular Myogenic Response
Davis, M. J., & Hill, M. A. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.387 · Cited by 992
Signaling to Chromatin through Histone Modifications
Cheung, P., Allis, C. D., & Sassone-Corsi, P. (2000) · Cell · doi:10.1016/s0092-8674(00)00118-5 · Cited by 989
Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart
Torre-Amione, G., Kapadia, S., Lee, J., Durand, J.-B., Bies, R. D., Young, J. B., & Mann, D. L. (1996) · Circulation · doi:10.1161/01.cir.93.4.704 · Cited by 989
Blood Pressure Control—Special Role of the Kidneys and Body Fluids
Guyton, A. C. (1991) · Science · doi:10.1126/science.2063193 · Cited by 966
Screening, Early Detection, and Diagnosis of Pulmonary Arterial Hypertension
McGoon, M., Gutterman, D., Steen, V., Barst, R., McCrory, D. C., Fortin, T. A., & Loyd, J. E. (2004) · Chest · doi:10.1378/chest.126.1_suppl.14s · Cited by 932
SIRT1 Promotes Endothelium-Dependent Vascular Relaxation by Activating Endothelial Nitric Oxide Synthase
Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., & Irani, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704329104 · Cited by 881
Mechanobiology and diseases of mechanotransduction
Ingber, D. (2003) · Annals of Medicine · doi:10.1080/07853890310016333 · Cited by 843
Medical Therapy For Pulmonary Arterial Hypertension
Badesch, D. B., Abman, S. H., Ahearn, G. S., Barst, R. J., McCrory, D. C., Simonneau, G., & McLaughlin, V. V. (2004) · Chest · doi:10.1378/chest.126.1_suppl.35s · Cited by 829
Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
Force, T., Krause, D. S., & Van Etten, R. A. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2106 · Cited by 801
Vasoregulation by the β1 subunit of the calcium-activated potassium channel
Brenner, R., Peréz, G. J., Bonev, A. D., Eckman, D. M., Kosek, J. C., Wiler, S. W., Patterson, A. J., Nelson, M. T., & Aldrich, R. W. (2000) · Nature · doi:10.1038/35038011 · Cited by 796
Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals
Morrison, D. K., & Davis, R. J. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111401.091942 · Cited by 786
Mitochondrial Fission Inhibitors Suppress Endothelin-1-Induced Artery Constriction
Chen, C., Gao, J.-L., Liu, M.-Y., Li, S.-L., Xuan, X.-C., Zhang, X.-Z., Zhang, X.-Y., Wei, Y.-Y., Zhen, C.-L., Jin, J., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479536 · Cited by 782
Endothelium-dependent vasodilation is attenuated in patients with heart failure.
Kubo, S. H., Rector, T. S., Bank, A. J., Williams, R. E., & Heifetz, S. M. (1991) · Circulation · doi:10.1161/01.cir.84.4.1589 · Cited by 775
Epigenetic Control of Smooth Muscle Cell Differentiation and Phenotypic Switching in Vascular Development and Disease
Alexander, M. R., & Owens, G. K. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142315 · Cited by 773
Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease: A Scientific Statement From the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention
Rosendorff, C., Black, H. R., Cannon, C. P., Gersh, B. J., Gore, J., Izzo, J. L., Kaplan, N. M., O’Connor, C. M., O’Gara, P. T., & Oparil, S. (2007) · Circulation · doi:10.1161/circulationaha.107.183885 · Cited by 757
Tissue Angiotensin and Pathobiology of Vascular Disease: A Unifying Hypothesis
Dzau, V. J. (2001) · Hypertension · doi:10.1161/01.hyp.37.4.1047 · Cited by 750
Mechanical properties of arteries
