Endothelin

Davenport, Anthony P., Hyndman, Kelly A., Dhaun, Neeraj, Southan, Christopher, Kohan, Donald E., Pollock, Jennifer S., Pollock, David M., Webb, David J. +1 more·2016·Pharmacological Reviews

DOI 10.1124/pr.115.011833

Cites (650)

Items 401–600 of 650

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Endothelin-receptor blockade improves endothelial vasomotor dysfunction in heart failure
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Increased response to big endothelin‐1 in atherosclerotic human coronary artery: functional evidence for up‐regulation of endothelin‐converting enzyme activity in disease
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Endothelin-A receptors mediate contraction in human cerebral, meningeal and temporal arteries
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Macitentan Does Not Interfere with Hepatic Bile Salt Transport
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Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia
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Differential expression of endothelin-2 along the mouse intestinal tract
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Functional and Binding Characterization of Endothelin Receptors in Human Bronchus: Evidence for a Novel Endothelin B Receptor Subtype?
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Failure of BQ123, a more potent antagonist of sarafotoxin 6b than of endothelin‐1, to distinguish between these agonists in binding experiments
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Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice
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Endothelin-1 (1–31): From chymase-dependent synthesis to cardiovascular pathologies
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Predictors of Atrasentan-Associated Fluid Retention and Change in Albuminuria in Patients with Diabetic Nephropathy
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Sustained Ca2+signaling and delayed internalization associated with endothelin receptor heterodimers linked through a PDZ fingerThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin.
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Dose-Dependent Acute and Sustained Renal Effects of the Endothelin Receptor Antagonist Avosentan in Healthy Subjects
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Targeted over-expression of endothelin-1 in astrocytes leads to more severe brain damage and vasospasm after subarachnoid hemorrhage
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Pharmacokinetics of the novel dual endothelin receptor antagonist macitentan in subjects with hepatic or renal impairment
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Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications
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EndothelinB receptor on guinea pig small intestinal smooth muscle cells
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Aspirin and Sodium Salicylate Inhibit Endothelin ETA Receptors by an Allosteric Type of Mechanism
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Characterization of Endothelin Isoforms in Human Heart: Endothelin-2 Demonstrated
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Endothelial Cell-specific Over-expression of Endothelin- 1 Leads to More Severe Cerebral Damage following Transient Middle Cerebral Artery Occlusion
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Endothelin in hypertension: A role for receptor antagonists?
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Vasoconstrictor activity of novel endothelin peptide, ET‐1(1 – 31), in human mammary and coronary arteries in vitro
Janet J. Maguire, Rhoda E. Kuc, Anthony P. Davenport · 2001 · British Journal of Pharmacology
Endothelin receptor type B agonist, IRL-1620, prevents beta amyloid (Aβ) induced oxidative stress and cognitive impairment in normal and diabetic rats
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Endothelin B receptor agonist, IRL 1620, enhances the anti-tumor efficacy of paclitaxel in breast tumor rats
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Comparison of Selective ETA and ETB Receptor Antagonists in Patients with Chronic Heart Failure
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Calcitonin Gene-Related Peptide Terminates Long-Lasting Vasopressor Responses to Endothelin 1 In Vivo
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The Kell Protein of the Common K2 Phenotype Is a Catalytically Active Metalloprotease, whereas the Rare Kell K1 Antigen Is Inactive
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Erythropoietin-induced hypertension and vascular injury in mice overexpressing human endothelin-1
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Endothelin family peptides in human plasma and urine: Their molecular forms and concentrations
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Cerebellar neurons and glia respond differentially to endothelins and sarafotoxin S6b
A. Jennifer Morton, Anthony P. Davenport · 1992 · Brain Research
Endothelin Antagonism and Its Role in the Treatment of Hypertension
Rebecca Moorhouse, David J. Webb, David Kluth · 2013 · Current Hypertension Reports
Truncation of N-terminal extracellular or C-terminal intracellular domains of human ETA receptor abrogated the binding activity to ET-1
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Endothelial Endothelin B Receptor-Mediated Prevention of Cerebrovascular Remodeling Is Attenuated in Diabetes Because of Up-Regulation of Smooth Muscle Endothelin Receptors
Aisha I. Kelly-Cobbs, Alex K. Harris, Mostafa M. Elgebaly · 2010 · Journal of Pharmacology and Experimental Therapeutics
Extrarenal ET B Plays a Significant Role in Controlling Cardiovascular Responses to High Dietary Sodium in Rats
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Renal protection by a dual ETA/ETB endothelin antagonist, L-754,142, after aortic cross-clamping in the dog.
