Endothelin

Davenport, Anthony P., Hyndman, Kelly A., Dhaun, Neeraj, Southan, Christopher, Kohan, Donald E., Pollock, Jennifer S., Pollock, David M., Webb, David J. +1 more·2016·Pharmacological Reviews

DOI 10.1124/pr.115.011833

Cites (650)

Items 201–400 of 650

Direct Action of Endothelin-1 on Podocytes Promotes Diabetic Glomerulosclerosis
Olivia Lenoir, Marine Milon, Anne Virsolvy, Carole Hénique, Alain Schmitt, Jean‐Marc Massé, Yuri V. Kotelevtsev, Masashi Yanagisawa, David John Webb, Sylvain Richard et al. · 2014 · Journal of the American Society of Nephrology
Chronic Endothelin Receptor Antagonism Preserves Coronary Endothelial Function in Experimental Hypercholesterolemia
Patricia J.M. Best, Charles J. McKenna, David Hasdai · 1999 · Circulation
Endothelin Receptors and Their Antagonists
Janet J. Maguire, Anthony P. Davenport · 2015 · Seminars in Nephrology
Macitentan: entry-into-humans study with a new endothelin receptor antagonist
Patricia N. Sidharta, Paul L. M. van Giersbergen, Atef Halabi, Jasper Dingemanse · 2011 · European Journal of Clinical Pharmacology
Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castration‐resistant prostate cancer and bone metastases who were pain‐free or mildly symptomatic for pain: a double‐blind, placebo‐controlled, randomized Phase II trial
Nicholas David James, Armelle Caty, Heather Ann Payne, Michael Borre, Bernard A. Zonnenberg, Philippe Beuzeboc, Stuart McIntosh, Thomas Morris, De Phung, Nancy Ann Dawson · 2010 · British Journal of Urology
A Novel Pathway Involving Progesterone Receptor, Endothelin-2, and Endothelin Receptor B Controls Ovulation in Mice
Gopinath S. Palanisamy, Yong‐Pil Cheon, Jaeyeon Kim, Athilakshmi Kannan, Quanxi Li, Marcey Sato, Srinivasa Raju Mantena, Regine L. Sitruk-Ware, Milan K. Bagchi, Indrani C. Bagchi · 2006 · Molecular Endocrinology
Efficacy and Safety of Darusentan in Patients With Resistant Hypertension: Results From a Randomized, Double‐Blind, Placebo‐Controlled Dose‐Ranging Study
Henry Richard Black, George L. Bakris, Michael A. Weber et al. · 2007 · Journal of Clinical Hypertension
Palmitoylation of Endothelin Receptor A
Angelika Horstmeyer, Henning Cramer, Tobias Sauer · 1996 · Journal of Biological Chemistry
Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture.
Michael W. Phelan, Susan P. Perrine, Mark J. Brauer, Douglas V. Faller · 1995 · Journal of Clinical Investigation
Endothelial Dysfunction and Mild Renal Insufficiency in Essential Hypertension
Francesco Perticone, Raffaele Maio, Giovanni Luigi Tripepi, Carmine Zoccali · 2004 · Circulation
EndothelinB receptor‐mediated contraction in human pulmonary resistance arteries
Kirsty M. McCulloch, Cheryl C. Docherty, Ian Morecroft · 1996 · British Journal of Pharmacology
Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality
Yuqiang Ge, Do Whan Ahn, Peter K. Stricklett · 2005 · American Journal of Physiology-Renal Physiology
Endothelin-1 Overexpression Exacerbates Atherosclerosis and Induces Aortic Aneurysms in Apolipoprotein E Knockout Mice
Melissa W. Li, Muhammad Oneeb Rehman Mian, Tlili Barhoumi · 2013 · Arteriosclerosis Thrombosis and Vascular Biology
Regional haemodynamic effects of endothelin-1 in rat and man: unexpected adverse reactions
Björn Dahlöf, David Gustafsson, Thomas Hedner · 1990 · Journal of Hypertension
Signaling by ALK5 mediates TGF-β-induced ET-1 expression in endothelial cells: a role for migration and proliferation
Cristina Castañares, Mariano Redondo‐Horcajo, Noemi Magán-Marchal, Peter ten Dijke, Santiago Lamas, Fernando Rodríguez‐Pascual · 2007 · Journal of Cell Science
Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention
Yuqiang Ge, Alan J. Bagnall, Peter K. Stricklett, David John Webb, Yuri V. Kotelevtsev, Donald E. Kohan · 2008 · American Journal of Physiology-Renal Physiology
A Role for Endothelin-2 and Its Receptors in Breast Tumor Cell Invasion
Matthew J. Grimshaw, Thorsten Hagemann, A. Ayhan, Cheryl Gillett, Claudia Rebecca Binder, Frances R. Balkwill · 2004 · Cancer Research
Endothelin
Anthony P. Davenport, Janet J. Maguire · 2006 · Springer eBooks
Regulation of the epithelial Na + channel by endothelin-1 in rat collecting duct
Vladislav Bugaj, Oleh M. Pochynyuk, Elena Mironova, Alain Vandewalle, Jorge Medina, James D. Stockand · 2008 · American Journal of Physiology-Renal Physiology
Subtype selectivity of a novel endothelin antagonist, FR139317, for the two endothelin receptors in transfected Chinese hamster ovary cells.