Dobrin, P. B. (1978) · Physiological Reviews · doi:10.1152/physrev.1978.58.2.397 · Cited by 746
The nitric oxide and cGMP signal transduction system: regulation and mechanism of action
Schmidt, H. H. H. W., Lohmann, S. M., & Walter, U. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(93)90006-b · Cited by 746
Long Noncoding RNAs in Cardiovascular Diseases
Uchida, S., & Dimmeler, S. (2015) · Circulation Research · doi:10.1161/circresaha.116.302521 · Cited by 739
Cardiovascular remodelling in coronary artery disease and heart failure
Heusch, G., Libby, P., Gersh, B., Yellon, D., Böhm, M., Lopaschuk, G., & Opie, L. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60107-0 · Cited by 734
Myosin Phosphorylation and the Cross-Bridge Cycle in Arterial Smooth Muscle
Dillon, P. F., Aksoy, M. O., Driska, S. P., & Murphy, R. A. (1981) · Science · doi:10.1126/science.6893872 · Cited by 705
The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles
Lacolley, P., Regnault, V., Nicoletti, A., Li, Z., & Michel, J.-B. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs135 · Cited by 701
G12-G13–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension
Wirth, A., Benyó, Z., Lukasova, M., Leutgeb, B., Wettschureck, N., Gorbey, S., Örsy, P., Horváth, B., Maser-Gluth, C., Greiner, E., et al. (2008) · Nature Medicine · doi:10.1038/nm1666 · Cited by 681
Pathogenesis of Hypertension
Oparil, S., Zaman, M. A., & Calhoun, D. A. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-9-200311040-00011 · Cited by 680
Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure
Knot, H. J., & Nelson, M. T. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.199br.x · Cited by 670
Effect of enalapril on myocardial infarction and unstable angina in patients with low ejection fractions
Yusuf, S., Pepine, C. J., Garces, C., Pouleur, H., Rousseau, M., Salem, D., Kostis, J., Benedict, C., Bourassa, M., & Pitt, B. (1992) · The Lancet · doi:10.1016/0140-6736(92)92889-n · Cited by 666
Neuronal Ca2+/Calmodulin-Dependent Protein Kinase II: The Role of Structure and Autoregulation in Cellular Function
Hudmon, A., & Schulman, H. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135410 · Cited by 658
Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics
Sotiropoulos, A., Gineitis, D., Copeland, J., & Treisman, R. (1999) · Cell · doi:10.1016/s0092-8674(00)81011-9 · Cited by 655
Calcium sparks in smooth muscle
Jaggar, J. H., Porter, V. A., Lederer, W. J., & Nelson, M. T. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.2.c235 · Cited by 652
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster
Boettger, T., Beetz, N., Kostin, S., Schneider, J., Krüger, M., Hein, L., & Braun, T. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38864 · Cited by 651
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury
Xin, M., Small, E. M., Sutherland, L. B., Qi, X., McAnally, J., Plato, C. F., Richardson, J. A., Bassel-Duby, R., & Olson, E. N. (2009) · Genes & Development · doi:10.1101/gad.1842409 · Cited by 649
Ageing of the conduit arteries
Greenwald, S. (2007) · The Journal of Pathology · doi:10.1002/path.2101 · Cited by 637
Development of microRNA therapeutics is coming of age
van Rooij, E., & Kauppinen, S. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201100899 · Cited by 625
Arterial stiffness, systolic blood pressure, and logical treatment of arterial hypertension.