Stephen M. Krause, T F Walsh, William J. Greenlee · 1997 · Journal of the American Society of Nephrology
Renal phenotype of Et-1 transgenic mice is modulated by androgens
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A snake bite by the Burrowing Asp, Atractaspis engaddensis
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Localization of Endothelin-1 (ET-1), ET-2, and ET-3, Mouse VIC, and Sarafotoxin S6b Binding Sites in Mammalian Heart and Kidney
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ET ‐1 increases reactive oxygen species following hypoxia and high‐salt diet in the mouse glomerulus
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A Live-Cell Assay for Studying Extracellular and Intracellular Endothelin-Converting Enzyme Activity
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Alternatively Spliced mRNAs for Human Endothelin-2 and Their Tissue Distribution
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Presence of a phosphoramidon-sensitive endothelin-converting enzyme which converts big-endothelin-1, but not big-endothelin-3, in the rat vas deferens
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Cellular Expression of Isoforms of Endothelin-Converting Enzyme-1 (ECE-1c, ECE-1b and ECE-1a) and Endothelin-Converting Enzyme-2
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Endothelin-converting enzyme in human tissues
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Nitric Oxide Inhibition of Endothelin-1 Release in the Vasculature
Robert M. Rapoport · 2014 · Hypertension
Reduced endogenous endothelin-1–mediated vascular tone in chronic renal failure
Malcolm F. Hand, William Geoffrey Haynes, David J. Webb · 1999 · Kidney International
Receptor binding and antagonist properties of a novel endothelin receptor antagonist, TAK-044 [cyclo[D-alpha-aspartyl-3-[(4-phenylpiperazin-1-yl) carbonyl]-L-alanyl-L-alpha-aspartyl-D-2-(2-thienyl) glycyl-L-leucyl-D-tryptophyl]disodium salt], in human endothelinA and endothelinB receptors.
Y Masuda, Tsukasa Sugo, Takao Kikuchi · 1996 · Journal of Pharmacology and Experimental Therapeutics
Endothelin B receptors contribute to sex differences in blood pressure elevation in angiotensin II hypertensive rats on a high salt diet
W. Kittikulsuth, Stephen W. Looney, David M. Pollock · 2013 · Clinical and Experimental Pharmacology and Physiology
Sandwich-Enzyme Immunoassays for Endothelin Family Peptides
Nobuhiro Suzuki, Hirokazu Matsumoto, Takashi Miyauchi · 1991 · Journal of Cardiovascular Pharmacology
Pharmacological Differences Between Rat and Human Endothelin B Receptors
Elwood E. Reynolds, O. Hwang, M.A. Flynn · 1995 · Biochemical and Biophysical Research Communications
Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice
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Bibrotoxin, a novel member of the endothelin/sarafotoxin peptide family, from the venom of the burrowing asp Atractaspis bibroni
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Intestinal relaxation by endothelin isopeptides: involvement of Ca2+-activated K+ channels
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Analysis of the role of endothelin-A and endothelin-B receptors on nociceptive information transmission in the spinal cord with FR139317, an endothelin-A receptor antagonist, and sarafotoxin S6c, an endothelin-B receptor agonist.