Ichiro Aramori, Hisataka Nirei, Miwako Shoubo · 1993 · Molecular Pharmacology
Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure
Yuqiang Ge, Peter K. Stricklett, Alisa K. Hughes · 2005 · American Journal of Physiology-Renal Physiology
Relationship between endothelin‐1 binding site densities and constrictor activities in human and animal airway smooth muscle
Peter J. Henry, Paul J. Rigby, Glenn J. Self · 1990 · British Journal of Pharmacology
Metabolism of Big endothelin-1 (1–38) and (22–38) in the human circulation in relation to production of endothelin-1 (1–21)
Anette Hemsén, Gunvor AHLBORG, A. Ottosson-Seeberger · 1995 · Regulatory Peptides
Deletion of Endothelial Cell Endothelin B Receptors Does Not Affect Blood Pressure or Sensitivity to Salt
Alan J. Bagnall, Nicholas F. Kelland, Fiona Gulliver-Sloan, Anthony P. Davenport, Gillian A. Gray, Masashi Yanagisawa, David John Webb, Yuri V. Kotelevtsev · 2006 · Hypertension
MCP-1-mediated chemotaxis requires activation of non-overlapping signal transduction pathways
Hua-hsing Yen, Yujun Zhang, Sonya S. Penfold · 1997 · Journal of Leukocyte Biology
Endothelin‐1‐induced ETA receptor‐mediated nociception, hyperalgesia and oedema in the mouse hind‐paw: modulation by simultaneous ETB receptor activation
Anna Paula Piovezan, Pedro D’Orléans-Juste, Glória Emília Petto de Souza · 2000 · British Journal of Pharmacology
Low Blood Pressure in Endothelial Cell–Specific Endothelin 1 Knockout Mice
Yaz Y. Kisanuki, Noriaki Emoto, Takashi Ohuchi et al. · 2010 · Hypertension
Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter?
Christian F. Opitz, Ralf Ewert, Wilhelm Kirch, David Pittrow · 2008 · European Heart Journal
The role of the paracrine/autocrine mediator endothelin‐1 in regulation of cardiac contractility and growth
Faye Drawnel, Caroline R. Archer, H. Llewelyn Roderick · 2012 · British Journal of Pharmacology
Localization of endothelin peptides in human kidney
Fiona E. Karet, Anthony P. Davenport · 1996 · Kidney International
A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy
Xinyu Weng, Liming Yu, Peng Liang, Luyang Li, Xin Jun Dai, Bisheng Zhou, Xiaoyan Wu, Huihui Xu, Mingming Fang, Qi Chen et al. · 2015 · Journal of Molecular and Cellular Cardiology
Endothelin-1 in chronic renal failure and hypertension
Richard Larivière, Marcel Lebel · 2003 · Canadian Journal of Physiology and Pharmacology
Multiple‐Dose Pharmacokinetics, Safety, and Tolerability of Bosentan, an Endothelin Receptor Antagonist, in Healthy Male Volunteers
Cornelia Weber, Rita Schmitt, Herbert Birnboeck, Gérard Hopfgartner D, Herwig Eggers, Joseph Meyer, Sjoerd van Marle, H.W. Visscher, Jan H. G. Jonkman · 1999 · The Journal of Clinical Pharmacology
Clinical trials with endothelin receptor antagonists: What went wrong and where can we improve?
Donald E. Kohan, John G.F. Cleland, Lewis J. Rubin, Dan Theodorescu, Matthias Barton · 2012 · Life Sciences
β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling
Laura Rosanò, Roberta Cianfrocca, Piera Tocci · 2012 · Oncogene
Novel Mutations of the Endothelin B Receptor Gene in Patients with Hirschsprung's Disease and Their Characterization
Hirokazu Tanaka, Kayoko Moroi, Jun Iwai et al. · 1998 · Journal of Biological Chemistry
Characterization of the Renal Phenotype of Transgenic Rats Expressing the Human Endothelin-2 Gene
Berthold Hocher, Lutz Liefeldt, Christa Thöne‐Reineke · 1996 · Hypertension
Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in the rat
Petter J Vikman, Saema Beg, Tejvir Khurana · 2006 · Journal of neurosurgery
Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1
Takayuki Shindo, Hiroki Kurihara, Koji Maemura et al. · 2002 · Journal of Molecular Medicine
Dual Angiotensin II and Endothelin A Receptor Antagonists: Synthesis of 2‘-Substituted N-3-Isoxazolyl Biphenylsulfonamides with Improved Potency and Pharmacokinetics
Natesan Murugesan, Zhengxiang Gu, Leena Fadnis et al. · 2004 · Journal of Medicinal Chemistry
Expression of endothelin-1, ETAand ETBreceptors, and ECE and distribution of endothelin-1 in failing rat heart
Tsutomu Kobayashi, Takashi Miyauchi, Satoshi Sakai · 1999 · American Journal of Physiology-Heart and Circulatory Physiology
Collecting Duct-Derived Endothelin Regulates Arterial Pressure and Na Excretion via Nitric Oxide
Markus Peter Schneider, Yuqiang Ge, David M. Pollock, Jennifer S. Pollock, Donald E. Kohan · 2008 · Hypertension
The crystal structure of human endothelin
Robert W. Janes, Diane H. Peapus, Bonnie Ann Wallace · 1994 · Nature Structural & Molecular Biology
Pharmacology and Physiopathology of the Brain Endothelin System: An Overview
Sergio Schinelli · 2006 · Current Medicinal Chemistry
ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy
Suko Adiarto, Susi Heiden, Nicolas Vignon‐Zellweger, Kazuhiko Nakayama, Keiko Yagi, Masashi Yanagisawa, Noriaki Emoto · 2012 · Life Sciences
Systemic ETA receptor antagonism with BQ‐123 blocks ET‐1 induced forearm vasoconstriction and decreases peripheral vascular resistance in healthy men
James Spratt, Jane G. Goddard, Neil Patel, Fiona E. Strachan, Andrew J. Rankin, David John Webb · 2001 · British Journal of Pharmacology
Effects of Endothelin-1 and Endothelin-1 Receptor Blockade on Cardiac Output, Aortic Pressure, and Pulse Wave Velocity in Humans
Tycho Vuurmans, Peter de Boer, Hein A. Koomans · 2003 · Hypertension
Endogenous Endothelin-1 Is Required for Cardiomyocyte Survival In Vivo
Xiao-Song Zhao, Wentong Pan, Raffi Bekeredjian · 2006 · Circulation
Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1
Tomoyuki Kuwaki, W. H. Cao, Yukiko Kurihara, Hiroki Kurihara, G.Y. Ling, M. Onodera, K. Ju, Y Yazaki, M. Kumada · 1996 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy
Ralph V. Shohet, Yaz Y. Kisanuki, Xiao-Song Zhao · 2004 · Proceedings of the National Academy of Sciences
Vascular Endothelin-B Receptor System In Vivo Plays a Favorable Inhibitory Role in Vascular Remodeling After Injury Revealed by Endothelin-B Receptor–Knockout Mice
Nobuyuki Murakoshi, Takashi Miyauchi, Yoshihiko Kakinuma, Takashi Ohuchi, Katsutoshi Goto, Masashi Yanagisawa, Iwao Yamaguchi · 2002 · Circulation
Contribution of Endothelin A Receptors in Endothelin 1–Dependent Natriuresis in Female Rats
Daisuke Nakano, David M. Pollock · 2008 · Hypertension
Endothelin in hypertension
Yohann Rautureau, Ernesto L. Schiffrin · 2012 · Current Opinion in Nephrology & Hypertension
Vascular Endothelin-1 Gene Expression and Synthesis and Effect on Renal Type I Collagen Synthesis and Nephroangiosclerosis During Nitric Oxide Synthase Inhibition in Rats
Pierre‐Louis Tharaux, Christos Chatziantoniou, Daniel Casellas, Laura Fouassier, Raymond Ardaillou, Jean‐Claude Dussaule · 1999 · Circulation
Endothelin-converting Enzymes Degrade Intracellular β-Amyloid Produced within the Endosomal/Lysosomal Pathway and Autophagosomes*
Javier Pacheco-Quinto, E. Eckman · 2013 · Journal of Biological Chemistry
Endothelin Receptor B Inhibition Triggers Apoptosis and Enhances Angiogenesis in Melanomas
Ronit Lahav, Mario-Luca Suvà, Donata Rimoldi, Paul H. Patterson, Ivan Stamenkovic · 2004 · Cancer Research
Differential activities of two distinct endothelin family peptides on ileum and coronary artery
Norio Ishida, Keiji Tsujioka, Masaaki Tomoi · 1989 · FEBS Letters
Elevation of blood pressure by genetic and pharmacological disruption of the ETBreceptor in mice
Takashi Ohuchi, Tomoyuki Kuwaki, Guang‐Yi Ling, Damiane deWit, Kihwan Ju, Makoto Onodera, Weihua Cao, Masashi Yanagisawa, Mamoru Kumada · 1999 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Cardiomyocyte-Specific Endothelin A Receptor Knockout Mice Have Normal Cardiac Function and an Unaltered Hypertrophic Response to Angiotensin II and Isoproterenol
Rafal M. Kedzierski, Paul Arthur Grayburn, Yaz Y. Kisanuki · 2003 · Molecular and Cellular Biology
Endothelin Receptor Antagonists for Aneurysmal Subarachnoid Hemorrhage
Mervyn D. I. Vergouwen, Ale Algra, Gabriël J.E. Rinkel · 2012 · Stroke
Endothelin Receptor Antagonist Increases Cerebral Perfusion and Reduces Ischaemic Damage in Feline Focal Cerebral Ischaemia
Toshal R. Patel, S Galbraith, David Ian Graham · 1996 · Journal of Cerebral Blood Flow & Metabolism
Renal medullary ETBreceptors produce diuresis and natriuresis via NOS1
Daisuke Nakano, Jennifer S. Pollock, David M. Pollock · 2008 · American Journal of Physiology-Renal Physiology
Blockade of endothelin receptors markedly reduces atherosclerosis in LDL receptor deficient mice: role of endothelin in macrophage foam cell formation
Saeid Babaei · 2000 · Cardiovascular Research
Pharmacokinetics and Safety of Ambrisentan in Combination With Sildenafil in Healthy Volunteers
Rebecca Spence, Arun Mandagere, Christopher Dufton · 2008 · The Journal of Clinical Pharmacology
Safety, tolerability, pharmacokinetics, and pharmacodynamics of macitentan, an endothelin receptor antagonist, in an ascending multiple‐dose study in healthy subjects
Patricia N. Sidharta, Paul L. M. van Giersbergen, Jasper Dingemanse · 2013 · The Journal of Clinical Pharmacology
A reversible radioligand specific for the ETB receptor: [125I]Tyr13-Suc-[Glu9,Ala11,15]-endothelin-1(8–21), [125I]IRL 1620
Tadashi Watakabe, Yoshihiro Urade, Michihiro Takai · 1992 · Biochemical and Biophysical Research Communications
Endothelin Receptor Antagonists and Cerebral Vasospasm: An Update
Michael Chow, Aaron S. Dumont, Neal F. Kassell · 2002 · Neurosurgery
Endothelium-derived relaxing factor modulates endothelin action in afferent arterioles.