O'Rourke, M. (1990) · Hypertension · doi:10.1161/01.hyp.15.4.339 · Cited by 622
Integrating signals from RTKs to ERK/MAPK
McKay, M. M., & Morrison, D. K. (2007) · Oncogene · doi:10.1038/sj.onc.1210394 · Cited by 621
DREAM is a Ca2+-regulated transcriptional repressor
Carrión, A. M., Link, W. A., Ledo, F., Mellström, B., & Naranjo, J. R. (1999) · Nature · doi:10.1038/18044 · Cited by 573
Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial
(2002) · The Lancet · doi:10.1016/s0140-6736(02)08265-x · Cited by 573
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
Kato, N., Takeuchi, F., Tabara, Y., Kelly, T. N., Go, M. J., Sim, X., Tay, W. T., Chen, C.-H., Zhang, Y., Yamamoto, K., et al. (2011) · Nature Genetics · doi:10.1038/ng.834 · Cited by 566
Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns
Lundby, A., Lage, K., Weinert, B. T., Bekker-Jensen, D. B., Secher, A., Skovgaard, T., Kelstrup, C. D., Dmytriyev, A., Choudhary, C., Lundby, C., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.07.006 · Cited by 547
RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits
Watson, N., Linder, M. E., Druey, K. M., Kehrl, J. H., & Blumer, K. J. (1996) · Nature · doi:10.1038/383172a0 · Cited by 546
Racial differences in response to therapy for heart failure: Analysis of the vasodilator-heart failure trials
Carson, P., Ziesche, S., Johnson, G., & Cohn, J. N. (1999) · Journal of Cardiac Failure · doi:10.1016/s1071-9164(99)90001-5 · Cited by 533
HYPERTENSION: Trends in Prevalence, Incidence, and Control
Hajjar, I., Kotchen, J. M., & Kotchen, T. A. (2006) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.27.021405.102132 · Cited by 531
Constitutive modelling of arteries
Holzapfel, G. A., & Ogden, R. W. (2010) · Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences · doi:10.1098/rspa.2010.0058 · Cited by 528
Regulation of Myosin Phosphatase by a Specific Interaction with cGMP- Dependent Protein Kinase Iα
Surks, H. K., Mochizuki, N., Kasai, Y., Georgescu, S. P., Tang, K. M., Ito, M., Lincoln, T. M., & Mendelsohn, M. E. (1999) · Science · doi:10.1126/science.286.5444.1583 · Cited by 527
Calcium microdomains: Organization and function
Berridge, M. J. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.09.002 · Cited by 525
Invited Review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression
Lincoln, T. M., Dey, N., & Sellak, H. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1421 · Cited by 510
Sirtuins, Aging, and Medicine
Guarente, L. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1100831 · Cited by 510
HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions
Valenzuela-Fernández, A., Cabrero, J. R., Serrador, J. M., & Sánchez-Madrid, F. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.04.003 · Cited by 505
Effect of nicorandil on coronary events in patients with stable angina: the Impact of Nicorandil in Angina (IONA) randomised trial
(2002) · ACC Current Journal Review · doi:10.1016/s1062-1458(02)00678-5 · Cited by 501
Defective smooth muscle regulation in cGMP kinase I-deficient mice
Pfeifer, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3045 · Cited by 497
Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System
Brown, D. I., & Griendling, K. K. (2015) · Circulation Research · doi:10.1161/circresaha.116.303584 · Cited by 496
LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity
Wu, G., Cai, J., Han, Y., Chen, J., Huang, Z.-P., Chen, C., Cai, Y., Huang, H., Yang, Y., Liu, Y., et al. (2014) · Circulation · doi:10.1161/circulationaha.114.011675 · Cited by 485
Basic Science of Pulmonary Arterial Hypertension for Clinicians: New Concepts and Experimental Therapies
Archer, S. L., Weir, E. K., & Wilkins, M. R. (2010) · Circulation · doi:10.1161/circulationaha.108.847707 · Cited by 485
Vascular smooth muscle cells differ from other smooth muscle cells: predominance of vimentin filaments and a specific alpha-type actin.
Gabbiani, G., Schmid, E., Winter, S., Chaponnier, C., de Ckhastonay, C., Vandekerckhove, J., Weber, K., & Franke, W. W. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.1.298 · Cited by 484
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
Zhu, Y., Bian, Z., Lu, P., Karas, R. H., Bao, L., Cox, D., Hodgin, J., Shaul, P. W., Thorén, P., Smithies, O., et al. (2002) · Science · doi:10.1126/science.1065250 · Cited by 482
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
Dioum, E. M., Chen, R., Alexander, M. S., Zhang, Q., Hogg, R. T., Gerard, R. D., & Garcia, J. A. (2009) · Science · doi:10.1126/science.1169956 · Cited by 472
Elastin in Large Artery Stiffness and Hypertension
Wagenseil, J. E., & Mecham, R. P. (2012) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-012-9349-8 · Cited by 462
Structure and Mechanical Properties of Resistance Arteries in Hypertension: Role of Adhesion Molecules and Extracellular Matrix Determinants
Intengan, H. D., & Schiffrin, E. L. (2000) · Hypertension · doi:10.1161/01.hyp.36.3.312 · Cited by 459
Age-related vascular stiffening: causes and consequences
Kohn, J. C., Lampi, M. C., & Reinhart-King, C. A. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00112 · Cited by 440 · cited 2×
“underlying mechanisms causative of changes in the physical properties of blood vessels (Kohn et al., 2015).”