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Expressional Changes in Cerebrovascular Receptors after Experimental Transient Forebrain Ischemia
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Pharmacokinetic and pharmacodynamic evaluation of macitentan, a novel endothelin receptor antagonist for the treatment of pulmonary arterial hypertension
Patricia N. Sidharta, Stephan Krähenbühl, Jasper Dingemanse · 2015 · Expert Opinion on Drug Metabolism & Toxicology
The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans
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Early progress in epigenetic regulation of endothelin pathway genes
AK Welch, ME Jacobs, Charles S. Wingo, Brian D. Cain · 2012 · British Journal of Pharmacology
Endothelin in Human Brain and Pituitary Gland
Kazuhiro Takahashi, Mohamed A. Ghatei, Peter M. Jones · 1991 · Journal of Cardiovascular Pharmacology
Immunocytochemical studies on endothelin in mast cells and macrophages in the rat gastrointestinal tract
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Regional and maturation-associated expression of endothelin 2 in rat gastrointestinal tract.
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The endothelin system in pulmonary and renal vasculopathy: les liaisons dangereuses
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Effects of Endothelin Receptor Antagonism Relate to the Degree of Renin-Angiotensin System Blockade in Chronic Proteinuric Kidney Disease
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Endothelin receptor expression and pharmacology in human saphenous vein graft
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Is Big Endothelin Converted to Endothelin-1 in Circulating Blood?
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Endothelin-1 and ETAReceptor Expression in Vascular Smooth Muscle Cells from Human Placenta: A New ETAReceptor Messenger Ribonucleic Acid Is Generated by Alternative Splicing of Exon 31
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Disruption of the endothelin A receptor in the nephron causes mild fluid volume expansion
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Impaired sodium excretion, decreased glomerular filtration rate and elevated blood pressure in endothelin receptor type B deficient rats
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Endothelin-1 overexpression restores diastolic function in eNOS knockout mice
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Heart ischaemia–reperfusion induces local up‐regulation of vasoconstrictor endothelin ETB receptors in rat coronary arteries downstream of occlusion
Gry Freja Skovsted, Lars Schack Kruse, Rune Larsen · 2014 · British Journal of Pharmacology
Endothelin-1/Endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis
Jian‐peng Teoh, Kyoung‐mi Park, Yongchao Wang · 2014 · Cellular Signalling
Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts
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Endothelin B receptor-deficient mice develop endothelial dysfunction independently of salt loading
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Selectivity of [125I]‐PD 151242 for human, rat and porcine endothelin ETA receptors in the heart
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Receptor kinetics differ for endothelin-1 and endothelin-2 binding to Swiss 3T3 fibroblasts
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Nitric oxide and the A and B of endothelin of sodium homeostasis
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Endogenous endothelin generation maintains vascular tone in humans.
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Imaging Endothelin ET B Receptors Using [ 18 F]-BQ3020: In Vitro Characterization and Positron Emission Tomography (MicroPET)
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Affinity and Selectivity of PD156707, A Novel Nonpeptide Endothelin Antagonist, for Human ETA and ETBReceptors
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Identification of endothelin-1, endothelin-2 and endothelin-3 in human endometrium
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Forearm Vasoconstriction to Endothelin-1 Is Mediated by ETA and ETB Receptors In Vivo in Humans
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Inhibition of Both Neutral Endopeptidase and Endothelin-Converting Enzyme by SLV306 Reduces Proteinuria and Urinary Albumin Excretion in Diabetic Rats
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Rapid Changes in the Phosphoproteome Show Diverse Cellular Responses Following Stimulation of Human Lung Fibroblasts with Endothelin-1
Corinne Stannard, Vukić Šoškić, Jasminka Godovac‐Zimmermann · 2003 · Biochemistry
Increase in nitric oxide bioavailability improves endothelial function in endothelin-1 transgenic mice
Thomas Quaschning · 2003 · Nephrology Dialysis Transplantation
Enhanced blood pressure sensitivity to DOCA‐salt treatment in endothelin ETB receptor‐deficient rats
Yasuo Matsumura, Toshihiko Kuro, Fumiko Konishi · 2000 · British Journal of Pharmacology
Characterization of endothelin receptors in human brain cortex, gliomas, and meningiomas.