Sadayoshi Ito, Luis Augusto Juncos, Noboru Nushiro, Cynthia S. Johnson, Oscar A. Carretero · 1991 · Hypertension
Analysis of two pharmacologically predicted endothelin B receptor subtypes by using the endothelin B receptor gene knockout mouse
Tadahiko Mizuguchi, Mariko Nishiyama, Kayoko Moroi · 1997 · British Journal of Pharmacology
Endothelin‐1 Receptor Binding and Cellular Signal Transduction in Cultured Human Brain Endothelial Cells
Danica B Stanimirovic, Toshifumi Yamamoto, Sumio Uematsu · 1994 · Journal of Neurochemistry
Anatomical localization and pharmacological activity of mature endothelins and their precursors in human vascular tissue
Paisley G. Howard, Christopher Plumpton, Anthony P. Davenport · 1992 · Journal of Hypertension
Coronary Vasodilation and Improvement in Endothelial Dysfunction With Endothelin ET A Receptor Blockade
Julian Halcox, Khaled R.A. Nour, Gloria Zalos · 2001 · Circulation Research
Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans
Shirin Bruderer, Gérard Hopfgartner, Michael Seiberling · 2012 · Xenobiotica
Efficacy, safety and clinical pharmacology of macitentan in comparison to other endothelin receptor antagonists in the treatment of pulmonary arterial hypertension
Dingemanse, Jasper, Sidharta, Patricia N, Maddrey, Willis C, Rubin, Lewis J, Mickail, Hani · 2014 · Expert Opinion on Drug Safety
[125I]‐PD 151242: a selective radioligand for human ETA receptors
Anthony P. Davenport, Rhoda E. Kuc, Fiona Fitzgerald · 1994 · British Journal of Pharmacology
Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells.
Matthew J. Grimshaw, Stuart Naylor, Frances R. Balkwill · 2002 · PubMed
Relationship between Albuminuria and Cardiovascular Disease in Type 2 Diabetes
Barry I. Freedman, Carl D. Langefeld, Kurt K. Lohman · 2005 · Journal of the American Society of Nephrology
Endothelin Receptor Dimers Evaluated by FRET, Ligand Binding, and Calcium Mobilization
Nathan J. Evans, Jeffery W. Walker · 2008 · Biophysical Journal
Chronic hypertension produced by infusion of endothelin in rats.
Luke H. Mortensen, C M Pawloski, Nancy Lapp Kanagy · 1990 · Hypertension
On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancer
Martin Smollich, Martin Götte, George W. Yip · 2007 · Breast Cancer Research and Treatment
Selective and mixed endothelin receptor antagonism in cardiovascular disease
Neeraj Dhaun, David M. Pollock, J. Goddard · 2007 · Trends in Pharmacological Sciences
Recent heart failure trials of neurohormonal modulation (OVERTURE and ENABLE): Approaching the asymptote of efficacy?
John R. Teerlink · 2002 · Journal of Cardiac Failure
Regional Hemodynamic Effects and Clearance of Endothelin-1 in Humans
Slobodan Gasic, Oswald F Wagner, Heinrich Vierhapper · 1992 · Journal of Cardiovascular Pharmacology
Endothelin‐2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer
Lowell Ling, Janet J. Maguire, Anthony P. Davenport · 2011 · British Journal of Pharmacology
The mechanism of action of endothelin in human lung
Karen McKay, Judith Lee Black, Carol Lyn Armour · 1991 · British Journal of Pharmacology
Gender Differences in ET and NOS Systems in ET B Receptor–Deficient Rats
Traci A. Taylor, Cheryl E. Gariepy, David M. Pollock · 2003 · Hypertension
Development and persistence of catecholaminergic neurons in cultured explants of fetal murine vagus nerves and bowel
Greg Baetge, Kerry Schneider, Michael David Gershon · 1990 · Development
MicroRNAs in pulmonary arterial remodeling
Jennifer S. Grant, Kevin White, Margaret R. MacLean, Andrew Howard Baker · 2013 · Cellular and Molecular Life Sciences
Cardiac-specific knockout of ETA receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction
Yingmei Zhang, Linlin Li, Yinan Hua, Jennifer M. Nunn, Feng Dong, Masashi Yanagisawa, Jun Tao Ren · 2012 · Journal of Molecular Cell Biology
Role of endothelin in acute renal failure due to rhabdomyolysis in rats.
Habib Karam, Patrick Bruneval, Jean‐Paul Clozel · 1995 · Journal of Pharmacology and Experimental Therapeutics
Presence of messenger ribonucleic acid for endothelin-1, endothelin-2, and endothelin-3 in human endometrium and a change in the ratio of ETA and ETB receptor subtype across the menstrual cycle
G O'Reilly, David S. Jones, Anthony P. Davenport, I T Cameron, S. Kaye Smith · 1992 · The Journal of Clinical Endocrinology & Metabolism
Two distinct human endothelin B receptors generated by alternative splicing from a single gene.
V Shyamala, Moulthrop Th, Jennifer R. Stratton-Thomas · 1994 · PubMed
In-vivo interaction of nitric oxide and endothelin
Berthold Hocher, Anja Schwarz, Torsten Slowinski · 2003 · Journal of Hypertension
Endothelin receptors in human coronary artery and aorta
Caragh R. Bacon, Anthony P. Davenport · 1996 · British Journal of Pharmacology
β-Arrestin 1 is required for endothelin-1-induced NF-κB activation in ovarian cancer cells
Roberta Cianfrocca, Piera Tocci, Elisa Semprucci · 2014 · Life Sciences
Vasoconstrictor endothelin receptors characterized in human renal artery and vein in vitro
Janet J. Maguire, Rhoda E. Kuc, Gillian O'Reilly · 1994 · British Journal of Pharmacology
Ambrisentan, a Non‐peptide Endothelin Receptor Antagonist
Hartmut Vatter, Volker Seifert · 2006 · Cardiovascular Drug Reviews
Endothelial cell-specific ETB receptor knockout: autoradiographic and histological characterisation and crucial role in the clearance of endothelin-1This article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.