Background
Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle
Droogmans, G., & Casteels, R. (1984) · Developments in Cardiovascular Medicine · doi:10.1007/978-1-4757-1171-4_35 · Cited by 431
Transmural organization of the arterial media. The lamellar unit revisited.
Clark, J. M., & Glagov, S. (1985) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.5.1.19 · Cited by 431
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Study, L. C., Wain, L. V., EchoGen consortium, AortaGen Consortium, CHARGE Consortium Heart Failure Working Group, KidneyGen consortium, CKDGen consortium, Cardiogenics consortium, CardioGram, Verwoert, G. C., et al. (2011) · Nature Genetics · doi:10.1038/ng.922 · Cited by 428
Explaining the Phenomenon of Nitrate Tolerance
Münzel, T., Daiber, A., & Mülsch, A. (2005) · Circulation Research · doi:10.1161/01.res.0000184694.03262.6d · Cited by 424
Structural and Functional Insights into the Myosin Motor Mechanism
Sweeney, H. L., & Houdusse, A. (2010) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.050708.133751 · Cited by 422
Transient Receptor Potential Channels in the Vasculature
Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420
Smooth muscle calponin. Inhibition of actomyosin MgATPase and regulation by phosphorylation.
Winder, S. J., & Walsh, M. P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38792-7 · Cited by 409
Increased Homocysteine and S-Adenosylhomocysteine Concentrations and DNA Hypomethylation in Vascular Disease
Castro, R., Rivera, I., Struys, E. A., Jansen, E. E. W., Ravasco, P., Camilo, M. E., Blom, H. J., Jakobs, C., & Tavares de Almeida, I. (2003) · Clinical Chemistry · doi:10.1373/49.8.1292 · Cited by 409
Myosin light chain phosphatase: subunit composition, interactions and regulation
Hartshorne, D. J., Ito, M., & Erdo¨di, F. (1998) · Journal of Muscle Research & Cell Motility · doi:10.1023/a:1005385302064 · Cited by 403
A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans
Adeyemo, A., Gerry, N., Chen, G., Herbert, A., Doumatey, A., Huang, H., Zhou, J., Lashley, K., Chen, Y., Christman, M., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000564 · Cited by 392
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure
Tang, M., Wang, G., Lu, P., Karas, R. H., Aronovitz, M., Heximer, S. P., Kaltenbronn, K. M., Blumer, K. J., Siderovski, D. P., Zhu, Y., et al. (2003) · Nature Medicine · doi:10.1038/nm958 · Cited by 385
Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction
Gunst, S. J., & Zhang, W. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00253.2008 · Cited by 375
The AT 1 -Type Angiotensin Receptor in Oxidative Stress and Atherogenesis: Part I: Oxidative Stress and Atherogenesis
Nickenig, G., & Harrison, D. G. (2002) · Circulation · doi:10.1161/hc0302.102618 · Cited by 366
MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation
Boon, R. A., Seeger, T., Heydt, S., Fischer, A., Hergenreider, E., Horrevoets, A. J. G., Vinciguerra, M., Rosenthal, N., Sciacca, S., Pilato, M., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.255737 · Cited by 366
TrpC1 Is a Membrane-Spanning Subunit of Store-Operated Ca 2+ Channels in Native Vascular Smooth Muscle Cells
Xu, S.-Z., & Beech, D. J. (2001) · Circulation Research · doi:10.1161/01.res.88.1.84 · Cited by 361