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Generation and characterization of rendomab-B1, a monoclonal antibody displaying potent and specific antagonism of the human endothelin B receptor
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Transgenic rats expressing the human ET-2 gene: a model for the study of endothelin actions in vivo
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5 Endothelin Receptor Antagonists: Status and Learning 20 Years On
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Relative Contribution of Endothelin A and Endothelin B Receptors to Vasoconstriction in Small Arteries from Human Heart and Brain
Lisa N. Pierre, Anthony P. Davenport · 1998 · Journal of Cardiovascular Pharmacology
The effect of endothelin-2 (ET-2) on migration and changes in cytosolic free calcium of neutrophils
Jan G.R. Elferink, Ben M. de Koster · 1996 · Naunyn-Schmiedeberg s Archives of Pharmacology
Selective endothelin ETA and dual ETA/ETB receptor blockade improve endothelium-dependent vasodilatation in patients with type 2 diabetes and coronary artery disease
Arnar Thor Rafnsson, Alexey Shemyakin, John Pernow · 2014 · Life Sciences
Deletion of the endothelin-A receptor gene within the developing mandible
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Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion
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DORADO: Opportunity Postponed
David John Webb · 2010 · Hypertension
Endothelin receptor subtypes and their functional relevance in human small coronary arteries
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Superoxide-dependent hypertension in male and female endothelin B receptor-deficient rats.
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Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice
Lowell Ling, Rhoda E. Kuc, Janet J. Maguire · 2012 · Life Sciences
Endothelin-1 and ETA Receptor Expression in Vascular Smooth Muscle Cells from Human Placenta: A New ETA Receptor Messenger Ribonucleic Acid Is Generated by Alternative Splicing of Exon 3
C. Bourgeois · 1997 · The Journal of Clinical Endocrinology & Metabolism
Functional Diversity of Endothelin Pathways in Human Lung Fibroblasts May Be Based on Structural Diversity of the Endothelin Receptors
Corinne Stannard, Petri P Lehenkari, Jasminka Godovac‐Zimmermann · 2003 · Biochemistry
Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma
Hai‐Qiang Mai, Zong Yuan Zeng, Kai‐Tao Feng · 2006 · Cancer Science
Discovery of phenoxybutanoic acid derivatives as potent endothelin antagonists with antihypertensive activity
Jin Cai, Ligang Liu, Kwon Ho Hong et al. · 2015 · Bioorganic & Medicinal Chemistry
Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development
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Pivotal Role of Mouse Mast Cell Protease 4 in the Conversion and Pressor Properties of Big-Endothelin-1
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Functional Analysis of Five Endothelin-B Receptor Mutations Found in Human Hirschsprung Disease Patients
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Characterization of Endothelin Receptors in Human Brain Cortex, Gliomas, and Meningiomas
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Role of the renin–angiotensin–aldosterone system in collecting duct-derived endothelin-1 regulation of blood pressureThis article is one of a selection of papers published in the special issue (part 1 of 2) on Forefronts in Endothelin.
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High Levels of Endothelin (ET)-1 and Aneurysm Diameter Independently Predict Growth of Stable Abdominal Aortic Aneurysms
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Why two endothelins and two receptors for ovulation and luteal regulation?
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Vascular Endothelium Derived Endothelin-1 Is Required for Normal Heart Function after Chronic Pressure Overload in Mice
Susi Heiden, Nicolas Vignon‐Zellweger, Shigeru Masuda · 2014 · PLoS ONE
Stimulation of phospholipase C in cultured microvascular endothelial cells from human frontal lobe by histamine, endothelin and purinoceptor agonists
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Twenty-four-hour endothelin-1 secretory pattern in stroke patients
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Endothelial ETB Limits Vascular Remodelling and Development of Pulmonary Hypertension during Hypoxia
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Allosteric Inhibition of Endothelin ETA Receptors by 3,5-Dibromosalicylic Acid
Virginie Blandin, Paul Vigne, Jean Philippe Breittmayer · 2000 · Molecular Pharmacology
β-Arrestin-biased signaling of PTH analogs of the type 1 parathyroid hormone receptor
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Renoprotective effects of combined endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 in acute and chronic experimental renal damage.
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Truncated human endothelin receptor A produced by alternative splicing and its expression in melanoma
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Differences between endothelin receptors mediating contraction of guinea-pig aorta and pig coronary artery
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