Nicholas F. Kelland, Rhoda E. Kuc, Danielle L. McLean et al. · 2010 · Canadian Journal of Physiology and Pharmacology
Endothelin-1 stimulates NO production and inhibits cAMP accumulation in rat inner medullary collecting duct through independent pathways
Peter K. Stricklett, Alisa K. Hughes, Donald E. Kohan · 2005 · American Journal of Physiology-Renal Physiology
Endothelin Is a Potent Constrictor of Human Intracranial Arteries and Veins
Jan Erik Hardebo, J. Kåhrström, Christer Owman · 2008 · Blood Vessels
Nitric oxide‐mediated modulation of the endothelin‐1 signalling pathway in the human cardiovascular system
Katherine E. Wiley, Anthony P. Davenport · 2001 · British Journal of Pharmacology
Sulfenic Acid Modification of Endothelin B Receptor is Responsible for the Benefit of a Nonsteroidal Mineralocorticoid Receptor Antagonist in Renal Ischemia
Jonatan Barrera‐Chimal, Sonia Prince, Fouad Fadel, Soumaya El Moghrabi, David G. Warnock, Peter Kolkhof, Frédéric Jaisser · 2015 · Journal of the American Society of Nephrology
Molecular Characterization of a Novel Human Endothelin Receptor Splice Variant
Nabil A. Elshourbagy, John E. Adamou, Alison W. Gagnon · 1996 · Journal of Biological Chemistry
Characterization of two new ETB selective radioligands, [125I]‐BQ3020 and [125I]‐[Ala1,3,11,15]ET‐1 in human heart
Peter C. M. Molenaar, Rhoda E. Kuc, Anthony P. Davenport · 1992 · British Journal of Pharmacology
The increase in human plasma immunoreactive endothelin but not big endothelin‐1 or its C‐terminal fragment induced by systemic administration of the endothelin antagonist TAK‐044
Christopher Plumpton, Charles Joseph Ferro, William Geoffrey Haynes · 1996 · British Journal of Pharmacology
Sitaxsentan Treatment for Patients With Pulmonary Arterial Hypertension Discontinuing Bosentan
Raymond L. Benza, Sanjay Mehta, ANNE M. KEOGH · 2007 · The Journal of Heart and Lung Transplantation
Positron emission tomography using 18F‐labelled endothelin‐1 reveals prevention of binding to cardiac receptors owing to tissue‐specific clearance by ETB receptors in vivo
Peter Johnström, Tim D. Fryer, Hugh K. Richards · 2004 · British Journal of Pharmacology
Lack of Endothelial Nitric Oxide Synthase Promotes Endothelin-Induced Hypertension
Thomas Quaschning, Florian Voß, Katharina Relle et al. · 2007 · Journal of the American Society of Nephrology
Acute alterations of endothelin-1 and iNOS expression and control of the brain microcirculation after head trauma
Theodor Petrov, José A. Rafols · 2001 · Neurological Research
Coupling of endothelin receptors to the ERK/MAP kinase pathway
Henning Cramer, Kai Schmenger, Khristina Heinrich · 2001 · European Journal of Biochemistry
Collecting duct-specific endothelin B receptor knockout increases ENaC activity
Vladislav Bugaj, Elena Mironova, Donald E. Kohan, James D. Stockand · 2011 · American Journal of Physiology-Cell Physiology
Reversal of established responses to endothelin‐1 in vivo and in vitro by the endothelin receptor antagonists, BQ‐123 and PD 145065
Timothy David Warner, Graham H. Allcock, John Robert Vane · 1994 · British Journal of Pharmacology
Functional properties of cultured endothelial cells derived from large microvessels of human brain
Maria Spatz, N. Kawai, N. Merkel · 1997 · American Journal of Physiology-Cell Physiology
A Phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma
Richard F. Kefford, Jane McNeil Beith, Guy A. Van Hazel et al. · 2006 · Investigational New Drugs
Evidence for the endothelin system as an emerging therapeutic target for the treatment of chronic pain
Terika P. Smith, Tami Haymond, Sherika N. Smith · 2014 · Journal of Pain Research
Endothelin-1 Signaling in Vascular Physiology and Pathophysiology
Yessica-Haydee Gomez Sandoval, Mohammed Atef, Louis-Olivier Lévesque · 2014 · Current Vascular Pharmacology
Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies
Jerry L. Wessale, Andrew L. Adler, Eugene I. Novosad et al. · 2002 · Clinical Science
Endothelium‐dependent vascular activities of endothelin‐like peptides in the isolated superior mesenteric arterial bed of the rat
Stephen A. Douglas, C. Robin Hiley · 1990 · British Journal of Pharmacology
ET-1 deletion from endothelial cells protects the kidney during the extension phase of ischemia/reperfusion injury
Nur Arfian, Noriaki Emoto, Nicolas Vignon‐Zellweger · 2012 · Biochemical and Biophysical Research Communications
Control of Vascular Tone by Endogenous Endothelin-1 in Human Pial Arteries
Éric Thorin, Thanh-Dung Nguyen, Alain Bouthillier · 1998 · Stroke
A review of the profile of endothelin axis in cancer and its management
Soussan Irani, Ali Salajegheh, Robert Anthony Smith, Alfred King-yin Lam · 2013 · Critical Reviews in Oncology/Hematology
ETAreceptor blockade attenuates the hypertension but not renal dysfunction in DOCA-salt rats
Graham H. Allcock, Richard C. Venema, David M. Pollock · 1998 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Expression of EndothelinA Receptors in Human Gliomas and Meningiomas, with High Affinity for the Selective Antagonist PD156707
Spencer P. Harland, Rhoda E. Kuc, John Douglas Pickard · 1998 · Neurosurgery
Exaggerated Vascular and Renal Pathology in Endothelin-B Receptor–Deficient Rats With Deoxycorticosterone Acetate–Salt Hypertension
Yasuo Matsumura, Toshihiko Kuro, Yutaka Kobayashi, Fumiko Konishi, Masanori Takaoka, Jerry L. Wessale, Terry J. Opgenorth, Cheryl E. Gariepy, Masashi Yanagisawa · 2000 · Circulation
Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men
Christian M. Westby, Brian Raymond Weil, Jared J. Greiner, Brian L. Stauffer, Christopher A. DeSouza · 2011 · Clinical Science
Receptors for endothelin‐1 in asthmatic human peripheral lung
Patrick G. Knott, Angela C. D'Aprile, Peter J. Henry · 1995 · British Journal of Pharmacology
Endothelin@25 – new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR R eview 12
Janet J. Maguire, Anthony P. Davenport · 2014 · British Journal of Pharmacology
Endothelin A Receptor Antagonism and Angiotensin-Converting Enzyme Inhibition Are Synergistic via an Endothelin B Receptor–Mediated and Nitric Oxide–Dependent Mechanism
Jane G. Goddard, Corine Eckhart, Neil Russell Johnston · 2004 · Journal of the American Society of Nephrology
Characterization of Endothelin-converting Enzyme-2
Nino Mzhavia, Hui‐Lin Pan, Fa‐Yun Che, Lloyd D. Fricker, Lakshmi A. Devi · 2003 · Journal of Biological Chemistry
Endogenous Endothelin in Human Coronary Vascular Function
Julian Halcox, Khaled R.A. Nour, Gloria Zalos · 2007 · Hypertension
Impaired development of the thyroid and thymus in endothelin-1 knockout mice.