Chronic Hypoxia–Induced Upregulation of Store-Operated and Receptor-Operated Ca 2+ Channels in Pulmonary Arterial Smooth Muscle Cells: A Novel Mechanism of Hypoxic Pulmonary Hypertension
Lin, M.-J., Leung, G. P. H., Zhang, W.-M., Yang, X.-R., Yip, K.-P., Tse, C.-M., & Sham, J. S. K. (2004) · Circulation Research · doi:10.1161/01.res.0000138952.16382.ad · Cited by 358
The actin gene family: Function follows isoform
Perrin, B. J., & Ervasti, J. M. (2010) · Cytoskeleton · doi:10.1002/cm.20475 · Cited by 358
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
Crowley, S. D., Gurley, S. B., Oliverio, M. I., Pazmino, A. K., Griffiths, R., Flannery, P. J., Spurney, R. F., Kim, H.-S., Smithies, O., Le, T. H., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23378 · Cited by 351
Role of nitric oxide in cardiovascular disease: focus on the endothelium
Cannon, R. O. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.8.1809 · Cited by 349
Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers
Veigel, C., Molloy, J. E., Schmitz, S., & Kendrick-Jones, J. (2003) · Nature Cell Biology · doi:10.1038/ncb1060 · Cited by 345
AKAP79/150 Anchoring of Calcineurin Controls Neuronal L-Type Ca2+ Channel Activity and Nuclear Signaling
Oliveria, S. F., Dell'Acqua, M. L., & Sather, W. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.032 · Cited by 344
Mice With Disrupted BK Channel β1 Subunit Gene Feature Abnormal Ca 2+ Spark/STOC Coupling and Elevated Blood Pressure
Plüger, S., Faulhaber, J., Fürstenau, M., Löhn, M., Waldschütz, R., Gollasch, M., Haller, H., Luft, F. C., Ehmke, H., & Pongs, O. (2000) · Circulation Research · doi:10.1161/01.res.87.11.e53 · Cited by 342
Short Communication: Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging
Qiu, H., Zhu, Y., Sun, Z., Trzeciakowski, J. P., Gansner, M., Depre, C., Resuello, R. R. G., Natividad, F. F., Hunter, W. C., Genin, G. M., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.221846 · Cited by 340
Agonists Trigger G Protein-mediated Activation of the CPI-17 Inhibitor Phosphoprotein of Myosin Light Chain Phosphatase to Enhance Vascular Smooth Muscle Contractility
Kitazawa, T., Eto, M., Woodsome, T. P., & Brautigan, D. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.9897 · Cited by 336
Identification and Characterization of Nonmuscle Myosin II-C, a New Member of the Myosin II Family
Golomb, E., Ma, X., Jana, S. S., Preston, Y. A., Kawamoto, S., Shoham, N. G., Goldin, E., Conti, M. A., Sellers, J. R., & Adelstein, R. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309981200 · Cited by 336
Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B
Congrains, A., Kamide, K., Oguro, R., Yasuda, O., Miyata, K., Yamamoto, E., Kawai, T., Kusunoki, H., Yamamoto, H., Takeya, Y., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.11.017 · Cited by 331
Rho Kinase–Mediated Vasoconstriction Is Important in Severe Occlusive Pulmonary Arterial Hypertension in Rats
Oka, M., Homma, N., Taraseviciene-Stewart, L., Morris, K. G., Kraskauskas, D., Burns, N., Voelkel, N. F., & McMurtry, I. F. (2007) · Circulation Research · doi:10.1161/01.res.0000261658.12024.18 · Cited by 331
G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle.