Yukiko Kurihara, Hiroki Kurihara, K Maemura, Tomoyuki Kuwaki, M Kumada, Yoshio Yazaki · 1995 · PubMed
Endothelins activate Ca2+-gated K+channels via endothelin B receptors in CD-1 mouse erythrocytes
Alicia Rivera, Michelle A. Rotter, Carlo Brugnara · 1999 · American Journal of Physiology-Cell Physiology
ETA Receptors Predominate in the Human Vasculature and Mediate Constriction
Anthony P. Davenport, Rhoda E. Kuc, Janet J. Maguire · 1995 · Journal of Cardiovascular Pharmacology
Endothelin Receptor Antagonists and Cerebral Vasospasm: An Update
Michael Chow, Aaron S. Dumont, Neal F. Kassell · 2002 · Neurosurgery
Localization of immunoreactive endothelin and proendothelin in the human lung
Stefan John Marciniak, Christopher Plumpton, Pat J. Barker · 1992 · Pulmonary Pharmacology
A review of pulmonary arterial hypertension: role of ambrisentan.
Robyn J. Barst · 2007 · PubMed Central
Endothelin B receptor agonist, IRL-1620, enhances angiogenesis and neurogenesis following cerebral ischemia in rats
Mary G. Leonard, Anil Gulati · 2013 · Brain Research
Endothelin B receptor agonist, IRL-1620, reduces neurological damage following permanent middle cerebral artery occlusion in rats
Mary G. Leonard, Seema Briyal, Anil Gulati · 2011 · Brain Research
Phosphoramidon inhibition of the in vivo conversion of big endothelin‐1 to endothelin‐1 in the human forearm
Christopher Plumpton, William Geoffrey Haynes, David John Webb · 1995 · British Journal of Pharmacology
Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade
Catherine K. Hathaway, Ruriko Grant, John R. Hagaman, Sylvia Hiller, Feng Li, Longquan Xu, Albert S. Chang, Victoria J. Madden, C. Robert Bagnell, Mauricio Rojas et al. · 2015 · Proceedings of the National Academy of Sciences
Endothelin-receptor antagonist treatment of portopulmonary hypertension
Lukas Hinterhuber, I Graziadei, Christian M. Kähler · 2004 · Clinical Gastroenterology and Hepatology
The interplay between hypoxia, endothelial and melanoma cells regulates vascularization and cell motility through endothelin-1 and vascular endothelial growth factor
Francesca Spinella, Valentina Caprara, Roberta Cianfrocca, Laura Rosanò, Valeriana Di Castro, Emirena Garrafa, Pier Giorgio Natali, Anna Bagnato · 2014 · Carcinogenesis
ETA Receptors Predominate in the Human Vasculature and Mediate Constriction
Anthony P. Davenport, Rhoda E. Kuc, Janet J. Maguire · 1995 · Journal of Cardiovascular Pharmacology
Subtype-Specific Desensitization of Human Endothelin ETA and ETB Receptors Reflects Differential Receptor Phosphorylation
Henning Cramer, Werner Müller‐Esterl, Christian Schroeder · 1997 · Biochemistry
Endothelium-Dependent Modulation of Responses to Endothelin-1 in Human Veins
William Geoffrey Haynes, David J. Webb · 1993 · Clinical Science
Specific expression of human endothelin‐2 (ET‐2) gene in a renal adenocarcinoma cell line
Shoichi Ohkubo, K Ogi, Masaki Hosoya · 1990 · FEBS Letters
The Prepro Vasoactive Intestinal Contractor (VIC)/Endothelin-2 Gene (EDN2): Structure, Evolution, Production, and Embryonic Expression
Kaname Saida, Masao Hashimoto, Youji Mitsui · 2000 · Genomics
Endothelin, Kidney Disease, and Hypertension
Joshua S. Speed, David M. Pollock · 2013 · Hypertension
Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease
Neeraj Dhaun, Charles Joseph Ferro, Anthony P. Davenport · 2007 · Nephrology Dialysis Transplantation
Nitric oxide inhibits endothelin-1 production through the suppression of nuclear factor κB
Mamoru Ohkita, Masanori Takaoka, Yasuko Shiota, Rumi Nojiri, Yasuo Matsumura · 2002 · Clinical Science
Cloning and Sequencing of a Human Endothelin Converting Enzyme in Renal Adenocarcinoma (ACHN) Cells Producing Endothelin-2
Kazuyuki Yorimitsu, Kayoko Moroi, Nobuya Inagaki · 1995 · Biochemical and Biophysical Research Communications
The ovarian endothelin network: an evolving story
Rina Meidan, Nitzan Levy · 2007 · Trends in Endocrinology and Metabolism
Modeling and Docking the Endothelin G-Protein-Coupled Receptor
Andrew J. W. Orry, Bonnie Ann Wallace · 2000 · Biophysical Journal
Endothelin receptors, renal effects and blood pressure
Erika Ingrid Boesen · 2014 · Current Opinion in Pharmacology
Effects of endothelin-1 on capsaicin-induced nociception in mice
Anna Paula Piovezan, Pedro D’Orléans-Juste, Carlos Rogério Tonussi · 1998 · European Journal of Pharmacology
Renal sympathetic nerve activity in mice: comparison between mice and rats and between normal and endothelin-1 deficient mice
Guang‐Yi Ling, Wei-Hua Cao, Makoto Onodera, Kihwan Ju, Hiroki Kurihara, Yukiko Kurihara, Yoshio Yazaki, Mamoru Kumada, Yasuichiro Fukuda, Tomoyuki Kuwaki · 1998 · Brain Research
Macitentan: First Global Approval
Trina Patel, Kate McKeage · 2013 · Drugs
Detection of Endothelin Receptors in Human Coronary Artery Vascular Smooth Muscle Cells But Not Endothelial Cells by Using Electron Microscope Autoradiography
Fraser D. Russell, Jeremy N. Skepper, Anthony P. Davenport · 1997 · Journal of Cardiovascular Pharmacology
Improvement of Postischemic Acute Renal Failure with the Novel Orally Active Endothelin-A Receptor Antagonist LU 135252 in the Rat
Rainer Birck, Thomas Martin Knoll, Claude Braun · 1998 · Journal of Cardiovascular Pharmacology
Impaired Development of the Thyroid and Thymus in Endothelin-1 Knockout Mice
Yukiko Kurihara, Hiroki Kurihara, Koji Maemura, Tomoyuki Kuwaki, Mamoru Kumada, Yoshio Yazaki · 1995 · Journal of Cardiovascular Pharmacology
Epigenetic inactivation of endothelin‐2 and endothelin‐3 in colon cancer
Rong Wang, Christiane V. Löhr, Kay A. Fischer · 2012 · International Journal of Cancer
Characterization of the endothelin receptor selective agonist, BQ3020 and antagonists BQ123, FR139317, BQ788, 50235, Ro462005 and bosentan in the heart
Markus G. Peter, Anthony P. Davenport · 1996 · British Journal of Pharmacology
Expression of the Endothelin-Converting Enzyme Gene in Human Tissues
Gian Paolo Rossi, Giovanna Albertin, Elisa Franchin · 1995 · Biochemical and Biophysical Research Communications
Abnormalities of Endothelial Function in the Pathogenesis of Stroke: The Importance of Endothelin
Massimo Volpe, Francesco Cosentino · 2000 · Journal of Cardiovascular Pharmacology
Salt-dependency of endothelin-induced, chronic hypertension in conscious rats.
Luke H. Mortensen, Gregory D. Fink · 1992 · Hypertension
Loss of Endothelial Furin Leads to Cardiac Malformation and Early Postnatal Death
Woo Jin Kim, Rachid Essalmani, Dorota Szumska · 2012 · Molecular and Cellular Biology
Processing of proendothelin‐1 by members of the subtilisin‐like pro‐protein convertase family
Véronique Blais, Martin Fugère, Jean‐Bernard Denault · 2002 · FEBS Letters
Chronic ETA receptor blockade prevents endothelial dysfunction of small arteries in apolipoprotein E-deficient mice
Livius V. d’Uscio · 2002 · Cardiovascular Research
Physiological antagonism of endothelin‐1 in human conductance and resistance coronary artery
Katherine E. Wiley, Anthony P. Davenport · 2001 · British Journal of Pharmacology
ENDOTHELIN IN THE CENTRAL CONTROL OF CARDIOVASCULAR AND RESPIRATORY FUNCTIONS
Tomoyuki Kuwaki, Gy Ling, M Onodera et al. · 1999 · Clinical and Experimental Pharmacology and Physiology
Blockade and Reversal of Endothelin-Induced Constriction in Pial Arteries From Human Brain
Lisa N. Pierre, Anthony P. Davenport · 1999 · Stroke
Characterization of the binding of endothelin ETB selective ligands in human and rat heart
Fraser D. Russell, Anthony P. Davenport · 1996 · British Journal of Pharmacology
Endothelin B receptor agonist, IRL-1620, provides long-term neuroprotection in cerebral ischemia in rats
Mary G. Leonard, Seema Briyal, Anil Gulati · 2012 · Brain Research
Endothelin and neural crest development.