Kitazawa, T., Masuo, M., & Somlyo, A. P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9307 · Cited by 320
Activation of RhoA and Inhibition of Myosin Phosphatase as Important Components in Hypertension in Vascular Smooth Muscle
Seko, T., Ito, M., Kureishi, Y., Okamoto, R., Moriki, N., Onishi, K., Isaka, N., Hartshorne, D. J., & Nakano, T. (2003) · Circulation Research · doi:10.1161/01.res.0000059987.90200.44 · Cited by 320
G-protein-mediated Ca2+ sensitization of smooth muscle contraction through myosin light chain phosphorylation
Kitazawa, T., Gaylinn, B. D., Denney, G. H., & Somlyo, A. P. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52353-x · Cited by 318
Invited Review: Regulation of myosin phosphorylation in smooth muscle
Pfitzer, G. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.1.497 · Cited by 315
Myosin Light Chain Kinase Functions Downstream of Ras/ERK to Promote Migration of Urokinase-Type Plasminogen Activator-Stimulated Cells in an Integrin-Selective Manner
Nguyen, D. H. D., Catling, A. D., Webb, D. J., Sankovic, M., Walker, L. A., Somlyo, A. V., Weber, M. J., & Gonias, S. L. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.1.149 · Cited by 311
Possible Involvement of Rho-Kinase in the Pathogenesis of Hypertension in Humans
Masumoto, A., Hirooka, Y., Shimokawa, H., Hironaga, K., Setoguchi, S., & Takeshita, A. (2001) · Hypertension · doi:10.1161/hy1201.096541 · Cited by 307
STIM1 Gates TRPC Channels, but Not Orai1, by Electrostatic Interaction
Zeng, W., Yuan, J. P., Kim, M. S., Choi, Y. J., Huang, G. N., Worley, P. F., & Muallem, S. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.020 · Cited by 306
Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development
Maegdefessel, L., Azuma, J., Toh, R., Merk, D. R., Deng, A., Chin, J. T., Raaz, U., Schoelmerich, A. M., Raiesdana, A., Leeper, N. J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61598 · Cited by 306
Effect of phosphorylation of smooth muscle myosin on actin activation and Ca2+ regulation.
Chacko, S., Conti, M. A., & Adelstein, R. S. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.1.129 · Cited by 305
ELECTROMECHANICAL AND PHARMACOMECHANICAL COUPLING IN VASCULAR SMOOTH MUSCLE
Somlyo, A. V., & Somlyo, A. P. (1968) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27848-x · Cited by 303
A Novel Protein Phosphatase-1 Inhibitory Protein Potentiated by Protein Kinase C. Isolation from Porcine Aorta Media and Characterization1
Eto, M., Ohmori, T., Suzuki, M., Furuya, K., & Morita, F. (1995) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124993 · Cited by 301
Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension
Sitbon, O., Humbert, M., Jagot, J., Taravella, O., Fartoukh, M., Parent, F., Herve, P., & Simonneau, G. (1998) · European Respiratory Journal · doi:10.1183/09031936.98.12020265 · Cited by 301
Endothelium-Derived Relaxing Factor: Discovery, Early Studies, and Identification as Nitric Oxide
Furchgott, R. F. (1999) · Bioscience Reports · doi:10.1023/a:1020537506008 · Cited by 298
Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis
Nagai, R., Kuro‐o, M., Babij, P., & Periasamy, M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81717-3 · Cited by 295
Identification and Initial Functional Characterization of a Human Vascular Cell–Enriched Long Noncoding RNA
Bell, R. D., Long, X., Lin, M., Bergmann, J. H., Nanda, V., Cowan, S. L., Zhou, Q., Han, Y., Spector, D. L., Zheng, D., et al. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.303240 · Cited by 292
Scaffold proteins of MAP-kinase modules
Dhanasekaran, D. N., Kashef, K., Lee, C. M., Xu, H., & Reddy, E. P. (2007) · Oncogene · doi:10.1038/sj.onc.1210411 · Cited by 288
Inhibition of Myosin Phosphatase by Upregulated Rho-Kinase Plays a Key Role for Coronary Artery Spasm in a Porcine Model With Interleukin-1β
Kandabashi, T., Shimokawa, H., Miyata, K., Kunihiro, I., Kawano, Y., Fukata, Y., Higo, T., Egashira, K., Takahashi, S., Kaibuchi, K., et al. (2000) · Circulation · doi:10.1161/01.cir.101.11.1319 · Cited by 287
β1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol
Johnson, J. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(03)00068-7 · Cited by 285
Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo
McDonald, O. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26505 · Cited by 284
Recent Advances in Arterial Stiffness and Wave Reflection in Human Hypertension
Laurent, S., & Boutouyrie, P. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.076166 · Cited by 281
Relating biochemistry and function in the myosin superfamily
De La Cruz, E. M., & Ostap, E. M. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.11.011 · Cited by 281
RETIRED: Obstetrical Complications Associated With Abnormal Maternal Serum Markers Analytes
Gagnon, A., Wilson, R. D., Audibert, F., Allen, V. M., Blight, C., Brock, J.-A., Désilets, V. A., Gagnon, A., Johnson, J.-A., Langlois, S., et al. (2008) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)32973-5 · Cited by 281
Calcium Signaling in Smooth Muscle
Hill-Eubanks, D. C., Werner, M. E., Heppner, T. J., & Nelson, M. T. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004549 · Cited by 280
Evolution of portal hypertension and mechanisms involved in its maintenance in a rat model
Sikuler, E., Kravetz, D., & Groszmann, R. J. (1985) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1985.248.6.g618 · Cited by 279
Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension
MUKAI, Y., SHIMOKAWA, H., MATOBA, T., KANDABASHI, T., SATOH, S., HIROKI, J., KAIBUCHI, K., & TAKESHITA, A. (2001) · The FASEB Journal · doi:10.1096/fj.00-0735fje · Cited by 278
A Critical Role of Cavin (Polymerase I and Transcript Release Factor) in Caveolae Formation and Organization
Liu, L., & Pilch, P. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707890200 · Cited by 274
Phenotypic changes of human smooth muscle cells during development: Late expression of heavy caldesmon and calponin
Frid, M. G., Shekhonin, B. V., Koteliansky, V. E., & Glukhova, M. A. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90104-o · Cited by 273
Mechanism of platelet inhibition by nitric oxide: In vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase
Wang, G.-R., Zhu, Y., Halushka, P. V., Lincoln, T. M., & Mendelsohn, M. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.4888 · Cited by 271
Potassium Channel Function in Vascular Disease
Sobey, C. G. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.21.1.28 · Cited by 271
Invited Review: Arteriolar smooth muscle mechanotransduction: Ca2+signaling pathways underlying myogenic reactivity
Hill, M. A., Zou, H., Potocnik, S. J., Meininger, G. A., & Davis, M. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.973 · Cited by 269
Novel Long Noncoding RNAs Are Regulated by Angiotensin II in Vascular Smooth Muscle Cells
Leung, A., Trac, C., Jin, W., Lanting, L., Akbany, A., Sætrom, P., Schones, D. E., & Natarajan, R. (2013) · Circulation Research · doi:10.1161/circresaha.112.300849 · Cited by 268
Gene Expression Patterns in the Lungs of Patients With Primary Pulmonary Hypertension: A Gene Microarray Analysis
Geraci, M. W., Moore, M., Gesell, T., Yeager, M. E., Alger, L., Golpon, H., Gao, B., Loyd, J. E., Tuder, R. M., & Voelkel, N. F. (2001) · Circulation Research · doi:10.1161/01.res.88.6.555 · Cited by 267
Cross-Sectional Correlates of Increased Aortic Stiffness in the Community: The Framingham Heart Study
Mitchell, G. F., Guo, C.-Y., Benjamin, E. J., Larson, M. G., Keyes, M. J., Vita, J. A., Vasan, R. S., & Levy, D. (2007) · Circulation · doi:10.1161/circulationaha.106.667733 · Cited by 265
Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.
Shimizu, H., Ito, M., Miyahara, M., Ichikawa, K., Okubo, S., Konishi, T., Naka, M., Tanaka, T., Hirano, K., & Hartshorne, D. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43828-8 · Cited by 264
Evidence for STIM1‐ and Orail‐dependent storeoperated calcium influx through I CRAC in vascular smooth muscle cells: role in proliferation and migration
Potier, M., Gonzalez, J. C., Motiani, R. K., Abdullaev, I. F., Bisaillon, J. M., Singer, H. A., & Trebak, M. (2009) · The FASEB Journal · doi:10.1096/fj.09-131128 · Cited by 263
Inhibition of endogenous TRP1 decreases capacitative Ca2+entry and attenuates pulmonary artery smooth muscle cell proliferation
Sweeney, M., Yu, Y., Platoshyn, O., Zhang, S., McDaniel, S. S., & Yuan, J. X.-J. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00412.2001 · Cited by 261
Modulation of the molecular composition of large conductance, Ca2+ activated K+ channels in vascular smooth muscle during hypertension
Amberg, G. C., Bonev, A. D., Rossow, C. F., Nelson, M. T., & Santana, L. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18684 · Cited by 259
Vascular smooth muscle: The first recorded Ca2+ transients
Morgan, J. P., & Morgan, K. G. (1982) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00584972 · Cited by 258
Self-citation
Plasticity in canine airway smooth muscle.