Hiroki Kurihara, Yukiko Kurihara, R Nagai · 1999 · PubMed
Novel Selective Quinazoline Inhibitors of Endothelin Converting Enzyme-1
Kyunghye Ahn, Andre M. Sisneros, Sarah B. Herman et al. · 1998 · Biochemical and Biophysical Research Communications
Time- and pressure-dependent changes in blood-brain barrier permeability after temporary middle cerebral artery occlusion in rats
Daniel J. Cole, Jerry S. Matsumura, John C. Drummond · 1991 · Acta Neuropathologica
Endothelin1 activates and sensitizes human C-nociceptors
Barbara Namer, Marita Hilliges, Kristin Ørstavik · 2007 · Pain
Myocardial, Smooth Muscle, Nephron, and Collecting Duct Gene Targeting Reveals the Organ Sites of Endothelin A Receptor Antagonist Fluid Retention
Deborah Stuart, Mark Chapman, Sara Rees · 2013 · Journal of Pharmacology and Experimental Therapeutics
Sex Differences in Renal Medullary Endothelin Receptor Function in Angiotensin II Hypertensive Rats
Wararat Kittikulsuth, Jennifer S. Pollock, David M. Pollock · 2011 · Hypertension
Differential distribution of endothelin peptides and receptors in human adrenal gland
Anthony P. Davenport, Sarah L. Hoskins, Rhoda E. Kuc, Christopher Plumpton · 1996 · The Histochemical Journal
Coordinated Upregulation of the Cardiac Endothelin System in a Rat Model of Heart Failure
Pierre Picard, Paula Smith, Juan Carlos Monge · 1998 · Journal of Cardiovascular Pharmacology
Endothelin receptors in the human coronary artery, ventricle and atrium
Willem A. Bax, Anne T. Bruinvels, Robert‐Jan van Suylen · 1993 · Naunyn-Schmiedeberg s Archives of Pharmacology
In vitro characterisation of Ro 46‐8443, the first non‐peptide antagonist selective for the endothelin ETB receptor
Volker Breu, Martine Clozel, Kaspar F. Burri · 1996 · FEBS Letters
Plasma Endothelin Levels and Blood Pressure in Hemodialysis and in Capd Patients. Effect of Subcutaneous Erythropoietin Replacement Therapy
Marcel Lebel, John H. Grose, Iris Kingma · 1994 · Clinical and Experimental Hypertension
Endothelin-1 potentiation of angiotensin II stimulation of aldosterone production
Eduardo N. Cozza, Shirley Chiou, Celso E. Gómez-Sánchez · 1992 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Species differences in the binding characteristics of [125I]IRL-1620, a potent agonist specific for endothelin-B receptors.
Ponnal Nambi, M Pullen, W. S. Spielman · 1994 · Journal of Pharmacology and Experimental Therapeutics
Effect of single doses of SLV306, an inhibitor of both neutral endopeptidase and endothelin-converting enzyme, on pulmonary pressures in congestive heart failure
Kenneth Dickstein, Hanka J. de Voogd, Milutin Mirić, Roland Willenbrock, Veselin L. Mitrović, Richard Pacher, P. Koopman · 2004 · The American Journal of Cardiology
Vascular gene expression in mice overexpressing human endothelin-1 targeted to the endothelium
Stefania Simeone, Melissa W. Li, Pierre Paradis · 2010 · Physiological Genomics
[125I]‐PD151242: a selective ligand for endothelin ETA receptors in human kidney which localizes to renal vasculature
Anthony P. Davenport, Rhoda E. Kuc, Sarah L. Hoskins · 1994 · British Journal of Pharmacology
Effects of bosentan (Ro 47–0203), an ETA‐, ETB‐receptor antagonist, on regional haemodynamic responses to endothelins in conscious rats
Sheila Margaret Gardiner, P.A. Kemp, Julie E. March · 1994 · British Journal of Pharmacology
NOS1-dependent negative feedback regulation of the epithelial sodium channel in the collecting duct
Kelly A. Hyndman, Vladislav Bugaj, Elena Mironova · 2014 · American Journal of Physiology-Renal Physiology
Effect on blood pressure of combined inhibition of endothelin-converting enzyme and neutral endopeptidase with daglutril in patients with type 2 diabetes who have albuminuria: a randomised, crossover, double-blind, placebo-controlled trial
Aneliya Ilieva Parvanova, Irene M. van der Meer, Ilian Petrov Iliev, Annalisa Perna, Flavio Gaspari, Roberto Trevisan, Antonio Carlo Bossi, Giuseppe Remuzzi, Ariela Benigni, Piero Luigi Ruggenenti · 2013 · The Lancet Diabetes & Endocrinology
Endothelin‐1 induces vasodilation in human skin by nociceptor fibres and release of nitric oxide
René R. Wenzel, Stefan Zbinden, Georg Noll · 1998 · British Journal of Clinical Pharmacology
G protein–coupled receptor modulation with pepducins: moving closer to the clinic
Patricia Fitzpatrick Dimond, Kenneth E. Carlson, Michel Bouvier, Craig J Gerard, Lei Xu, Lidija Covic, Anika Agarwal, Oliver P. Ernst, Jay M. Janz, Thue Walter Schwartz et al. · 2011 · Annals of the New York Academy of Sciences
Different pharmacological profiles of big‐endothelin‐3 and big‐endothelin‐1 in vivo and in vitro
Pedro D’Orléans-Juste, Sabine Télémaque, Audrey Claing · 1991 · British Journal of Pharmacology
Perinatal hypoxia-/ischemia-induced endothelin-1 mRNA in astrocyte-like and endothelial cells
Margaret C. S. Tsang, Acy Lo, Pik To Cheung · 2001 · Neuroreport
Endothelin receptor antagonism and cancer
A. Bhalla, Samer‐ul Haque, I Taylor · 2009 · European Journal of Clinical Investigation
[3H]BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype
Masaki Ihara, Rie Yamanaka, Kenji Ohwaki · 1995 · European Journal of Pharmacology
Endothelin receptor antagonism in patients with chronic heart failure
Michael P. Love · 2000 · Cardiovascular Research
Endothelin-Converting Enzyme/Neutral Endopeptidase Inhibitor SLV338 Prevents Hypertensive Cardiac Remodeling in a Blood Pressure–Independent Manner
Philipp Kalk, Yuliya Sharkovska, Elena V. Kashina et al. · 2011 · Hypertension