Pratusevich, V. R., Seow, C. Y., & Ford, L. E. (1995) · The Journal of general physiology · doi:10.1085/jgp.105.1.73 · Cited by 256
Skin blood flow responses to the iontophoresis of acetylcholine and sodium nitroprusside in man: possible mechanisms.
Morris, S. J., & Shore, A. C. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021704 · Cited by 254
Kinetic Mechanism of Non-muscle Myosin IIB
Wang, F., Kovács, M., Hu, A., Limouze, J., Harvey, E. V., & Sellers, J. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302510200 · Cited by 253
MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function
Albinsson, S., Suarez, Y., Skoura, A., Offermanns, S., Miano, J. M., & Sessa, W. C. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.200873 · Cited by 253
Hypothesis for the Initiation of Vasomotion
Peng, H., Matchkov, V., Ivarsen, A., Aalkjær, C., & Nilsson, H. (2001) · Circulation Research · doi:10.1161/hh0801.089603 · Cited by 251
Cyclic GMP and mechanisms of vasodilation
Lincoln, T. M. (1989) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(89)90127-7 · Cited by 250
Functional Divergence of Human Cytoplasmic Myosin II
Kovács, M., Wang, F., Hu, A., Zhang, Y., & Sellers, J. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305453200 · Cited by 249
Contribution of Collagen, Elastin, and Smooth Muscle to In Vivo Human Brachial Artery Wall Stress and Elastic Modulus
Bank, A. J., Wang, H., Holte, J. E., Mullen, K., Shammas, R., & Kubo, S. H. (1996) · Circulation · doi:10.1161/01.cir.94.12.3263 · Cited by 248
DNA hypomethylation and methyltransferase expression in atherosclerotic lesions
Hiltunen, M. O., Turunen, M. P., Häkkinen, T. P., Rutanen, J., Hedman, M., Mäkinen, K., Turunen, A.-M., Aalto-Setalä, K., & Ylä-Herttuala, S. (2002) · Vascular Medicine · doi:10.1191/1358863x02vm418oa · Cited by 245
Impaired Cerebral Autoregulation in Patients With Malignant Hypertension
Immink, R. V., van den Born, B.-J. H., van Montfrans, G. A., Koopmans, R. P., Karemaker, J. M., & van Lieshout, J. J. (2004) · Circulation · doi:10.1161/01.cir.0000144472.08647.40 · Cited by 243
Management of hypertension before, during, and after pregnancy
James, P. R., & Nelson-Piercy, C. (2004) · Heart · doi:10.1136/hrt.2004.035444 · Cited by 243

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Guo, J., Huang, X., Dou, L., Yan, M., Shen, T., Tang, W., & Li, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01251-0 · Cited by 1,718
Vascular smooth muscle contraction in hypertension
Touyz, R. M., Alves-Lopes, R., Rios, F. J., Camargo, L. L., Anagnostopoulou, A., Arner, A., & Montezano, A. C. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy023 · Cited by 697
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Frismantiene, A., Philippova, M., Erne, P., & Resink, T. J. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.08.019 · Cited by 406
From nano to micro to macro: Electrospun hierarchically structured polymeric fibers for biomedical applications
Yang, G., Li, X., He, Y., Ma, J., Ni, G., & Zhou, S. (2018) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2017.12.003 · Cited by 336
Inhibition of ROCK ameliorates pulmonary fibrosis by suppressing M2 macrophage polarisation through phosphorylation of STAT3
Li, Q., Cheng, Y., Zhang, Z., Bi, Z., Ma, X., Wei, Y., & Wei, X. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1036 · Cited by 77

See all 542

Authors: Brozovich, F. V., Nicholson, C. J., Degen, C. V., Gao, Y. Z., Aggarwal, M., & Morgan, K. G.
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 2016-04
Volume: 68
Issue: 2
Pages: 476-532
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1124/pr.115.010652
OpenAlex: W2325318720
Cited by: 542
References: 572
FWCI: 17.76
Type: journal article
Language: en
Open access: hybrid

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Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders

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